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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this... See more...
Aliases for CRK Gene
Aliases for CRK Gene
External Ids for CRK Gene
- HGNC: 2362
- Entrez Gene: 1398
- Ensembl: ENSG00000167193
- OMIM: 164762
- UniProtKB: P46108
Previous GeneCards Identifiers for CRK Gene
- GC17M001318
- GC17M001659
- GC17M001533
- GC17M001534
- GC17M001272
- GC17M001323
Summaries for CRK Gene
-
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRK Gene
CRK (CRK Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRK include Chromosome 17P13.3, Centromeric, Duplication Syndrome and Miller-Dieker Lissencephaly Syndrome. Among its related pathways are Signal transduction_JNK pathway and Development FGFR signaling pathway. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.
UniProtKB/Swiss-Prot Summary for CRK Gene
-
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRK Gene
Genomics for CRK Gene
GeneHancer (GH) Regulatory Elements for CRK Gene
Promoters and enhancers for CRK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRK gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- c-Myc
- Max1
Genomic Locations for CRK Gene
Genomic Locations for CRK Gene
- chr17:1,420,689-1,463,162
- (GRCh38/hg38)
- Size:
- 42,474 bases
- Orientation:
- Minus strand
- chr17:1,323,983-1,366,456
- (GRCh37/hg19)
- Size:
- 42,474 bases
- Orientation:
- Minus strand
Genomic View for CRK Gene
Genes around CRK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
CRK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRK Gene
Proteins for CRK Gene
-
Protein details for CRK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46108-CRK_HUMAN
- Recommended name:
- Adapter molecule crk
- Protein Accession:
- P46108
- A8MWE8
- B0LPE8
- D3DTH6
- Q96GA9
- Q96HJ0
Protein attributes for CRK Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33831 Da
- Quaternary structure:
-
- Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with CBLC. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.
Three dimensional structures from OCA and Proteopedia for CRK Gene
Protein Expression for CRK Gene
Post-translational modifications for CRK Gene
- Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
- Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.
- Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CRK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CrkII Antibody and Immunotag™ Phospho-CrkII (Tyr221) Antibody
- NSJ Bioreagents Crk Antibody p38
- Atlas Antibodies Anti-CRK Antibody
-
Creative Diagnostics
- Anti-CRK monoclonal antibody, clone FQS5095(3)
- Anti-CRK monoclonal antibody, clone 4H22D2
- Anti-CRK monoclonal antibody, clone 4I8-F6-I9
- Rabbit Anti-Human CRK Polyclonal antibody
- Mouse anti-Human CRK polyclonal antibody
- Rabbit anti-Human Crk p38 polyclonal antibody
- Rabbit Anti-Human CRK Polyclonal Antibody
-
Creative Biolabs
- Mouse Anti-CRK Recombinant Antibody (CBFYC-2214)
- Mouse Anti-CRK Recombinant Antibody (1D4B)
- Recombinant Mouse anti-Human CRK Monoclonal antibody (3320D2b)
- Mouse Anti-CRK Recombinant Antibody (12K73)
- Mouse Anti-CRK Recombinant Antibody (3G11C1)
- Mouse Anti-CRK Recombinant Antibody (7A10)
- Mouse Anti-CRK Recombinant Antibody (CBFYC-2211)
- Mouse Anti-CRK Recombinant Antibody (3B10)
- Mouse Anti-CRK Recombinant Antibody (3H7-E5-H8)
- Hi-Affi™ Recombinant Rabbit Anti-CRK Monoclonal Antibody (DS807AB)
- Mouse Anti-CRK Recombinant Antibody (13B190)
- Mouse Anti-CRK Recombinant Antibody (2210C1a)
- Mouse Anti-CRK Recombinant Antibody (463414)
- Mouse Anti-CRK Recombinant Antibody (5E8)
- Mouse Anti-CRK (AA 102-304) Recombinant Antibody (CBFYC-2213)
- Mouse Anti-CRK Recombinant Antibody (13B191)
- Mouse Anti-CRK Recombinant Antibody (15C11)
- Mouse Anti-CRK (AA 205-304) Recombinant Antibody (CBFYC-2212)
- Mouse Anti-CRK Recombinant Antibody (13k37)
