Aliases for CRK Gene
Aliases for CRK Gene
External Ids for CRK Gene
- HGNC: 2362
- Entrez Gene: 1398
- Ensembl: ENSG00000167193
- OMIM: 164762
- UniProtKB: P46108
Previous GeneCards Identifiers for CRK Gene
- GC17M001318
- GC17M001659
- GC17M001533
- GC17M001534
- GC17M001272
- GC17M001323
Summaries for CRK Gene
-
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRK Gene
CRK (CRK Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRK include Sarcoma and Chromosome 17P13.3, Centromeric, Duplication Syndrome. Among its related pathways are RET signaling and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.
UniProtKB/Swiss-Prot for CRK Gene
-
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRK Gene
Genomics for CRK Gene
GeneHancer (GH) Regulatory Elements for CRK Gene
Promoters and enhancers for CRK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CRK on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CRK Gene
Genomic Locations for CRK Gene
- chr17:1,420,689-1,463,162
- (GRCh38/hg38)
- Size:
- 42,474 bases
- Orientation:
- Minus strand
- chr17:1,323,983-1,366,456
- (GRCh37/hg19)
Genomic View for CRK Gene
Genes around CRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by Ensembl
- 17p13.3 by Entrez Gene
- 17p13.3 by HGNC
CRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRK Gene
Proteins for CRK Gene
-
Protein details for CRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46108-CRK_HUMAN
- Recommended name:
- Adapter molecule crk
- Protein Accession:
- P46108
- A8MWE8
- B0LPE8
- D3DTH6
- Q96GA9
- Q96HJ0
Protein attributes for CRK Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33831 Da
- Quaternary structure:
-
- Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the Tyr-9 phosphorylated form of PDPK1. Interacts with CBLC. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.
Three dimensional structures from OCA and Proteopedia for CRK Gene
Protein Expression for CRK Gene
Post-translational modifications for CRK Gene
- Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.
- Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
- Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
Other Protein References for CRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRK (Crk)
- Cell Signaling Technology (CST) Antibodies for CRK (CRK)
-
Custom Antibody ServicesOriGene Antibodies for CRK
- Novus Biologicals Antibodies for CRK
-
Abcam antibodies for CRK
- Invitrogen Antibodies for CRK
- antibodies-online: Search results for 145 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
-
Recommended
- 2 IHC (p) Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 47 WB Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 38 WB Antibodies (anti-rat)
- 1 IF Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 5 DB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 93 WB Antibodies (anti-human)
- GeneTex CRK antibody for CRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRK
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- ProSpec Recombinant Proteins for CRK
- Search GeneTex for Proteins for CRK
-
Abcam proteins for CRK
Assay Products
No data available for DME Specific Peptides for CRK Gene
Domains & Families for CRK Gene
Gene Families for CRK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CRK Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46108UniProtKB/Swiss-Prot:
CRK_HUMAN :- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- Belongs to the CRK family.
- Domain:
-
- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
- Family:
-
- Belongs to the CRK family.
Function for CRK Gene
Molecular function for CRK Gene
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) homolog
- UniProtKB/Swiss-Prot Function:
- Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Phenotypes From GWAS Catalog for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0005070 | SH3/SH2 adaptor activity | IEA,IDA | 12384576 |
| GO:0005159 | insulin-like growth factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 7561682 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for CRK Gene
- MGI mutant phenotypes for CRK:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CRK:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Decreased cell number
Animal Models for CRK Gene
- MGI Knock Outs for CRK:
-
- Crk tm1.1Cur
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRK
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CRK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRK gene
- Search ViGene Biosciences for CRK
CRISPR Products
-
OriGene CRISPR knockouts for CRK
- genomics-online: gRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- Applied Biological Materials CRISPR for CRK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
- GenScript: Design CRISPR guide RNA sequences for CRK
miRNA for CRK Gene
- miRTarBase miRNAs that target CRK
-
- hsa-mir-126-3p (MIRT002993)
- hsa-mir-132-3p (MIRT007166)
- hsa-mir-125a-5p (MIRT021297)
- hsa-mir-215-5p (MIRT024820)
- hsa-mir-10a-5p (MIRT025620)
- hsa-mir-192-5p (MIRT026885)
- hsa-mir-106b-3p (MIRT038548)
- hsa-mir-129-1-3p (MIRT038706)
- hsa-mir-15b-5p (MIRT046474)
- hsa-let-7e-5p (MIRT051574)
- hsa-mir-1260b (MIRT052687)
- hsa-mir-1257 (MIRT144777)
- hsa-mir-4320 (MIRT195992)
- hsa-mir-8485 (MIRT285743)
- hsa-mir-205-3p (MIRT386618)
- hsa-mir-10b-5p (MIRT439131)
- hsa-let-7c-5p (MIRT439167)
- hsa-mir-20a-5p (MIRT440876)
- hsa-mir-106b-5p (MIRT440877)
- hsa-mir-5096 (MIRT512084)
- hsa-mir-3941 (MIRT512085)
- hsa-mir-613 (MIRT512086)
- hsa-mir-206 (MIRT512087)
- hsa-mir-1-3p (MIRT512088)
- hsa-mir-3140-3p (MIRT512089)
- hsa-mir-6893-3p (MIRT512090)
- hsa-mir-6128 (MIRT512091)
- hsa-mir-370-3p (MIRT512092)
- hsa-mir-6765-3p (MIRT512093)
- hsa-mir-3622b-3p (MIRT512094)
- hsa-mir-3622a-3p (MIRT512095)
- hsa-mir-619-3p (MIRT512096)
- hsa-mir-603 (MIRT512097)
- hsa-mir-362-3p (MIRT512098)
- hsa-mir-329-3p (MIRT512099)
- hsa-mir-216b-3p (MIRT524335)
- hsa-mir-7156-3p (MIRT543004)
- hsa-mir-127-5p (MIRT543005)
- hsa-mir-4284 (MIRT543006)
- hsa-mir-7843-3p (MIRT543007)
- hsa-mir-1184 (MIRT543008)
- hsa-mir-1304-3p (MIRT543009)
- hsa-mir-6741-3p (MIRT543010)
- hsa-mir-4726-3p (MIRT543011)
- hsa-mir-6764-5p (MIRT543012)
- hsa-mir-1915-3p (MIRT543013)
- hsa-mir-6840-3p (MIRT543014)
- hsa-mir-6890-3p (MIRT543015)
- hsa-mir-1306-5p (MIRT543016)
- hsa-mir-509-5p (MIRT543017)
- hsa-mir-509-3-5p (MIRT543018)
- hsa-mir-4418 (MIRT543019)
- hsa-mir-30e-3p (MIRT548709)
- hsa-mir-30d-3p (MIRT548710)
- hsa-mir-30a-3p (MIRT548711)
- hsa-mir-6516-5p (MIRT548712)
- hsa-mir-1273h-3p (MIRT548713)
- hsa-mir-3678-3p (MIRT548714)
- hsa-mir-190a-3p (MIRT548715)
- hsa-mir-4524b-5p (MIRT548716)
- hsa-mir-4524a-5p (MIRT548717)
- hsa-mir-298 (MIRT548718)
- hsa-mir-3163 (MIRT548719)
- hsa-mir-5680 (MIRT548720)
- hsa-mir-646 (MIRT548721)
- hsa-mir-580-5p (MIRT548722)
- hsa-mir-410-3p (MIRT548723)
- hsa-mir-16-5p (MIRT548724)
- hsa-mir-503-5p (MIRT548725)
- hsa-mir-6838-5p (MIRT548726)
- hsa-mir-15a-5p (MIRT548727)
- hsa-mir-195-5p (MIRT548728)
- hsa-mir-424-5p (MIRT548729)
- hsa-mir-497-5p (MIRT548730)
- hsa-mir-9-3p (MIRT567908)
- hsa-mir-423-3p (MIRT567909)
- hsa-mir-31-3p (MIRT567910)
- hsa-mir-502-3p (MIRT567911)
- hsa-mir-5590-3p (MIRT567912)
- hsa-mir-501-3p (MIRT567913)
- hsa-mir-142-5p (MIRT567914)
- hsa-mir-4796-3p (MIRT567915)
- hsa-mir-3609 (MIRT567916)
- hsa-mir-548ah-5p (MIRT567917)
- hsa-mir-320d (MIRT567918)
- hsa-mir-320b (MIRT567919)
- hsa-mir-320a (MIRT567920)
- hsa-mir-4429 (MIRT567921)
- hsa-mir-320c (MIRT567922)
- hsa-mir-20b-5p (MIRT567923)
- hsa-mir-93-5p (MIRT567924)
- hsa-mir-526b-3p (MIRT567925)
- hsa-mir-106a-5p (MIRT567926)
- hsa-mir-519d-3p (MIRT567927)
- hsa-mir-17-5p (MIRT567928)
- hsa-mir-302d-3p (MIRT567929)
- hsa-mir-520b (MIRT567930)
- hsa-mir-520a-3p (MIRT567931)
- hsa-mir-373-3p (MIRT567932)
- hsa-mir-520c-3p (MIRT567933)
- hsa-mir-520d-3p (MIRT567934)
- hsa-mir-302a-3p (MIRT567935)
- hsa-mir-372-3p (MIRT567936)
- hsa-mir-302e (MIRT567937)
- hsa-mir-302b-3p (MIRT567938)
- hsa-mir-520e (MIRT567939)
- hsa-mir-302c-3p (MIRT567940)
- hsa-mir-135b-3p (MIRT567941)
- hsa-mir-664b-5p (MIRT567942)
- hsa-mir-6814-5p (MIRT567943)
- hsa-mir-4733-5p (MIRT567944)
- hsa-mir-548l (MIRT567945)
- hsa-mir-186-5p (MIRT567946)
- hsa-mir-548n (MIRT567947)
- hsa-mir-6818-5p (MIRT572161)
- hsa-mir-5196-5p (MIRT572162)
- hsa-mir-4747-5p (MIRT572163)
- hsa-mir-6821-3p (MIRT572164)
- hsa-mir-6790-3p (MIRT572165)
- hsa-mir-4790-3p (MIRT572166)
- hsa-mir-4652-3p (MIRT639243)
- hsa-mir-640 (MIRT639244)
- hsa-mir-367-5p (MIRT639245)
- hsa-mir-1267 (MIRT639246)
- hsa-mir-6787-3p (MIRT639247)
- hsa-mir-6891-3p (MIRT639248)
- hsa-mir-6072 (MIRT639249)
- hsa-mir-1207-3p (MIRT639250)
- hsa-mir-4778-5p (MIRT639251)
- hsa-mir-510-5p (MIRT639252)
- hsa-mir-512-5p (MIRT639253)
- hsa-mir-126-5p (MIRT734618)
- hsa-mir-138-2-3p (MIRT762600)
- hsa-mir-1910-3p (MIRT763277)
- hsa-mir-2110 (MIRT763779)
- hsa-mir-3065-5p (MIRT764546)
- hsa-mir-30c-1-3p (MIRT764652)
- hsa-mir-30c-2-3p (MIRT764697)
- hsa-mir-3150a-3p (MIRT765022)
- hsa-mir-3192-5p (MIRT765416)
- hsa-mir-33a-5p (MIRT765694)
- hsa-mir-33b-5p (MIRT765703)
- hsa-mir-3680-3p (MIRT766737)
- hsa-mir-3714 (MIRT767145)
- hsa-mir-4260 (MIRT768194)
- hsa-mir-4271 (MIRT768254)
- hsa-mir-4463 (MIRT769406)
- hsa-mir-4477a (MIRT769488)
- hsa-mir-4487 (MIRT769650)
- hsa-mir-450a-2-3p (MIRT769868)
- hsa-mir-4725-3p (MIRT771624)
- hsa-mir-548c-3p (MIRT774303)
- hsa-mir-5572 (MIRT774687)
- hsa-mir-605-3p (MIRT775415)
- hsa-mir-6511a-5p (MIRT776775)
- hsa-mir-6731-5p (MIRT777976)
- hsa-mir-6763-5p (MIRT778482)
- hsa-mir-6780b-5p (MIRT779045)
- hsa-mir-6788-5p (MIRT779229)
- hsa-mir-6810-5p (MIRT779755)
- hsa-mir-6857-5p (MIRT780507)
- hsa-mir-6878-5p (MIRT780771)
- hsa-mir-7-1-3p (MIRT781487)
- hsa-mir-7-2-3p (MIRT781699)
- hsa-mir-7851-3p (MIRT782195)
- hsa-mir-8085 (MIRT782419)
- hsa-mir-873-3p (MIRT782455)
- hsa-mir-95-5p (MIRT782993)
miRNA Products
- Search ViGene Biosciences for CRK
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- genomics-online: shRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CRK gene
Clone Products
- Sino Biological Human cDNA Clone for CRK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CRK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRK
- Applied Biological Materials Clones for CRK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CRK
-
ViGene Biosciences adenoviral particle packaged cDNA for CRK gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CRK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRK gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRK Gene
Localization for CRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRK Gene
- Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 2 |
| endosome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10748058 |
| GO:0005737 | cytoplasm | IC,IEA | 11870224 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0015629 | actin cytoskeleton | IEA | -- |
Pathways & Interactions for CRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway | ||
| 3 | MET promotes cell motility |
.45
|
|
| 4 | ErbB signaling pathway | ||
| 5 | Focal Adhesion |
.62
.62
|
|
Pathways by source for CRK Gene
2 Sino Biological pathways for CRK Gene
1 GeneTex pathway for CRK Gene
1 Cell Signaling Technology pathway for CRK Gene
33 BioSystems pathways for CRK Gene
29 Reactome pathways for CRK Gene
1 PharmGKB pathway for CRK Gene
15 KEGG pathways for CRK Gene
8 GeneGo (Thomson Reuters) pathways for CRK Gene
2 R&D Systems pathways for CRK Gene
15 Qiagen pathways for CRK Gene
Interacting Proteins for CRK Gene
Selected Interacting proteins:
P46108-CRK_HUMAN
ENSP00000300574
for CRK Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0001878 | response to yeast | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10748058 |
| GO:0008360 | regulation of cell shape | IMP | 17515907 |
| GO:0009966 | regulation of signal transduction | IDA | 17515907 |
Transcripts for CRK Gene
mRNA/cDNA for CRK Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (333) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CRK Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRK
- genomics-online: gRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- Applied Biological Materials CRISPR for CRK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
- GenScript: Design CRISPR guide RNA sequences for CRK
miRNA Products
- Search ViGene Biosciences for CRK
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- genomics-online: shRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CRK gene
Clone Products
- Sino Biological Human cDNA Clone for CRK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CRK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRK
- Applied Biological Materials Clones for CRK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: |
Expression for CRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Uterus (6.2) and Oral epithelium (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CRK Gene:
CRKSOURCE GeneReport for Unigene cluster for CRK Gene:
Hs.461896Evidence on tissue expression from TISSUES for CRK Gene
- Lung(4.4)
- Liver(4.3)
- Eye(4.2)
- Nervous system(3.8)
- Kidney(2.3)
- Heart(2.2)
- Adrenal gland(2.1)
- Muscle(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for CRK
-
OriGene qPCR primer pairs and template standards for CRK
- genomics-online: primer clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRK Gene
Orthologs for CRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRK 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CRK 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CRK 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Crk 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crk 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRK 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CRK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crk 33 |
|
||
| Str.6504 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68492 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crk 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4632 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Crk 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009499 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ced-2 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 34 |
|
OneToMany |
- Species where no ortholog for CRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CRK Gene
(6) SIMAP similar genes for CRK Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for CRK Gene
Variants for CRK Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000109630 | -- | 1,434,938(-) | G/C/T | intron_variant | |
| rs1000191302 | -- | 1,448,531(-) | G/A | intron_variant | |
| rs1000253683 | -- | 1,445,802(-) | T/C/G | intron_variant | |
| rs1000283127 | -- | 1,446,089(-) | T/C | intron_variant | |
| rs1000457943 | -- | 1,433,516(-) | T/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv833334 | CNV | loss | 17160897 |
| nsv470567 | CNV | gain | 18288195 |
| nsv1057782 | CNV | gain | 25217958 |
| esv3639685 | CNV | loss | 21293372 |
| esv2715463 | CNV | deletion | 23290073 |
| esv1931977 | CNV | deletion | 18987734 |
Residual Variation Intolerance Score:
18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRK Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRK Gene
