The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, a... See more...

Aliases for CRHR2 Gene

Aliases for CRHR2 Gene

  • Corticotropin Releasing Hormone Receptor 2 2 3 5
  • Corticotropin-Releasing Factor Receptor 2 3 4
  • CRF-RB 2 3
  • HM-CRF 2 3
  • CRH-R2 3 4
  • CRF2 2 3
  • Corticotropin-Releasing Hormone Receptor 2 4
  • CRF2 Receptor, Beta Isoform 3
  • CRH Receptor 2 Variant B 3
  • CRF-R-2 4
  • CRH-R-2 4
  • CRF-R2 4
  • CRFR-2 4
  • CRFR2 3
  • CRHR2 5
  • CRF2R 4
  • CRH2R 4

External Ids for CRHR2 Gene

Previous GeneCards Identifiers for CRHR2 Gene

  • GC07M030334
  • GC07M030434
  • GC07M030465
  • GC07M030658
  • GC07M030574

Summaries for CRHR2 Gene

Entrez Gene Summary for CRHR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for CRHR2 Gene

CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include Anxiety and Irritable Bowel Syndrome. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone activity. An important paralog of this gene is CRHR1.

UniProtKB/Swiss-Prot Summary for CRHR2 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Tocris Summary for CRHR2 Gene

  • The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.

Gene Wiki entry for CRHR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRHR2 Gene

Genomics for CRHR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRHR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRHR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRHR2

Top Transcription factor binding sites by QIAGEN in the CRHR2 gene promoter:
  • aMEF-2
  • HNF-4alpha1
  • HTF
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • RORalpha2
  • Zic1

Genomic Locations for CRHR2 Gene

Genomic Locations for CRHR2 Gene
chr7:30,649,406-30,700,129
(GRCh38/hg38)
Size:
50,724 bases
Orientation:
Minus strand
chr7:30,691,559-30,739,745
(GRCh37/hg19)
Size:
48,187 bases
Orientation:
Minus strand

Genomic View for CRHR2 Gene

Genes around CRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR2 Gene

Proteins for CRHR2 Gene

  • Protein details for CRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13324-CRFR2_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 2
    Protein Accession:
    Q13324
    Secondary Accessions:
    • B2R967
    • B3SXS6
    • B3SXS7
    • B3SXS8
    • B3SXT0
    • F8WA81
    • O43461
    • Q4QRJ4
    • Q99431

    Protein attributes for CRHR2 Gene

    Size:
    411 amino acids
    Molecular mass:
    47688 Da
    Quaternary structure:
    • Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

    Three dimensional structures from OCA and Proteopedia for CRHR2 Gene

    Alternative splice isoforms for CRHR2 Gene

neXtProt entry for CRHR2 Gene

Post-translational modifications for CRHR2 Gene

  • A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
  • Glycosylation at Asn41, Asn74, Asn86, and Asn94
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRHR2 Gene

Domains & Families for CRHR2 Gene

Gene Families for CRHR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CRHR2 Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Corticotropin releasing factor receptor signature
  • Corticotropin releasing factor type 2 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for CRHR2 Gene

GenScript: Design optimal peptide antigens:
  • CRF2 receptor isoform D (B3SXS6_HUMAN)
  • CRF2 receptor isoform E (B3SXS7_HUMAN)
  • CRF2 recepter isoform F (B3SXS8_HUMAN)
  • CRF2 receptor isoform G (B3SXS9_HUMAN)
  • CRF2a receptor isoform desQ (B3SXT0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13324

UniProtKB/Swiss-Prot:

CRFR2_HUMAN :
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • Belongs to the G-protein coupled receptor 2 family.
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR2: view

Function for CRHR2 Gene

Molecular function for CRHR2 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
GENATLAS Biochemistry:
corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

Phenotypes From GWAS Catalog for CRHR2 Gene

Gene Ontology (GO) - Molecular Function for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 11329063
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0015056 corticotrophin-releasing factor receptor activity IBA 21873635
genes like me logo Genes that share ontologies with CRHR2: view
genes like me logo Genes that share phenotypes with CRHR2: view

Animal Models for CRHR2 Gene

MGI Knock Outs for CRHR2:

Animal Model Products

CRISPR Products

miRNA for CRHR2 Gene

miRTarBase miRNAs that target CRHR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR2

Clone Products

  • Addgene plasmids for CRHR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHR2 Gene

Localization for CRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8536644
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IBA --
genes like me logo Genes that share ontologies with CRHR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHR2 Gene

Pathways & Interactions for CRHR2 Gene

genes like me logo Genes that share pathways with CRHR2: view

Pathways by source for CRHR2 Gene

3 Qiagen pathways for CRHR2 Gene
  • Activation of cAMP-Dependent PKA
  • cAMP Pathway
  • CRHR Pathway

Gene Ontology (GO) - Biological Process for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS 8536644
GO:0009755 hormone-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with CRHR2: view

No data available for SIGNOR curated interactions for CRHR2 Gene

Drugs & Compounds for CRHR2 Gene

(33) Drugs for CRHR2 Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 597
Salbutamol Approved, Vet_approved Pharma Agonist, Partial agonist 0
Astressin Pharma Antagonist 2
Sauvagine Pharma Agonist, Full agonist CRF agonist 0
Antisauvagine-30 Pharma Potent, selective and competitive CRF2 antagonist 0

(2) Additional Compounds for CRHR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for CRHR2 Gene

Compound Action Cas Number
Antisauvagine-30 Potent, selective and competitive CRF2 antagonist 220673-95-0
Astressin 2B Selective CRF2 antagonist 681260-70-8
K 41498 Highly selective and potent CRF2 antagonist 434938-41-7

(9) ApexBio Compounds for CRHR2 Gene

Compound Action Cas Number
Antisauvagine-30 220673-95-0
Astressin 170809-51-5
Astressin 2B 681260-70-8
CRF (6-33) 120066-38-8
CRF (human, rat) 86784-80-7
K 41498 434938-41-7
Sauvagine 74434-59-6
Urocortin (human) 176591-49-4
α-helical CRF 9-41 Antagonist of corticotropin releasing factor receptor 90880-23-2
genes like me logo Genes that share compounds with CRHR2: view

Drug Products

Transcripts for CRHR2 Gene

mRNA/cDNA for CRHR2 Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR2

Clone Products

  • Addgene plasmids for CRHR2

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - -
SP9:
SP10: - - - - - - - - - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CRHR2 Gene

GeneLoc Exon Structure for
CRHR2

Expression for CRHR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRHR2 Gene

mRNA differential expression in normal tissues according to GTEx for CRHR2 Gene

This gene is overexpressed in Pituitary (x7.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRHR2

SOURCE GeneReport for Unigene cluster for CRHR2 Gene:

Hs.546246

Evidence on tissue expression from TISSUES for CRHR2 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Adrenal gland(3.3)
  • Intestine(2.2)
  • Blood(2.1)
  • Thyroid gland(2.1)
  • Heart(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CRHR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHR2 Gene

Orthologs for CRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CRHR2 30 31
  • 99.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CRHR2 30 31
  • 93.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CRHR2 30 31
  • 92.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Crhr2 30
  • 89.35 (n)
Mouse
(Mus musculus)
Mammalia Crhr2 30 17 31
  • 88.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CRHR2 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CRHR2 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CRHR2 30 31
  • 77.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CRHR2 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia crhr2 30
  • 76.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia crhr2-A 30
Zebrafish
(Danio rerio)
Actinopterygii CRHR2 31
  • 77 (a)
OneToOne
LOC100335005 30
  • 72.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH2 30
  • 53.67 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Dh44-R1 30 31
  • 53.08 (n)
ManyToMany
CG12370 32
  • 40 (a)
CG8422 32
  • 39 (a)
Dh44-R2 31
  • 34 (a)
ManyToMany
EG:BACR25B3.3 32
  • 31 (a)
Species where no ortholog for CRHR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CRHR2 Gene

ENSEMBL:
Gene Tree for CRHR2 (if available)
TreeFam:
Gene Tree for CRHR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRHR2: view image

Paralogs for CRHR2 Gene

(13) SIMAP similar genes for CRHR2 Gene using alignment to 5 proteins:

  • CRFR2_HUMAN
  • B3SXS9_HUMAN
  • C9JZM9_HUMAN
  • F2Z2M6_HUMAN
  • Q99432_HUMAN
genes like me logo Genes that share paralogs with CRHR2: view

Variants for CRHR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRHR2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
726063 Likely Benign: not provided 30,655,713(-) T/C MISSENSE_VARIANT
736865 Likely Benign: not provided 30,656,017(-) A/T INTRON_VARIANT
778299 Benign: not provided 30,689,279(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
780674 Benign: not provided 30,653,465(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
rs386352294 Uncertain Significance: not provided 30,655,929(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CRHR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRHR2 Gene

Variant ID Type Subtype PubMed ID
dgv6316n100 CNV gain 25217958
esv1664845 CNV insertion 17803354
esv2734201 CNV deletion 23290073
esv2761316 CNV gain 21179565
nsv1068321 OTHER inversion 25765185
nsv1129280 CNV insertion 24896259
nsv1146657 CNV insertion 26484159
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv527038 CNV gain 19592680
nsv830938 CNV gain 17160897

Variation tolerance for CRHR2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRHR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR2 Gene

Disorders for CRHR2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CRHR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
irritable bowel syndrome
  • ibd
eating disorder
  • eating disorders
aids phobia
borderline personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search CRHR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRHR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CRHR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHR2 Gene

Publications for CRHR2 Gene

  1. A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth. (PMID: 20164545) Schmid M … Egarter C (Disease markers 2010) 3 23 41
  2. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. (PMID: 19813023) Gu X … Gao C (Human genetics 2010) 3 23 41
  3. Association of HPA axis genes with suicidal behaviour in schizophrenia. (PMID: 18838498) De Luca V … Kennedy JL (Journal of psychopharmacology (Oxford, England) 2010) 3 23 41
  4. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck ME … Binder EB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  5. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. (PMID: 18408560) Poon AH … Weiss ST (Pharmacogenetics and genomics 2008) 3 23 41

Products for CRHR2 Gene

  • Addgene plasmids for CRHR2

Sources for CRHR2 Gene