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Aliases for CRISPLD2 Gene
Aliases for CRISPLD2 Gene
External Ids for CRISPLD2 Gene
- HGNC: 25248
- Entrez Gene: 83716
- Ensembl: ENSG00000103196
- OMIM: 612434
- UniProtKB: Q9H0B8
Previous HGNC Symbols for CRISPLD2 Gene
- LCRISP2
Previous GeneCards Identifiers for CRISPLD2 Gene
- GC16P083412
- GC16P084853
- GC16P070606
Summaries for CRISPLD2 Gene
GeneCards Summary for CRISPLD2 Gene
CRISPLD2 (Cysteine Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. Diseases associated with CRISPLD2 include Orofacial Cleft 15 and Cleft Lip. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is CRISPLD1.
UniProtKB/Swiss-Prot Summary for CRISPLD2 Gene
-
Promotes matrix assembly.
Additional gene information for CRISPLD2 Gene
- HGNC(25248)
- Entrez Gene(83716)
- Ensembl(ENSG00000103196)
- OMIM(612434)
- UniProtKB(Q9H0B8)
- Open Targets Platform(ENSG00000103196)
- Monarch Initiative
- Search for CRISPLD2 at DataMed
- Search for CRISPLD2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRISPLD2 Gene
Genomics for CRISPLD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRISPLD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRISPLD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRISPLD2
- Top Transcription factor binding sites by QIAGEN in the CRISPLD2 gene promoter:
-
- AP-1
- ER-alpha
- FAC1
- GR
- GR-alpha
- Hlf
- HNF-4alpha1
- RP58
- RREB-1
Genomic Locations for CRISPLD2 Gene
Genomic Locations for CRISPLD2 Gene
- chr16:84,819,981-84,920,768
- (GRCh38/hg38)
- Size:
- 100,788 bases
- Orientation:
- Plus strand
- chr16:84,853,587-84,954,374
- (GRCh37/hg19)
- Size:
- 100,788 bases
- Orientation:
- Plus strand
Genomic View for CRISPLD2 Gene
Genes around CRISPLD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.1 by HGNC
- 16q24.1 by Entrez Gene
- 16q24.1 by Ensembl
CRISPLD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRISPLD2 Gene
Proteins for CRISPLD2 Gene
-
Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0B8-CRLD2_HUMAN
- Recommended name:
- Cysteine-rich secretory protein LCCL domain-containing 2
- Protein Accession:
- Q9H0B8
- D3DUM0
- Q6P590
- Q6UWH0
- Q6UXC6
- Q96IB1
- Q96K61
Protein attributes for CRISPLD2 Gene
- Size:
- 497 amino acids
- Molecular mass:
- 55920 Da
- Quaternary structure:
-
- Binds to heparin, dermatan sulfate and chondroitin sulfate.
Protein Expression for CRISPLD2 Gene
Post-translational modifications for CRISPLD2 Gene
Other Protein References for CRISPLD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CRISPLD2
- Novus Biologicals Antibodies for CRISPLD2
-
Abcam antibodies for CRISPLD2
- Invitrogen Antibodies for CRISPLD2 (AFLGC-CRISPLD2)
-
Boster Bio Antibodies for CRISPLD2
- Sino Biological Antibodies for CRISPLD2
Protein Products
-
OriGene Purified Proteins for CRISPLD2
- Search Origene for MassSpec and Protein Over-expression Lysates for CRISPLD2
- Origene Custom Protein Services for CRISPLD2
- antibodies-online: Show 5 available Trypsin Inhibitor Proteins ranked by validation data
- Compare Top Trypsin Inhibitor Proteins
-
Quality Products:
-
Abcam proteins for CRISPLD2
No data available for DME Specific Peptides for CRISPLD2 Gene
Domains & Families for CRISPLD2 Gene
Gene Families for CRISPLD2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CRISPLD2 Gene
- InterPro:
- Blocks:
-
- Allergen V5/Tpx-1 related
- ProtoNet:
Suggested Antigen Peptide Sequences for CRISPLD2 Gene
- GenScript: Design optimal peptide antigens:
-
- LCCL domain-containing cysteine-rich secretory protein 2 (CRLD2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H0B8- Family:
-
- Belongs to the CRISP family.
Function for CRISPLD2 Gene
Molecular function for CRISPLD2 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes matrix assembly.
Phenotypes From GWAS Catalog for CRISPLD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005539 | glycosaminoglycan binding | IBA | 21873635 |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for CRISPLD2 Gene
- MGI mutant phenotypes for CRISPLD2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CRISPLD2:
Animal Models for CRISPLD2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CRISPLD2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRISPLD2 - Select products 50% OFF >
- * CRISPLD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRISPLD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRISPLD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRISPLD2
miRNA for CRISPLD2 Gene
- miRTarBase miRNAs that target CRISPLD2
-
- hsa-miR-335-5p (MIRT016863)
- hsa-miR-6780a-5p (MIRT478828)
- hsa-miR-6779-5p (MIRT478829)
- hsa-miR-3689c (MIRT478830)
- hsa-miR-3689b-3p (MIRT478831)
- hsa-miR-3689a-3p (MIRT478832)
- hsa-miR-30b-3p (MIRT478833)
- hsa-miR-1273h-5p (MIRT478834)
- hsa-miR-1273e (MIRT478835)
- hsa-miR-6807-5p (MIRT478836)
- hsa-miR-6778-5p (MIRT478837)
- hsa-miR-1233-5p (MIRT478838)
- hsa-miR-6799-5p (MIRT478839)
- hsa-miR-6883-5p (MIRT478840)
- hsa-miR-6785-5p (MIRT478841)
- hsa-miR-4728-5p (MIRT478842)
- hsa-miR-149-3p (MIRT478843)
- hsa-miR-7106-5p (MIRT478844)
- hsa-miR-650 (MIRT478845)
- hsa-miR-3612 (MIRT478846)
- hsa-miR-6894-5p (MIRT478847)
- hsa-miR-7160-5p (MIRT478848)
- hsa-miR-661 (MIRT478849)
- hsa-miR-2467-3p (MIRT478850)
- hsa-miR-6134 (MIRT478851)
- hsa-miR-6884-5p (MIRT478852)
- hsa-miR-7854-3p (MIRT478853)
- hsa-miR-485-5p (MIRT478854)
- hsa-miR-6823-3p (MIRT478855)
- hsa-miR-1827 (MIRT478856)
- hsa-miR-2114-3p (MIRT478857)
- hsa-miR-3192-5p (MIRT478858)
- hsa-miR-7162-3p (MIRT478859)
- hsa-miR-665 (MIRT478860)
- hsa-miR-4478 (MIRT478861)
- hsa-miR-4419b (MIRT478862)
- hsa-miR-3929 (MIRT478863)
- hsa-miR-6511a-5p (MIRT478864)
- hsa-miR-1910-3p (MIRT478865)
- hsa-miR-4695-5p (MIRT478866)
- hsa-miR-5089-5p (MIRT510005)
- hsa-miR-5589-5p (MIRT510006)
- hsa-miR-6506-5p (MIRT510007)
- hsa-miR-4731-5p (MIRT510008)
- hsa-miR-619-5p (MIRT510009)
- hsa-miR-6504-3p (MIRT510010)
- hsa-miR-512-3p (MIRT510011)
- hsa-miR-3120-3p (MIRT510012)
- hsa-miR-520e (MIRT510013)
- hsa-miR-520d-3p (MIRT510014)
- hsa-miR-520c-3p (MIRT510015)
- hsa-miR-520b (MIRT510016)
- hsa-miR-520a-3p (MIRT510017)
- hsa-miR-373-3p (MIRT510018)
- hsa-miR-372-3p (MIRT510019)
- hsa-miR-302e (MIRT510020)
- hsa-miR-302d-3p (MIRT510021)
- hsa-miR-302c-3p (MIRT510022)
- hsa-miR-302b-3p (MIRT510023)
- hsa-miR-302a-3p (MIRT510024)
- hsa-miR-93-5p (MIRT510025)
- hsa-miR-526b-3p (MIRT510026)
- hsa-miR-519d-3p (MIRT510027)
- hsa-miR-20b-5p (MIRT510028)
- hsa-miR-20a-5p (MIRT510029)
- hsa-miR-17-5p (MIRT510030)
- hsa-miR-106b-5p (MIRT510031)
- hsa-miR-106a-5p (MIRT510032)
- hsa-miR-4252 (MIRT519082)
- hsa-miR-1273g-3p (MIRT519083)
- hsa-miR-6848-3p (MIRT538366)
- hsa-miR-6843-3p (MIRT538367)
- hsa-miR-6131 (MIRT538368)
- hsa-miR-6821-3p (MIRT538369)
- hsa-miR-6790-3p (MIRT538370)
- hsa-miR-3663-5p (MIRT538371)
- hsa-miR-6078 (MIRT538372)
- hsa-miR-614 (MIRT538373)
- hsa-miR-8485 (MIRT540743)
- hsa-miR-4643 (MIRT540744)
- mmu-miR-186-5p (MIRT584127)
- mmu-miR-695 (MIRT605104)
- hsa-miR-6768-5p (MIRT607140)
