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This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] See more...
Aliases for CRKL Gene
Aliases for CRKL Gene
External Ids for CRKL Gene
- HGNC: 2363
- Entrez Gene: 1399
- Ensembl: ENSG00000099942
- OMIM: 602007
- UniProtKB: P46109
Previous GeneCards Identifiers for CRKL Gene
- GC22P017970
- GC22P019596
- GC22P021272
- GC22P004539
Summaries for CRKL Gene
-
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid. Among its related pathways are JNK signaling in the CD4+ TCR pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot Summary for CRKL Gene
-
May mediate the transduction of intracellular signals.
Additional gene information for CRKL Gene
- HGNC(2363)
- Entrez Gene(1399)
- Ensembl(ENSG00000099942)
- OMIM(602007)
- UniProtKB(P46109)
- Open Targets Platform(ENSG00000099942)
- Monarch Initiative
- Search for CRKL at DataMed
- Search for CRKL at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRKL Gene
Genomics for CRKL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRKL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRKL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRKL
- Top Transcription factor binding sites by QIAGEN in the CRKL gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- MRF-2
- PPAR-alpha
- STAT1
- STAT1alpha
- STAT1beta
- XBP-1
Genomic Locations for CRKL Gene
Genomic Locations for CRKL Gene
- chr22:20,917,407-20,953,747
- (GRCh38/hg38)
- Size:
- 36,341 bases
- Orientation:
- Plus strand
- chr22:21,271,714-21,308,037
- (GRCh37/hg19)
- Size:
- 36,324 bases
- Orientation:
- Plus strand
Genomic View for CRKL Gene
Genes around CRKL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
CRKL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRKL Gene
Proteins for CRKL Gene
-
Protein details for CRKL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46109-CRKL_HUMAN
- Recommended name:
- Crk-like protein
- Protein Accession:
- P46109
- A8KA44
- D3DX35
Protein attributes for CRKL Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33777 Da
- Quaternary structure:
-
- Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
Protein Expression for CRKL Gene
Post-translational modifications for CRKL Gene
Other Protein References for CRKL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Phospho-CrkL (Tyr207) Antibody
-
Custom Antibody ServicesOriGene Antibodies for CRKL
- Novus Biologicals Antibodies for CRKL
-
Abcam antibodies for CRKL
- Invitrogen Antibodies for CRKL (AFLGC-CRKL)
- antibodies-online: Show 100 available CrkL Antibodies ranked by validation data
- Compare Top CrkL Antibodies
-
Recommended
- 148 WB Antibodies (anti-human)
- 23 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 45 WB Antibodies (anti-rat)
- 23 IF (p) Antibodies (anti-rat)
- 3 ICS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 72 WB Antibodies (anti-mouse)
- 23 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for CRKL
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
- Sino Biological Antibodies for CRKL
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CRKL
- Origene Custom Protein Services for CRKL
- ProSpec Recombinant Proteins for CRKL
-
Abcam proteins for CRKL
No data available for DME Specific Peptides for CRKL Gene
Domains & Families for CRKL Gene
Gene Families for CRKL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CRKL Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- SH3 domain signature
- Variant SH3
- ProtoNet:
Suggested Antigen Peptide Sequences for CRKL Gene
- GenScript: Design optimal peptide antigens:
-
- Crk-like protein (CRKL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46109- Family:
-
- Belongs to the CRK family.
Function for CRKL Gene
Molecular function for CRKL Gene
- UniProtKB/Swiss-Prot Function:
- May mediate the transduction of intracellular signals.
