Aliases for CRKL Gene
Aliases for CRKL Gene
External Ids for CRKL Gene
- HGNC: 2363
- Entrez Gene: 1399
- Ensembl: ENSG00000099942
- OMIM: 602007
- UniProtKB: P46109
Previous GeneCards Identifiers for CRKL Gene
- GC22P017970
- GC22P019596
- GC22P021272
- GC22P004539
Summaries for CRKL Gene
-
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Chromosome 6Pter-P24 Deletion Syndrome. Among its related pathways are EGF/EGFR Signaling Pathway and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot for CRKL Gene
-
May mediate the transduction of intracellular signals.
Additional gene information for CRKL Gene
- Monarch Initiative
- Search for CRKL at DataMed
- Search for CRKL at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRKL Gene
Genomics for CRKL Gene
GeneHancer (GH) Regulatory Elements for CRKL Gene
Promoters and enhancers for CRKL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRKL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRKL gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- XBP-1
- MRF-2
- PPAR-alpha
- STAT1
- STAT1alpha
- STAT1beta
- AREB6
Regulatory Element Products
Genomic Locations for CRKL Gene
Genomic Locations for CRKL Gene
- chr22:20,917,398-20,953,749
- (GRCh38/hg38)
- Size:
- 36,352 bases
- Orientation:
- Plus strand
- chr22:21,271,714-21,308,037
- (GRCh37/hg19)
- Size:
- 36,324 bases
- Orientation:
- Plus strand
Genomic View for CRKL Gene
Genes around CRKL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
- 22q11.21 by Ensembl
CRKL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRKL Gene
Proteins for CRKL Gene
-
Protein details for CRKL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46109-CRKL_HUMAN
- Recommended name:
- Crk-like protein
- Protein Accession:
- P46109
- A8KA44
- D3DX35
Protein attributes for CRKL Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33777 Da
- Quaternary structure:
-
- Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
Protein Expression for CRKL Gene
Post-translational modifications for CRKL Gene
Other Protein References for CRKL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRKL (CrkL)
-
Custom Antibody ServicesOriGene Antibodies for CRKL
- Novus Biologicals Antibodies for CRKL
-
Abcam antibodies for CRKL
- Invitrogen Antibodies for CRKL (AFLGC-CRKL)
- antibodies-online: Search results for 189 available CrkL Antibodies ranked by validation data
- Compare Top CrkL Antibodies
-
Recommended
- 132 WB Antibodies (anti-human)
- 23 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 36 WB Antibodies (anti-rat)
- 23 IF (p) Antibodies (anti-rat)
- 3 ICS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 58 WB Antibodies (anti-mouse)
- 23 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- GeneTex CRKL Antibody for CRKL
-
Boster Bio Antibodies for CRKL
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
Protein Products
-
OriGene Purified Proteins for CRKL
- Search Origene for MassSpec and Protein Over-expression Lysates for CRKL
- Origene Custom Protein Services for CRKL
- ProSpec Recombinant Proteins for CRKL
- Search GeneTex for Proteins for CRKL
-
Abcam proteins for CRKL
Assay Products
No data available for DME Specific Peptides for CRKL Gene
Domains & Families for CRKL Gene
Gene Families for CRKL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CRKL Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRKL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46109- Family:
-
- Belongs to the CRK family.
Function for CRKL Gene
Molecular function for CRKL Gene
- UniProtKB/Swiss-Prot Function:
- May mediate the transduction of intracellular signals.
