This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the... See more...

Aliases for CRISP3 Gene

Aliases for CRISP3 Gene

  • Cysteine Rich Secretory Protein 3 2 3 5
  • Cysteine-Rich Secretory Protein 3 3 4
  • CRISP-3 3 4
  • SGP28 3 4
  • Specific Granule Protein Of 28 KDa 4
  • Specific Granule Protein (28 KDa) 3
  • DJ442L6.3 3
  • Aeg2 3
  • CRS3 3

External Ids for CRISP3 Gene

Previous GeneCards Identifiers for CRISP3 Gene

  • GC06M049696
  • GC06M049741
  • GC06M049805
  • GC06M049425

Summaries for CRISP3 Gene

Entrez Gene Summary for CRISP3 Gene

  • This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

GeneCards Summary for CRISP3 Gene

CRISP3 (Cysteine Rich Secretory Protein 3) is a Protein Coding gene. Diseases associated with CRISP3 include Prostate Cancer and Fanconi Anemia, Complementation Group I. Among its related pathways are Innate Immune System. An important paralog of this gene is CRISP2.

Gene Wiki entry for CRISP3 Gene

Additional gene information for CRISP3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRISP3 Gene

Genomics for CRISP3 Gene

GeneHancer (GH) Regulatory Elements for CRISP3 Gene

Promoters and enhancers for CRISP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049744 Promoter 0.7 EPDnew 500.7 +0.0 47 0.1 ZNF217 CUX1 CTBP1 FOS CEBPB ELF1 FOXA1 EP300 DPF2 SMARCE1 CRISP3 ENSG00000279127 lnc-C6orf141-4 ENSG00000235122
GH06J049745 Promoter 0.5 Ensembl 500.7 +0.4 354 0.2 ZNF217 CUX1 CRISP3 ENSG00000235122 ENSG00000279127 lnc-C6orf141-4
GH06J049645 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.4 +97.4 97354 3.8 GTF2E2 PHB2 ZBTB11 AFF1 TARDBP REST DNMT1 HES1 MYC CTBP1 RHAG ENSG00000235122 ENSG00000226707 CRISP3 C6orf141 CRISP2 CENPQ lnc-C6orf141-3
GH06J049666 Enhancer 1.1 Ensembl ENCODE 11.2 +76.5 76454 2.4 ZNF217 CLOCK AFF1 TARDBP CUX1 TOE1 EP300 CTBP1 GATAD2B NCOR1 CRISP3 PGK2 C6orf141 CRISP2 ENSG00000235122 HSALNG0050504 lnc-C6orf141-3
GH06J049766 Enhancer 0.9 ENCODE 11.8 -24.2 -24239 4.5 EP300 NCOR1 KDM6A TCF7 ZBTB25 TGIF2 TEAD1 ZKSCAN8 ZSCAN9 KMT2B ENSG00000235122 CRISP3 ENSG00000226707 MMUT CRISP2 C6orf141 PGK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRISP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRISP3

Top Transcription factor binding sites by QIAGEN in the CRISP3 gene promoter:
  • Evi-1
  • HNF-3beta

Genomic Locations for CRISP3 Gene

Genomic Locations for CRISP3 Gene
chr6:49,727,376-49,744,455
(GRCh38/hg38)
Size:
17,080 bases
Orientation:
Minus strand
chr6:49,695,089-49,712,168
(GRCh37/hg19)
Size:
17,080 bases
Orientation:
Minus strand

Genomic View for CRISP3 Gene

Genes around CRISP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP3 Gene

Proteins for CRISP3 Gene

  • Protein details for CRISP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54108-CRIS3_HUMAN
    Recommended name:
    Cysteine-rich secretory protein 3
    Protein Accession:
    P54108
    Secondary Accessions:
    • A8K9S1
    • B2R8I8
    • Q15512
    • Q3MJ82
    • Q53FA9
    • Q5JW83
    • Q9H108

    Protein attributes for CRISP3 Gene

    Size:
    245 amino acids
    Molecular mass:
    27630 Da
    Quaternary structure:
    • Interacts with A1BG.
    SequenceCaution:
    • Sequence=AAH69580.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH69602.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG36185.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA63984.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA64527.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CRISP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISP3 Gene

Post-translational modifications for CRISP3 Gene

  • Glycosylation at Asn239
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CRIS3_HUMAN (1163)

Other Protein References for CRISP3 Gene

Protein Products

  • Signalway Proteins for CRISP3
  • Abcam proteins for CRISP3

Assay Products

  • Boster Bio ELISA Kits for CRISP3
  • Abcam assays for CRISP3

No data available for DME Specific Peptides for CRISP3 Gene

Domains & Families for CRISP3 Gene

Gene Families for CRISP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CRISP3 Gene