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) related
Phenotypes From GWAS Catalog for CRKL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 8626543 |
| GO:0042802 | identical protein binding | IPI | 17161365 |
Phenotypes for CRKL Gene
- MGI mutant phenotypes for CRKL:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- mortality/aging
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CRKL:
-
- no effect
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased viability
- Reduced mammosphere formation
- Increased shRNA abundance
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
- Decreased viability in pancreas lineage
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRKL - Select products 50% OFF >
- * CRKL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
miRNA for CRKL Gene
- miRTarBase miRNAs that target CRKL
-
- hsa-miR-107 (MIRT004697)
- hsa-miR-15a-5p (MIRT006177)
- mmu-miR-425-5p (MIRT008634)
- mmu-miR-149-5p (MIRT014658)
- hsa-miR-126-3p (MIRT021281)
- hsa-miR-98-5p (MIRT027796)
- hsa-miR-32-5p (MIRT028306)
- hsa-miR-16-5p (MIRT031998)
- hsa-let-7b-5p (MIRT032482)
- hsa-miR-193b-5p (MIRT038006)
- hsa-miR-425-5p (MIRT039301)
- hsa-miR-23b-3p (MIRT046303)
- hsa-miR-29a-3p (MIRT049982)
- hsa-miR-5002-3p (MIRT087118)
- hsa-miR-6867-5p (MIRT087122)
- hsa-miR-31-3p (MIRT087125)
- hsa-miR-922 (MIRT087128)
- hsa-miR-3134 (MIRT087129)
- hsa-miR-3944-5p (MIRT087130)
- hsa-miR-4534 (MIRT087131)
- hsa-miR-1245b-3p (MIRT087132)
- hsa-miR-8082 (MIRT087133)
- hsa-miR-622 (MIRT254556)
- hsa-miR-3158-5p (MIRT254560)
- hsa-miR-650 (MIRT300559)
- hsa-miR-1827 (MIRT300560)
- hsa-miR-3612 (MIRT300561)
- hsa-miR-4459 (MIRT300562)
- hsa-miR-4695-5p (MIRT300563)
- hsa-miR-1252-5p (MIRT300569)
- hsa-miR-3908 (MIRT300570)
- hsa-miR-6770-5p (MIRT300571)
- hsa-miR-7112-5p (MIRT300572)
- hsa-miR-4290 (MIRT300590)
- hsa-miR-371b-3p (MIRT300592)
- hsa-miR-541-5p (MIRT329142)
- hsa-miR-3159 (MIRT329144)
- hsa-miR-5692c (MIRT329145)
- hsa-miR-5692b (MIRT329146)
- hsa-miR-7-5p (MIRT352289)
- hsa-miR-214-3p (MIRT367265)
- hsa-miR-15b-5p (MIRT367266)
- hsa-miR-195-5p (MIRT367267)
- hsa-miR-330-3p (MIRT367268)
- hsa-miR-424-5p (MIRT367269)
- hsa-miR-497-5p (MIRT367270)
- hsa-miR-761 (MIRT367272)
- hsa-miR-3065-5p (MIRT367274)
- hsa-miR-3619-5p (MIRT367276)
- hsa-miR-3529-3p (MIRT367278)
- hsa-miR-6165 (MIRT367279)
- hsa-miR-6838-5p (MIRT367281)
- hsa-miR-4433a-3p (MIRT478827)
- hsa-miR-17-3p (MIRT507625)
- hsa-miR-1205 (MIRT507626)
- hsa-miR-1184 (MIRT507627)
- hsa-miR-1253 (MIRT512082)
- hsa-miR-3667-5p (MIRT512083)
- hsa-let-7c-3p (MIRT524334)
- hsa-miR-873-5p (MIRT548708)
- hsa-miR-944 (MIRT567900)
- hsa-miR-340-5p (MIRT567901)
- hsa-miR-143-5p (MIRT567902)
- hsa-miR-1255b-5p (MIRT567903)
- hsa-miR-1255a (MIRT567904)
- hsa-miR-6744-5p (MIRT567905)
- hsa-miR-103a-3p (MIRT567906)
- hsa-miR-455-5p (MIRT567907)
- hsa-miR-1273g-3p (MIRT572879)
- mmu-miR-3100-5p (MIRT584121)
- mmu-miR-450b-3p (MIRT584123)
- mmu-miR-1953 (MIRT584124)
- mmu-miR-10b-5p (MIRT584125)
- mmu-miR-10a-5p (MIRT584126)
- mmu-miR-298-5p (MIRT605098)
- mmu-miR-3090-3p (MIRT605099)
- mmu-miR-384-3p (MIRT605100)
- mmu-miR-3057-3p (MIRT605101)
- mmu-miR-3082-5p (MIRT605102)
- mmu-miR-5113 (MIRT605103)
- hsa-miR-6736-5p (MIRT659350)
- hsa-miR-4701-3p (MIRT659351)
- hsa-miR-1262 (MIRT659352)
- hsa-miR-6720-5p (MIRT659353)
- hsa-miR-6512-3p (MIRT659354)
- hsa-miR-661 (MIRT659355)
- hsa-miR-4252 (MIRT659356)
- hsa-miR-5186 (MIRT659357)
- hsa-miR-4793-3p (MIRT659358)
- hsa-miR-766-3p (MIRT659359)
- hsa-miR-6742-3p (MIRT659360)
- hsa-miR-6849-3p (MIRT659361)
- hsa-miR-508-5p (MIRT659362)
- hsa-miR-665 (MIRT675982)
- hsa-miR-887-5p (MIRT675983)
- hsa-miR-6780a-5p (MIRT675984)
- hsa-miR-6779-5p (MIRT675985)
- hsa-miR-3689c (MIRT675986)
- hsa-miR-3689b-3p (MIRT675987)
- hsa-miR-3689a-3p (MIRT675988)
- hsa-miR-30b-3p (MIRT675989)
- hsa-miR-1273h-5p (MIRT675990)
- hsa-miR-6788-5p (MIRT675991)
- hsa-miR-30c-2-3p (MIRT675992)
- hsa-miR-30c-1-3p (MIRT675993)
- hsa-miR-203b-3p (MIRT675994)
- hsa-miR-7158-3p (MIRT675995)
- hsa-miR-6799-5p (MIRT675996)
- hsa-miR-6883-5p (MIRT675997)
- hsa-miR-6785-5p (MIRT675998)
- hsa-miR-4728-5p (MIRT675999)
- hsa-miR-149-3p (MIRT676000)
- hsa-miR-7106-5p (MIRT676001)
- hsa-miR-7160-5p (MIRT676002)
- hsa-miR-4722-5p (MIRT676003)
- hsa-miR-6884-5p (MIRT676004)
- hsa-miR-485-5p (MIRT676005)
- hsa-miR-4680-5p (MIRT676006)
