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This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] See more...
Aliases for CRKL Gene
Aliases for CRKL Gene
External Ids for CRKL Gene
- HGNC: 2363
- NCBI Entrez Gene: 1399
- Ensembl: ENSG00000099942
- OMIM®: 602007
- UniProtKB/Swiss-Prot: P46109
Previous GeneCards Identifiers for CRKL Gene
- GC22P017970
- GC22P019596
- GC22P021272
- GC22P004539
Summaries for CRKL Gene
-
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid. Among its related pathways are Development HGF signaling pathway and Regulation of signaling by CBL. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot Summary for CRKL Gene
-
May mediate the transduction of intracellular signals.
Additional gene information for CRKL Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRKL Gene
Genomics for CRKL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRKL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRKL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRKL
- Top Transcription factor binding sites by QIAGEN in the CRKL gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- MRF-2
- PPAR-alpha
- STAT1
- STAT1alpha
- STAT1beta
- XBP-1
Genomic Locations for CRKL Gene
Latest Assembly
- chr22:20,917,407-20,953,747
- (GRCh38/hg38)
- Size:
- 36,341 bases
- Orientation:
- Plus strand
Previous Assembly
- chr22:21,271,695-21,308,035
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 36,341 bases
- Orientation:
- Plus strand
Genomic View for CRKL Gene
Genes around CRKL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
CRKL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRKL Gene
Proteins for CRKL Gene
-
Protein details for CRKL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46109-CRKL_HUMAN
- Recommended name:
- Crk-like protein
- Protein Accession:
- P46109
- A8KA44
- D3DX35
Protein attributes for CRKL Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33777 Da
- Quaternary structure:
-
- Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
Protein Expression for CRKL Gene
Post-translational modifications for CRKL Gene
Other Protein References for CRKL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CRKL Antibody
- G Biosciences Immunotag™ Phospho-CrkL (Tyr207) Antibody
-
Custom Antibody ServicesOriGene Antibodies for CRKL
- Novus Biologicals Antibodies for CRKL
-
Abcam antibodies for CRKL
- Invitrogen Antibodies for CRKL (AFLGC-CRKL)
- antibodies-online: Show 100 available CrkL Antibodies ranked by validation data
- Compare Top CrkL Antibodies
-
Recommended
- 148 WB Antibodies (anti-human)
- 23 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 45 WB Antibodies (anti-rat)
- 23 IF (p) Antibodies (anti-rat)
- 3 ICS Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 72 WB Antibodies (anti-mouse)
- 23 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for CRKL
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
- Sino Biological Antibodies for CRKL
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CRKL
- Origene Custom Protein Services for CRKL
- ProSpec Recombinant Proteins for CRKL
-
Abcam proteins for CRKL
No data available for DME Specific Peptides for CRKL Gene
Domains & Families for CRKL Gene
Gene Families for CRKL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CRKL Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- SH3 domain signature
- Variant SH3
Suggested Antigen Peptide Sequences for CRKL Gene
- GenScript: Design optimal peptide antigens:
-
- Crk-like protein (CRKL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46109- Family:
-
- Belongs to the CRK family.
Function for CRKL Gene
Molecular function for CRKL Gene
- UniProtKB/Swiss-Prot Function:
- May mediate the transduction of intracellular signals.
