This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] See more...

Aliases for CRIP2 Gene

Aliases for CRIP2 Gene

  • Cysteine Rich Protein 2 2 3 5
  • CRP2 2 3 4
  • Cysteine-Rich Protein 2 3 4
  • ESP1 2 3
  • Cysteine-Rich Intestinal Protein 3
  • LIM Domain Protein ESP1/CRP2 3
  • Protein ESP1 4
  • CRIP2 5
  • CRP-2 4
  • CRIP 3

External Ids for CRIP2 Gene

Previous GeneCards Identifiers for CRIP2 Gene

  • GC14U990010
  • GC14P099932
  • GC14P103911
  • GC14P103912
  • GC14P105012
  • GC14P105939
  • GC14P086136

Summaries for CRIP2 Gene

Entrez Gene Summary for CRIP2 Gene

  • This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for CRIP2 Gene

CRIP2 (Cysteine Rich Protein 2) is a Protein Coding gene. An important paralog of this gene is CRIP3.

Gene Wiki entry for CRIP2 Gene

Additional gene information for CRIP2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRIP2 Gene

Genomics for CRIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRIP2

Top Transcription factor binding sites by QIAGEN in the CRIP2 gene promoter:
  • CUTL1
  • GATA-2
  • Lmo2
  • MyoD
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-5

Genomic Locations for CRIP2 Gene

Genomic Locations for CRIP2 Gene
7,226 bases
Plus strand
7,202 bases
Plus strand

Genomic View for CRIP2 Gene

Genes around CRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP2 Gene

Proteins for CRIP2 Gene

  • Protein details for CRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 2
    Protein Accession:
    Secondary Accessions:
    • A1A4U1
    • B7Z6C0
    • E9PD13

    Protein attributes for CRIP2 Gene

    208 amino acids
    Molecular mass:
    22493 Da
    Quaternary structure:
    • Interacts with TGFB1I1.

    Three dimensional structures from OCA and Proteopedia for CRIP2 Gene

    Alternative splice isoforms for CRIP2 Gene


neXtProt entry for CRIP2 Gene

Post-translational modifications for CRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIP2 Gene

Antibody Products

  • Boster Bio Antibodies for CRIP2

No data available for DME Specific Peptides for CRIP2 Gene

Domains & Families for CRIP2 Gene

Gene Families for CRIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRIP2 Gene

  • Zn-binding protein, LIM

Suggested Antigen Peptide Sequences for CRIP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56946, highly similar to Cysteine-rich protein 2 (B7Z6C0_HUMAN)
  • Protein ESP1 (CRIP2_HUMAN)
genes like me logo Genes that share domains with CRIP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CRIP2 Gene

Function for CRIP2 Gene

Molecular function for CRIP2 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 2

Phenotypes From GWAS Catalog for CRIP2 Gene

Gene Ontology (GO) - Molecular Function for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21540330
GO:0008270 zinc ion binding TAS 8824798
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP2: view
genes like me logo Genes that share phenotypes with CRIP2: view

Animal Model Products

CRISPR Products

miRNA for CRIP2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRIP2 Gene

Localization for CRIP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIP2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with CRIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP2 Gene

Pathways & Interactions for CRIP2 Gene

PathCards logo

SuperPathways for CRIP2 Gene

No Data Available

SIGNOR curated interactions for CRIP2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with CRIP2: view

No data available for Pathways by source for CRIP2 Gene

Drugs & Compounds for CRIP2 Gene

(2) Drugs for CRIP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CRIP2: view

Transcripts for CRIP2 Gene

mRNA/cDNA for CRIP2 Gene

20 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP2

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - -

Relevant External Links for CRIP2 Gene

GeneLoc Exon Structure for

Expression for CRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRIP2 Gene

mRNA differential expression in normal tissues according to GTEx for CRIP2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.8) and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for CRIP2 Gene

This gene is overexpressed in Hair follicle (9.4) and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRIP2 Gene

Protein tissue co-expression partners for CRIP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRIP2

SOURCE GeneReport for Unigene cluster for CRIP2 Gene:


mRNA Expression by UniProt/SwissProt for CRIP2 Gene:

Tissue specificity: Widespread tissue expression; highest levels in the heart.

