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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this... See more...
Aliases for CRK Gene
Aliases for CRK Gene
External Ids for CRK Gene
- HGNC: 2362
- NCBI Entrez Gene: 1398
- Ensembl: ENSG00000167193
- OMIM®: 164762
- UniProtKB/Swiss-Prot: P46108
Previous GeneCards Identifiers for CRK Gene
- GC17M001318
- GC17M001659
- GC17M001533
- GC17M001534
- GC17M001272
- GC17M001323
Summaries for CRK Gene
-
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRK Gene
CRK (CRK Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRK include Sarcoma and Chromosome 17P13.3, Centromeric, Duplication Syndrome. Among its related pathways are Immune response IL-23 signaling pathway and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.
UniProtKB/Swiss-Prot Summary for CRK Gene
-
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
-
[Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity).
Additional gene information for CRK Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRK Gene
Genomics for CRK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRK
- Top Transcription factor binding sites by QIAGEN in the CRK gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- c-Myc
- Max1
Genomic Locations for CRK Gene
Latest Assembly
- chr17:1,420,689-1,463,162
- (GRCh38/hg38)
- Size:
- 42,474 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:1,323,987-1,359,526
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 35,540 bases
- Orientation:
- Minus strand
Alternative Locations (GRCh38/hg38)
- chr17(ALT_REF_LOCI_1):362,719-379,185 (-)
Genomic View for CRK Gene
Genes around CRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
CRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRK Gene
Proteins for CRK Gene
-
Protein details for CRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46108-CRK_HUMAN
- Recommended name:
- Adapter molecule crk
- Protein Accession:
- P46108
- A8MWE8
- B0LPE8
- D3DTH6
- Q96GA9
- Q96HJ0
Protein attributes for CRK Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33831 Da
- Quaternary structure:
-
- Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with SH2D3C (via C-terminus), and BCAR1/CAS (PubMed:12432078). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases (PubMed:19381274). Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with CBLC.
- [Isoform Crk-II]: Interacts (via SH2 domain) with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated) (PubMed:10733900). Interacts with EPHA3 (phosphorylated); upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent and mediates EFNA5-EPHA3 signaling through RHOA GTPase activation (PubMed:11870224). Interacts with KIT (PubMed:12878163). Interacts with PEAK3; the interaction requires PEAK3 homodimerization (PubMed:31311869).
Three dimensional structures from OCA and Proteopedia for CRK Gene
Protein Expression for CRK Gene
Post-translational modifications for CRK Gene
- Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:17515907). Isoform Crk-II: Phosphorylated by KIT (By similarity).
- Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ CrkII Antibody and Immunotag™ Phospho-CrkII (Tyr221) Antibody
- NSJ Bioreagents Crk Antibody p38
-
Custom Antibody ServicesOriGene Antibodies for CRK
- Novus Biologicals Antibodies for CRK
-
Abcam antibodies for CRK
- Invitrogen Antibodies for CRK (AFLGC-Crk)
- antibodies-online: Show 97 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
-
Recommended
- 104 WB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 6 DB Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 40 WB Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for CRK
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRK
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- ProSpec Recombinant Proteins for CRK
- antibodies-online: Show 10 available Crk Proteins ranked by validation data
- Compare Top Crk Proteins
-
Abcam proteins for CRK
Assay products for research
- G Biosciences Immunotag™ Adapter molecule crk ELISA Kit
- RayBiotech Custom Human Crk ELISA
No data available for DME Specific Peptides for CRK Gene
Domains & Families for CRK Gene
Gene Families for CRK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CRK Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- SH3 domain signature
- Variant SH3
Suggested Antigen Peptide Sequences for CRK Gene
- GenScript: Design optimal peptide antigens:
-
- p38 (CRK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46108UniProtKB/Swiss-Prot:
CRK_HUMAN :- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- Belongs to the CRK family.
- Domain:
-
- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
- Family:
-
- Belongs to the CRK family.
Function for CRK Gene
Molecular function for CRK Gene
- UniProtKB/Swiss-Prot Function:
- Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
- UniProtKB/Swiss-Prot Function:
- [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity).
