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Aliases for CRHR2 Gene

Aliases for CRHR2 Gene

  • Corticotropin Releasing Hormone Receptor 2 2 3 5
  • CRH-R2 3 4
  • Corticotropin-Releasing Hormone Receptor 2 4
  • Corticotropin-Releasing Factor Receptor 2 3
  • CRF2 Receptor, Beta Isoform 3
  • CRH Receptor 2 Variant B 3
  • CRF-R-2 4
  • CRH-R-2 4
  • CRF-RB 3
  • HM-CRF 3
  • CRF-R2 4
  • CRFR-2 4
  • CRFR2 3
  • CRF2R 4
  • CRH2R 4
  • CRF2 3

External Ids for CRHR2 Gene

Previous GeneCards Identifiers for CRHR2 Gene

  • GC07M030334
  • GC07M030434
  • GC07M030465
  • GC07M030658
  • GC07M030574

Summaries for CRHR2 Gene

Entrez Gene Summary for CRHR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for CRHR2 Gene

CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include Anxiety and Irritable Bowel Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is CRHR1.

UniProtKB/Swiss-Prot for CRHR2 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Tocris Summary for CRHR2 Gene

  • The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.

Gene Wiki entry for CRHR2 Gene

Additional gene information for CRHR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHR2 Gene

Genomics for CRHR2 Gene

GeneHancer (GH) Regulatory Elements for CRHR2 Gene

Promoters and enhancers for CRHR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J030681 Promoter/Enhancer 1.2 EPDnew Ensembl 650.4 +18.0 18004 1.9 CTCF MXI1 ZNF777 ZNF837 MAX RAD21 ZNF335 ZFHX2 GLIS2 ZBTB48 CRHR2 ENSG00000244480 GC07P030686 PIR57163
GH07J030700 Enhancer 0.3 ENCODE 650.7 -0.2 -211 0.2 SIN3A CRHR2 LOC105375220 INMT LOC105375219
GH07J030726 Enhancer 1 Ensembl ENCODE 27.6 -27.2 -27168 1.8 PKNOX1 TCF12 ZNF766 SCRT2 ZNF143 CAVIN1 CEBPB MEF2D SP1 ATF4 LOC105375219 CRHR2 ENSG00000264520 PLEKHA8 FKBP14 ENSG00000226874 ENSG00000223419 INMT LOC105375220
GH07J030748 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 10.7 -51.0 -51036 5.8 CTCF ZNF282 FOXA2 REST NR2F2 YY1 SP1 NFIC CBX5 IKZF1 MINDY4 INMT INMT-MINDY4 CRHR2 ENSG00000244480 ENSG00000223419 LOC105375220
GH07J030755 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 11.3 -56.5 -56504 2.7 CTCF HLF TEAD2 RCOR1 ZBTB33 CHD2 NR2F2 INMT MINDY4 CRHR2 INMT-MINDY4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRHR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRHR2 gene promoter:
  • RORalpha2
  • HTF
  • HNF-4alpha1
  • MEF-2A
  • MEF-2
  • aMEF-2
  • POU2F1
  • POU2F1a
  • Zic1

Genomic Locations for CRHR2 Gene

Genomic Locations for CRHR2 Gene
chr7:30,651,843-30,700,129
(GRCh38/hg38)
Size:
48,287 bases
Orientation:
Minus strand
chr7:30,691,559-30,739,745
(GRCh37/hg19)
Size:
48,187 bases
Orientation:
Minus strand

Genomic View for CRHR2 Gene

Genes around CRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR2 Gene

Proteins for CRHR2 Gene

  • Protein details for CRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13324-CRFR2_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 2
    Protein Accession:
    Q13324
    Secondary Accessions:
    • B2R967
    • B3SXS6
    • B3SXS7
    • B3SXS8
    • B3SXT0
    • F8WA81
    • O43461
    • Q4QRJ4
    • Q99431

    Protein attributes for CRHR2 Gene

    Size:
    411 amino acids
    Molecular mass:
    47688 Da
    Quaternary structure:
    • Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

    Three dimensional structures from OCA and Proteopedia for CRHR2 Gene

    Alternative splice isoforms for CRHR2 Gene

neXtProt entry for CRHR2 Gene

Post-translational modifications for CRHR2 Gene

  • A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
  • Glycosylation at posLast=9494, posLast=8686, posLast=7474, and posLast=4141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRHR2 Gene

Domains & Families for CRHR2 Gene

Gene Families for CRHR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q13324

UniProtKB/Swiss-Prot:

CRFR2_HUMAN :
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • Belongs to the G-protein coupled receptor 2 family.
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • The uncleaved pseudo signal peptide prevents receptors oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR2: view

Function for CRHR2 Gene

Molecular function for CRHR2 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
GENATLAS Biochemistry:
corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

Phenotypes From GWAS Catalog for CRHR2 Gene

Gene Ontology (GO) - Molecular Function for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 11329063
GO:0015056 corticotrophin-releasing factor receptor activity TAS 9717834
genes like me logo Genes that share ontologies with CRHR2: view
genes like me logo Genes that share phenotypes with CRHR2: view

Animal Models for CRHR2 Gene

MGI Knock Outs for CRHR2:

Animal Model Products

CRISPR Products

miRNA for CRHR2 Gene

miRTarBase miRNAs that target CRHR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR2

Clone Products

  • Addgene plasmids for CRHR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHR2 Gene

Localization for CRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8536644
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRHR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHR2 Gene

