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This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid. Among its related pathways are JNK signaling in the CD4+ TCR pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005070 | SH3/SH2 adaptor activity | TAS | -- |
GO:0005515 | protein binding | IPI | 8626543 |
GO:0042802 | identical protein binding | IPI | 17161365 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0031594 | neuromuscular junction | IEA | -- |
GO:0032991 | protein-containing complex | IEA | -- |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling | ||
2 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Development Neurotrophin family signaling
.44
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3 | MET promotes cell motility |
.45
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|
4 | Kit receptor signaling pathway | ||
5 | ErbB signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | TAS | -- |
GO:0000187 | activation of MAPK activity | IEA | -- |
GO:0001558 | regulation of cell growth | IEA | -- |
GO:0001568 | blood vessel development | IEA | -- |
GO:0001655 | urogenital system development | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRKL 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CRKL 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crkl 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CRKL 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crkl 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CRKL 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CRKL 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CRKL 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crkl 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | crkl 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Crk 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ced-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
733871 | Likely Benign: not provided | 20,934,166(+) | A/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
735924 | Likely Benign: not provided | 20,918,183(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
740575 | Likely Benign: not provided | 20,949,722(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
756908 | Likely Benign: not provided | 20,934,001(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
770308 | Benign: not provided | 20,934,128(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4483n100 | CNV | gain | 25217958 |
dgv4484n100 | CNV | gain | 25217958 |
dgv4485n100 | CNV | gain | 25217958 |
dgv7993n54 | CNV | gain | 21841781 |
dgv7994n54 | CNV | gain | 21841781 |
esv2678175 | CNV | deletion | 23128226 |
esv2763693 | CNV | gain | 21179565 |
esv3647304 | CNV | loss | 21293372 |
esv3647305 | CNV | gain | 21293372 |
esv3893441 | CNV | gain+loss | 25118596 |
nsv1056614 | CNV | loss | 25217958 |
nsv1065617 | CNV | gain | 25217958 |
nsv1066625 | CNV | gain | 25217958 |
nsv1123578 | CNV | deletion | 24896259 |
nsv436864 | CNV | insertion | 17901297 |
nsv523162 | CNV | loss | 19592680 |
nsv588305 | CNV | loss | 21841781 |
nsv834140 | CNV | loss | 17160897 |
nsv834141 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 22q11.2 deletion syndrome, distal |
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leukemia, chronic myeloid |
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sarcoma |
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papillary thyroid microcarcinoma |
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digeorge syndrome |
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