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) homolog
Phenotypes From GWAS Catalog for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0005159 | insulin-like growth factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 7561682 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
| GO:0017124 | SH3 domain binding | IPI | 12384576 |
Phenotypes for CRK Gene
- MGI mutant phenotypes for CRK:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CRK:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability ratio
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in ovarian lineage
- Decreased cell number
- Increased shRNA abundance (Z-score > 2)
- Decreased cell migration
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation, increased cell elongation
Animal Models for CRK Gene
- MGI Knock Outs for CRK:
-
- Crk Crk<tm1.1Cur>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRK - Starting at $85 >
- * CRK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
miRNA for CRK Gene
- miRTarBase miRNAs that target CRK
-
- hsa-miR-126-3p (MIRT002993)
- hsa-miR-132-3p (MIRT007166)
- mmu-miR-340-5p (MIRT010382)
- mmu-let-7b-5p (MIRT012083)
- mmu-miR-181a-5p (MIRT014211)
- hsa-miR-125a-5p (MIRT021297)
- hsa-miR-215-5p (MIRT024820)
- hsa-miR-10a-5p (MIRT025620)
- hsa-miR-192-5p (MIRT026885)
- hsa-miR-106b-3p (MIRT038548)
- hsa-miR-129-1-3p (MIRT038706)
- hsa-miR-15b-5p (MIRT046474)
- hsa-let-7e-5p (MIRT051574)
- hsa-miR-1260b (MIRT052687)
- hsa-miR-1257 (MIRT144777)
- hsa-miR-4320 (MIRT195992)
- hsa-miR-8485 (MIRT285743)
- hsa-miR-205-3p (MIRT386618)
- hsa-miR-10b-5p (MIRT439131)
- hsa-let-7c-5p (MIRT439167)
- hsa-miR-20a-5p (MIRT440876)
- hsa-miR-106b-5p (MIRT440877)
- hsa-miR-5096 (MIRT512084)
- hsa-miR-3941 (MIRT512085)
- hsa-miR-613 (MIRT512086)
- hsa-miR-206 (MIRT512087)
- hsa-miR-1-3p (MIRT512088)
- hsa-miR-3140-3p (MIRT512089)
- hsa-miR-6893-3p (MIRT512090)
- hsa-miR-6128 (MIRT512091)
- hsa-miR-370-3p (MIRT512092)
- hsa-miR-6765-3p (MIRT512093)
- hsa-miR-3622b-3p (MIRT512094)
- hsa-miR-3622a-3p (MIRT512095)
- hsa-miR-619-3p (MIRT512096)
- hsa-miR-603 (MIRT512097)
- hsa-miR-362-3p (MIRT512098)
- hsa-miR-329-3p (MIRT512099)
- hsa-miR-216b-3p (MIRT524335)
- hsa-miR-7156-3p (MIRT543004)
- hsa-miR-127-5p (MIRT543005)
- hsa-miR-4284 (MIRT543006)
- hsa-miR-7843-3p (MIRT543007)
- hsa-miR-1184 (MIRT543008)
- hsa-miR-1304-3p (MIRT543009)
- hsa-miR-6741-3p (MIRT543010)
- hsa-miR-4726-3p (MIRT543011)
- hsa-miR-6764-5p (MIRT543012)
- hsa-miR-1915-3p (MIRT543013)
- hsa-miR-6840-3p (MIRT543014)
- hsa-miR-6890-3p (MIRT543015)
- hsa-miR-1306-5p (MIRT543016)
- hsa-miR-509-5p (MIRT543017)
- hsa-miR-509-3-5p (MIRT543018)
- hsa-miR-4418 (MIRT543019)
- hsa-miR-30e-3p (MIRT548709)
- hsa-miR-30d-3p (MIRT548710)
- hsa-miR-30a-3p (MIRT548711)
- hsa-miR-6516-5p (MIRT548712)
- hsa-miR-1273h-3p (MIRT548713)
- hsa-miR-3678-3p (MIRT548714)
- hsa-miR-190a-3p (MIRT548715)
- hsa-miR-4524b-5p (MIRT548716)
- hsa-miR-4524a-5p (MIRT548717)
- hsa-miR-298 (MIRT548718)
- hsa-miR-3163 (MIRT548719)
- hsa-miR-5680 (MIRT548720)
- hsa-miR-646 (MIRT548721)
- hsa-miR-580-5p (MIRT548722)
- hsa-miR-410-3p (MIRT548723)
- hsa-miR-16-5p (MIRT548724)
- hsa-miR-503-5p (MIRT548725)
- hsa-miR-6838-5p (MIRT548726)
- hsa-miR-15a-5p (MIRT548727)
- hsa-miR-195-5p (MIRT548728)
- hsa-miR-424-5p (MIRT548729)
- hsa-miR-497-5p (MIRT548730)
- hsa-miR-9-3p (MIRT567908)
- hsa-miR-423-3p (MIRT567909)
- hsa-miR-31-3p (MIRT567910)
- hsa-miR-502-3p (MIRT567911)
- hsa-miR-5590-3p (MIRT567912)
- hsa-miR-501-3p (MIRT567913)
- hsa-miR-142-5p (MIRT567914)
- hsa-miR-4796-3p (MIRT567915)
- hsa-miR-3609 (MIRT567916)
- hsa-miR-548ah-5p (MIRT567917)
- hsa-miR-320d (MIRT567918)
- hsa-miR-320b (MIRT567919)
- hsa-miR-320a (MIRT567920)
- hsa-miR-4429 (MIRT567921)
- hsa-miR-320c (MIRT567922)
- hsa-miR-20b-5p (MIRT567923)
- hsa-miR-93-5p (MIRT567924)
- hsa-miR-526b-3p (MIRT567925)
- hsa-miR-106a-5p (MIRT567926)
- hsa-miR-519d-3p (MIRT567927)
- hsa-miR-17-5p (MIRT567928)
- hsa-miR-302d-3p (MIRT567929)
