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Aliases for CRIPAK Gene

Aliases for CRIPAK Gene

  • Cysteine Rich PAK1 Inhibitor 2 3
  • UV Stimulated Scaffold Protein A 5
  • Cysteine-Rich Inhibitor Of PAK1 3
  • Cysteine-Rich PAK1 Inhibitor 3
  • CRIPak 4
  • UVSSA 5

External Ids for CRIPAK Gene

Previous GeneCards Identifiers for CRIPAK Gene

  • GC04P001378
  • GC04P001385

Summaries for CRIPAK Gene

Entrez Gene Summary for CRIPAK Gene

  • CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIPAK Gene

CRIPAK (Cysteine Rich PAK1 Inhibitor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CRIPAK Gene

  • Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.

Additional gene information for CRIPAK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIPAK Gene

Genomics for CRIPAK Gene

GeneHancer (GH) Regulatory Elements for CRIPAK Gene

Promoters and enhancers for CRIPAK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J001344 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 699.8 -0.4 -376 4.3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YY1 E2F8 ZNF207 ZNF143 CRIPAK UVSSA GC04M001342 MAEA CTBP1 SLC49A3
GH04J001197 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 46.1 -142.6 -142616 13.8 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B DMAP1 IRF4 YY1 SLC30A9 SPON2 CRIPAK UVSSA CTBP1-DT CTBP1 MAEA RNF212 ENSG00000273179 LOC100130872 LOC101928548
GH04J000472 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 37.3 -873.5 -873472 2.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF721 LOC100533735 ABCA11P PIGG CRIPAK PCGF3 GAK MAEA ENSG00000272588 ZNF718
GH04J000929 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.8 -415.6 -415637 3.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 GAK TMEM175 PCGF3 DGKQ CRIPAK PIGG MAEA ZNF141 ZNF718 ENSG00000281016
GH04J001867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.6 +523.9 523924 7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B NSD2 GC04M001869 RNF4 HAUS3 NELFA FAM193A GAK CRIPAK MAEA ENSG00000270195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRIPAK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRIPAK gene promoter:
  • YY1
  • Brachyury
  • E2F-1
  • E2F
  • Chx10
  • FOXO4
  • Pax-6
  • GATA-1
  • HOXA5
  • C/EBPbeta

Genomic Locations for CRIPAK Gene

Genomic Locations for CRIPAK Gene
48,729 bases
Plus strand
4,443 bases
Plus strand

Genomic View for CRIPAK Gene

Genes around CRIPAK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIPAK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIPAK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIPAK Gene

Proteins for CRIPAK Gene

  • Protein details for CRIPAK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich PAK1 inhibitor
    Protein Accession:
    Secondary Accessions:
    • Q8NB03

    Protein attributes for CRIPAK Gene

    446 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    • Interacts with PAK1.

neXtProt entry for CRIPAK Gene

Post-translational modifications for CRIPAK Gene

No Post-translational modifications

Other Protein References for CRIPAK Gene

No data available for DME Specific Peptides for CRIPAK Gene

Domains & Families for CRIPAK Gene

Gene Families for CRIPAK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRIPAK Gene


Suggested Antigen Peptide Sequences for CRIPAK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRIPAK: view

No data available for UniProtKB/Swiss-Prot for CRIPAK Gene

Function for CRIPAK Gene

Molecular function for CRIPAK Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen.

Phenotypes From GWAS Catalog for CRIPAK Gene

Gene Ontology (GO) - Molecular Function for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16278681
genes like me logo Genes that share ontologies with CRIPAK: view
genes like me logo Genes that share phenotypes with CRIPAK: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIPAK Gene

Localization for CRIPAK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIPAK Gene

Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonal treatment by estrogen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIPAK gene
Compartment Confidence
plasma membrane 4
nucleus 4
endoplasmic reticulum 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16278681
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA 16278681
GO:0005783 endoplasmic reticulum IDA 16278681
genes like me logo Genes that share ontologies with CRIPAK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRIPAK Gene

