This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] See more...

Aliases for CRMP1 Gene

Aliases for CRMP1 Gene

  • Collapsin Response Mediator Protein 1 2 3 4 5
  • Dihydropyrimidinase-Related Protein 1 3 4
  • Inactive Dihydropyrimidinase 3 4
  • Unc-33-Like Phosphoprotein 3 3 4
  • CRMP-1 3 4
  • DPYSL1 3 4
  • ULIP-3 3 4
  • DRP-1 3 4
  • Dihydropyrimidinase-Like 1 3
  • ULIP3 4
  • DRP1 3

External Ids for CRMP1 Gene

Previous GeneCards Identifiers for CRMP1 Gene

  • GC04M005704
  • GC04P005871
  • GC04M005815
  • GC04M005887
  • GC04M005940

Summaries for CRMP1 Gene

Entrez Gene Summary for CRMP1 Gene

  • This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRMP1 Gene

CRMP1 (Collapsin Response Mediator Protein 1) is a Protein Coding gene. Diseases associated with CRMP1 include Chromosome 1P32-P31 Deletion Syndrome. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot Summary for CRMP1 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413).

Gene Wiki entry for CRMP1 Gene

Additional gene information for CRMP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRMP1 Gene

Genomics for CRMP1 Gene

GeneHancer (GH) Regulatory Elements for CRMP1 Gene

Promoters and enhancers for CRMP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J005886 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 521.9 +5.4 5385 2.6 EP300 ZBTB10 SAP30 KLF7 MXI1 ZNF341 EZH2 SP2 ZNF263 YY1 CRMP1 lnc-EVC-2
GH04J005893 Promoter 1.1 EPDnew Ensembl 518.5 +0.2 185 1.4 MXI1 EZH2 SMC3 POLR2A RNF2 CTCF PBX3 BCL3 SUZ12 RBBP5 CRMP1 lnc-EVC-2
GH04J006687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.5 -799.6 -799627 9.9 EP300 FOXK2 ZNF217 TCF12 POLR2G NCOR1 GTF2E2 JUND FOS ZFX S100P ENSG00000279859 HSALNG0032647 LINC02481 BLOC1S4 ENSG00000170846 CRMP1 MRFAP1 MRFAP1L1 LINC02482
GH04J005889 Promoter/Enhancer 1 Ensembl ENCODE 20.8 +2.5 2533 1.7 EP300 NRF1 MYC USF1 REST SAP30 MXI1 ZNF341 MIER1 HDAC2 CRMP1 lnc-EVC-2
GH04J006806 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 13.5 -914.3 -914330 2.5 LEF1 NCOR1 ZNF316 NFE2 FOSL1 EHMT2 MNT NFE2L1 TAL1 HDAC2 KIAA0232 CRMP1 MRFAP1 MRFAP1L1 TBC1D14 TADA2B piR-31534-504 lnc-KIAA0232-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRMP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRMP1

Top Transcription factor binding sites by QIAGEN in the CRMP1 gene promoter:
  • E47
  • MyoD
  • NRSF form 1
  • NRSF form 2
  • Tal-1beta

Genomic Locations for CRMP1 Gene

Genomic Locations for CRMP1 Gene
chr4:5,748,084-5,893,086
(GRCh38/hg38)
Size:
145,003 bases
Orientation:
Minus strand
chr4:5,749,811-5,894,785
(GRCh37/hg19)
Size:
144,975 bases
Orientation:
Minus strand

Genomic View for CRMP1 Gene

Genes around CRMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRMP1 Gene

Proteins for CRMP1 Gene

  • Protein details for CRMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14194-DPYL1_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 1
    Protein Accession:
    Q14194
    Secondary Accessions:
    • A0EJG6
    • Q13024
    • Q4W5F1
    • Q96TC8

    Protein attributes for CRMP1 Gene

    Size:
    572 amino acids
    Molecular mass:
    62184 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts with PLXNA1 (By similarity). Interacts with FLNA (via calponin-homology (CH) domain 1 and filamin repeat 24); the interaction alters FLNA ternary structure and thus promotes FLNA dissociation from F-actin (PubMed:25358863).

    Three dimensional structures from OCA and Proteopedia for CRMP1 Gene

    Alternative splice isoforms for CRMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRMP1 Gene

Post-translational modifications for CRMP1 Gene

  • Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRMP1 Gene

No data available for DME Specific Peptides for CRMP1 Gene

Domains & Families for CRMP1 Gene

Gene Families for CRMP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRMP1 Gene

Blocks:
  • Amidohydrolase-like
  • Dihydroorotase region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRMP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ37406 fis, clone BRAMY2028282, highly similar to Dihydropyrimidinase-related protein 1 (B3KT07_HUMAN)
  • Unc-33-like phosphoprotein 3 (DPYL1_HUMAN)
  • CRMP1 protein (Q96I11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14194

UniProtKB/Swiss-Prot:

DPYL1_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with CRMP1: view

Function for CRMP1 Gene

Molecular function for CRMP1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413).