- hsa-miR-4649-3p (MIRT676007)
- hsa-miR-3664-3p (MIRT676008)
- hsa-miR-4768-3p (MIRT676009)
- hsa-miR-5690 (MIRT676010)
- hsa-miR-4478 (MIRT676011)
- hsa-miR-4419b (MIRT676012)
- hsa-miR-3929 (MIRT676013)
- hsa-miR-940 (MIRT676014)
- hsa-miR-6893-5p (MIRT676015)
- hsa-miR-6808-5p (MIRT676016)
- hsa-miR-890 (MIRT676017)
- hsa-miR-510-5p (MIRT676018)
- hsa-miR-335-5p (MIRT734082)
- hsa-miR-320a (MIRT734134)
- hsa-miR-200b-3p (MIRT734346)
- hsa-miR-200c-3p (MIRT734347)
- hsa-miR-429 (MIRT734348)
- hsa-miR-125a-3p (MIRT736624)
- hsa-miR-203a-5p (MIRT738806)
- hsa-miR-218-1-3p (MIRT739041)
- hsa-miR-3692-3p (MIRT742527)
- hsa-miR-3934-5p (MIRT743094)
- hsa-miR-764 (MIRT759526)
- hsa-miR-876-3p (MIRT760358)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
Clone Products
- Applied Biological Materials (abm): Clones for CRKL - Select products 50% OFF >
- * CRKL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRKL Gene
Localization for CRKL Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031594 | neuromuscular junction | IEA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRKL Gene
Pathways & Interactions for CRKL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Development Neurotrophin family signaling
.44
|
|
| 3 | MET promotes cell motility |
.45
|
|
| 4 | Kit receptor signaling pathway | ||
| 5 | ErbB signaling pathway | ||
Pathways by source for CRKL Gene
21 BioSystems pathways for CRKL Gene
17 Reactome pathways for CRKL Gene
10 GeneGo (Thomson Reuters) pathways for CRKL Gene
- Chemotaxis CXCR4 signaling pathway
- Development EPO-induced Jak-STAT pathway
- Development EPO-induced MAPK pathway
- Development Flt3 signaling
- Development HGF signaling pathway
5 Qiagen pathways for CRKL Gene
- HGF Pathway
- Internalin Pathway
- JNK Pathway
- MAPK Family Pathway
- Rap1 Pathway
1 Cell Signaling Technology pathway for CRKL Gene
Interacting Proteins for CRKL Gene
Selected Interacting proteins:
P46109-CRKL_HUMAN
ENSP00000346300
for CRKL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRKL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0001655 | urogenital system development | IEA | -- |
Transcripts for CRKL Gene
mRNA/cDNA for CRKL Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354336 5342 nts (view in UCSC)
- ENST00000411769 2037 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRKL - Select products 50% OFF >
- * CRKL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
Clone Products
- Applied Biological Materials (abm): Clones for CRKL - Select products 50% OFF >
- * CRKL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
Relevant External Links for CRKL Gene
- GeneLoc Exon Structure for
- CRKL
Expression for CRKL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRKL Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRKL
SOURCE GeneReport for Unigene cluster for CRKL Gene:
Hs.5613Evidence on tissue expression from TISSUES for CRKL Gene
- Nervous system(4.5)
- Liver(4.5)
- Skin(4.5)
- Spleen(4.5)
- Blood(2.9)
- Bone marrow(2.8)
- Muscle(2.7)
- Kidney(2.7)
- Stomach(2.7)
- Heart(2.7)
- Intestine(2.5)
- Lymph node(2.4)
- Lung(2.2)
- Thyroid gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CRKL Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for CRKL
-
OriGene qPCR primer pairs and template standards for CRKL
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRKL Gene
Orthologs for CRKL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRKL 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRKL 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crkl 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRKL 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crkl 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRKL 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRKL 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRKL 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crkl 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | crkl 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Crk 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ced-2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 31 |
|
OneToMany |
- Species where no ortholog for CRKL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CRKL Gene
- ENSEMBL:
- Gene Tree for CRKL (if available)
- TreeFam:
- Gene Tree for CRKL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRKL: view image
