Aliases for CRIP2 Gene
Aliases for CRIP2 Gene
External Ids for CRIP2 Gene
- HGNC: 2361
- Entrez Gene: 1397
- Ensembl: ENSG00000182809
- OMIM: 601183
- UniProtKB: P52943
Previous GeneCards Identifiers for CRIP2 Gene
- GC14U990010
- GC14P099932
- GC14P103911
- GC14P103912
- GC14P105012
- GC14P105939
- GC14P086136
Summaries for CRIP2 Gene
-
This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for CRIP2 Gene
CRIP2 (Cysteine Rich Protein 2) is a Protein Coding gene. An important paralog of this gene is CRIP3.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP2 Gene
Genomics for CRIP2 Gene
GeneHancer (GH) Regulatory Elements for CRIP2 Gene
Promoters and enhancers for CRIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CRIP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRIP2 gene promoter:
Regulatory Element Products
Genomic Locations for CRIP2 Gene
Genomic Locations for CRIP2 Gene
- chr14:105,472,938-105,480,170
- (GRCh38/hg38)
- Size:
- 7,233 bases
- Orientation:
- Plus strand
- chr14:105,939,299-105,946,500
- (GRCh37/hg19)
Genomic View for CRIP2 Gene
Genes around CRIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
CRIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRIP2 Gene
Proteins for CRIP2 Gene
-
Protein details for CRIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52943-CRIP2_HUMAN
- Recommended name:
- Cysteine-rich protein 2
- Protein Accession:
- P52943
- A1A4U1
- B7Z6C0
- E9PD13
Protein attributes for CRIP2 Gene
- Size:
- 208 amino acids
- Molecular mass:
- 22493 Da
- Quaternary structure:
-
- Interacts with TGFB1I1.
Protein Expression for CRIP2 Gene
Post-translational modifications for CRIP2 Gene
Other Protein References for CRIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CRIP2
- Novus Biologicals Antibodies for CRIP2
-
Abcam antibodies for CRIP2
- Invitrogen Antibodies for CRIP2
- GeneTex CRIP2 antibody for CRIP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRIP2
- Sino Biological Antibodies for CRIP2
Protein Products
-
OriGene Purified Proteins for CRIP2
- Search Origene for MassSpec and Protein Over-expression Lysates for CRIP2
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- Sino Biological Cell Lysates for CRIP2
- Sino Biological Recombinant Proteins for CRIP2
- Search GeneTex for Proteins for CRIP2
Assay Products
No data available for DME Specific Peptides for CRIP2 Gene
Domains & Families for CRIP2 Gene
Gene Families for CRIP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CRIP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CRIP2 Gene
Function for CRIP2 Gene
Molecular function for CRIP2 Gene
- GENATLAS Biochemistry:
- cysteine-rich heart protein 2
Phenotypes From GWAS Catalog for CRIP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21540330 |
| GO:0008270 | zinc ion binding | TAS | 8824798 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CRIP2 Gene
- GenomeRNAi human phenotypes for CRIP2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CRIP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for CRIP2
- genomics-online: gRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
- Applied Biological Materials CRISPR for CRIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRIP2
- GenScript: Design CRISPR guide RNA sequences for CRIP2
miRNA for CRIP2 Gene
- miRTarBase miRNAs that target CRIP2
miRNA Products
- Search ViGene Biosciences for CRIP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CRIP2
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- genomics-online: shRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CRIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CRIP2
-
ViGene Biosciences adenoviral particle packaged cDNA for CRIP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CRIP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRIP2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRIP2 Gene
Localization for CRIP2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
- Nucleoli (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005938 | cell cortex | IEA | -- |
| GO:0031012 | colocalizes_with extracellular matrix | IDA | 20551380 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP2 Gene
Pathways & Interactions for CRIP2 Gene
No Data Available
Interacting Proteins for CRIP2 Gene
Selected Interacting proteins:
P52943-CRIP2_HUMAN
ENSP00000328521
for CRIP2 Gene via
IID
MINT
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0030097 | hemopoiesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CRIP2 Gene
Transcripts for CRIP2 Gene
mRNA/cDNA for CRIP2 Gene
- (3) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (367) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CRIP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRIP2
- genomics-online: gRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
- Applied Biological Materials CRISPR for CRIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRIP2
- GenScript: Design CRISPR guide RNA sequences for CRIP2
miRNA Products
- Search ViGene Biosciences for CRIP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CRIP2
- Browse OriGene Inhibitory RNA Products For CRIP2
- genomics-online: shRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CRIP2 gene
Clone Products
- Sino Biological Human cDNA Clone for CRIP2
- VectorBuilder custom plasmid, inducible vectors for CRIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CRIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: |
Expression for CRIP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Adipose (Muscoskeletal System)
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Umbilical Cord (Extraembryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for CRIP2 Gene
This gene is overexpressed in Heart - Atrial Appendage (x5.8) and Heart - Left Ventricle (x5.6).
This gene is overexpressed in Hair follicle (9.4) and Fetal heart (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CRIP2 Gene:
CRIP2SOURCE GeneReport for Unigene cluster for CRIP2 Gene:
Hs.534309mRNA Expression by UniProt/SwissProt for CRIP2 Gene:
P52943-CRIP2_HUMAN
Tissue specificity:
Widespread tissue expression; highest levels in the heart.
Evidence on tissue expression from TISSUES for CRIP2 Gene
- Heart(4.7)
- Lung(4.6)
- Nervous system(4.3)
- Liver(4.2)
- Pancreas(3.6)
- Muscle(2.7)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for CRIP2
-
OriGene qPCR primer pairs and template standards for CRIP2
- genomics-online: primer clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP2 Gene
Orthologs for CRIP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CRIP2 33 |
|
||
| dog (Canis familiaris) |
Mammalia | CRIP2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Crip2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CRIP2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | RGD1563606 33 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRIP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRIP2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CRIP2 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.28352 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crip2 33 34 |
|
||
| zgc:101840 34 |
|
ManyToMany | |||
| Dr.5660 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9800 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | exc-9 34 |
|
ManyToMany | |
| valv-1 34 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7243 33 |
|
- Species where no ortholog for CRIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CRIP2 Gene
(14) SIMAP similar genes for CRIP2 Gene using alignment to 3 proteins:
Variants for CRIP2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001013417 | -- | 105,474,085(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1002227634 | -- | 105,473,699(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1002460344 | -- | 105,479,338(+) | T/C | intron_variant | |
| rs1002740023 | -- | 105,478,188(+) | G/C/T | intron_variant | |
| rs1003117198 | -- | 105,478,294(+) | C/T | coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant |
Gene Damage Index Score:
0.99;
20.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRIP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP2 Gene
Disorders for CRIP2 Gene
Additional Disease Information for CRIP2
No disorders were found for CRIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP2 Gene
Publications for CRIP2 Gene
- A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. (PMID: 8843343) Tsui SK … Lee CY (Biochemistry and molecular biology international 1996) 2 3 4 58
- Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. (PMID: 8824798) Karim MA … Indo Y (Genomics 1996) 3 4 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. (PMID: 12839623) van Ham M … Hendriks W (Genes to cells : devoted to molecular & cellular mechanisms 2003) 3 22 58
Products for CRIP2 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CRIP2
- VectorBuilder custom plasmid, inducible vectors for CRIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRIP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available CRIP2 Antibodies ranked by validation data
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- antibodies-online: Search results for available CRIP2 related products ranked by validation data
- antibodies-online: Search results for 15 available CRIP2 Proteins ranked by validation data
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- Quality Products:
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- Search ViGene Biosciences for CRIP2
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- genomics-online: cdna clones - Search results for 143 available CRIP2 gene related products
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- Overview of 143 available CRIP2 gene related products
- genomics-online: gRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
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- Overview of 143 available CRIP2 gene related products
- genomics-online: shRNA clones - Search results for 143 available CRIP2 gene related products
- Overview of 143 available CRIP2 gene related products
Sources for CRIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
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