- hsa-miR-8057 (MIRT608080)
- hsa-miR-6836-3p (MIRT608081)
- hsa-miR-5001-3p (MIRT608082)
- hsa-miR-24-3p (MIRT608083)
- hsa-miR-3194-3p (MIRT608084)
- hsa-miR-6829-3p (MIRT608085)
- hsa-miR-6791-3p (MIRT608086)
- hsa-miR-6778-3p (MIRT608087)
- hsa-miR-2276-3p (MIRT608088)
- hsa-miR-4532 (MIRT608089)
- hsa-miR-1247-3p (MIRT608090)
- hsa-miR-6890-3p (MIRT608091)
- hsa-miR-6796-3p (MIRT608092)
- hsa-miR-197-3p (MIRT608093)
- hsa-miR-143-5p (MIRT608094)
- hsa-miR-4430 (MIRT608095)
- hsa-miR-3652 (MIRT608096)
- hsa-miR-4284 (MIRT608097)
- hsa-miR-4634 (MIRT608098)
- hsa-miR-504-3p (MIRT608099)
- hsa-miR-3135b (MIRT608100)
- hsa-miR-6499-3p (MIRT608101)
- hsa-miR-4638-5p (MIRT608102)
- hsa-miR-1307-3p (MIRT608103)
- hsa-miR-6511b-3p (MIRT608104)
- hsa-miR-6511a-3p (MIRT608105)
- hsa-miR-6741-3p (MIRT608106)
- hsa-miR-5693 (MIRT608107)
- hsa-miR-4659b-3p (MIRT624267)
- hsa-miR-4659a-3p (MIRT624268)
- hsa-miR-4303 (MIRT624269)
- hsa-miR-22-5p (MIRT624270)
- hsa-miR-4668-5p (MIRT624271)
- hsa-miR-6081 (MIRT624272)
- hsa-miR-3182 (MIRT624273)
- hsa-miR-6761-5p (MIRT624274)
- hsa-miR-4329 (MIRT624275)
- hsa-miR-4251 (MIRT624276)
- hsa-miR-3613-3p (MIRT624277)
- hsa-miR-548p (MIRT624278)
- hsa-miR-148a-5p (MIRT624279)
- hsa-miR-765 (MIRT628289)
- hsa-miR-7154-3p (MIRT628290)
- hsa-miR-766-5p (MIRT628291)
- hsa-miR-4717-3p (MIRT628292)
- hsa-miR-4802-5p (MIRT628293)
- hsa-miR-4802-3p (MIRT628294)
- hsa-miR-574-5p (MIRT628295)
- hsa-miR-6867-5p (MIRT628296)
- hsa-miR-4711-3p (MIRT628297)
- hsa-miR-6812-3p (MIRT628298)
- hsa-miR-8064 (MIRT636599)
- hsa-miR-4768-3p (MIRT637868)
- hsa-miR-5584-3p (MIRT659363)
- hsa-miR-215-3p (MIRT659364)
- hsa-miR-6773-3p (MIRT659365)
- hsa-miR-651-5p (MIRT668888)
- hsa-miR-4266 (MIRT668889)
- hsa-miR-7977 (MIRT668890)
- hsa-miR-383-3p (MIRT668891)
- hsa-miR-708-5p (MIRT668892)
- hsa-miR-3139 (MIRT668893)
- hsa-miR-28-5p (MIRT668894)
- hsa-miR-524-5p (MIRT675649)
- hsa-miR-520d-5p (MIRT675650)
- hsa-miR-7853-5p (MIRT675651)
- hsa-miR-105-5p (MIRT675652)
- hsa-miR-4707-3p (MIRT688627)
- hsa-miR-150-5p (MIRT688628)
- hsa-miR-7107-5p (MIRT688629)
- hsa-miR-1234-3p (MIRT688630)
- hsa-miR-186-3p (MIRT688631)
- hsa-miR-520h (MIRT688632)
- hsa-miR-520g-3p (MIRT688633)
- hsa-miR-2355-3p (MIRT696129)
- hsa-miR-676-3p (MIRT696130)
- hsa-miR-6727-3p (MIRT696131)
- hsa-miR-4722-3p (MIRT696132)
- hsa-miR-1203 (MIRT696133)
- hsa-miR-7111-3p (MIRT719616)
- hsa-miR-642a-5p (MIRT719617)
- hsa-miR-6515-3p (MIRT719618)
- hsa-miR-381-3p (MIRT719619)
- hsa-miR-300 (MIRT719620)
- hsa-miR-6867-3p (MIRT789184)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRISPLD2
- Browse OriGene Inhibitory RNA Products For CRISPLD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRISPLD2
Clone Products
- Applied Biological Materials (abm): Clones for CRISPLD2 - Select products 50% OFF >
- * CRISPLD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRISPLD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRISPLD2
Cell Line Products
-
Horizon Cell Lines for CRISPLD2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISPLD2 Gene
Localization for CRISPLD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0030133 | transport vesicle | IDA | -- |
| GO:0031012 | extracellular matrix | IEA | -- |
| GO:0034774 | secretory granule lumen | TAS | -- |
Pathways & Interactions for CRISPLD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for CRISPLD2 Gene