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) related
Phenotypes From GWAS Catalog for CRKL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 8626543 |
| GO:0042802 | identical protein binding | IPI | 17161365 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
Phenotypes for CRKL Gene
- MGI mutant phenotypes for CRKL:
-
inferred from 4 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CRKL:
-
- Decreased viability
- shRNA abundance <= 50%
- Reduced mammosphere formation
- no effect
- Decreased viability ratio
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in pancreas lineage
- Increased shRNA abundance
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRKL - Starting at $85 >
- * CRKL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
miRNA for CRKL Gene
- miRTarBase miRNAs that target CRKL
-
- hsa-miR-107 (MIRT004697)
- hsa-miR-15a-5p (MIRT006177)
- mmu-miR-425-5p (MIRT008634)
- mmu-miR-149-5p (MIRT014658)
- hsa-miR-126-3p (MIRT021281)
- hsa-miR-98-5p (MIRT027796)
- hsa-miR-32-5p (MIRT028306)
- hsa-miR-16-5p (MIRT031998)
- hsa-let-7b-5p (MIRT032482)
- hsa-miR-193b-5p (MIRT038006)
- hsa-miR-425-5p (MIRT039301)
- hsa-miR-23b-3p (MIRT046303)
- hsa-miR-29a-3p (MIRT049982)
- hsa-miR-5002-3p (MIRT087118)
- hsa-miR-6867-5p (MIRT087122)
- hsa-miR-31-3p (MIRT087125)
- hsa-miR-922 (MIRT087128)
- hsa-miR-3134 (MIRT087129)
- hsa-miR-3944-5p (MIRT087130)
- hsa-miR-4534 (MIRT087131)
- hsa-miR-1245b-3p (MIRT087132)
- hsa-miR-8082 (MIRT087133)
- hsa-miR-622 (MIRT254556)
- hsa-miR-3158-5p (MIRT254560)
- hsa-miR-650 (MIRT300559)
- hsa-miR-1827 (MIRT300560)
- hsa-miR-3612 (MIRT300561)
- hsa-miR-4459 (MIRT300562)
- hsa-miR-4695-5p (MIRT300563)
- hsa-miR-1252-5p (MIRT300569)
- hsa-miR-3908 (MIRT300570)
- hsa-miR-6770-5p (MIRT300571)
- hsa-miR-7112-5p (MIRT300572)
- hsa-miR-4290 (MIRT300590)
- hsa-miR-371b-3p (MIRT300592)
- hsa-miR-541-5p (MIRT329142)
- hsa-miR-3159 (MIRT329144)
- hsa-miR-5692c (MIRT329145)
- hsa-miR-5692b (MIRT329146)
- hsa-miR-7-5p (MIRT352289)
- hsa-miR-214-3p (MIRT367265)
- hsa-miR-15b-5p (MIRT367266)
- hsa-miR-195-5p (MIRT367267)
- hsa-miR-330-3p (MIRT367268)
- hsa-miR-424-5p (MIRT367269)
- hsa-miR-497-5p (MIRT367270)
- hsa-miR-761 (MIRT367272)
- hsa-miR-3065-5p (MIRT367274)
- hsa-miR-3619-5p (MIRT367276)
- hsa-miR-3529-3p (MIRT367278)
- hsa-miR-6165 (MIRT367279)
- hsa-miR-6838-5p (MIRT367281)
- hsa-miR-4433a-3p (MIRT478827)
- hsa-miR-17-3p (MIRT507625)
- hsa-miR-1205 (MIRT507626)
- hsa-miR-1184 (MIRT507627)
- hsa-miR-1253 (MIRT512082)
- hsa-miR-3667-5p (MIRT512083)
- hsa-let-7c-3p (MIRT524334)
- hsa-miR-873-5p (MIRT548708)
- hsa-miR-944 (MIRT567900)
- hsa-miR-340-5p (MIRT567901)
- hsa-miR-143-5p (MIRT567902)
- hsa-miR-1255b-5p (MIRT567903)
- hsa-miR-1255a (MIRT567904)
- hsa-miR-6744-5p (MIRT567905)
- hsa-miR-103a-3p (MIRT567906)
- hsa-miR-455-5p (MIRT567907)
- hsa-miR-1273g-3p (MIRT572879)
- mmu-miR-3100-5p (MIRT584121)
- mmu-miR-450b-3p (MIRT584123)
- mmu-miR-1953 (MIRT584124)
- mmu-miR-10b-5p (MIRT584125)
- mmu-miR-10a-5p (MIRT584126)
- mmu-miR-298-5p (MIRT605098)
- mmu-miR-3090-3p (MIRT605099)
- mmu-miR-384-3p (MIRT605100)
- mmu-miR-3057-3p (MIRT605101)
- mmu-miR-3082-5p (MIRT605102)
- mmu-miR-5113 (MIRT605103)
- hsa-miR-6736-5p (MIRT659350)
- hsa-miR-4701-3p (MIRT659351)
- hsa-miR-1262 (MIRT659352)
- hsa-miR-6720-5p (MIRT659353)
- hsa-miR-6512-3p (MIRT659354)
- hsa-miR-661 (MIRT659355)
- hsa-miR-4252 (MIRT659356)
- hsa-miR-5186 (MIRT659357)
- hsa-miR-4793-3p (MIRT659358)
- hsa-miR-766-3p (MIRT659359)
- hsa-miR-6742-3p (MIRT659360)
- hsa-miR-6849-3p (MIRT659361)
- hsa-miR-508-5p (MIRT659362)
- hsa-miR-665 (MIRT675982)
- hsa-miR-887-5p (MIRT675983)
- hsa-miR-6780a-5p (MIRT675984)
- hsa-miR-6779-5p (MIRT675985)
- hsa-miR-3689c (MIRT675986)
- hsa-miR-3689b-3p (MIRT675987)
- hsa-miR-3689a-3p (MIRT675988)
- hsa-miR-30b-3p (MIRT675989)
- hsa-miR-1273h-5p (MIRT675990)
- hsa-miR-6788-5p (MIRT675991)
- hsa-miR-30c-2-3p (MIRT675992)
- hsa-miR-30c-1-3p (MIRT675993)
- hsa-miR-203b-3p (MIRT675994)
- hsa-miR-7158-3p (MIRT675995)
- hsa-miR-6799-5p (MIRT675996)
- hsa-miR-6883-5p (MIRT675997)
- hsa-miR-6785-5p (MIRT675998)
- hsa-miR-4728-5p (MIRT675999)
- hsa-miR-149-3p (MIRT676000)
- hsa-miR-7106-5p (MIRT676001)
- hsa-miR-7160-5p (MIRT676002)
- hsa-miR-4722-5p (MIRT676003)
- hsa-miR-6884-5p (MIRT676004)
- hsa-miR-485-5p (MIRT676005)
- hsa-miR-4680-5p (MIRT676006)
- hsa-miR-4649-3p (MIRT676007)
- hsa-miR-3664-3p (MIRT676008)
- hsa-miR-4768-3p (MIRT676009)
- hsa-miR-5690 (MIRT676010)
- hsa-miR-4478 (MIRT676011)
- hsa-miR-4419b (MIRT676012)
- hsa-miR-3929 (MIRT676013)
- hsa-miR-940 (MIRT676014)
- hsa-miR-6893-5p (MIRT676015)
- hsa-miR-6808-5p (MIRT676016)