- hsa-miR-520b (MIRT567930)
- hsa-miR-520a-3p (MIRT567931)
- hsa-miR-373-3p (MIRT567932)
- hsa-miR-520c-3p (MIRT567933)
- hsa-miR-520d-3p (MIRT567934)
- hsa-miR-302a-3p (MIRT567935)
- hsa-miR-372-3p (MIRT567936)
- hsa-miR-302e (MIRT567937)
- hsa-miR-302b-3p (MIRT567938)
- hsa-miR-520e (MIRT567939)
- hsa-miR-302c-3p (MIRT567940)
- hsa-miR-135b-3p (MIRT567941)
- hsa-miR-664b-5p (MIRT567942)
- hsa-miR-6814-5p (MIRT567943)
- hsa-miR-4733-5p (MIRT567944)
- hsa-miR-548l (MIRT567945)
- hsa-miR-186-5p (MIRT567946)
- hsa-miR-548n (MIRT567947)
- hsa-miR-6818-5p (MIRT572161)
- hsa-miR-5196-5p (MIRT572162)
- hsa-miR-4747-5p (MIRT572163)
- hsa-miR-6821-3p (MIRT572164)
- hsa-miR-6790-3p (MIRT572165)
- hsa-miR-4790-3p (MIRT572166)
- hsa-miR-4652-3p (MIRT639243)
- hsa-miR-640 (MIRT639244)
- hsa-miR-367-5p (MIRT639245)
- hsa-miR-1267 (MIRT639246)
- hsa-miR-6787-3p (MIRT639247)
- hsa-miR-6891-3p (MIRT639248)
- hsa-miR-6072 (MIRT639249)
- hsa-miR-1207-3p (MIRT639250)
- hsa-miR-4778-5p (MIRT639251)
- hsa-miR-510-5p (MIRT639252)
- hsa-miR-512-5p (MIRT639253)
- hsa-miR-126-5p (MIRT734618)
- hsa-miR-138-2-3p (MIRT762600)
- hsa-miR-1910-3p (MIRT763277)
- hsa-miR-2110 (MIRT763779)
- hsa-miR-3065-5p (MIRT764546)
- hsa-miR-30c-1-3p (MIRT764652)
- hsa-miR-30c-2-3p (MIRT764697)
- hsa-miR-3150a-3p (MIRT765022)
- hsa-miR-3192-5p (MIRT765416)
- hsa-miR-33a-5p (MIRT765694)
- hsa-miR-33b-5p (MIRT765703)
- hsa-miR-3680-3p (MIRT766737)
- hsa-miR-3714 (MIRT767145)
- hsa-miR-4260 (MIRT768194)
- hsa-miR-4271 (MIRT768254)
- hsa-miR-4463 (MIRT769406)
- hsa-miR-4477a (MIRT769488)
- hsa-miR-4487 (MIRT769650)
- hsa-miR-450a-2-3p (MIRT769868)
- hsa-miR-4725-3p (MIRT771624)
- hsa-miR-548c-3p (MIRT774303)
- hsa-miR-5572 (MIRT774687)
- hsa-miR-605-3p (MIRT775415)
- hsa-miR-6511a-5p (MIRT776775)
- hsa-miR-6731-5p (MIRT777976)
- hsa-miR-6763-5p (MIRT778482)
- hsa-miR-6780b-5p (MIRT779045)
- hsa-miR-6788-5p (MIRT779229)
- hsa-miR-6810-5p (MIRT779755)
- hsa-miR-6857-5p (MIRT780507)
- hsa-miR-6878-5p (MIRT780771)
- hsa-miR-7-1-3p (MIRT781487)
- hsa-miR-7-2-3p (MIRT781699)
- hsa-miR-7851-3p (MIRT782195)
- hsa-miR-8085 (MIRT782419)
- hsa-miR-873-3p (MIRT782455)
- hsa-miR-95-5p (MIRT782993)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
Clone products for research
- Applied Biological Materials (abm): Clones for CRK - Starting at $45 >
- * CRK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204260
- MR204260
- MR204260L3
- MR204260L4
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L2
- RC201701L3
- RC201701L4
- RC203438
- RC203438L3
- RC203438L4
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L4
- MR204260L3V
- MR204260L4V
- RC201701L1V
- RC201701L2V
- RC201701L3V
- RC201701L4V
- RC203438L3V
- RC203438L4V
- RR201929L3V
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRK
- Addgene plasmids for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
Cell Lines for research
-
Horizon Cell Lines for CRK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRK Gene
Localization for CRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRK Gene
- Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| cytoskeleton | 4 |
| nucleus | 4 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10748058 |
| GO:0005737 | cytoplasm | IEA,IC | 11870224 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0015629 | actin cytoskeleton | IEA | -- |
Pathways & Interactions for CRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
|
|
| 3 | MET promotes cell motility |
.45
|
|
| 4 | ErbB signaling pathway | ||
| 5 | Focal Adhesion |
.61
.61
|
|
Pathways by source for CRK Gene
1 Sino Biological pathway for CRK Gene
33 BioSystems pathways for CRK Gene
29 Reactome pathways for CRK Gene
1 PharmGKB pathway for CRK Gene
8 GeneGo (Thomson Reuters) pathways for CRK Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling FAK signaling
- Development Angiopoietin - Tie2 signaling
- Development FGFR signaling pathway
2 R&D Systems pathways for CRK Gene
15 Qiagen pathways for CRK Gene