3 Reactome pathways for CRISPLD2 Gene
Interacting Proteins for CRISPLD2 Gene
GPS-Prot Interaction Network for CRISPLD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030198 | extracellular matrix organization | IEA | -- |
| GO:0030324 | lung development | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0060325 | face morphogenesis | IMP | 21254358 |
No data available for SIGNOR curated interactions for CRISPLD2 Gene
Transcripts for CRISPLD2 Gene
mRNA/cDNA for CRISPLD2 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262424 4583 nts (view in UCSC)
- ENST00000566151 538 nts (view in UCSC)
- ENST00000567845 2178 nts (view in UCSC)
- ENST00000566431 1083 nts (view in UCSC)
- ENST00000565561 1739 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRISPLD2 - Select products 50% OFF >
- * CRISPLD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRISPLD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRISPLD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRISPLD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRISPLD2
- Browse OriGene Inhibitory RNA Products For CRISPLD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRISPLD2
Clone Products
- Applied Biological Materials (abm): Clones for CRISPLD2 - Select products 50% OFF >
- * CRISPLD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRISPLD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRISPLD2
Relevant External Links for CRISPLD2 Gene
- GeneLoc Exon Structure for
- CRISPLD2
Expression for CRISPLD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Spleen (Hematopoietic System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Ovary (Reproductive System)
This gene is overexpressed in Lavage (57.7) and Placenta (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRISPLD2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRISPLD2
SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene:
Hs.513779Evidence on tissue expression from TISSUES for CRISPLD2 Gene
- Blood(4.5)
- Nervous system(2.5)
- Lung(2.4)
- Intestine(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for CRISPLD2
-
OriGene qPCR primer pairs and template standards for CRISPLD2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISPLD2 Gene
Orthologs for CRISPLD2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRISPLD2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRISPLD2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRISPLD2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRISPLD2 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crispld2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Crispld2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRISPLD2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRISPLD2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CRISPLD2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crispld2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100535149 30 |
|
||
| CRISPLD2 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8483 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | scl-23 31 |
|
ManyToMany | |
| vap-1 31 |
|
ManyToMany | |||
| scl-22 31 |
|
ManyToMany |
- Species where no ortholog for CRISPLD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CRISPLD2 Gene
- ENSEMBL:
- Gene Tree for CRISPLD2 (if available)
- TreeFam:
- Gene Tree for CRISPLD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRISPLD2: view image
Paralogs for CRISPLD2 Gene
Paralogs for CRISPLD2 Gene
(4) SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:
- CRLD2_HUMAN
- H3BS62_HUMAN
- H3BSZ9_HUMAN
- H3BTI0_HUMAN
- H3BTP0_HUMAN
- J3QKP2_HUMAN
Variants for CRISPLD2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRISPLD2 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710712 | Likely Benign: not provided | 84,849,457(+) | C/A | MISSENSE_VARIANT | |
| 720481 | Benign: not provided | 84,854,801(+) | C/T | SYNONYMOUS_VARIANT | |
| 733927 | Benign: not provided | 84,880,580(+) | C/G | MISSENSE_VARIANT | |
| 768803 | Benign: not provided | 84,873,915(+) | A/C | INTRON_VARIANT | |
| 770793 | Benign: not provided | 84,868,917(+) | CCTGTGCTGGGCTGTC | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5269n54 | CNV | loss | 21841781 |
| esv3639442 | CNV | gain | 21293372 |
| esv3639445 | CNV | gain | 21293372 |
| esv3639446 | CNV | gain | 21293372 |
| esv3639447 | CNV | gain | 21293372 |
| esv3639448 | CNV | gain | 21293372 |
| nsv1056758 | CNV | gain | 25217958 |
| nsv1066260 | CNV | gain | 25217958 |
| nsv1113825 | CNV | deletion | 24896259 |
| nsv1131282 | CNV | deletion | 24896259 |
| nsv457606 | CNV | gain | 19166990 |
| nsv457608 | CNV | loss | 19166990 |
| nsv457610 | CNV | loss | 19166990 |
| nsv483044 | CNV | gain | 15286789 |
| nsv573466 | CNV | gain | 21841781 |
| nsv573470 | CNV | loss | 21841781 |
| nsv573471 | CNV | loss | 21841781 |
| nsv573472 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.58;
94.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRISPLD2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene
Disorders for CRISPLD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| orofacial cleft 15 |
|
|
| cleft lip |
|
|
| cleft palate, isolated |
|
|
| van der woude syndrome 1 |
|
|
| orofacial cleft |
|
|
Search CRISPLD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRISPLD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRISPLD2 Gene
Publications for CRISPLD2 Gene
- CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet BT … Hecht JT (Human molecular genetics 2007) 3 23 41
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
- CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. (PMID: 27597766) Zhang H … Kaplan F (Physiological reports 2016) 2 3
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PMID: 19937600) Carter TC … Mills JL (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 41
ExternalLinks
Products for CRISPLD2 Gene
- Custom Antibody ServicesOriGene Antibodies for CRISPLD2
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- Horizon Cell Lines for CRISPLD2
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- Boster Bio Antibodies for CRISPLD2
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Sources for CRISPLD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (50) miRBase
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- (55) TGDB
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
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- (96) Taconic Biosciences
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- (104) diseasecard
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- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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