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Aliases for CRISP2 Gene

Aliases for CRISP2 Gene

  • Cysteine Rich Secretory Protein 2 2 3 5
  • Cancer/Testis Antigen 36 2 3 4
  • Testis Specific Protein 1 (Probe H4-1 P3-1) 2 3
  • Testis-Specific Protein TPX-1 3 4
  • CRISP-2 3 4
  • GAPDL5 3 4
  • TPX1 3 4
  • CT36 3 4
  • Glyceraldehyde-3-Phosphate Dehydrogenase-Like 5 3
  • Cysteine-Rich Secretory Protein 2 3
  • Testicular Tissue Protein Li 43 3
  • TSP1 3

External Ids for CRISP2 Gene

Previous HGNC Symbols for CRISP2 Gene

  • GAPDL5
  • TPX1

Previous GeneCards Identifiers for CRISP2 Gene

  • GC06M049661
  • GC06M049706
  • GC06M049768
  • GC06M049390

Summaries for CRISP2 Gene

GeneCards Summary for CRISP2 Gene

CRISP2 (Cysteine Rich Secretory Protein 2) is a Protein Coding gene. Diseases associated with CRISP2 include Epididymitis and Cholecystolithiasis. An important paralog of this gene is CRISP3.

UniProtKB/Swiss-Prot for CRISP2 Gene

  • May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Gene Wiki entry for CRISP2 Gene

Additional gene information for CRISP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP2 Gene

Genomics for CRISP2 Gene

GeneHancer (GH) Regulatory Elements for CRISP2 Gene

Promoters and enhancers for CRISP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049713 Promoter 0.6 EPDnew 650.7 +0.6 637 0.1 ZBTB33 CRISP2 LOC101927020 RHAG
GH06J049668 Enhancer 0.7 ENCODE 7.2 +46.1 46054 0.3 MEIS2 CLOCK ESRRA NEUROD1 CEBPG CTBP1 GATA3 BRD9 FOSL2 FOS CRISP3 PGK2 CRISP2 LOC101927020 RHAG
GH06J049766 Enhancer 0.9 ENCODE 5 -54.5 -54496 4.5 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 ZNF280A ATF7 NFKBIZ RXRA LOC101927020 CRISP3 LOC101927048 MUT CRISP2 C6orf141 PGK2
GH06J049645 Enhancer 1.2 FANTOM5 ENCODE 0.2 +67.2 67245 3.4 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 CAVIN1 RHAG LOC101927048 LOC101927020 CRISP3 C6orf141 CENPQ CRISP2
GH06J049676 Enhancer 0.6 ENCODE 0.3 +37.3 37335 0.2 SMARCE1 JUN CEBPB DPF2 EP300 ZNF217 CTBP1 JUND GATA3 CREB1 LOC101927020 LOC101927048 CRISP3 PGK2 CRISP2 RHAG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRISP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRISP2 gene promoter:
  • GATA-6
  • MRF-2
  • RFX1
  • Pax-4a
  • CREB
  • STAT5A
  • Max1
  • c-Myc
  • USF2
  • USF1

Genomic Locations for CRISP2 Gene

Genomic Locations for CRISP2 Gene
37,540 bases
Minus strand
21,228 bases
Minus strand

Genomic View for CRISP2 Gene

Genes around CRISP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP2 Gene

Proteins for CRISP2 Gene

  • Protein details for CRISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K8M0
    • Q53FF2
    • Q5U8Z9
    • Q7Z7B2

    Protein attributes for CRISP2 Gene

    243 amino acids
    Molecular mass:
    27259 Da
    Quaternary structure:
    • Interacts with NSUN4 isoform 3.

    Three dimensional structures from OCA and Proteopedia for CRISP2 Gene

    Alternative splice isoforms for CRISP2 Gene


neXtProt entry for CRISP2 Gene

Post-translational modifications for CRISP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRISP2 Gene

Domains & Families for CRISP2 Gene

Gene Families for CRISP2 Gene

Suggested Antigen Peptide Sequences for CRISP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP2: view

Function for CRISP2 Gene

Molecular function for CRISP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Phenotypes From GWAS Catalog for CRISP2 Gene

genes like me logo Genes that share phenotypes with CRISP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISP2

miRNA for CRISP2 Gene

miRTarBase miRNAs that target CRISP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISP2 Gene

Localization for CRISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISP2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CRISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8665901
genes like me logo Genes that share ontologies with CRISP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRISP2 Gene

Pathways & Interactions for CRISP2 Gene

SuperPathways for CRISP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRISP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRISP2 Gene

Drugs & Compounds for CRISP2 Gene

(3) Drugs for CRISP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
calcium Approved Nutra 0

(1) Additional Compounds for CRISP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRISP2: view

Transcripts for CRISP2 Gene

mRNA/cDNA for CRISP2 Gene

Unigene Clusters for CRISP2 Gene

Cysteine-rich secretory protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -

Relevant External Links for CRISP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRISP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP2 Gene

This gene is overexpressed in Testis (x49.1).

Protein differential expression in normal tissues from HIPED for CRISP2 Gene

This gene is overexpressed in Ovary (49.0) and Testis (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRISP2 Gene

Protein tissue co-expression partners for CRISP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRISP2 Gene:


SOURCE GeneReport for Unigene cluster for CRISP2 Gene:


mRNA Expression by UniProt/SwissProt for CRISP2 Gene:

Tissue specificity: Testis and epididymis.
genes like me logo Genes that share expression patterns with CRISP2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISP2 Gene

Orthologs for CRISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRISP2 34 33
  • 99.59 (n)
(Canis familiaris)
Mammalia CRISP2 34 33
  • 86.69 (n)
(Bos Taurus)
Mammalia CRISP2 34 33
  • 85.19 (n)
(Mus musculus)
Mammalia Crisp2 16 34 33
  • 78.06 (n)
(Rattus norvegicus)
Mammalia Crisp2 33
  • 76.65 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
(Gallus gallus)
Aves CRISP2 33
  • 61.23 (n)
-- 34
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
-- 34
  • 50 (a)
(Danio rerio)
Actinopterygii LOC100536500 33
  • 51.24 (n)
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009085 33
  • 47.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
CSA.10077 34
  • 16 (a)
Species where no ortholog for CRISP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP2 Gene

Gene Tree for CRISP2 (if available)
Gene Tree for CRISP2 (if available)
Evolutionary constrained regions (ECRs) for CRISP2: view image

Paralogs for CRISP2 Gene

(5) SIMAP similar genes for CRISP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRISP2: view

Variants for CRISP2 Gene

Sequence variations from dbSNP and Humsavar for CRISP2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000005963 -- 49,690,796(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000032616 -- 49,695,432(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000067331 -- 49,690,130(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000128221 -- 49,696,358(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000220330 -- 49,715,263(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRISP2 Gene

Variant ID Type Subtype PubMed ID
esv3608949 CNV loss 21293372

Variation tolerance for CRISP2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRISP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISP2 Gene

Disorders for CRISP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRISP2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • inflammation of testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRISP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRISP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISP2 Gene

Publications for CRISP2 Gene

  1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Krätzschmar J … Schleuning WD (European journal of biochemistry 1996) 2 3 4 22 58
  2. Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. (PMID: 18550510) Jamsai D … O'Bryan MK (Human reproduction (Oxford, England) 2008) 3 22 44 58
  3. Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. (PMID: 2613236) Kasahara M … Goodfellow PN (Genomics 1989) 2 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CRISP2 Gene

Sources for CRISP2 Gene

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