- hsa-miR-890 (MIRT676017)
- hsa-miR-510-5p (MIRT676018)
- hsa-miR-335-5p (MIRT734082)
- hsa-miR-320a (MIRT734134)
- hsa-miR-200b-3p (MIRT734346)
- hsa-miR-200c-3p (MIRT734347)
- hsa-miR-429 (MIRT734348)
- hsa-miR-125a-3p (MIRT736624)
- hsa-miR-203a-5p (MIRT738806)
- hsa-miR-218-1-3p (MIRT739041)
- hsa-miR-3692-3p (MIRT742527)
- hsa-miR-3934-5p (MIRT743094)
- hsa-miR-764 (MIRT759526)
- hsa-miR-876-3p (MIRT760358)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
Clone products for research
- Applied Biological Materials (abm): Clones for CRKL - Starting at $45 >
- * CRKL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRKL Gene
Localization for CRKL Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031594 | neuromuscular junction | IEA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRKL Gene
Pathways & Interactions for CRKL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Development Neurotrophin family signaling
.44
|
|
| 3 | MET promotes cell motility |
.45
|
|
| 4 | Kit receptor signaling pathway | ||
| 5 | ErbB signaling pathway | ||
Pathways by source for CRKL Gene
21 BioSystems pathways for CRKL Gene
17 Reactome pathways for CRKL Gene
10 GeneGo (Thomson Reuters) pathways for CRKL Gene
- Chemotaxis CXCR4 signaling pathway
- Development EPO-induced Jak-STAT pathway
- Development EPO-induced MAPK pathway
- Development Flt3 signaling
- Development HGF signaling pathway
5 Qiagen pathways for CRKL Gene
- HGF Pathway
- Internalin Pathway
- JNK Pathway
- MAPK Family Pathway
- Rap1 Pathway
1 Cell Signaling Technology pathway for CRKL Gene
Interacting Proteins for CRKL Gene
Selected Interacting proteins:
P46109-CRKL_HUMAN
ENSP00000346300
for CRKL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRKL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0001568 | blood vessel development | IEA | -- |
| GO:0001655 | urogenital system development | IEA | -- |
Transcripts for CRKL Gene
mRNA/cDNA for CRKL Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354336 5342 nts (view in UCSC)
- ENST00000411769 2037 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRKL - Starting at $85 >
- * CRKL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRKL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRKL
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRKL
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRKL
- Browse OriGene Inhibitory RNA Products For CRKL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRKL
Clone products for research
- Applied Biological Materials (abm): Clones for CRKL - Starting at $45 >
- * CRKL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CRKL
- Addgene plasmids for CRKL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRKL
Relevant External Links for CRKL Gene
- GeneLoc Exon Structure for
- CRKL
Expression for CRKL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRKL Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRKL
SOURCE GeneReport for Unigene cluster for CRKL Gene:
Hs.5613Evidence on tissue expression from TISSUES for CRKL Gene
- Nervous system(4.5)
- Liver(4.5)
- Skin(4.5)
- Spleen(4.5)
- Blood(2.7)
- Muscle(2.6)
- Bone marrow(2.6)
- Stomach(2.6)
- Kidney(2.6)
- Heart(2.5)
- Intestine(2.4)
- Lymph node(2.3)
- Lung(2.1)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CRKL Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- skin
Primer products for research
-
OriGene qPCR primer pairs for CRKL
-
OriGene qPCR primer pairs and template standards for CRKL
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRKL Gene
Orthologs for CRKL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRKL 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRKL 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crkl 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRKL 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crkl 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRKL 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRKL 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRKL 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crkl 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | crkl 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Crk 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ced-2 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 30 |
|
OneToMany |
- Species where no ortholog for CRKL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CRKL Gene
- ENSEMBL:
- Gene Tree for CRKL (if available)
- TreeFam:
- Gene Tree for CRKL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRKL: view image
- Alliance of Genome Resources:
- Additional Orthologs for CRKL
Paralogs for CRKL Gene