Pathways & Interactions for CRIPAK Gene

SuperPathways for CRIPAK Gene

No Data Available

SIGNOR curated interactions for CRIPAK Gene


Gene Ontology (GO) - Biological Process for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006283 transcription-coupled nucleotide-excision repair IMP --
GO:0006469 negative regulation of protein kinase activity IDA 16278681
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0009411 response to UV IMP --
genes like me logo Genes that share ontologies with CRIPAK: view

No data available for Pathways by source for CRIPAK Gene

Drugs & Compounds for CRIPAK Gene

(1) Drugs for CRIPAK Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IPA-3 Pharma Non-ATP competitive Pak1 inhibitor 0
genes like me logo Genes that share compounds with CRIPAK: view

Transcripts for CRIPAK Gene


(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRIPAK Gene

Cysteine-rich PAK1 inhibitor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIPAK Gene

No ASD Table

Relevant External Links for CRIPAK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIPAK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRIPAK Gene

NURSA nuclear receptor signaling pathways regulating expression of CRIPAK Gene:


SOURCE GeneReport for Unigene cluster for CRIPAK Gene:


mRNA Expression by UniProt/SwissProt for CRIPAK Gene:

Tissue specificity: Widely expressed with a highest expression observed in trachea, prostate and adrenal glands. Expressed in many cancer cell lines including breast cancer cells.

Evidence on tissue expression from TISSUES for CRIPAK Gene

  • Lung(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CRIPAK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIPAK Gene

Orthologs for CRIPAK Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIPAK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UVSSA 34
  • 99 (a)
  • 92.72 (n)
(Canis familiaris)
Mammalia UVSSA 34
  • 70 (a)
(Mus musculus)
Mammalia Uvssa 34
  • 70 (a)
(Bos Taurus)
Mammalia UVSSA 34
  • 67 (a)
(Monodelphis domestica)
Mammalia UVSSA 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia UVSSA 34
  • 57 (a)
(Gallus gallus)
Aves UVSSA 34
  • 55 (a)
(Anolis carolinensis)
Reptilia UVSSA 34
  • 54 (a)
(Danio rerio)
Actinopterygii uvssa 34
  • 50 (a)
(Caenorhabditis elegans)
Secernentea ZK742.2 34
  • 24 (a)
Species where no ortholog for CRIPAK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CRIPAK Gene

Gene Tree for CRIPAK (if available)
Gene Tree for CRIPAK (if available)
Evolutionary constrained regions (ECRs) for CRIPAK: view image

Paralogs for CRIPAK Gene

No data available for Paralogs for CRIPAK Gene

Variants for CRIPAK Gene

Sequence variations from dbSNP and Humsavar for CRIPAK Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10012320 -- 1,390,644(+) G/A upstream_transcript_variant
rs1001645765 -- 1,389,898(+) A/T upstream_transcript_variant
rs1002161501 -- 1,396,356(+) A/G downstream_transcript_variant
rs1002215315 -- 1,391,564(+) A/T 5_prime_UTR_variant
rs1003290305 -- 1,395,934(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CRIPAK Gene

Variant ID Type Subtype PubMed ID
esv1697030 CNV deletion 17803354
esv21856 CNV gain+loss 19812545
esv2726793 CNV deletion 23290073
nsv1073287 CNV deletion 25765185
nsv4197 CNV insertion 18451855
nsv593278 CNV loss 21841781
nsv593302 CNV loss 21841781
nsv822425 CNV loss 20364138

Variation tolerance for CRIPAK Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.50; 97.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRIPAK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIPAK Gene

Disorders for CRIPAK Gene

Additional Disease Information for CRIPAK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CRIPAK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIPAK Gene

Publications for CRIPAK Gene

  1. CRIPak, a novel endogenous Pak1 inhibitor. (PMID: 16278681) Talukder AH … Kumar R (Oncogene 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
  4. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3 58

Products for CRIPAK Gene

Sources for CRIPAK Gene

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