Pathways & Interactions for CRHR2 Gene

genes like me logo Genes that share pathways with CRHR2: view

Gene Ontology (GO) - Biological Process for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 8536644
GO:0071376 cellular response to corticotropin-releasing hormone stimulus IEA --
genes like me logo Genes that share ontologies with CRHR2: view

No data available for SIGNOR curated interactions for CRHR2 Gene

Drugs & Compounds for CRHR2 Gene

(33) Drugs for CRHR2 Gene - From: PharmGKB, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 526
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
Astressin Pharma Antagonist 2
Sauvagine Pharma Full agonist, Agonist CRF agonist 0
Antisauvagine-30 Pharma Potent, selective and competitive CRF2 antagonist 0

(2) Additional Compounds for CRHR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for CRHR2 Gene

Compound Action Cas Number
Antisauvagine-30 Potent, selective and competitive CRF2 antagonist 220673-95-0
Astressin 2B Selective CRF2 antagonist 681260-70-8
K 41498 Highly selective and potent CRF2 antagonist 434938-41-7
genes like me logo Genes that share compounds with CRHR2: view

Transcripts for CRHR2 Gene

Unigene Clusters for CRHR2 Gene

Corticotropin releasing hormone receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR2

Clone Products

  • Addgene plasmids for CRHR2

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - -
SP9:
SP10: - - - - - - - - - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CRHR2 Gene

GeneLoc Exon Structure for
CRHR2
ECgene alternative splicing isoforms for
CRHR2

Expression for CRHR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRHR2 Gene

mRNA differential expression in normal tissues according to GTEx for CRHR2 Gene

This gene is overexpressed in Pituitary (x7.1).

NURSA nuclear receptor signaling pathways regulating expression of CRHR2 Gene:

CRHR2

SOURCE GeneReport for Unigene cluster for CRHR2 Gene:

Hs.546246

Evidence on tissue expression from TISSUES for CRHR2 Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Adrenal gland(2.8)
genes like me logo Genes that share expression patterns with CRHR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHR2 Gene

Orthologs for CRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRHR2 34 33
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRHR2 34 33
  • 93.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRHR2 34 33
  • 92.44 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crhr2 33
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Crhr2 16 34 33
  • 88.24 (n)
oppossum
(Monodelphis domestica)
Mammalia CRHR2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHR2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRHR2 34 33
  • 77.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRHR2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crhr2 33
  • 76.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia crhr2-A 33
zebrafish
(Danio rerio)
Actinopterygii CRHR2 34
  • 77 (a)
OneToOne
LOC100335005 33
  • 72.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH2 33
  • 53.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dh44-R1 34 33
  • 53.08 (n)
ManyToMany
CG12370 35
  • 40 (a)
CG8422 35
  • 39 (a)
Dh44-R2 34
  • 34 (a)
ManyToMany
EG:BACR25B3.3 35
  • 31 (a)
Species where no ortholog for CRHR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRHR2 Gene

ENSEMBL:
Gene Tree for CRHR2 (if available)
TreeFam:
Gene Tree for CRHR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRHR2: view image

Paralogs for CRHR2 Gene

Paralogs for CRHR2 Gene

(13) SIMAP similar genes for CRHR2 Gene using alignment to 5 proteins:

  • CRFR2_HUMAN
  • B3SXS9_HUMAN
  • C9JZM9_HUMAN
  • F2Z2M6_HUMAN
  • Q99432_HUMAN
genes like me logo Genes that share paralogs with CRHR2: view

Variants for CRHR2 Gene

Sequence variations from dbSNP and Humsavar for CRHR2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs7793837 drug-response, salbutamol response - Efficacy, selective beta-2-adrenoreceptor agonists response - Efficacy 30,687,161(-) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs386352294 uncertain-significance, not provided 30,655,929(-) G/A coding_sequence_variant, synonymous_variant
rs1000001973 -- 30,653,181(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000046878 -- 30,664,045(-) C/T intron_variant
rs1000096222 -- 30,678,733(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRHR2 Gene

Variant ID Type Subtype PubMed ID
dgv6316n100 CNV gain 25217958
esv1664845 CNV insertion 17803354
esv2734201 CNV deletion 23290073
esv2761316 CNV gain 21179565
nsv1068321 OTHER inversion 25765185
nsv1129280 CNV insertion 24896259
nsv1146657 CNV insertion 26484159
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv527038 CNV gain 19592680
nsv830938 CNV gain 17160897

Variation tolerance for CRHR2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRHR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR2 Gene

Disorders for CRHR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRHR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
irritable bowel syndrome
  • ibd
panic disorder
  • panic disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search CRHR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRHR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRHR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHR2 Gene

Publications for CRHR2 Gene

  1. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. (PMID: 19813023) Gu X … Gao C (Human genetics 2010) 3 22 44 58
  2. A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth. (PMID: 20164545) Schmid M … Egarter C (Disease markers 2010) 3 22 44 58
  3. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. (PMID: 18408560) Poon AH … Weiss ST (Pharmacogenetics and genomics 2008) 3 22 44 58
  4. Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder. (PMID: 17532191) De Luca V … Kennedy JL (European psychiatry : the journal of the Association of European Psychiatrists 2007) 3 22 44 58
  5. Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits. (PMID: 16884458) Tochigi M … Sasaki T (Psychiatry and clinical neurosciences 2006) 3 22 44 58

Products for CRHR2 Gene

Sources for CRHR2 Gene

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