Variants for CRKL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRKL Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs145813322 | Benign: not provided | 20,934,128(+) |
G/A NM_005207.4(CRKL):c.661G>A (p.Gly221Ser) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs148703254 | Likely Benign: not provided | 20,918,183(+) |
C/T NM_005207.4(CRKL):c.249C>T (p.Ala83=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs150673692 | Benign: not provided | 20,917,970(+) |
C/T NM_005207.4(CRKL):c.36C>T (p.Ser12=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs752182830 | Likely Benign: not provided | 20,934,001(+) |
C/T NM_005207.4(CRKL):c.534C>T (p.Val178=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs769606385 | Uncertain Significance: not provided | 20,949,773(+) |
C/T NM_005207.4(CRKL):c.840C>T (p.Asn280=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4483n100 | CNV | gain | 25217958 |
| dgv4484n100 | CNV | gain | 25217958 |
| dgv4485n100 | CNV | gain | 25217958 |
| dgv7993n54 | CNV | gain | 21841781 |
| dgv7994n54 | CNV | gain | 21841781 |
| esv2678175 | CNV | deletion | 23128226 |
| esv2763693 | CNV | gain | 21179565 |
| esv3647304 | CNV | loss | 21293372 |
| esv3647305 | CNV | gain | 21293372 |
| esv3893441 | CNV | gain+loss | 25118596 |
| nsv1056614 | CNV | loss | 25217958 |
| nsv1065617 | CNV | gain | 25217958 |
| nsv1066625 | CNV | gain | 25217958 |
| nsv1123578 | CNV | deletion | 24896259 |
| nsv436864 | CNV | insertion | 17901297 |
| nsv523162 | CNV | loss | 19592680 |
| nsv588305 | CNV | loss | 21841781 |
| nsv834140 | CNV | loss | 17160897 |
| nsv834141 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.78;
16.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRKL Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRKL Gene
Disorders for CRKL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 22q11.2 deletion syndrome, distal |
|
|
| leukemia, chronic myeloid |
|
|
| sarcoma |
|
|
| papillary thyroid microcarcinoma |
|
|
| digeorge syndrome |
|
|
Search CRKL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRKL
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRKL Gene
Publications for CRKL Gene
- Isolation and chromosomal localization of CRKL, a human crk-like gene. (PMID: 8361759) ten Hoeve J … Groffen J (Oncogene 1993) 2 3 4 22
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 22
- DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PMID: 12393632) Nishihara H … Tanaka S (Blood 2002) 3 4 22
- CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PMID: 11443118) Arai A … Miura O (The Journal of biological chemistry 2001) 3 4 22
- Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PMID: 10022120) Elly C … Liu YC (Oncogene 1999) 3 4 22
ExternalLinks
Products for CRKL Gene
- Custom Antibody ServicesOriGene Antibodies for CRKL
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- VectorBuilder Virus packaging for CRKL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CRKL
- Addgene plasmids for CRKL
- antibodies-online: Show 100 available CrkL Antibodies ranked by validation data
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- antibodies-online: Show 23 available CrkL Elisa Kits ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for CRKL
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Sources for CRKL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (29) HomoloGene
- (30) PanEnsembl
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- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
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- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
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- (46) HUGE
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- (48) Leiden
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- (50) DME
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- (52) PubMed
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- (54) Tocris
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- (59) GenScript
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- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
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- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
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- (91) PathCards
- (92) GeneReviews
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- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
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- (102) diseasecard
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- (146) RNAcentral
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- (176) Alliance of Genome Resources