Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[suppli... See more...

Aliases for CRIP1 Gene

Aliases for CRIP1 Gene

  • Cysteine Rich Protein 1 2 3 5
  • Cysteine-Rich Protein 1 (Intestinal) 2 3
  • Cysteine-Rich Intestinal Protein 3 4
  • Cysteine-Rich Heart Protein 3 4
  • Cysteine-Rich Protein 1 3 4
  • CRP-1 3 4
  • CRHP 3 4
  • CRIP 3 4
  • CRP1 3 4
  • HCRHP 4

External Ids for CRIP1 Gene

Previous GeneCards Identifiers for CRIP1 Gene

  • GC22P021804
  • GC14P099944
  • GC14P103925
  • GC14P105024
  • GC14P105952
  • GC14P086151

Summaries for CRIP1 Gene

Entrez Gene Summary for CRIP1 Gene

  • Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIP1 Gene

CRIP1 (Cysteine Rich Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptide binding and AT DNA binding. An important paralog of this gene is ENSG00000257341.

UniProtKB/Swiss-Prot Summary for CRIP1 Gene

  • Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Gene Wiki entry for CRIP1 Gene

Additional gene information for CRIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRIP1 Gene

Genomics for CRIP1 Gene

GeneHancer (GH) Regulatory Elements for CRIP1 Gene

Promoters and enhancers for CRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J105470 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -4.9 -4875 22.3 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 CRIP1 MG828531 lnc-BRF1-3 CRIP2 TEDC1 MTA1 ENSG00000257270 CDCA4 ENSG00000258811 ENSG00000225200
GH14J105074 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 -410.8 -410796 1.2 ZIC2 ZBTB11 MYC POLR2A KDM5B TCF12 SRF NCOR1 POLR2G ARNT lnc-GPR132-1 lnc-CLBA1-6 GPR132 CLBA1 JAG2 NUDT14 LINC02298 PLD4 CRIP1 lnc-CLBA1-4
GH14J105031 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -452.9 -452935 3.2 ZNF217 ZSCAN5C CLOCK ZBTB26 RFX1 CHD1 CTBP1 SIN3A ELK1 ZNF592 HSALNG0104180 GPR132 CLBA1 CRIP1 lnc-CLBA1-3 lnc-GPR132-2
GH14J105068 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 1.1 -416.1 -416128 2.8 SIN3A SP1 EP300 RELA MEF2C TRIM22 EZH2 BCL11A POLR2A TCF12 GPR132 JAG2 NUDT14 CLBA1 CRIP1 lnc-GPR132-1 lnc-CLBA1-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRIP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRIP1

Top Transcription factor binding sites by QIAGEN in the CRIP1 gene promoter:
  • MyoD
  • NF-1
  • NF-1/L
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CRIP1 Gene

Genomic Locations for CRIP1 Gene
chr14:105,486,317-105,488,947
(GRCh38/hg38)
Size:
2,631 bases
Orientation:
Plus strand
chr14:105,952,654-105,955,284
(GRCh37/hg19)
Size:
2,631 bases
Orientation:
Plus strand

Genomic View for CRIP1 Gene

Genes around CRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP1 Gene

Proteins for CRIP1 Gene

  • Protein details for CRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50238-CRIP1_HUMAN
    Recommended name:
    Cysteine-rich protein 1
    Protein Accession:
    P50238
    Secondary Accessions:
    • H3BPI2
    • Q13628
    • Q53XY7
    • Q96J34

    Protein attributes for CRIP1 Gene

    Size:
    77 amino acids
    Molecular mass:
    8533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRIP1 Gene

Post-translational modifications for CRIP1 Gene

  • Ubiquitination at Lys9
  • Modification sites at PhosphoSitePlus

Other Protein References for CRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRIP1 Gene

Domains & Families for CRIP1 Gene

Gene Families for CRIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CRIP1 Gene

Blocks:
  • Zn-binding protein, LIM
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRIP1 Gene

GenScript: Design optimal peptide antigens:
  • Cysteine-rich intestinal protein (CRIP1_HUMAN)
genes like me logo Genes that share domains with CRIP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CRIP1 Gene

Function for CRIP1 Gene

Molecular function for CRIP1 Gene

UniProtKB/Swiss-Prot Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
GENATLAS Biochemistry:
cysteine-rich heart protein 1,playing a role in processes of cellular repair (located in a region of multiple breakpoint)

Phenotypes From GWAS Catalog for CRIP1 Gene

Gene Ontology (GO) - Molecular Function for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003680 AT DNA binding IDA 20108983
GO:0008270 zinc ion binding IBA,IDA 9126610
GO:0008301 DNA binding, bending IDA 20108983
GO:0042277 peptide binding IDA 18670594
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP1: view
genes like me logo Genes that share phenotypes with CRIP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP1 Gene

Localization for CRIP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIP1 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9126610
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP1 Gene

Pathways & Interactions for CRIP1 Gene

PathCards logo

SuperPathways for CRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEP 20415737
GO:0007507 heart development TAS 7999070
GO:0008283 cell proliferation TAS 9126610
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 20415737
GO:0010033 response to organic substance IEP 17486081
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for CRIP1 Gene

Drugs & Compounds for CRIP1 Gene

(3) Drugs for CRIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CRIP1: view

Transcripts for CRIP1 Gene

mRNA/cDNA for CRIP1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRIP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP1 Gene

No ASD Table

Relevant External Links for CRIP1 Gene

GeneLoc Exon Structure for
CRIP1

Expression for CRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRIP1 Gene

This gene is overexpressed in Breast (8.1) and Fetal heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRIP1 Gene



Protein tissue co-expression partners for CRIP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRIP1

SOURCE GeneReport for Unigene cluster for CRIP1 Gene:

Hs.70327

Evidence on tissue expression from TISSUES for CRIP1 Gene

  • Heart(4.4)
  • Intestine(4.4)
  • Lung(2.3)
  • Skin(2.2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CRIP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP1 Gene

Orthologs for CRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 96 (a)
OneToMany
CRIP1 30
  • 91.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CRIP1 31 30
  • 90.04 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Crip1 30
  • 89.18 (n)
mouse
(Mus musculus)
Mammalia Crip1 17 31 30
  • 88.74 (n)
chicken
(Gallus gallus)
Aves -- 31
  • 91 (a)
OneToMany
CRIP1 30
  • 84.85 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia crip1 30
  • 76.62 (n)
zebrafish
(Danio rerio)
Actinopterygii crip1 31 30
  • 78.35 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0496.7 32
  • 74 (a)
valv-1 31 30
  • 66.22 (n)
ManyToMany
exc-9 31
  • 61 (a)
ManyToMany
Species where no ortholog for CRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP1 Gene

ENSEMBL:
Gene Tree for CRIP1 (if available)
TreeFam:
Gene Tree for CRIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRIP1: view image

Paralogs for CRIP1 Gene

(23) SIMAP similar genes for CRIP1 Gene using alignment to 3 proteins:

  • CRIP1_HUMAN
  • H3BRQ4_HUMAN
  • K4DIB9_HUMAN

Pseudogenes.org Pseudogenes for CRIP1 Gene

genes like me logo Genes that share paralogs with CRIP1: view

Variants for CRIP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRIP1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
770784 Benign: not provided 105,488,350(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CRIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv3987n54 CNV loss 21841781
dgv3996n54 CNV gain 21841781
dgv3998n54 CNV loss 21841781
dgv3999n54 CNV loss 21841781
nsv1054190 CNV gain 25217958
nsv470679 CNV loss 18288195
nsv517055 CNV gain+loss 19592680
nsv566206 CNV loss 21841781
nsv566210 CNV gain 21841781
nsv827088 CNV gain 20364138
nsv952282 CNV deletion 24416366

Variation tolerance for CRIP1 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRIP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP1 Gene

Disorders for CRIP1 Gene

Additional Disease Information for CRIP1

No disorders were found for CRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP1 Gene

Publications for CRIP1 Gene

  1. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. (PMID: 9480758) Garcia-Barcelo M … Waye MM (Genomics 1998) 2 3 23 54
  2. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. (PMID: 9126610) Khoo C … Cousins RJ (Protein expression and purification 1997) 3 4 23 54
  3. Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart. (PMID: 7999070) Tsui SK … Waye MM (Biochemical and biophysical research communications 1994) 3 4 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. (PMID: 9507743) Dubé JY … Tremblay RR (Archives of andrology 1998) 3 23 54

Products for CRIP1 Gene

Sources for CRIP1 Gene