Blocks:
  • Allergen V5/Tpx-1 related
  • Cysteine-rich secretory protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRISP3 Gene

GenScript: Design optimal peptide antigens:
  • Specific granule protein of 28 kDa (CRIS3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54108

UniProtKB/Swiss-Prot:

CRIS3_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP3: view

Function for CRISP3 Gene

Phenotypes From GWAS Catalog for CRISP3 Gene

Gene Ontology (GO) - Molecular Function for CRISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CRISP3: view
genes like me logo Genes that share phenotypes with CRISP3: view

Animal Model Products

CRISPR Products

miRNA for CRISP3 Gene

miRTarBase miRNAs that target CRISP3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISP3 Gene

Localization for CRISP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP3 Gene

Secreted. Note=In neutrophils, localized in specific granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISP3 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CRISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix NAS 12223513
genes like me logo Genes that share ontologies with CRISP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRISP3 Gene

Pathways & Interactions for CRISP3 Gene

PathCards logo

SuperPathways for CRISP3 Gene

genes like me logo Genes that share pathways with CRISP3: view

Pathways by source for CRISP3 Gene

3 Reactome pathways for CRISP3 Gene

Gene Ontology (GO) - Biological Process for CRISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response NAS 12647793
GO:0043312 neutrophil degranulation TAS --
GO:0045087 innate immune response NAS 12223513
genes like me logo Genes that share ontologies with CRISP3: view

No data available for SIGNOR curated interactions for CRISP3 Gene

Drugs & Compounds for CRISP3 Gene

(1) Additional Compounds for CRISP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRISP3: view

Transcripts for CRISP3 Gene

mRNA/cDNA for CRISP3 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP3 Gene

No ASD Table

Relevant External Links for CRISP3 Gene

GeneLoc Exon Structure for
CRISP3

Expression for CRISP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRISP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP3 Gene

This gene is overexpressed in Minor Salivary Gland (x37.2), Esophagus - Mucosa (x6.3), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for CRISP3 Gene

This gene is overexpressed in Cervix (29.0), Serum (7.8), and Saliva (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRISP3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRISP3

SOURCE GeneReport for Unigene cluster for CRISP3 Gene:

Hs.404466

mRNA Expression by UniProt/SwissProt for CRISP3 Gene:

P54108-CRIS3_HUMAN
Tissue specificity: Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

Evidence on tissue expression from TISSUES for CRISP3 Gene

  • Stomach(4.1)
  • Bone(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with CRISP3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISP3 Gene

Orthologs for CRISP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRISP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISP3 31 30
  • 99.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481834 30
  • 77.43 (n)
cow
(Bos Taurus)
Mammalia CRISP3 31
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crisp1 31
  • 55 (a)
OneToMany
Crisp3 31
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CRISP3 31
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
ManyToMany
CSA.10077 31
  • 16 (a)
ManyToMany
-- 31
  • 15 (a)
ManyToMany
Species where no ortholog for CRISP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP3 Gene

ENSEMBL:
Gene Tree for CRISP3 (if available)
TreeFam:
Gene Tree for CRISP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRISP3: view image

Paralogs for CRISP3 Gene

(5) SIMAP similar genes for CRISP3 Gene using alignment to 4 proteins:

  • CRIS3_HUMAN
  • I3L0A1_HUMAN
  • J3KPA1_HUMAN
  • J3KQX0_HUMAN
genes like me logo Genes that share paralogs with CRISP3: view

Variants for CRISP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRISP3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1864312 - p.Ala134Ser
rs495335 - p.Ser106Pro

Additional dbSNP identifiers (rs#s) for CRISP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRISP3 Gene

Variant ID Type Subtype PubMed ID
esv3397770 CNV insertion 20981092
esv3608949 CNV loss 21293372

Variation tolerance for CRISP3 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRISP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRISP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISP3 Gene

Disorders for CRISP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRISP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
fanconi anemia, complementation group i
  • fanci
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRISP3

genes like me logo Genes that share disorders with CRISP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISP3 Gene

Publications for CRISP3 Gene

  1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Krätzschmar J … Schleuning WD (European journal of biochemistry 1996) 2 3 4 23 54
  2. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PMID: 15461460) Udby L … Kjeldsen L (Biochemistry 2004) 3 4 23 54
  3. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PMID: 12223513) Udby L … Kjeldsen L (Journal of leukocyte biology 2002) 2 3 23 54
  4. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. (PMID: 8601434) Kjeldsen L … Borregaard N (FEBS letters 1996) 3 4 23 54
  5. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L … Borregaard N (Biochimica et biophysica acta 2010) 3 23 54

Products for CRISP3 Gene

Sources for CRISP3 Gene