- Chemokine Signaling
- CXCR4 Pathway
- Epithelial Adherens Junctions
- FAK1 Signaling
- GPCR Pathway
1 Cell Signaling Technology pathway for CRK Gene
1 GeneTex pathway for CRK Gene
Interacting Proteins for CRK Gene
Selected Interacting proteins:
P46108-CRK_HUMAN
ENSP00000300574
for CRK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRK
SIGNOR curated interactions for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001878 | response to yeast | IEA | -- |
| GO:0002685 | regulation of leukocyte migration | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10748058 |
Transcripts for CRK Gene
mRNA/cDNA for CRK Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300574 3850 nts (view in UCSC)
- ENST00000398970 3675 nts (view in UCSC)
- ENST00000572145 830 nts (view in UCSC)
- ENST00000574295 1391 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRK - Starting at $85 >
- * CRK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
Clone products for research
- Applied Biological Materials (abm): Clones for CRK - Starting at $45 >
- * CRK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
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- MG204260
- MR204260
- MR204260L3
- MR204260L4
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L2
- RC201701L3
- RC201701L4
- RC203438
- RC203438L3
- RC203438L4
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L4
- MR204260L3V
- MR204260L4V
- RC201701L1V
- RC201701L2V
- RC201701L3V
- RC201701L4V
- RC203438L3V
- RC203438L4V
- RR201929L3V
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRK
- Addgene plasmids for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: |
Relevant External Links for CRK Gene
- GeneLoc Exon Structure for
- CRK
Expression for CRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Uterus (6.2) and Oral epithelium (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRK Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRK
SOURCE GeneReport for Unigene cluster for CRK Gene:
Hs.461896Evidence on tissue expression from TISSUES for CRK Gene
- Liver(4.5)
- Lung(4.5)
- Eye(4.4)
- Nervous system(4)
- Kidney(2.7)
- Heart(2.6)
- Muscle(2.5)
- Skin(2.5)
- Blood(2.4)
- Intestine(2.4)
- Thyroid gland(2.3)
- Stomach(2.3)
- Spleen(2.3)
- Lymph node(2.2)
- Adrenal gland(2.2)
Primer products for research
-
OriGene qPCR primer pairs for CRK
-
OriGene qPCR primer pairs and template standards for CRK
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRK Gene
Orthologs for CRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRK 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRK 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRK 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crk 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crk 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRK 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRK 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRK 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CRK 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crk 29 |
|
||
| Str.6504 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68492 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | crk 29 30 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4632 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Crk 29 30 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009499 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ced-2 29 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 30 |
|
OneToMany |
- Species where no ortholog for CRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CRK Gene
- ENSEMBL:
- Gene Tree for CRK (if available)
- TreeFam:
- Gene Tree for CRK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRK: view image
- Alliance of Genome Resources:
- Additional Orthologs for CRK
Paralogs for CRK Gene
(6) SIMAP similar genes for CRK Gene using alignment to 3 proteins:
- CRK_HUMAN
- I3L297_HUMAN
- L7RT18_HUMAN
Pseudogenes.org Pseudogenes for CRK Gene
Variants for CRK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRK Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1168918851 | Likely Benign: not provided | 1,436,797(-) |
C/T NM_016823.4(CRK):c.600G>A (p.Leu200=) |
SYNONYMOUS | |
| rs141635865 | Benign: not provided | 1,455,938(-) |
G/A NM_016823.4(CRK):c.180C>T (p.Tyr60=) |
SYNONYMOUS | |
| rs146930761 | Benign: not provided | 1,437,022(-) |
A/G NM_016823.4(CRK):c.375T>C (p.Ser125=) |
SYNONYMOUS | |
| rs61762263 | Benign: not provided | 1,455,914(-) |
G/C NM_016823.4(CRK):c.204C>G (p.Arg68=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1931977 | CNV | deletion | 18987734 |
| esv2715463 | CNV | deletion | 23290073 |
| esv3639685 | CNV | loss | 21293372 |
| nsv1057782 | CNV | gain | 25217958 |
| nsv470567 | CNV | gain | 18288195 |
| nsv833334 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRK Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRK Gene
Disorders for CRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma |
|
|
| chromosome 17p13.3, centromeric, duplication syndrome |
|
|
| avian influenza |
|
|
| miller-dieker lissencephaly syndrome |
|
|
| lissencephaly |
|
|
Search CRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRK
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRK Gene
Publications for CRK Gene
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 22
- Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PMID: 10733900) Matsumoto T … Mori S (Biochemical and biophysical research communications 2000) 3 4 22
- Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval AP … LeRoith D (The Journal of biological chemistry 1998) 3 4 22
- Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PMID: 8662907) Matsuda M … Kurata T (The Journal of biological chemistry 1996) 3 4 22
- Two species of human CRK cDNA encode proteins with distinct biological activities. (PMID: 1630456) Matsuda M … Shibuya M (Molecular and cellular biology 1992) 3 4 22
ExternalLinks
Products for CRK Gene
- Custom Antibody ServicesOriGene Antibodies for CRK
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- OriGene qPCR primer pairs for CRK
- OriGene qPCR primer pairs and template standards for CRK
- OriGene CRISPR knockouts for CRK
- MG204260
- MR204260
- MR204260L3
- MR204260L4
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L2
- RC201701L3
- RC201701L4
- RC203438
- RC203438L3
- RC203438L4
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L4
- MR204260L3V
- MR204260L4V
- RC201701L1V
- RC201701L2V
- RC201701L3V
- RC201701L4V
- RC203438L3V
- RC203438L4V
- RR201929L3V
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRK
- Sino Biological Human cDNA Clone for CRK
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CRK
- Novus Biologicals proteins and lysates for CRK
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRK
- Abcam proteins for CRK
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for CRK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CRK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CRK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CRK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CRK
- Addgene plasmids for CRK
- antibodies-online: Show 97 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
- Recommended
- 104 WB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 6 DB Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 40 WB Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 16 available Crk Elisa Kits ranked by validation data
- Compare Top Crk Elisa Kits
- antibodies-online: Show 10 available Crk Proteins ranked by validation data
- Compare Top Crk Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CRK
- Search Santa Cruz Biotechnology (SCBT) for CRK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRK
- Horizon Cell Lines for CRK
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
- Boster Bio Antibodies for CRK
Sources for CRK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources