Aliases for CRHR2 Gene
External Ids for CRHR2 Gene
Previous GeneCards Identifiers for CRHR2 Gene
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
GeneCards Summary for CRHR2 Gene
CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include Anxiety and Irritable Bowel Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is CRHR1.
UniProtKB/Swiss-Prot for CRHR2 Gene
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.