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Aliases for CRLF2 Gene

Aliases for CRLF2 Gene

  • Cytokine Receptor Like Factor 2 2 3 5
  • Thymic Stromal Lymphopoietin Protein Receptor 3 4
  • Cytokine Receptor-Like Factor 2 3 4
  • TSLP Receptor 3 4
  • IL-XR 3 4
  • TSLPR 3 4
  • CRL2 3 4
  • Thymic Stromal-Derived Lymphopoietin Receptor 3
  • Cytokine Receptor CRL2 Precusor 3
  • Cytokine Receptor-Like 2 4
  • CRLF2Y 3
  • ILXR 4

External Ids for CRLF2 Gene

Previous GeneCards Identifiers for CRLF2 Gene

  • GC00U990849
  • GC0YU900015
  • GC0XM9W0034
  • GC0XP9W0020

Summaries for CRLF2 Gene

Entrez Gene Summary for CRLF2 Gene

  • This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

CIViC summary for CRLF2 Gene

GeneCards Summary for CRLF2 Gene

CRLF2 (Cytokine Receptor Like Factor 2) is a Protein Coding gene. Diseases associated with CRLF2 include Lymphoblastic Leukemia, Acute, With Lymphomatous Features and Down Syndrome. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Th2 Differentiation Pathway. An important paralog of this gene is IL6ST.

UniProtKB/Swiss-Prot for CRLF2 Gene

  • Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

Gene Wiki entry for CRLF2 Gene

Additional gene information for CRLF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRLF2 Gene

Genomics for CRLF2 Gene

GeneHancer (GH) Regulatory Elements for CRLF2 Gene

Promoters and enhancers for CRLF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ001212 Promoter 1.1 Ensembl 600.7 +0.3 314 0.6 SP1 CREM MLLT1 IKZF1 ZNF600 BACH1 IKZF2 ZNF639 TRIM22 ZNF629 CRLF2 RPL14P5
GH0XJ001239 Enhancer 0.8 FANTOM5 3.7 -27.0 -27031 0.3 SP1 ZNF687 CREM MLLT1 IKZF1 BACH1 IKZF2 CBFB DPF2 EED CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT SLC25A6 P2RY8
GH0XJ001249 Promoter/Enhancer 1.3 EPDnew FANTOM5 2.1 -36.8 -36838 0.4 ELF3 ZNF121 SP1 REST POLR2A GABPA ETV6 OSR2 MAX MXI1 CSF2RA IL3RA ASMTL AKAP17A P2RY8 ASMT CRLF2 SLC25A6
GH0XJ001247 Enhancer 0.6 FANTOM5 4.1 -35.8 -35813 0.5 ZNF652 PRDM10 POLR2A CHD2 SP1 TCF7L2 CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT SLC25A6 P2RY8
GH0XJ001505 Enhancer 1.1 FANTOM5 dbSUPER 2.4 -292.5 -292515 0.1 ZFX ZNF687 BACH1 TRIM24 SP1 ZNF639 SMARCA4 MTA1 CAVIN1 ATF1 AKAP17A CSF2RA IL3RA ASMTL P2RY8 ASMT CRLF2 SLC25A6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRLF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CRLF2 Gene

Genomic Locations for CRLF2 Gene
chrX:1,190,449-1,212,815
(GRCh38/hg38)
Size:
22,367 bases
Orientation:
Minus strand
chrX:1,314,869-1,331,616
(GRCh37/hg19)
Size:
16,748 bases
Orientation:
Minus strand

Genomic View for CRLF2 Gene

Genes around CRLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRLF2 Gene

Proteins for CRLF2 Gene

  • Protein details for CRLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC73-CRLF2_HUMAN
    Recommended name:
    Cytokine receptor-like factor 2
    Protein Accession:
    Q9HC73
    Secondary Accessions:
    • J3QKD1
    • Q5G7M1
    • Q9H5R3

    Protein attributes for CRLF2 Gene

    Size:
    371 amino acids
    Molecular mass:
    42013 Da
    Quaternary structure:
    • Heterodimer of CRLF2 and IL7R.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Three dimensional structures from OCA and Proteopedia for CRLF2 Gene

    Alternative splice isoforms for CRLF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRLF2 Gene

Post-translational modifications for CRLF2 Gene

  • Glycosylation at isoforms=3169, isoforms=255, isoforms=2101, and isoforms=247
  • Modification sites at PhosphoSitePlus

Assay Products

  • Abcam assays for CRLF2

No data available for DME Specific Peptides for CRLF2 Gene

Domains & Families for CRLF2 Gene

Gene Families for CRLF2 Gene

Protein Domains for CRLF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRLF2 Gene

GenScript: Design optimal peptide antigens:
  • Thymic stromal lymphopoietin protein receptor (CRLF2_HUMAN)
  • Thymic stromal-derived lymphopoietin receptor transcript variant 2 (Q5G7M1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HC73

UniProtKB/Swiss-Prot:

CRLF2_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is important for association with JAKs.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with CRLF2: view

Function for CRLF2 Gene

Molecular function for CRLF2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
UniProtKB/Swiss-Prot Induction:
Up-regulated in activated peripheral monocytes and THP-1 cells.

