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Aliases for CRIP3 Gene

Aliases for CRIP3 Gene

  • Cysteine Rich Protein 3 2 3 5
  • Chromosome 6 LIM Domain Only Protein 3 4
  • H6LIMo 3 4
  • CRP-3 3 4
  • Thymus LIM Protein TLP-A 3
  • Cysteine-Rich Protein 3 3
  • BA480N24.2 3
  • TLP-A 3
  • CRP3 4
  • TLP 3

External Ids for CRIP3 Gene

Previous GeneCards Identifiers for CRIP3 Gene

  • GC00U914157
  • GC06U900618
  • GC06M043382
  • GC06M043267
  • GC06M042991

Summaries for CRIP3 Gene

GeneCards Summary for CRIP3 Gene

CRIP3 (Cysteine Rich Protein 3) is a Protein Coding gene. An important paralog of this gene is CRIP2.

Additional gene information for CRIP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP3 Gene

Genomics for CRIP3 Gene

GeneHancer (GH) Regulatory Elements for CRIP3 Gene

Promoters and enhancers for CRIP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J043308 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +0.9 913 1.4 HDGF FOXA2 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 SP3 RXRA CRIP3 RPL12P47 SLC22A7 ABCC10 RPL7L1 ZNF318 POLR1C CUL7
GH06J043390 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 -82.8 -82838 3.5 HDGF PKNOX1 ARNT TCF12 ZNF766 GATA2 ZFP91 NCOA1 MCM5 ZNF592 LOC105375065 GTPBP2 POLH ABCC10 CRIP3 RPL12P47 UBR2 DLK2 TTBK1 DNPH1
GH06J043261 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.5 +47.2 47249 1.4 ELF3 SAP130 ERF CEBPG ZIC2 ZNF644 RAD21 ZNF48 ZSCAN9 RARA DNPH1 SLC22A7 ZNF318 CRIP3 RPL12P47 DLK2 ENSG00000245261 CUL9 YIPF3 POLR1C
GH06J043382 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -74.2 -74244 2.7 PKNOX1 SMAD1 STAT5A BMI1 YBX1 BATF KLF5 IRF4 YY1 ATF7 GC06P043382 SLC22A7 ABCC10 CRIP3 RPL12P47 DLK2 TTBK1 DNPH1 RNU6-1113P TJAP1
GH06J043334 Enhancer 1.1 Ensembl ENCODE 12.2 -25.7 -25672 1.8 ELF3 PKNOX1 ARID4B DMAP1 ZBTB40 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 SLC22A7 RPL12P47 CRIP3 ZNF318 DLK2 LRRC73 POLR1C YIPF3 RPL34P14 GC06P043362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CRIP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRIP3 gene promoter:

Genomic Locations for CRIP3 Gene

Genomic Locations for CRIP3 Gene
chr6:43,299,710-43,309,614
(GRCh38/hg38)
Size:
9,905 bases
Orientation:
Minus strand
chr6:43,267,448-43,276,535
(GRCh37/hg19)

Genomic View for CRIP3 Gene

Genes around CRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP3 Gene

Proteins for CRIP3 Gene

  • Protein details for CRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q6R5-CRIP3_HUMAN
    Recommended name:
    Cysteine-rich protein 3
    Protein Accession:
    Q6Q6R5
    Secondary Accessions:
    • A2A436
    • Q5T043
    • Q6Q6R4
    • Q6Q6R6
    • Q6Q6R7

    Protein attributes for CRIP3 Gene

    Size:
    217 amino acids
    Molecular mass:
    24088 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRIP3 Gene

Post-translational modifications for CRIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRIP3 Gene

Domains & Families for CRIP3 Gene

Gene Families for CRIP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRIP3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRIP3: view

No data available for UniProtKB/Swiss-Prot for CRIP3 Gene

Function for CRIP3 Gene

Phenotypes From GWAS Catalog for CRIP3 Gene

Gene Ontology (GO) - Molecular Function for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP3: view
genes like me logo Genes that share phenotypes with CRIP3: view

Animal Models for CRIP3 Gene

MGI Knock Outs for CRIP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP3 Gene

Localization for CRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIP3 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CRIP3: view

Pathways & Interactions for CRIP3 Gene

SuperPathways for CRIP3 Gene

No Data Available

Interacting Proteins for CRIP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361650%0d%0a9606.ENSP00000384863%0d%0a9606.ENSP00000429084%0d%0a9606.ENSP00000287647%0d%0a9606.ENSP00000346453%0d%0a9606.ENSP00000216487%0d%0a
Selected Interacting proteins: Q6Q6R5-CRIP3_HUMAN ENSP00000361650 for CRIP3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CRIP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRIP3 Gene

Drugs & Compounds for CRIP3 Gene

No Compound Related Data Available

Transcripts for CRIP3 Gene

Unigene Clusters for CRIP3 Gene

Cysteine-rich protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for CRIP3 Gene

GeneLoc Exon Structure for
CRIP3
ECgene alternative splicing isoforms for
CRIP3

Expression for CRIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRIP3 Gene

mRNA differential expression in normal tissues according to GTEx for CRIP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for CRIP3 Gene

This gene is overexpressed in Platelet (46.2) and Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRIP3 Gene



Protein tissue co-expression partners for CRIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRIP3 Gene:

CRIP3

SOURCE GeneReport for Unigene cluster for CRIP3 Gene:

Hs.653165

mRNA Expression by UniProt/SwissProt for CRIP3 Gene:

Q6Q6R5-CRIP3_HUMAN
Tissue specificity: Expressed in most tissues, but not in skeletal muscle.
genes like me logo Genes that share expression patterns with CRIP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP3 Gene

Orthologs for CRIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRIP3 34 33
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRIP3 34 33
  • 92.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRIP3 34 33
  • 90.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crip3 33
  • 88.4 (n)
mouse
(Mus musculus)
Mammalia Crip3 16 34 33
  • 88.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CRIP3 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRIP3 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crip3 33
  • 69.02 (n)
zebrafish
(Danio rerio)
Actinopterygii CRIP3 34
  • 68 (a)
OneToOne
LOC556515 33
  • 66.67 (n)
worm
(Caenorhabditis elegans)
Secernentea valv-1 34
  • 52 (a)
ManyToMany
exc-9 34
  • 48 (a)
ManyToMany
Species where no ortholog for CRIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP3 Gene

ENSEMBL:
Gene Tree for CRIP3 (if available)
TreeFam:
Gene Tree for CRIP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRIP3: view image

Paralogs for CRIP3 Gene

Paralogs for CRIP3 Gene

(6) SIMAP similar genes for CRIP3 Gene using alignment to 3 proteins:

  • CRIP3_HUMAN
  • H0Y7Q9_HUMAN
  • Q5T045_HUMAN
genes like me logo Genes that share paralogs with CRIP3: view

Variants for CRIP3 Gene

Sequence variations from dbSNP and Humsavar for CRIP3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000368292 -- 43,311,020(-) G/A upstream_transcript_variant
rs1002130301 -- 43,306,679(-) T/C intron_variant
rs1002162974 -- 43,306,956(-) C/T intron_variant
rs1002798038 -- 43,309,582(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002870266 -- 43,309,870(-) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRIP3 Gene

Variant ID Type Subtype PubMed ID
nsv1017398 CNV gain 25217958
nsv602998 CNV loss 21841781
nsv602999 CNV loss 21841781
nsv950170 CNV deletion 24416366
nsv970114 CNV duplication 23825009

Variation tolerance for CRIP3 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRIP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP3 Gene

Disorders for CRIP3 Gene

Additional Disease Information for CRIP3

No disorders were found for CRIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP3 Gene

Publications for CRIP3 Gene

  1. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. (PMID: 15380775) Casrouge A … Kanellopoulos J (Microbes and infection 2004) 2 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CRIP3 Gene

Sources for CRIP3 Gene

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