Aliases for CRISPLD2 Gene

Aliases for CRISPLD2 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 2 2 3 5
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 2 3 4
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 2 3 4
  • Cysteine-Rich Secretory Protein 11 3 4
  • Late Gestation Lung 1 2 3
  • CRISP-11 3 4
  • CRISP11 3 4
  • LCRISP2 3 4
  • LGL1 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 2 2
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Trypsin Inhibitor 3
  • DKFZP434B044 2
  • CRISPLD2 5

External Ids for CRISPLD2 Gene

Previous HGNC Symbols for CRISPLD2 Gene


Previous GeneCards Identifiers for CRISPLD2 Gene

  • GC16P083412
  • GC16P084853
  • GC16P070606

Summaries for CRISPLD2 Gene

GeneCards Summary for CRISPLD2 Gene

CRISPLD2 (Cysteine Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. Diseases associated with CRISPLD2 include Cleft Lip and Orofacial Cleft 15. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is CRISPLD1.

UniProtKB/Swiss-Prot Summary for CRISPLD2 Gene

Gene Wiki entry for CRISPLD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRISPLD2 Gene

Genomics for CRISPLD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRISPLD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRISPLD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRISPLD2

Top Transcription factor binding sites by QIAGEN in the CRISPLD2 gene promoter:
  • AP-1
  • ER-alpha
  • FAC1
  • GR
  • GR-alpha
  • Hlf
  • HNF-4alpha1
  • RP58
  • RREB-1

Genomic Locations for CRISPLD2 Gene

Latest Assembly
100,788 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
89,524 bases
Plus strand

(GRCh37/hg19 by Ensembl)
100,785 bases
Plus strand

Genomic View for CRISPLD2 Gene

Genes around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD2 Gene

Proteins for CRISPLD2 Gene

  • Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Protein Accession:
    Secondary Accessions:
    • D3DUM0
    • Q6P590
    • Q6UWH0
    • Q6UXC6
    • Q96IB1
    • Q96K61

    Protein attributes for CRISPLD2 Gene

    497 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Binds to heparin, dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for CRISPLD2 Gene


neXtProt entry for CRISPLD2 Gene

Post-translational modifications for CRISPLD2 Gene

  • Glycosylation at Asn27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRISPLD2 Gene

Domains & Families for CRISPLD2 Gene

Gene Families for CRISPLD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CRISPLD2 Gene

  • Allergen V5/Tpx-1 related

Suggested Antigen Peptide Sequences for CRISPLD2 Gene

GenScript: Design optimal peptide antigens:
  • LCCL domain-containing cysteine-rich secretory protein 2 (CRLD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD2: view

Function for CRISPLD2 Gene

Molecular function for CRISPLD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly.

Phenotypes From GWAS Catalog for CRISPLD2 Gene

Gene Ontology (GO) - Molecular Function for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005539 glycosaminoglycan binding IBA 21873635
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CRISPLD2: view
genes like me logo Genes that share phenotypes with CRISPLD2: view

Animal Models for CRISPLD2 Gene

MGI Knock Outs for CRISPLD2:

Animal Models for research

  • Taconic Biosciences Mouse Models for CRISPLD2

miRNA for CRISPLD2 Gene

miRTarBase miRNAs that target CRISPLD2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRISPLD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISPLD2 Gene

Localization for CRISPLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISPLD2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0030133 transport vesicle IDA --
GO:0031012 extracellular matrix IEA --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with CRISPLD2: view

Pathways & Interactions for CRISPLD2 Gene

PathCards logo

SuperPathways for CRISPLD2 Gene

genes like me logo Genes that share pathways with CRISPLD2: view

Pathways by source for CRISPLD2 Gene

3 Reactome pathways for CRISPLD2 Gene

Interacting Proteins for CRISPLD2 Gene

Gene Ontology (GO) - Biological Process for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0030324 lung development IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD2: view

No data available for SIGNOR curated interactions for CRISPLD2 Gene

Drugs & Compounds for CRISPLD2 Gene

No Compound Related Data Available

Transcripts for CRISPLD2 Gene


16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRISPLD2

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD2 Gene

No ASD Table

Relevant External Links for CRISPLD2 Gene

GeneLoc Exon Structure for

Expression for CRISPLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRISPLD2 Gene