Phenotypes From GWAS Catalog for CRMP1 Gene

Gene Ontology (GO) - Molecular Function for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 NOT dihydropyrimidinase activity IBA 21873635
GO:0005515 protein binding IPI 15383276
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA 21873635
genes like me logo Genes that share ontologies with CRMP1: view
genes like me logo Genes that share phenotypes with CRMP1: view

Animal Models for CRMP1 Gene

MGI Knock Outs for CRMP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRMP1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRMP1 Gene

Localization for CRMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRMP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cell projection, growth cone. Cytoplasm, cytoskeleton. Perikaryon. Note=Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250 UniProtKB:P97427, ECO:0000269 PubMed:11562390}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRMP1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with CRMP1: view

Pathways & Interactions for CRMP1 Gene

PathCards logo

SuperPathways for CRMP1 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Semaphorin interactions
3 Guidance Cues and Growth Cone Motility
-
4 Semaphorin Signaling
-
genes like me logo Genes that share pathways with CRMP1: view

Pathways by source for CRMP1 Gene

2 Qiagen pathways for CRMP1 Gene
  • Guidance Cues and Growth Cone Motility
  • Semaphorin Signaling

SIGNOR curated interactions for CRMP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0006208 NOT pyrimidine nucleobase catabolic process IBA 21873635
GO:0007399 nervous system development TAS,IEA 8973361
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with CRMP1: view

Drugs & Compounds for CRMP1 Gene

No Compound Related Data Available

Transcripts for CRMP1 Gene

mRNA/cDNA for CRMP1 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CRMP1 Gene

GeneLoc Exon Structure for
CRMP1

Expression for CRMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRMP1 Gene

This gene is overexpressed in Fetal Brain (37.3), Brain (11.3), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRMP1 Gene



Protein tissue co-expression partners for CRMP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRMP1

SOURCE GeneReport for Unigene cluster for CRMP1 Gene:

Hs.135270

mRNA Expression by UniProt/SwissProt for CRMP1 Gene:

Q14194-DPYL1_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for CRMP1 Gene

  • Nervous system(5)
  • Eye(4.6)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with CRMP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRMP1 Gene

Orthologs for CRMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRMP1 31 30
  • 99.51 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRMP1 31
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRMP1 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRMP1 31 30
  • 91.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRMP1 31 30
  • 91.16 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crmp1 17 31 30
  • 89.26 (n)
rat
(Rattus norvegicus)
Mammalia Crmp1 30
  • 88.13 (n)
chicken
(Gallus gallus)
Aves CRMP1B 31
  • 87 (a)
OneToOne
CRMP1 30
  • 81.75 (n)
lizard
(Anolis carolinensis)
Reptilia CRMP1 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crmp1 30
  • 75.11 (n)
zebrafish
(Danio rerio)
Actinopterygii crmp1 31 30
  • 72.87 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 32
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-2 32
  • 48 (a)
dhp-1 32
  • 46 (a)
unc-33 32
  • 32 (a)
Species where no ortholog for CRMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRMP1 Gene

ENSEMBL:
Gene Tree for CRMP1 (if available)
TreeFam:
Gene Tree for CRMP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRMP1: view image

Paralogs for CRMP1 Gene

Paralogs for CRMP1 Gene

(5) SIMAP similar genes for CRMP1 Gene using alignment to 4 proteins:

  • DPYL1_HUMAN
  • B3KT07_HUMAN
  • E9PD68_HUMAN
  • Q96I11_HUMAN
genes like me logo Genes that share paralogs with CRMP1: view

Variants for CRMP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRMP1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
711907 Benign: not provided 5,843,169(-) A/G INTRON_VARIANT
712545 Benign: not provided 5,825,642(-) C/G SYNONYMOUS_VARIANT
732507 Benign: not provided 5,836,819(-) G/C SYNONYMOUS_VARIANT
744151 Benign: not provided 5,856,264(-) A/C SYNONYMOUS_VARIANT
750183 Likely Benign: not provided 5,835,954(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CRMP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRMP1 Gene

Variant ID Type Subtype PubMed ID
dgv2923e59 CNV duplication 20981092
dgv311e215 CNV deletion 23714750
esv2279377 CNV deletion 18987734
esv2678074 CNV deletion 23128226
esv2726978 CNV deletion 23290073
esv2726979 CNV deletion 23290073
esv29375 CNV gain+loss 19812545
esv34196 OTHER inversion 12058347
esv7115 CNV loss 19470904
nsv1073298 CNV deletion 25765185
nsv1125797 CNV tandem duplication 24896259
nsv1126678 CNV deletion 24896259
nsv1153630 CNV insertion 26484159
nsv293630 CNV deletion 16902084
nsv822449 CNV gain 20364138
nsv829844 CNV gain 17160897
nsv829845 CNV loss 17160897
nsv949775 CNV deletion 24416366
nsv954403 CNV deletion 24416366

Variation tolerance for CRMP1 Gene

Residual Variation Intolerance Score: 8.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRMP1 Gene

Human Gene Mutation Database (HGMD)
CRMP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRMP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRMP1 Gene

Disorders for CRMP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRMP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1p32-p31 deletion syndrome
  • 1p31p32 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CRMP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRMP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRMP1 Gene

Publications for CRMP1 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 4 23 54
  2. Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients. (PMID: 19362386) Pan SH … Yang PC (Lung cancer (Amsterdam, Netherlands) 2010) 3 4 23 54
  3. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PMID: 11562390) Shih JY … Yang PC (Journal of the National Cancer Institute 2001) 3 4 23 54
  4. Genomic organization and localization of the human CRMP-1 gene. (PMID: 10048489) Torres R … Polymeropoulos MH (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 23 54
  5. Structure of human collapsin response mediator protein 1: a possible role of its C-terminal tail. (PMID: 26249678) Liu SH … Lin YH (Acta crystallographica. Section F, Structural biology communications 2015) 3 4 54

Products for CRMP1 Gene

Sources for CRMP1 Gene