Evidence on tissue expression from TISSUES for CRIP2 Gene

  • Heart(4.8)
  • Lung(4.7)
  • Nervous system(4.5)
  • Liver(4.4)
  • Pancreas(3.8)
  • Muscle(3.2)
  • Skin(2.7)
  • Kidney(2.7)
  • Intestine(2.4)
  • Stomach(2.3)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with CRIP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP2 Gene

Orthologs for CRIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRIP2 30
  • 89.74 (n)
(Canis familiaris)
Mammalia CRIP2 30 31
  • 88.46 (n)
(Mus musculus)
Mammalia Crip2 31
  • 88 (a)
(Monodelphis domestica)
Mammalia CRIP2 31
  • 86 (a)
(Rattus norvegicus)
Mammalia RGD1563606 30
  • 84.65 (n)
(Pan troglodytes)
Mammalia -- 31
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia CRIP2 31
  • 63 (a)
(Gallus gallus)
Aves CRIP2 31
  • 81 (a)
(Anolis carolinensis)
Reptilia CRIP2 31
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28352 30
(Danio rerio)
Actinopterygii crip2 30 31
  • 70.71 (n)
zgc:101840 31
  • 69 (a)
Dr.5660 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9800 30
(Caenorhabditis elegans)
Secernentea valv-1 31
  • 58 (a)
exc-9 31
  • 58 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7243 30
Species where no ortholog for CRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CRIP2 Gene

Gene Tree for CRIP2 (if available)
Gene Tree for CRIP2 (if available)
Evolutionary constrained regions (ECRs) for CRIP2: view image

Paralogs for CRIP2 Gene

(14) SIMAP similar genes for CRIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRIP2: view

Variants for CRIP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRIP2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
729187 Benign: not provided 105,479,441(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CRIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv3987n54 CNV loss 21841781
dgv3988n54 CNV gain 21841781
dgv3989n54 CNV gain 21841781
dgv3990n54 CNV gain 21841781
dgv3991n54 CNV loss 21841781
dgv3992n54 CNV gain+loss 21841781
dgv3993n54 CNV gain 21841781
dgv3994n54 CNV gain 21841781
dgv3995n54 CNV loss 21841781
dgv3996n54 CNV gain 21841781
dgv3997n54 CNV loss 21841781
dgv3998n54 CNV loss 21841781
dgv3999n54 CNV loss 21841781
esv1004211 CNV insertion 20482838
esv1077360 CNV deletion 17803354
esv21791 CNV loss 19812545
esv2749298 CNV deletion 23290073
esv2760014 CNV loss 17122850
esv2856347 CNV duplication 24192839
esv3398322 CNV duplication 20981092
esv3635645 CNV gain 21293372
nsv1054190 CNV gain 25217958
nsv1113680 CNV deletion 24896259
nsv1160204 CNV duplication 26073780
nsv1440 CNV insertion 18451855
nsv470679 CNV loss 18288195
nsv513421 CNV insertion 21212237
nsv517055 CNV gain+loss 19592680
nsv566189 CNV gain 21841781
nsv566204 CNV gain 21841781
nsv566206 CNV loss 21841781
nsv566207 CNV loss 21841781
nsv566209 CNV gain+loss 21841781
nsv566210 CNV gain 21841781
nsv566218 CNV loss 21841781
nsv566219 CNV gain 21841781
nsv566220 CNV gain+loss 21841781
nsv566229 CNV loss 21841781
nsv566259 CNV gain+loss 21841781
nsv566265 CNV loss 21841781
nsv817647 CNV gain 17921354
nsv827088 CNV gain 20364138
nsv832890 CNV loss 17160897
nsv9177 CNV gain 18304495
nsv952282 CNV deletion 24416366

Variation tolerance for CRIP2 Gene

Gene Damage Index Score: 0.99; 20.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP2 Gene

Disorders for CRIP2 Gene

No disorders were found for CRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP2 Gene

Publications for CRIP2 Gene

  1. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. (PMID: 8824798) Karim MA … Indo Y (Genomics 1996) 3 4 23
  2. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. (PMID: 8843343) Tsui SK … Lee CY (Biochemistry and molecular biology international 1996) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. (PMID: 12839623) van Ham M … Hendriks W (Genes to cells : devoted to molecular & cellular mechanisms 2003) 3 23

Products for CRIP2 Gene

  • Signalway Proteins for CRIP2

Sources for CRIP2 Gene