Protein differential expression in normal tissues from HIPED for CRISPLD2 Gene

This gene is overexpressed in Lavage (57.7) and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRISPLD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRISPLD2

SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene:


Evidence on tissue expression from TISSUES for CRISPLD2 Gene

  • Blood(4.5)
  • Nervous system(2.4)
  • Lung(2.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CRISPLD2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISPLD2 Gene

Orthologs for CRISPLD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRISPLD2 30 31
  • 99.26 (n)
(Canis familiaris)
Mammalia CRISPLD2 30 31
  • 86.46 (n)
(Bos Taurus)
Mammalia CRISPLD2 30 31
  • 84.41 (n)
(Monodelphis domestica)
Mammalia CRISPLD2 31
  • 80 (a)
(Rattus norvegicus)
Mammalia Crispld2 30
  • 79.48 (n)
(Mus musculus)
Mammalia Crispld2 30 17 31
  • 79.08 (n)
(Ornithorhynchus anatinus)
Mammalia CRISPLD2 31
  • 76 (a)
(Gallus gallus)
Aves CRISPLD2 30 31
  • 72.7 (n)
(Anolis carolinensis)
Reptilia CRISPLD2 31
  • 71 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia crispld2 30
  • 67.95 (n)
(Danio rerio)
Actinopterygii LOC100535149 30
  • 66.25 (n)
  • 60 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8483 31
  • 27 (a)
(Caenorhabditis elegans)
Secernentea scl-23 31
  • 19 (a)
vap-1 31
  • 18 (a)
scl-22 31
  • 17 (a)
Species where no ortholog for CRISPLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CRISPLD2 Gene

Gene Tree for CRISPLD2 (if available)
Gene Tree for CRISPLD2 (if available)
Evolutionary constrained regions (ECRs) for CRISPLD2: view image

Paralogs for CRISPLD2 Gene

(4) SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:

  • H3BS62_HUMAN
genes like me logo Genes that share paralogs with CRISPLD2: view

Variants for CRISPLD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRISPLD2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs111454381 Benign: not provided 84,854,801(+) C/T
NM_031476.4(CRISPLD2):c.681C>T (p.Gly227=)
rs114234975 Benign: not provided 84,866,995(+) A/G
NM_031476.4(CRISPLD2):c.808A>G (p.Met270Val)
rs138500867 Likely Benign: not provided 84,849,457(+) C/A
NM_031476.4(CRISPLD2):c.432C>A (p.Ser144Arg)
rs139975503 Benign: not provided 84,880,571(+) A/G
NM_031476.4(CRISPLD2):c.1292A>G (p.Asn431Ser)
rs34925006 Benign: not provided 84,850,594(+) C/T
NM_031476.4(CRISPLD2):c.519C>T (p.Ile173=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CRISPLD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD2 Gene

Variant ID Type Subtype PubMed ID
dgv5269n54 CNV loss 21841781
esv3639442 CNV gain 21293372
esv3639445 CNV gain 21293372
esv3639446 CNV gain 21293372
esv3639447 CNV gain 21293372
esv3639448 CNV gain 21293372
nsv1056758 CNV gain 25217958
nsv1066260 CNV gain 25217958
nsv1113825 CNV deletion 24896259
nsv1131282 CNV deletion 24896259
nsv457606 CNV gain 19166990
nsv457608 CNV loss 19166990
nsv457610 CNV loss 19166990
nsv483044 CNV gain 15286789
nsv573466 CNV gain 21841781
nsv573470 CNV loss 21841781
nsv573471 CNV loss 21841781
nsv573472 CNV loss 21841781

Variation tolerance for CRISPLD2 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRISPLD2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Disorders for CRISPLD2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CRISPLD2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cleft lip
  • cheiloschisis
orofacial cleft 15
  • ofc15
cleft palate, isolated
  • cpi
van der woude syndrome 1
  • vws1
orofacial cleft
  • cleft, orofacial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRISPLD2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CRISPLD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISPLD2 Gene

Publications for CRISPLD2 Gene

  1. CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet BT … Hecht JT (Human molecular genetics 2007) 3 23 41
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  3. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. (PMID: 27597766) Zhang H … Kaplan F (Physiological reports 2016) 2 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PMID: 19937600) Carter TC … Mills JL (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 41

Products for CRISPLD2 Gene

Sources for CRISPLD2 Gene