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Aliases for CRISPLD2 Gene

Aliases for CRISPLD2 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 2 2 3 5
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 2 3 4
  • Cysteine-Rich Secretory Protein 11 3 4
  • Late Gestation Lung 1 2 3
  • CRISP-11 3 4
  • LCRISP2 3 4
  • CRISP11 3 4
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 2 2
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Trypsin Inhibitor 3
  • LGL1 3

External Ids for CRISPLD2 Gene

Previous HGNC Symbols for CRISPLD2 Gene

  • LCRISP2

Previous GeneCards Identifiers for CRISPLD2 Gene

  • GC16P083412
  • GC16P070606

Summaries for CRISPLD2 Gene

GeneCards Summary for CRISPLD2 Gene

CRISPLD2 (Cysteine Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. Diseases associated with CRISPLD2 include Orofacial Cleft. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is CRISPLD1.

UniProtKB/Swiss-Prot for CRISPLD2 Gene

  • Promotes matrix assembly.

Gene Wiki entry for CRISPLD2 Gene

Additional gene information for CRISPLD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD2 Gene

Genomics for CRISPLD2 Gene

GeneHancer (GH) Regulatory Elements for CRISPLD2 Gene

Promoters and enhancers for CRISPLD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J084818 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 657.1 +0.1 89 2.7 ATF1 RB1 NFIB SIN3A KLF14 ZNF48 ZNF335 GLIS2 SCRT2 EGR2 CRISPLD2 ENSG00000260859
GH16J085518 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +702.7 702682 8.2 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF548 NFYC SSRP1 ENSG00000270184 KLHL36 RNU1-103P RN7SL381P ZDHHC7 CRISPLD2 GSE1 TLDC1 EMC8 ENSG00000269898
GH16J084734 Enhancer 1.3 Ensembl ENCODE dbSUPER 22.7 -83.0 -82965 4.4 HDGF HNRNPUL1 FOXA2 PKNOX1 CLOCK ATF1 ARNT ARID4B SIN3A ZNF2 KLHL36 TAF1C ZDHHC7 CRISPLD2 USP10 ENSG00000261243 COTL1 ENSG00000260859 LOC105371378
GH16J084825 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +13.3 13254 15.3 PKNOX1 ATF1 BMI1 ZNF121 EGR1 SCRT2 ZNF143 FOS ATF7 RCOR1 CRISPLD2 GSE1 ZDHHC7 ENSG00000260859 ATP2C2-AS1 LOC123862
GH16J084927 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.8 +109.4 109438 3.2 HDAC1 HNRNPUL1 NFIB KLF17 KLF14 EGR1 KLF13 EGR2 SMARCA5 ZBTB2 LINC02176 ZDHHC7 CRISPLD2 ENSG00000261243 KLHL36 ENSG00000270184 TAF1C ENSG00000260859 RNU1-103P USP10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRISPLD2 gene promoter:

Genomic Locations for CRISPLD2 Gene

Genomic Locations for CRISPLD2 Gene
chr16:84,819,981-84,920,768
(GRCh38/hg38)
Size:
100,788 bases
Orientation:
Plus strand
chr16:84,853,587-84,954,374
(GRCh37/hg19)

Genomic View for CRISPLD2 Gene

Genes around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD2 Gene

Proteins for CRISPLD2 Gene

  • Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0B8-CRLD2_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Protein Accession:
    Q9H0B8
    Secondary Accessions:
    • D3DUM0
    • Q6P590
    • Q6UWH0
    • Q6UXC6
    • Q96IB1
    • Q96K61

    Protein attributes for CRISPLD2 Gene

    Size:
    497 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Binds to heparin, dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for CRISPLD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD2 Gene

Post-translational modifications for CRISPLD2 Gene

  • Glycosylation at Asn27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRISPLD2 Gene

Domains & Families for CRISPLD2 Gene

Gene Families for CRISPLD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CRISPLD2 Gene

Suggested Antigen Peptide Sequences for CRISPLD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0B8

UniProtKB/Swiss-Prot:

CRLD2_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD2: view

Function for CRISPLD2 Gene

Molecular function for CRISPLD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly.