Paralogs for CRKL Gene
Variants for CRKL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRKL Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 733871 | Likely Benign: not provided | 20,934,166(+) | A/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 735924 | Likely Benign: not provided | 20,918,183(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 740575 | Likely Benign: not provided | 20,949,722(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 756908 | Likely Benign: not provided | 20,934,001(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 770308 | Benign: not provided | 20,934,128(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4483n100 | CNV | gain | 25217958 |
| dgv4484n100 | CNV | gain | 25217958 |
| dgv4485n100 | CNV | gain | 25217958 |
| dgv7993n54 | CNV | gain | 21841781 |
| dgv7994n54 | CNV | gain | 21841781 |
| esv2678175 | CNV | deletion | 23128226 |
| esv2763693 | CNV | gain | 21179565 |
| esv3647304 | CNV | loss | 21293372 |
| esv3647305 | CNV | gain | 21293372 |
| esv3893441 | CNV | gain+loss | 25118596 |
| nsv1056614 | CNV | loss | 25217958 |
| nsv1065617 | CNV | gain | 25217958 |
| nsv1066625 | CNV | gain | 25217958 |
| nsv1123578 | CNV | deletion | 24896259 |
| nsv436864 | CNV | insertion | 17901297 |
| nsv523162 | CNV | loss | 19592680 |
| nsv588305 | CNV | loss | 21841781 |
| nsv834140 | CNV | loss | 17160897 |
| nsv834141 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.78;
16.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRKL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRKL Gene
Disorders for CRKL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 22q11.2 deletion syndrome, distal |
|
|
| leukemia, chronic myeloid |
|
|
| sarcoma |
|
|
| papillary thyroid microcarcinoma |
|
|
| digeorge syndrome |
|
|
Search CRKL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRKL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRKL Gene
Publications for CRKL Gene
- Isolation and chromosomal localization of CRKL, a human crk-like gene. (PMID: 8361759) ten Hoeve J … Groffen J (Oncogene 1993) 2 3 4 23
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 23
- DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PMID: 12393632) Nishihara H … Tanaka S (Blood 2002) 3 4 23
- CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PMID: 11443118) Arai A … Miura O (The Journal of biological chemistry 2001) 3 4 23
- Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PMID: 10022120) Elly C … Liu YC (Oncogene 1999) 3 4 23
ExternalLinks
Products for CRKL Gene
- Custom Antibody ServicesOriGene Antibodies for CRKL
- Browse OriGene ELISA Kits
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- OriGene qPCR primer pairs for CRKL
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- OriGene CRISPR knockouts for CRKL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRKL
- Sino Biological Human cDNA Clone for CRKL
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- VectorBuilder Custom and pre-made DNA vectors for CRKL (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for CRKL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CRKL
- Addgene plasmids for CRKL
- antibodies-online: Show 100 available CrkL Antibodies ranked by validation data
- Compare Top CrkL Antibodies
- Recommended
- 148 WB Antibodies (anti-human)
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- 45 WB Antibodies (anti-rat)
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- 3 ICS Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 23 available CrkL Elisa Kits ranked by validation data
- Compare Top CrkL Elisa Kits
- antibodies-online: Show 15 available CrkL Proteins ranked by validation data
- Compare Top CrkL Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
- Search Santa Cruz Biotechnology (SCBT) for CRKL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
- Signalway ELISA kits for CRKL
Sources for CRKL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
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- (57) Abcam
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
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- (148) RNACentral
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- (152) DiseaseEnhancer
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- (154) Biorbyt
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- (178) MirGeneDB