- Mouse Anti-CRK Recombinant Antibody (8C86)
- Mouse Anti-CRK Recombinant Antibody (CBYY-C0240)
- Mouse Anti-CRK Recombinant Antibody (3G11E8)
- Mouse Anti-CRK Recombinant Antibody (CBYY-C2861)
-
Custom Antibody ServicesOriGene Antibodies for CRK
- Novus Biologicals Antibodies for CRK
-
Abcam antibodies for CRK
- Invitrogen Antibodies for CRK (AFLGC-CRK)
- antibodies-online: Show 97 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
-
Recommended
- 104 WB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 6 DB Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 40 WB Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRK
Protein Products
- Atlas Antibodies PrEST Antigen CRK
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- ProSpec Recombinant Proteins for CRK
- antibodies-online: Show 10 available Crk Proteins ranked by validation data
- Compare Top Crk Proteins
-
Abcam proteins for CRK
Assay Products
- G Biosciences Immunotag™ Adapter molecule crk ELISA Kit
- RayBiotech Custom Human Crk ELISA
- Aviva Systems Biology CRK ELISA Kit (Human) (OKEH04968)
No data available for DME Specific Peptides for CRK Gene
Domains & Families for CRK Gene
Gene Families for CRK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CRK Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRK Gene
- GenScript: Design optimal peptide antigens:
-
- p38 (CRK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46108UniProtKB/Swiss-Prot:
CRK_HUMAN :- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- Belongs to the CRK family.
- Domain:
-
- The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
- The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
- Family:
-
- Belongs to the CRK family.
Function for CRK Gene
Molecular function for CRK Gene
- UniProtKB/Swiss-Prot Function:
- Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
- GENATLAS Biochemistry:
- avian sarcoma virus CT10 (v-crk) homolog
Phenotypes From GWAS Catalog for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0005070 | SH3/SH2 adaptor activity | IDA | 12384576 |
| GO:0005159 | insulin-like growth factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 7561682 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for CRK Gene
- MGI mutant phenotypes for CRK:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CRK:
-
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased cell migration
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
Animal Models for CRK Gene
- MGI Knock Outs for CRK:
-
- Crk Crk<tm1.1Cur>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for CRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
- genomics-online: gRNA clones - Search for available Crk gRNA products
- Overview of 144 available Crk gene related products
- Applied Biological Materials (abm): CRISPR Clones for CRK - Select products 50% OFF >
- * CRK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CRK CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
miRNA for CRK Gene
- miRTarBase miRNAs that target CRK
-
- hsa-mir-126-3p (MIRT002993)
- hsa-mir-132-3p (MIRT007166)
- hsa-mir-125a-5p (MIRT021297)
- hsa-mir-215-5p (MIRT024820)
- hsa-mir-10a-5p (MIRT025620)
- hsa-mir-192-5p (MIRT026885)
- hsa-mir-106b-3p (MIRT038548)
- hsa-mir-129-1-3p (MIRT038706)
- hsa-mir-15b-5p (MIRT046474)
- hsa-let-7e-5p (MIRT051574)
- hsa-mir-1260b (MIRT052687)
- hsa-mir-1257 (MIRT144777)
- hsa-mir-4320 (MIRT195992)
- hsa-mir-8485 (MIRT285743)
- hsa-mir-205-3p (MIRT386618)
- hsa-mir-10b-5p (MIRT439131)
- hsa-let-7c-5p (MIRT439167)
- hsa-mir-20a-5p (MIRT440876)
- hsa-mir-106b-5p (MIRT440877)
- hsa-mir-5096 (MIRT512084)
- hsa-mir-3941 (MIRT512085)
- hsa-mir-613 (MIRT512086)
- hsa-mir-206 (MIRT512087)
- hsa-mir-1-3p (MIRT512088)
- hsa-mir-3140-3p (MIRT512089)
- hsa-mir-6893-3p (MIRT512090)
- hsa-mir-6128 (MIRT512091)
- hsa-mir-370-3p (MIRT512092)