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) related
Phenotypes From GWAS Catalog for CRKL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004871 | obsolete signal transducer activity | TAS | -- |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | 8798523 |
| GO:0005515 | protein binding | IPI | 8626543 |
Phenotypes for CRKL Gene
- MGI mutant phenotypes for CRKL:
-
inferred from 3 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- nervous system phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CRKL:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- shRNA abundance <= 50%
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRKL
-
CRISPR Products
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
- genomics-online: gRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- Applied Biological Materials CRISPR for CRKL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
- GenScript: Design CRISPR guide RNA sequences for CRKL
miRNA for CRKL Gene
- miRTarBase miRNAs that target CRKL
-
- hsa-mir-107 (MIRT004697)
- hsa-mir-15a-5p (MIRT006177)
- hsa-mir-126-3p (MIRT021281)
- hsa-mir-98-5p (MIRT027796)
- hsa-mir-32-5p (MIRT028306)
- hsa-mir-16-5p (MIRT031998)
- hsa-let-7b-5p (MIRT032482)
- hsa-mir-193b-5p (MIRT038006)
- hsa-mir-425-5p (MIRT039301)
- hsa-mir-23b-3p (MIRT046303)
- hsa-mir-29a-3p (MIRT049982)
- hsa-mir-5002-3p (MIRT087118)
- hsa-mir-6867-5p (MIRT087122)
- hsa-mir-31-3p (MIRT087125)
- hsa-mir-922 (MIRT087128)
- hsa-mir-3134 (MIRT087129)
- hsa-mir-3944-5p (MIRT087130)
- hsa-mir-4534 (MIRT087131)
- hsa-mir-1245b-3p (MIRT087132)
- hsa-mir-8082 (MIRT087133)
- hsa-mir-622 (MIRT254556)
- hsa-mir-3158-5p (MIRT254560)
- hsa-mir-650 (MIRT300559)
- hsa-mir-1827 (MIRT300560)
- hsa-mir-3612 (MIRT300561)
- hsa-mir-4459 (MIRT300562)
- hsa-mir-4695-5p (MIRT300563)
- hsa-mir-1252-5p (MIRT300569)
- hsa-mir-3908 (MIRT300570)
- hsa-mir-6770-5p (MIRT300571)
- hsa-mir-7112-5p (MIRT300572)
- hsa-mir-4290 (MIRT300590)
- hsa-mir-371b-3p (MIRT300592)
- hsa-mir-541-5p (MIRT329142)
- hsa-mir-3159 (MIRT329144)
- hsa-mir-5692c (MIRT329145)
- hsa-mir-5692b (MIRT329146)
- hsa-mir-7-5p (MIRT352289)
- hsa-mir-214-3p (MIRT367265)
- hsa-mir-15b-5p (MIRT367266)
- hsa-mir-195-5p (MIRT367267)
- hsa-mir-330-3p (MIRT367268)
- hsa-mir-424-5p (MIRT367269)
- hsa-mir-497-5p (MIRT367270)
- hsa-mir-761 (MIRT367272)
- hsa-mir-3065-5p (MIRT367274)
- hsa-mir-3619-5p (MIRT367276)
- hsa-mir-3529-3p (MIRT367278)
- hsa-mir-6165 (MIRT367279)
- hsa-mir-6838-5p (MIRT367281)
- hsa-mir-4433a-3p (MIRT478827)
- hsa-mir-17-3p (MIRT507625)
- hsa-mir-1205 (MIRT507626)
- hsa-mir-1184 (MIRT507627)
- hsa-mir-1253 (MIRT512082)
- hsa-mir-3667-5p (MIRT512083)
- hsa-let-7c-3p (MIRT524334)
- hsa-mir-873-5p (MIRT548708)
- hsa-mir-944 (MIRT567900)
- hsa-mir-340-5p (MIRT567901)
- hsa-mir-143-5p (MIRT567902)
- hsa-mir-1255b-5p (MIRT567903)
- hsa-mir-1255a (MIRT567904)
- hsa-mir-6744-5p (MIRT567905)
- hsa-mir-103a-3p (MIRT567906)
- hsa-mir-455-5p (MIRT567907)
- hsa-mir-1273g-3p (MIRT572879)
- hsa-mir-6736-5p (MIRT659350)
- hsa-mir-4701-3p (MIRT659351)
- hsa-mir-1262 (MIRT659352)
- hsa-mir-6720-5p (MIRT659353)
- hsa-mir-6512-3p (MIRT659354)
- hsa-mir-661 (MIRT659355)
- hsa-mir-4252 (MIRT659356)
- hsa-mir-5186 (MIRT659357)
- hsa-mir-4793-3p (MIRT659358)
- hsa-mir-766-3p (MIRT659359)
- hsa-mir-6742-3p (MIRT659360)
- hsa-mir-6849-3p (MIRT659361)
- hsa-mir-508-5p (MIRT659362)
- hsa-mir-665 (MIRT675982)
- hsa-mir-887-5p (MIRT675983)
- hsa-mir-6780a-5p (MIRT675984)
- hsa-mir-6779-5p (MIRT675985)
- hsa-mir-3689c (MIRT675986)
- hsa-mir-3689b-3p (MIRT675987)
- hsa-mir-3689a-3p (MIRT675988)
- hsa-mir-30b-3p (MIRT675989)
- hsa-mir-1273h-5p (MIRT675990)
- hsa-mir-6788-5p (MIRT675991)
- hsa-mir-30c-2-3p (MIRT675992)
- hsa-mir-30c-1-3p (MIRT675993)
- hsa-mir-203b-3p (MIRT675994)
- hsa-mir-7158-3p (MIRT675995)
- hsa-mir-6799-5p (MIRT675996)
- hsa-mir-6883-5p (MIRT675997)
- hsa-mir-6785-5p (MIRT675998)
- hsa-mir-4728-5p (MIRT675999)
- hsa-mir-149-3p (MIRT676000)
- hsa-mir-7106-5p (MIRT676001)
- hsa-mir-7160-5p (MIRT676002)
- hsa-mir-4722-5p (MIRT676003)
- hsa-mir-6884-5p (MIRT676004)
- hsa-mir-485-5p (MIRT676005)
- hsa-mir-4680-5p (MIRT676006)
- hsa-mir-4649-3p (MIRT676007)
- hsa-mir-3664-3p (MIRT676008)
- hsa-mir-4768-3p (MIRT676009)
- hsa-mir-5690 (MIRT676010)
- hsa-mir-4478 (MIRT676011)
- hsa-mir-4419b (MIRT676012)
- hsa-mir-3929 (MIRT676013)
- hsa-mir-940 (MIRT676014)
- hsa-mir-6893-5p (MIRT676015)
- hsa-mir-6808-5p (MIRT676016)
- hsa-mir-890 (MIRT676017)
- hsa-mir-510-5p (MIRT676018)
- hsa-mir-335-5p (MIRT734082)
- hsa-mir-320a (MIRT734134)
- hsa-mir-200b-3p (MIRT734346)
- hsa-mir-200c-3p (MIRT734347)
- hsa-mir-429 (MIRT734348)
- hsa-mir-125a-3p (MIRT736624)
- hsa-mir-203a-5p (MIRT738806)
- hsa-mir-218-1-3p (MIRT739041)
- hsa-mir-3692-3p (MIRT742527)
- hsa-mir-3934-5p (MIRT743094)
- hsa-mir-764 (MIRT759526)
- hsa-mir-876-3p (MIRT760358)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
- genomics-online: shRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
Clone Products
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
- Applied Biological Materials Clones for CRKL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRKL Gene
Localization for CRKL Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| endosome | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 1 |
- Nucleoplasm (4)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRKL Gene
Pathways & Interactions for CRKL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway | ||
| 3 | MET promotes cell motility |
.45
|
|
| 4 | Kit receptor signaling pathway | ||
| 5 | ErbB signaling pathway | ||
Pathways by source for CRKL Gene
21 BioSystems pathways for CRKL Gene
17 Reactome pathways for CRKL Gene
15 KEGG pathways for CRKL Gene
10 GeneGo (Thomson Reuters) pathways for CRKL Gene
1 R&D Systems pathway for CRKL Gene
5 Qiagen pathways for CRKL Gene
1 Cell Signaling Technology pathway for CRKL Gene
Interacting Proteins for CRKL Gene
Selected Interacting proteins:
P46109-CRKL_HUMAN
ENSP00000346300
for CRKL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRKL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0007254 | JNK cascade | TAS | 8798523 |
| GO:0007265 | Ras protein signal transduction | TAS | 8798523 |
| GO:0007389 | pattern specification process | IEA | -- |
Transcripts for CRKL Gene
mRNA/cDNA for CRKL Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (362) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000354336 5325 bps (uc002ztf.2)
- ENST00000411769 2037 bps (uc062bvq.1)
Unigene Clusters for CRKL Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
- genomics-online: gRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- Applied Biological Materials CRISPR for CRKL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
- GenScript: Design CRISPR guide RNA sequences for CRKL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
- genomics-online: shRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
Clone Products
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
- Applied Biological Materials Clones for CRKL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CRKL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRKL Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CRKL Gene:
CRKLSOURCE GeneReport for Unigene cluster for CRKL Gene:
Hs.5613Evidence on tissue expression from TISSUES for CRKL Gene
- Nervous system(4.4)
- Liver(4.3)
- Spleen(4.3)
- Skin(4.2)
- Blood(2.6)
- Bone marrow(2.4)
- Heart(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CRKL Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for CRKL
-
OriGene qPCR primer pairs and template standards for CRKL
- genomics-online: primer clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRKL Gene
Orthologs for CRKL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRKL 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CRKL 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Crkl 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRKL 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Crkl 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRKL 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CRKL 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRKL 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crkl 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crkl 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Crk 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ced-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 34 |
|
OneToMany |
- Species where no ortholog for CRKL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CRKL Gene
- ENSEMBL:
- Gene Tree for CRKL (if available)
- TreeFam:
- Gene Tree for CRKL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRKL: view image
Paralogs for CRKL Gene
Variants for CRKL Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008362 | -- | 20,938,698(+) | T/C/G | intron_variant | |
| rs1000039785 | -- | 20,951,082(+) | T/G | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000065805 | -- | 20,944,975(+) | C/T | intron_variant | |
| rs1000164249 | -- | 20,932,543(+) | T/C | intron_variant | |
| rs1000177821 | -- | 20,934,730(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4483n100 | CNV | gain | 25217958 |
| dgv4484n100 | CNV | gain | 25217958 |
| dgv4485n100 | CNV | gain | 25217958 |
| dgv7993n54 | CNV | gain | 21841781 |
