Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRISP1 Gene

Aliases for CRISP1 Gene

  • Cysteine Rich Secretory Protein 1 2 3 5
  • Acidic Epididymal Glycoprotein Homolog 3 4
  • Acidic Epididymal Glycoprotein-Like 1 2 3
  • AEG-Like Protein 3 4
  • CRISP-1 3 4
  • AEGL1 3 4
  • ARP 3 4
  • Cysteine-Rich Secretory Protein-1 Delta 3
  • Epididymis Secretory Protein Li 57 3
  • Cysteine-Rich Secretory Protein 1 3
  • AEG-Related Protein 3
  • HEL-S-57 3
  • HUMARP 3

External Ids for CRISP1 Gene

Previous HGNC Symbols for CRISP1 Gene

  • AEGL1

Previous GeneCards Identifiers for CRISP1 Gene

  • GC06M049803
  • GC06M049848
  • GC06M049532

Summaries for CRISP1 Gene

Entrez Gene Summary for CRISP1 Gene

  • Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for CRISP1 Gene

CRISP1 (Cysteine Rich Secretory Protein 1) is a Protein Coding gene. Diseases associated with CRISP1 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Gene Ontology (GO) annotations related to this gene include calcium channel regulator activity. An important paralog of this gene is CRISP2.

UniProtKB/Swiss-Prot for CRISP1 Gene

  • May have a role in sperm-egg fusion and maturation.

Gene Wiki entry for CRISP1 Gene

Additional gene information for CRISP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP1 Gene

Genomics for CRISP1 Gene

GeneHancer (GH) Regulatory Elements for CRISP1 Gene

Promoters and enhancers for CRISP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J049866 Promoter 0.9 EPDnew 650.4 +10.6 10600 0.1 RFX1 RXRA GATAD2B DPF2 FOSL1 SMARCA4 GMEB1 TRIM24 CUX1 NR2C2 CRISP1 LOC101927048
GH06J049888 Enhancer 1 ENCODE 0.4 -11.8 -11787 0.2 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ZFP91 ATF7 CRISP1 GC06P049919
GH06J049826 Enhancer 0.7 ENCODE 0.2 +49.9 49895 1.2 BRD4 HDAC1 IRF2 ARNT NFRKB ZMYM3 ZBTB40 CHAMP1 ZNF316 POLR2A PGK2 CRISP3 LOC101927020 LOC101927048 CRISP1
GH06J049908 Enhancer 0.4 ENCODE 0.3 -32.4 -32397 1.7 ZNF316 MAFK GLYATL3 MUT GC06P049919 CRISP1
GH06J049918 Enhancer 0.4 ENCODE 0.3 -41.9 -41907 0.2 BACH1 EZH2 GC06P049919 CRISP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRISP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRISP1 gene promoter:
  • HSF2
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • FOXL1
  • FOXD1
  • HSF1short
  • HSF1 (long)

Genomic Locations for CRISP1 Gene

Genomic Locations for CRISP1 Gene
42,840 bases
Minus strand
42,840 bases
Minus strand

Genomic View for CRISP1 Gene

Genes around CRISP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP1 Gene

Proteins for CRISP1 Gene

  • Protein details for CRISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein 1
    Protein Accession:
    Secondary Accessions:
    • B5BU98
    • O00698
    • Q13248
    • Q14082
    • Q96SF6

    Protein attributes for CRISP1 Gene

    249 amino acids
    Molecular mass:
    28481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRISP1 Gene


neXtProt entry for CRISP1 Gene

Post-translational modifications for CRISP1 Gene

  • Glycosylation at Asn230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRISP1 Gene

Domains & Families for CRISP1 Gene

Gene Families for CRISP1 Gene

Suggested Antigen Peptide Sequences for CRISP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP1: view

Function for CRISP1 Gene

Molecular function for CRISP1 Gene

UniProtKB/Swiss-Prot Function:
May have a role in sperm-egg fusion and maturation.

