Aliases for CRHR1 Gene
External Ids for CRHR1 Gene
Previous HGNC Symbols for CRHR1 Gene
Previous GeneCards Identifiers for CRHR1 Gene
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
GeneCards Summary for CRHR1 Gene
CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Depression and Anxiety. Among its related pathways are GPCRs, Class B Secretin-like and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is CRHR2.
UniProtKB/Swiss-Prot Summary for CRHR1 Gene
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS, with major expression in the cortex, cerebellum, hippocampus and amygdala.