Aliases for CRISP1 Gene
External Ids for CRISP1 Gene
Previous HGNC Symbols for CRISP1 Gene
Previous GeneCards Identifiers for CRISP1 Gene
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for CRISP1 Gene
CRISP1 (Cysteine Rich Secretory Protein 1) is a Protein Coding gene. Diseases associated with CRISP1 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Gene Ontology (GO) annotations related to this gene include calcium channel regulator activity. An important paralog of this gene is CRISP2.
UniProtKB/Swiss-Prot for CRISP1 Gene
May have a role in sperm-egg fusion and maturation.