Phenotypes From GWAS Catalog for CRISPLD2 Gene

Gene Ontology (GO) - Molecular Function for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005539 glycosaminoglycan binding IBA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CRISPLD2: view
genes like me logo Genes that share phenotypes with CRISPLD2: view

Animal Models for CRISPLD2 Gene

MGI Knock Outs for CRISPLD2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISPLD2

miRNA for CRISPLD2 Gene

miRTarBase miRNAs that target CRISPLD2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISPLD2 Gene

Localization for CRISPLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISPLD2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
GO:0030133 transport vesicle IDA --
GO:0034774 secretory granule lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with CRISPLD2: view

Pathways & Interactions for CRISPLD2 Gene

genes like me logo Genes that share pathways with CRISPLD2: view

Pathways by source for CRISPLD2 Gene

3 Reactome pathways for CRISPLD2 Gene

Gene Ontology (GO) - Biological Process for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0030324 lung development IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD2: view

No data available for SIGNOR curated interactions for CRISPLD2 Gene

Drugs & Compounds for CRISPLD2 Gene

No Compound Related Data Available

Transcripts for CRISPLD2 Gene

mRNA/cDNA for CRISPLD2 Gene

Unigene Clusters for CRISPLD2 Gene

Cysteine-rich secretory protein LCCL domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD2 Gene

No ASD Table

Relevant External Links for CRISPLD2 Gene

GeneLoc Exon Structure for
CRISPLD2
ECgene alternative splicing isoforms for
CRISPLD2

Expression for CRISPLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRISPLD2 Gene

Protein differential expression in normal tissues from HIPED for CRISPLD2 Gene

This gene is overexpressed in Lavage (57.7) and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRISPLD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CRISPLD2 Gene:

CRISPLD2

SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene:

Hs.513779

Evidence on tissue expression from TISSUES for CRISPLD2 Gene

  • Blood(4.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with CRISPLD2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISPLD2 Gene

Orthologs for CRISPLD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD2 34 33
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRISPLD2 34 33
  • 86.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRISPLD2 34 33
  • 84.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRISPLD2 34
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crispld2 33
  • 79.48 (n)
mouse
(Mus musculus)
Mammalia Crispld2 16 34 33
  • 79.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRISPLD2 34 33
  • 72.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRISPLD2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld2 33
  • 67.95 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535149 33
  • 66.25 (n)
CRISPLD2 34
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8483 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-23 34
  • 19 (a)
ManyToMany
vap-1 34
  • 18 (a)
ManyToMany
scl-22 34
  • 17 (a)
ManyToMany
Species where no ortholog for CRISPLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD2 Gene

ENSEMBL:
Gene Tree for CRISPLD2 (if available)
TreeFam:
Gene Tree for CRISPLD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRISPLD2: view image

Paralogs for CRISPLD2 Gene

Paralogs for CRISPLD2 Gene

(4) SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:

  • CRLD2_HUMAN
  • H3BS62_HUMAN
  • H3BSZ9_HUMAN
  • H3BTI0_HUMAN
  • H3BTP0_HUMAN
  • J3QKP2_HUMAN
genes like me logo Genes that share paralogs with CRISPLD2: view

Variants for CRISPLD2 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000014450 -- 84,885,181(+) G/A intron_variant
rs1000023179 -- 84,894,926(+) C/A intron_variant
rs1000040452 -- 84,835,264(+) A/G intron_variant
rs1000043981 -- 84,865,992(+) A/C intron_variant
rs1000070121 -- 84,892,670(+) TT/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD2 Gene

Variant ID Type Subtype PubMed ID
dgv5269n54 CNV loss 21841781
esv3639442 CNV gain 21293372
esv3639445 CNV gain 21293372
esv3639446 CNV gain 21293372
esv3639447 CNV gain 21293372
esv3639448 CNV gain 21293372
nsv1056758 CNV gain 25217958
nsv1066260 CNV gain 25217958
nsv1113825 CNV deletion 24896259
nsv1131282 CNV deletion 24896259
nsv457606 CNV gain 19166990
nsv457608 CNV loss 19166990
nsv457610 CNV loss 19166990
nsv483044 CNV gain 15286789
nsv573466 CNV gain 21841781
nsv573470 CNV loss 21841781
nsv573471 CNV loss 21841781
nsv573472 CNV loss 21841781

Variation tolerance for CRISPLD2 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRISPLD2 Gene

Human Gene Mutation Database (HGMD)
CRISPLD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRISPLD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Disorders for CRISPLD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRISPLD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
orofacial cleft
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRISPLD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRISPLD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISPLD2 Gene

Publications for CRISPLD2 Gene

  1. CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet BT … Hecht JT (Human molecular genetics 2007) 3 22 44 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. (PMID: 27597766) Zhang H … Kaplan F (Physiological reports 2016) 2 3 58
  4. CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population. (PMID: 20662919) Shi J … Cao F (European journal of oral sciences 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for CRISPLD2 Gene

Sources for CRISPLD2 Gene

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