Phenotypes From GWAS Catalog for CRLF2 Gene

Gene Ontology (GO) - Molecular Function for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IMP 17242164
GO:0005515 protein binding IEA --
GO:0019955 cytokine binding IBA 21873635
genes like me logo Genes that share ontologies with CRLF2: view
genes like me logo Genes that share phenotypes with CRLF2: view

Animal Models for CRLF2 Gene

MGI Knock Outs for CRLF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRLF2

CRISPR Products

miRNA for CRLF2 Gene

miRTarBase miRNAs that target CRLF2

Clone Products

  • Applied Biological Materials (abm): Clones for CRLF2 - Now 50% OFF >
  • * CRLF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CRLF2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRLF2 Gene

Localization for CRLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRLF2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRLF2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRLF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRLF2 Gene

Pathways & Interactions for CRLF2 Gene

genes like me logo Genes that share pathways with CRLF2: view

Pathways by source for CRLF2 Gene

SIGNOR curated interactions for CRLF2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 11418668
GO:0019221 cytokine-mediated signaling pathway IDA 11418668
GO:0033005 positive regulation of mast cell activation IMP 17242164
GO:0038111 interleukin-7-mediated signaling pathway TAS --
GO:1904894 positive regulation of STAT cascade IDA 11418668
genes like me logo Genes that share ontologies with CRLF2: view

Drugs & Compounds for CRLF2 Gene

(1) Drugs for CRLF2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N/A Pharma inhibitor 0
genes like me logo Genes that share compounds with CRLF2: view

Transcripts for CRLF2 Gene

mRNA/cDNA for CRLF2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CRLF2 Gene

Cytokine receptor-like factor 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CRLF2 - Now 50% OFF >
  • * CRLF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CRLF2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CRLF2 Gene

No ASD Table

Relevant External Links for CRLF2 Gene

GeneLoc Exon Structure for
CRLF2
ECgene alternative splicing isoforms for
CRLF2

Expression for CRLF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRLF2 Gene

Protein differential expression in normal tissues from HIPED for CRLF2 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRLF2 Gene



Protein tissue co-expression partners for CRLF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRLF2 Gene:

CRLF2

SOURCE GeneReport for Unigene cluster for CRLF2 Gene:

Hs.287729

mRNA Expression by UniProt/SwissProt for CRLF2 Gene:

Q9HC73-CRLF2_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

Evidence on tissue expression from TISSUES for CRLF2 Gene

  • Blood(4.4)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with CRLF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRLF2 Gene

Orthologs for CRLF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRLF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRLF2 34
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia CRLF2 35 34
  • 71.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC529792 34
  • 67.86 (n)
CRLF2 35
  • 37 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crlf2 17 35 34
  • 50.1 (n)
rat
(Rattus norvegicus)
Mammalia Crlf2 34
  • 49.23 (n)
oppossum
(Monodelphis domestica)
Mammalia CRLF2 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRLF2 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC418668 34
  • 49.11 (n)
CRLF2 35
  • 25 (a)
OneToOne
Species where no ortholog for CRLF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRLF2 Gene

ENSEMBL:
Gene Tree for CRLF2 (if available)
TreeFam:
Gene Tree for CRLF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRLF2: view image

Paralogs for CRLF2 Gene

(2) SIMAP similar genes for CRLF2 Gene using alignment to 3 proteins:

  • CRLF2_HUMAN
  • J3QKD1_HUMAN
  • Q4V300_HUMAN
genes like me logo Genes that share paralogs with CRLF2: view

Variants for CRLF2 Gene

Sequence variations from dbSNP and Humsavar for CRLF2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057519743 pathogenic, Lymphoblastic leukemia, acute, with lymphomatous features 1,196,852(-) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs138899368 not-provided, not specified 1,202,479(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs151218732 not-provided, not specified 1,196,817(-) C/G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs200254974 not-provided, not specified 1,198,571(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs587778218 not-provided, not specified 1,206,513(-) T/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRLF2 Gene

Variant ID Type Subtype PubMed ID
esv21933 CNV gain+loss 19812545
esv2739631 CNV deletion 23290073
esv2739633 CNV deletion 23290073
esv2739634 CNV deletion 23290073
esv29996 CNV loss 17803354
esv3558469 CNV deletion 23714750
nsv1077569 CNV duplication 25765185
nsv1115919 CNV duplication 24896259
nsv1126938 CNV deletion 24896259
nsv1126959 CNV deletion 24896259
nsv953389 CNV deletion 24416366

Variation tolerance for CRLF2 Gene

Gene Damage Index Score: 1.93; 35.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRLF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRLF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRLF2 Gene

Disorders for CRLF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRLF2 Gene - From: ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CRLF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRLF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRLF2 Gene

Publications for CRLF2 Gene

  1. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. (PMID: 11237741) Zhang W … Cao X (Biochemical and biophysical research communications 2001) 2 3 4 23 58
  2. Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. (PMID: 11474172) Tonozuka Y … Kitamura T (Cytogenetics and cell genetics 2001) 2 3 4 23 58
  3. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. (PMID: 19965641) Hertzberg L … Izraeli S (Blood 2010) 3 23 58
  4. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. (PMID: 20128689) Wohlmann A … Friedrich K (Biological chemistry 2010) 3 23 58
  5. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. (PMID: 20236697) Semlali A … Chakir J (The Journal of allergy and clinical immunology 2010) 3 23 58

Products for CRLF2 Gene

Sources for CRLF2 Gene

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