- hsa-mir-6765-3p (MIRT512093)
- hsa-mir-3622b-3p (MIRT512094)
- hsa-mir-3622a-3p (MIRT512095)
- hsa-mir-619-3p (MIRT512096)
- hsa-mir-603 (MIRT512097)
- hsa-mir-362-3p (MIRT512098)
- hsa-mir-329-3p (MIRT512099)
- hsa-mir-216b-3p (MIRT524335)
- hsa-mir-7156-3p (MIRT543004)
- hsa-mir-127-5p (MIRT543005)
- hsa-mir-4284 (MIRT543006)
- hsa-mir-7843-3p (MIRT543007)
- hsa-mir-1184 (MIRT543008)
- hsa-mir-1304-3p (MIRT543009)
- hsa-mir-6741-3p (MIRT543010)
- hsa-mir-4726-3p (MIRT543011)
- hsa-mir-6764-5p (MIRT543012)
- hsa-mir-1915-3p (MIRT543013)
- hsa-mir-6840-3p (MIRT543014)
- hsa-mir-6890-3p (MIRT543015)
- hsa-mir-1306-5p (MIRT543016)
- hsa-mir-509-5p (MIRT543017)
- hsa-mir-509-3-5p (MIRT543018)
- hsa-mir-4418 (MIRT543019)
- hsa-mir-30e-3p (MIRT548709)
- hsa-mir-30d-3p (MIRT548710)
- hsa-mir-30a-3p (MIRT548711)
- hsa-mir-6516-5p (MIRT548712)
- hsa-mir-1273h-3p (MIRT548713)
- hsa-mir-3678-3p (MIRT548714)
- hsa-mir-190a-3p (MIRT548715)
- hsa-mir-4524b-5p (MIRT548716)
- hsa-mir-4524a-5p (MIRT548717)
- hsa-mir-298 (MIRT548718)
- hsa-mir-3163 (MIRT548719)
- hsa-mir-5680 (MIRT548720)
- hsa-mir-646 (MIRT548721)
- hsa-mir-580-5p (MIRT548722)
- hsa-mir-410-3p (MIRT548723)
- hsa-mir-16-5p (MIRT548724)
- hsa-mir-503-5p (MIRT548725)
- hsa-mir-6838-5p (MIRT548726)
- hsa-mir-15a-5p (MIRT548727)
- hsa-mir-195-5p (MIRT548728)
- hsa-mir-424-5p (MIRT548729)
- hsa-mir-497-5p (MIRT548730)
- hsa-mir-9-3p (MIRT567908)
- hsa-mir-423-3p (MIRT567909)
- hsa-mir-31-3p (MIRT567910)
- hsa-mir-502-3p (MIRT567911)
- hsa-mir-5590-3p (MIRT567912)
- hsa-mir-501-3p (MIRT567913)
- hsa-mir-142-5p (MIRT567914)
- hsa-mir-4796-3p (MIRT567915)
- hsa-mir-3609 (MIRT567916)
- hsa-mir-548ah-5p (MIRT567917)
- hsa-mir-320d (MIRT567918)
- hsa-mir-320b (MIRT567919)
- hsa-mir-320a (MIRT567920)
- hsa-mir-4429 (MIRT567921)
- hsa-mir-320c (MIRT567922)
- hsa-mir-20b-5p (MIRT567923)
- hsa-mir-93-5p (MIRT567924)
- hsa-mir-526b-3p (MIRT567925)
- hsa-mir-106a-5p (MIRT567926)
- hsa-mir-519d-3p (MIRT567927)
- hsa-mir-17-5p (MIRT567928)
- hsa-mir-302d-3p (MIRT567929)
- hsa-mir-520b (MIRT567930)
- hsa-mir-520a-3p (MIRT567931)
- hsa-mir-373-3p (MIRT567932)
- hsa-mir-520c-3p (MIRT567933)
- hsa-mir-520d-3p (MIRT567934)
- hsa-mir-302a-3p (MIRT567935)
- hsa-mir-372-3p (MIRT567936)
- hsa-mir-302e (MIRT567937)
- hsa-mir-302b-3p (MIRT567938)
- hsa-mir-520e (MIRT567939)
- hsa-mir-302c-3p (MIRT567940)
- hsa-mir-135b-3p (MIRT567941)
- hsa-mir-664b-5p (MIRT567942)
- hsa-mir-6814-5p (MIRT567943)
- hsa-mir-4733-5p (MIRT567944)
- hsa-mir-548l (MIRT567945)
- hsa-mir-186-5p (MIRT567946)
- hsa-mir-548n (MIRT567947)
- hsa-mir-6818-5p (MIRT572161)
- hsa-mir-5196-5p (MIRT572162)
- hsa-mir-4747-5p (MIRT572163)
- hsa-mir-6821-3p (MIRT572164)
- hsa-mir-6790-3p (MIRT572165)
- hsa-mir-4790-3p (MIRT572166)
- hsa-mir-4652-3p (MIRT639243)
- hsa-mir-640 (MIRT639244)
- hsa-mir-367-5p (MIRT639245)
- hsa-mir-1267 (MIRT639246)
- hsa-mir-6787-3p (MIRT639247)
- hsa-mir-6891-3p (MIRT639248)
- hsa-mir-6072 (MIRT639249)
- hsa-mir-1207-3p (MIRT639250)
- hsa-mir-4778-5p (MIRT639251)
- hsa-mir-510-5p (MIRT639252)
- hsa-mir-512-5p (MIRT639253)
- hsa-mir-126-5p (MIRT734618)
- hsa-mir-138-2-3p (MIRT762600)
- hsa-mir-1910-3p (MIRT763277)
- hsa-mir-2110 (MIRT763779)
- hsa-mir-3065-5p (MIRT764546)
- hsa-mir-30c-1-3p (MIRT764652)
- hsa-mir-30c-2-3p (MIRT764697)
- hsa-mir-3150a-3p (MIRT765022)
- hsa-mir-3192-5p (MIRT765416)
- hsa-mir-33a-5p (MIRT765694)
- hsa-mir-33b-5p (MIRT765703)
- hsa-mir-3680-3p (MIRT766737)
- hsa-mir-3714 (MIRT767145)
- hsa-mir-4260 (MIRT768194)
- hsa-mir-4271 (MIRT768254)
- hsa-mir-4463 (MIRT769406)
- hsa-mir-4477a (MIRT769488)
- hsa-mir-4487 (MIRT769650)
- hsa-mir-450a-2-3p (MIRT769868)
- hsa-mir-4725-3p (MIRT771624)
- hsa-mir-548c-3p (MIRT774303)
- hsa-mir-5572 (MIRT774687)
- hsa-mir-605-3p (MIRT775415)
- hsa-mir-6511a-5p (MIRT776775)
- hsa-mir-6731-5p (MIRT777976)