| dgv7994n54 | CNV | gain | 21841781 |
| esv2678175 | CNV | deletion | 23128226 |
| esv2763693 | CNV | gain | 21179565 |
| esv3647304 | CNV | loss | 21293372 |
| esv3647305 | CNV | gain | 21293372 |
| esv3893441 | CNV | gain+loss | 25118596 |
| nsv1056614 | CNV | loss | 25217958 |
| nsv1065617 | CNV | gain | 25217958 |
| nsv1066625 | CNV | gain | 25217958 |
| nsv1123578 | CNV | deletion | 24896259 |
| nsv436864 | CNV | insertion | 17901297 |
| nsv523162 | CNV | loss | 19592680 |
| nsv588305 | CNV | loss | 21841781 |
| nsv834140 | CNV | loss | 17160897 |
| nsv834141 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.78;
16.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRKL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRKL Gene
Disorders for CRKL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 22q11.2 deletion syndrome, distal |
|
|
| chromosome 6pter-p24 deletion syndrome |
|
|
| leukemia, chronic myeloid |
|
|
| sarcoma |
|
|
| papillary thyroid microcarcinoma |
|
|
Search CRKL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRKL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CRKL Gene
Publications for CRKL Gene
- Isolation and chromosomal localization of CRKL, a human crk-like gene. (PMID: 8361759) ten Hoeve J … Groffen J (Oncogene 1993) 2 3 4 22 58
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 22 58
- DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PMID: 12393632) Nishihara H … Tanaka S (Blood 2002) 3 4 22 58
- CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PMID: 11443118) Arai A … Miura O (The Journal of biological chemistry 2001) 3 4 22 58
- Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PMID: 10022120) Elly C … Liu YC (Oncogene 1999) 3 4 22 58
Products for CRKL Gene
- R&D Systems Antibodies for CRKL (CrkL)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CRKL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CRKL
- Search Origene for MassSpec and Protein Over-expression Lysates for CRKL
- Origene Custom Protein Services for CRKL
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- OriGene qPCR primer pairs for CRKL
- OriGene qPCR primer pairs and template standards for CRKL
- OriGene CRISPR knockouts for CRKL
- OriGene ORF clones in human for CRKL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRKL
- GenScript: Next-day shipping of latest version cDNA ORF clones for CRKL in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CRKL
- GenScript Custom Assay Services for CRKL
- GenScript Custom overexpressing Cell Line Services for CRKL
- GenScript: Design CRISPR guide RNA sequences for CRKL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CRKL
- Sino Biological Human cDNA Clone for CRKL
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CRKL
- Novus Biologicals proteins and lysates for CRKL
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRKL
- Abcam proteins for CRKL
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CRKL
- Invitrogen Antibodies for CRKL (AFLGC-CRKL)
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRKL
- Addgene plasmids for CRKL
- antibodies-online: Search results for 189 available CrkL Antibodies ranked by validation data
- Compare Top CrkL Antibodies
- Recommended
- 132 WB Antibodies (anti-human)
- 23 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 36 WB Antibodies (anti-rat)
- 23 IF (p) Antibodies (anti-rat)
- 3 ICS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 58 WB Antibodies (anti-mouse)
- 23 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for 20 available CrkL Elisa Kits ranked by validation data
- Compare Top CrkL Elisa Kits
- antibodies-online: Search results for 12 available CrkL Proteins ranked by validation data
- Compare Top CrkL Proteins
- GeneTex CRKL Antibody for CRKL
- Search GeneTex for Proteins for CRKL
- Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
- Search Santa Cruz Biotechnology (SCBT) for CRKL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
- genomics-online: cdna clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- orf clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- genomics-online: gRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- genomics-online: primer clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- genomics-online: shRNA clones - Search results for 125 available CrkL gene related products
- Overview of 125 available CrkL gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
- GeneCopoeia miRNA 3'UTR Target clone products for CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
- Boster Bio Antibodies for CRKL
- Browse Boster Bio ELISA Kits
Sources for CRKL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt