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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
CRK (CRK Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRK include Sarcoma and Chromosome 17P13.3, Centromeric, Duplication Syndrome. Among its related pathways are NGF Pathway and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
GO:0005070 | SH3/SH2 adaptor activity | IDA | -- |
GO:0005159 | insulin-like growth factor receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 7561682 |
GO:0008092 | cytoskeletal protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 10748058 |
GO:0005737 | cytoplasm | IEA,IC | 11870224 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0015629 | actin cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling | ||
2 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
|
|
3 | MET promotes cell motility |
.45
|
|
4 | ErbB signaling pathway | ||
5 | Focal Adhesion |
.61
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000186 | activation of MAPKK activity | TAS | -- |
GO:0001764 | neuron migration | IEA | -- |
GO:0001878 | response to yeast | IEA | -- |
GO:0002685 | regulation of leukocyte migration | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10748058 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||
SP2: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CRK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CRK 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crk 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crk 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CRK 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CRK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CRK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CRK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crk 30 |
|
||
Str.6504 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68492 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | crk 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4632 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Crk 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009499 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ced-2 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
758881 | Likely Benign: not provided | 1,436,797(-) | C/T | SYNONYMOUS_VARIANT | |
768814 | Benign: not provided | 1,455,914(-) | G/C | SYNONYMOUS_VARIANT | |
775157 | Benign: not provided | 1,437,022(-) | A/G | SYNONYMOUS_VARIANT | |
789896 | Benign: not provided | 1,455,938(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1931977 | CNV | deletion | 18987734 |
esv2715463 | CNV | deletion | 23290073 |
esv3639685 | CNV | loss | 21293372 |
nsv1057782 | CNV | gain | 25217958 |
nsv470567 | CNV | gain | 18288195 |
nsv833334 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sarcoma |
|
|
chromosome 17p13.3, centromeric, duplication syndrome |
|
|
avian influenza |
|
|
miller-dieker lissencephaly syndrome |
|
|
lissencephaly |
|
|