- hsa-mir-6763-5p (MIRT778482)
- hsa-mir-6780b-5p (MIRT779045)
- hsa-mir-6788-5p (MIRT779229)
- hsa-mir-6810-5p (MIRT779755)
- hsa-mir-6857-5p (MIRT780507)
- hsa-mir-6878-5p (MIRT780771)
- hsa-mir-7-1-3p (MIRT781487)
- hsa-mir-7-2-3p (MIRT781699)
- hsa-mir-7851-3p (MIRT782195)
- hsa-mir-8085 (MIRT782419)
- hsa-mir-873-3p (MIRT782455)
- hsa-mir-95-5p (MIRT782993)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
- genomics-online: shRNA clones - Search for available Crk shRNA products
- Overview of 144 available Crk gene related products
Clone Products
-
- MG204260
- MR204260
- MR204260L3
- MR204260L3V
- MR204260L4
- MR204260L4V
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L1V
- RC201701L2
- RC201701L2V
- RC201701L3
- RC201701L3V
- RC201701L4
- RC201701L4V
- RC203438
- RC203438L3
- RC203438L3V
- RC203438L4
- RC203438L4V
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L3V
- RR201929L4
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRK
- Addgene plasmids for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
- genomics-online: cdna clones - Search for available Crk CDNA products
- Overview of 144 available Crk gene related products
- orf clones - Search for available Crk ORF products
- Overview of 144 available Crk gene related products
- Applied Biological Materials (abm): Clones for CRK - Select products 50% OFF >
- * CRK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CRK tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CRK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRK Gene
Localization for CRK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRK Gene
- Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytoskeleton | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10748058 |
| GO:0005737 | cytoplasm | IEA,IC | 11870224 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0015629 | actin cytoskeleton | IEA | -- |
Pathways & Interactions for CRK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Development HGF signaling pathway | ||
| 3 | MET promotes cell motility |
.45
|
|
| 4 | ErbB signaling pathway | ||
| 5 | Focal Adhesion |
.62
.62
|
|
Pathways by source for CRK Gene
2 Sino Biological pathways for CRK Gene
33 BioSystems pathways for CRK Gene
29 Reactome pathways for CRK Gene
1 PharmGKB pathway for CRK Gene
8 GeneGo (Thomson Reuters) pathways for CRK Gene
2 R&D Systems pathways for CRK Gene
15 Qiagen pathways for CRK Gene
- Chemokine Signaling
- CXCR4 Pathway
- Epithelial Adherens Junctions
- FAK1 Signaling
- GPCR Pathway
1 Cell Signaling Technology pathway for CRK Gene
1 GeneTex pathway for CRK Gene
Interacting Proteins for CRK Gene
Selected Interacting proteins:
P46108-CRK_HUMAN
ENSP00000300574
for CRK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRK
SIGNOR curated interactions for CRK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | TAS | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001878 | response to yeast | IEA | -- |
| GO:0002685 | regulation of leukocyte migration | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10748058 |
Drugs & Compounds for CRK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CRK Gene
mRNA/cDNA for CRK Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (333) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000398970 3675 bps (ENST00000398970.5)
- ENST00000300574 3850 bps (ENST00000300574.2)
- ENST00000574295 1391 bps (ENST00000574295.1)
- ENST00000572145 830 bps (ENST00000572145.1)
CRISPR Products
-
OriGene CRISPR knockouts for CRK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
- genomics-online: gRNA clones - Search for available Crk gRNA products
- Overview of 144 available Crk gene related products
- Applied Biological Materials (abm): CRISPR Clones for CRK - Select products 50% OFF >
- * CRK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CRK CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRK
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
- genomics-online: shRNA clones - Search for available Crk shRNA products
- Overview of 144 available Crk gene related products
Clone Products
-
- MG204260
- MR204260
- MR204260L3
- MR204260L3V
- MR204260L4
- MR204260L4V
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L1V
- RC201701L2
- RC201701L2V
- RC201701L3
- RC201701L3V
- RC201701L4
- RC201701L4V
- RC203438
- RC203438L3
- RC203438L3V
- RC203438L4
- RC203438L4V
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L3V
- RR201929L4
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRK
- Addgene plasmids for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
- genomics-online: cdna clones - Search for available Crk CDNA products
- Overview of 144 available Crk gene related products
- orf clones - Search for available Crk ORF products
- Overview of 144 available Crk gene related products
- Applied Biological Materials (abm): Clones for CRK - Select products 50% OFF >
- * CRK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CRK tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: |
Expression for CRK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Uterus (6.2) and Oral epithelium (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CRK Gene:
CRKSOURCE GeneReport for Unigene cluster for CRK Gene:
Hs.461896Evidence on tissue expression from TISSUES for CRK Gene
- Lung(4.4)
- Liver(4.3)
- Eye(4.2)
- Nervous system(3.8)
- Kidney(2.3)
- Heart(2.2)
- Adrenal gland(2.1)
- Muscle(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for CRK
-
OriGene qPCR primer pairs and template standards for CRK
- genomics-online: primer clones - Search for available Crk Primer products
- Overview of 144 available Crk gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRK Gene
Orthologs for CRK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRK 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CRK 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CRK 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Crk 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crk 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRK 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRK 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRK 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CRK 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crk 32 |
|
||
| Str.6504 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68492 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crk 33 32 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4632 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Crk 33 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009499 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ced-2 33 32 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6350 33 |
|
OneToMany |
- Species where no ortholog for CRK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CRK Gene
- ENSEMBL:
- Gene Tree for CRK (if available)
- TreeFam:
- Gene Tree for CRK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRK: view image
Paralogs for CRK Gene
(6) SIMAP similar genes for CRK Gene using alignment to 3 proteins:
- CRK_HUMAN
- I3L297_HUMAN
- L7RT18_HUMAN
Pseudogenes.org Pseudogenes for CRK Gene
Variants for CRK Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000109630 | -- | 1,434,938(-) | G/C/T | intron_variant | |
| rs1000191302 | -- | 1,448,531(-) | G/A | intron_variant | |
| rs1000253683 | -- | 1,445,802(-) | T/C/G | intron_variant | |
| rs1000283127 | -- | 1,446,089(-) | T/C | intron_variant | |
| rs1000457943 | -- | 1,433,516(-) | T/A/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1931977 | CNV | deletion | 18987734 |
| esv2715463 | CNV | deletion | 23290073 |
| esv3639685 | CNV | loss | 21293372 |
| nsv1057782 | CNV | gain | 25217958 |
| nsv470567 | CNV | gain | 18288195 |
| nsv833334 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRK Gene
Disorders for CRK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17p13.3, centromeric, duplication syndrome |
|
|
| miller-dieker lissencephaly syndrome |
|
|
| shigellosis |
|
|
| childhood endodermal sinus tumor |
|
|
| avian influenza |
|
|
Search CRK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CRK Gene
Publications for CRK Gene
- DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 23 56
- Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PMID: 10733900) Matsumoto T … Mori S (Biochemical and biophysical research communications 2000) 3 4 23 56
- Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval AP … LeRoith D (The Journal of biological chemistry 1998) 3 4 23 56
- Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PMID: 8662907) Matsuda M … Kurata T (The Journal of biological chemistry 1996) 3 4 23 56
- Two species of human CRK cDNA encode proteins with distinct biological activities. (PMID: 1630456) Matsuda M … Shibuya M (Molecular and cellular biology 1992) 3 4 23 56
ExternalLinks
Products for CRK Gene
- Custom Antibody ServicesOriGene Antibodies for CRK
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CRK
- Origene Custom Protein Services for CRK
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CRK
- Browse OriGene Inhibitory RNA Products For CRK
- OriGene qPCR primer pairs for CRK
- OriGene qPCR primer pairs and template standards for CRK
- OriGene CRISPR knockouts for CRK
- MG204260
- MR204260
- MR204260L3
- MR204260L3V
- MR204260L4
- MR204260L4V
- MR227754
- MR228496
- RC201701
- RC201701L1
- RC201701L1V
- RC201701L2
- RC201701L2V
- RC201701L3
- RC201701L3V
- RC201701L4
- RC201701L4V
- RC203438
- RC203438L3
- RC203438L3V
- RC203438L4
- RC203438L4V
- RG201701
- RG203438
- RR201929
- RR201929L3
- RR201929L3V
- RR201929L4
- RR201929L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRK
- Sino Biological Human cDNA Clone for CRK
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CRK
- Novus Biologicals proteins and lysates for CRK
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRK
- Abcam proteins for CRK
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Addgene plasmids for CRK
- antibodies-online: Show 97 available Crk Antibodies ranked by validation data
- Compare Top Crk Antibodies
- Recommended
- 104 WB Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 6 DB Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 40 WB Antibodies (anti-rat)
- 21 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 52 WB Antibodies (anti-mouse)
- 21 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 16 available Crk Elisa Kits ranked by validation data
- Compare Top Crk Elisa Kits
- antibodies-online: Show 10 available Crk Proteins ranked by validation data
- Compare Top Crk Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CRK
- Search Santa Cruz Biotechnology (SCBT) for CRK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRK
- Horizon Cell Lines for CRK
- genomics-online: cdna clones - Search for available Crk CDNA products
- Overview of 144 available Crk gene related products
- orf clones - Search for available Crk ORF products
- Overview of 144 available Crk gene related products
- genomics-online: gRNA clones - Search for available Crk gRNA products
- Overview of 144 available Crk gene related products
- genomics-online: primer clones - Search for available Crk Primer products
- Overview of 144 available Crk gene related products
- genomics-online: shRNA clones - Search for available Crk shRNA products
- Overview of 144 available Crk gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CRK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRK
Sources for CRK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70)