Aliases for CRKL Gene
External Ids for CRKL Gene
Previous GeneCards Identifiers for CRKL Gene
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid. Among its related pathways are JNK signaling in the CD4+ TCR pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot Summary for CRKL Gene
May mediate the transduction of intracellular signals.