Gene Ontology (GO) - Molecular Function for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IEA --
genes like me logo Genes that share ontologies with CRISP1: view
genes like me logo Genes that share phenotypes with CRISP1: view

Animal Models for CRISP1 Gene

MGI Knock Outs for CRISP1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISP1 Gene

Localization for CRISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP1 Gene

Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISP1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 8543280
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with CRISP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRISP1 Gene

Pathways & Interactions for CRISP1 Gene

SuperPathways for CRISP1 Gene

No Data Available

Interacting Proteins for CRISP1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000338276 P54107-CRIS1_HUMAN for CRISP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization TAS 8838800
GO:0060046 regulation of acrosome reaction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with CRISP1: view

No data available for Pathways by source and SIGNOR curated interactions for CRISP1 Gene

Drugs & Compounds for CRISP1 Gene

(2) Drugs for CRISP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CRISP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRISP1: view

Transcripts for CRISP1 Gene

mRNA/cDNA for CRISP1 Gene

(6) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRISP1 Gene

Cysteine-rich secretory protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: -

Relevant External Links for CRISP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRISP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRISP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP1 Gene

This gene is overexpressed in Testis (x47.7).

Protein differential expression in normal tissues from HIPED for CRISP1 Gene

This gene is overexpressed in Seminal vesicle (36.3) and Prostate (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRISP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRISP1 Gene:


SOURCE GeneReport for Unigene cluster for CRISP1 Gene:


mRNA Expression by UniProt/SwissProt for CRISP1 Gene:

Tissue specificity: Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma.
genes like me logo Genes that share expression patterns with CRISP1: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISP1 Gene

Orthologs for CRISP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRISP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRISP1 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia CRISP1 34 33
  • 77.46 (n)
(Bos Taurus)
Mammalia CRISP1 34 33
  • 76.65 (n)
(Rattus norvegicus)
Mammalia Crisp4 33
  • 71.62 (n)
(Mus musculus)
Mammalia Crisp4 16 34 33
  • 71.51 (n)
(Monodelphis domestica)
Mammalia CRISP1 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia CRISP1 34
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
-- 34
  • 38 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
(Danio rerio)
Actinopterygii CRISP3 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
CSA.10077 34
  • 14 (a)
Species where no ortholog for CRISP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP1 Gene

Gene Tree for CRISP1 (if available)
Gene Tree for CRISP1 (if available)
Evolutionary constrained regions (ECRs) for CRISP1: view image

Paralogs for CRISP1 Gene

(3) SIMAP similar genes for CRISP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRISP1: view

Variants for CRISP1 Gene

Sequence variations from dbSNP and Humsavar for CRISP1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000133029 -- 49,857,212(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000150895 -- 49,844,411(-) T/ intron_variant
rs1000164697 -- 49,873,833(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000217778 -- 49,836,267(-) C/T intron_variant
rs1000255240 -- 49,878,731(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRISP1 Gene

Variant ID Type Subtype PubMed ID
esv3608949 CNV loss 21293372
esv3608951 CNV loss 21293372
esv3608952 CNV gain 21293372
esv3608953 CNV gain 21293372
nsv5294 CNV deletion 18451855

Variation tolerance for CRISP1 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRISP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISP1 Gene

Disorders for CRISP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRISP1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRISP1

genes like me logo Genes that share disorders with CRISP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISP1 Gene

Publications for CRISP1 Gene

  1. Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). (PMID: 8838800) Hayashi M … Kasahara M (Genomics 1996) 2 3 4 22 58
  2. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Krätzschmar J … Schleuning WD (European journal of biochemistry 1996) 3 4 22 58
  3. [Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization]. (PMID: 8543280) Hayashi M ([Hokkaido igaku zasshi] The Hokkaido journal of medical science 1995) 3 4 22 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PMID: 12206465) Evans JP (Human reproduction update 2002) 3 22 58

Products for CRISP1 Gene

Sources for CRISP1 Gene

Loading form....