Disorders for CRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma |
|
|
| chromosome 17p13.3, centromeric, duplication syndrome |
|
|
| shigellosis |
|
|
| avian influenza |
|
|
| miller-dieker lissencephaly syndrome |
|
|
Search CRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CRK Gene
Publications for CRK Gene
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 22 58
- Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PMID: 10733900) Matsumoto T … Mori S (Biochemical and biophysical research communications 2000) 3 4 22 58
- Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval AP … LeRoith D (The Journal of biological chemistry 1998) 3 4 22 58
- Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PMID: 8662907) Matsuda M … Kurata T (The Journal of biological chemistry 1996) 3 4 22 58
- Two species of human CRK cDNA encode proteins with distinct biological activities. (PMID: 1630456) Matsuda M … Shibuya M (Molecular and cellular biology 1992) 3 4 22 58
Products for CRK Gene
- R&D Systems Antibodies for CRK (Crk)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CRK
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- OriGene qPCR primer pairs and template standards for CRK
- OriGene qPCR primer pairs for CRK
- OriGene CRISPR knockouts for CRK
- OriGene ORF clones in human for CRK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRK
- GenScript: Next-day shipping of latest version cDNA ORF clones for CRK in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CRK
- GenScript Custom Assay Services for CRK
- GenScript Custom overexpressing Cell Line Services for CRK
- GenScript: Design CRISPR guide RNA sequences for CRK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CRK
- Cell Signaling Technology (CST) Antibodies for CRK (CRK)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CRK
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CRK
- Novus Biologicals lysates and proteins for CRK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRK
- Abcam proteins for CRK
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CRK
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CRK
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRK
- VectorBuilder custom plasmid, inducible vectors for CRK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRK
- antibodies-online: Search results for 145 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
- Recommended
- 93 WB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 5 DB Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 38 WB Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 47 WB Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for 13 available Crk Elisa Kits ranked by validation data
- Compare Top Crk Elisa Kits
- antibodies-online: Search results for 10 available Crk Proteins ranked by validation data
- Compare Top Crk Proteins
- GeneTex CRK antibody for CRK
- Search GeneTex for Proteins for CRK
- ViGene Biosciences adenoviral particle packaged cDNA for CRK gene
- ViGene Biosciences lentiviral particle packaged cDNA for CRK gene
- ViGene Biosciences ready-to-package AAV shRNAs for CRK gene
- Search ViGene Biosciences for CRK
- Santa Cruz Biotechnology (SCBT) Antibodies for CRK
- Search Santa Cruz Biotechnology (SCBT) for CRK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRK
- Horizon Cell Lines for CRK
- genomics-online: cdna clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- orf clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- genomics-online: gRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- genomics-online: primer clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
- genomics-online: shRNA clones - Search results for 130 available Crk gene related products
- Overview of 130 available Crk gene related products
Sources for CRK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew