This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity... See more...

Aliases for CRHR1 Gene

Aliases for CRHR1 Gene

  • Corticotropin Releasing Hormone Receptor 1 2 3 5
  • Corticotropin-Releasing Factor Receptor 1 3 4
  • CRF-R-1 3 4
  • CRH-R-1 3 4
  • CRF-R1 3 4
  • CRFR-1 3 4
  • CRH-R1 3 4
  • CRF-R 2 3
  • CRFR1 3 4
  • CRF1 2 3
  • CRHR 3 4
  • Corticotropin-Releasing Factor Type 1 Receptor 3
  • Corticotropin-Releasing Hormone Receptor 1 4
  • Corticotropin-Releasing Factor Receptor 2
  • Seven Transmembrane Helix Receptor 3
  • CRH Receptor 1 3
  • CRHR1L 3
  • CRHR1 5
  • CRFR 4

External Ids for CRHR1 Gene

Previous HGNC Symbols for CRHR1 Gene

  • CRHR

Previous GeneCards Identifiers for CRHR1 Gene

  • GC17P043455
  • GC17P046107
  • GC17P043872
  • GC17P044337
  • GC17P041217
  • GC17P039548
  • GC17P043699
  • GC17P043704
  • GC17P043733
  • GC17P045622

Summaries for CRHR1 Gene

Entrez Gene Summary for CRHR1 Gene

  • This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]

GeneCards Summary for CRHR1 Gene

CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Anxiety and Depression. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is CRHR2.

UniProtKB/Swiss-Prot Summary for CRHR1 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Tocris Summary for CRHR1 Gene

  • The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS, with major expression in the cortex, cerebellum, hippocampus and amygdala.

Gene Wiki entry for CRHR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRHR1 Gene

Genomics for CRHR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRHR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J045784 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 121 1.6 HNRNPL PRDM10 ZNF629 ZNF692 ZIC2 ZNF24 PATZ1 CTCF ZNF501 EZH2 CRHR1 LINC02210 LRRC37A HSALNG0141638 SPPL2C LINC02210-CRHR1
GH17J045619 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 -163.5 -163479 3.2 SP1 CREB1 PRDM10 DDX20 ZNF143 PKNOX1 PATZ1 TCF12 PBX2 IRF3 LINC02210 LINC02210-CRHR1 CRHR1 ENSG00000262372 ENSG00000224505 ARL17A KANSL1 ARL17B LRRC37A LRRC37A2
GH17J045783 Enhancer 0.8 ENCODE 600.7 -0.9 -850 0.1 CTCF ZBTB33 ZNF629 ZNF692 ZNF24 PATZ1 ZNF501 EZH2 ZNF600 KLF9 CRHR1 Hsa-Mir-95-P2_5p-003 LINC02210 LINC02210-CRHR1
GH17J045785 Promoter 0.7 Ensembl 600.7 +1.2 1220 0.2 HNRNPL EZH2 CTBP1 ZBTB26 ZFHX2 ZNF189 ZGPAT VEZF1 SMARCA4 RNF2 CRHR1 HSALNG0141638 SPPL2C LINC02210 LINC02210-CRHR1
GH17J045786 Enhancer 0.3 FANTOM5 602.5 +1.8 1792 0.1 EZH2 CRHR1 HSALNG0141638 SPPL2C LINC02210 LINC02210-CRHR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRHR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRHR1

Top Transcription factor binding sites by QIAGEN in the CRHR1 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • GATA-1
  • USF2

Genomic Locations for CRHR1 Gene

Genomic Locations for CRHR1 Gene
chr17:45,784,280-45,835,828
(GRCh38/hg38)
Size:
51,549 bases
Orientation:
Plus strand
chr17:43,697,710-43,913,194
(GRCh37/hg19)
Size:
215,485 bases
Orientation:
Plus strand

Genomic View for CRHR1 Gene

Genes around CRHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR1 Gene

Proteins for CRHR1 Gene

  • Protein details for CRHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34998-CRFR1_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 1
    Protein Accession:
    P34998
    Secondary Accessions:
    • B4DIE9
    • Q13008
    • Q4QRJ1
    • Q9UK64

    Protein attributes for CRHR1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50719 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding.
    Miscellaneous:
    • [Isoform CRF-R2]: Major isoform.
    • [Isoform CRF-R3]: Does not bind to CRF with high affinity.

    Three dimensional structures from OCA and Proteopedia for CRHR1 Gene

    Alternative splice isoforms for CRHR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRHR1 Gene

Post-translational modifications for CRHR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
  • Glycosylation at Asn38, Asn45, Asn90, Asn98, and Asn78
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRHR1 Gene

Domains & Families for CRHR1 Gene

Gene Families for CRHR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CRHR1 Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Corticotropin releasing factor receptor signature
  • Corticotropin releasing factor type 1 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for CRHR1 Gene

GenScript: Design optimal peptide antigens:
  • CRF1 receptor isoform I (B3SXS2_HUMAN)
  • CRF1 receptor isoform I variant B (B3TIK8_HUMAN)
  • cDNA FLJ60266, highly similar to Corticotropin-releasing factor receptor 1 (B4DIE9_HUMAN)
  • cDNA FLJ60308, highly similar to Corticotropin-releasing factor receptor 1 (B4DMR5_HUMAN)
  • Corticotropin-releasing hormone receptor 1 (CRFR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P34998

UniProtKB/Swiss-Prot:

CRFR1_HUMAN :
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.
  • Belongs to the G-protein coupled receptor 2 family.
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR1: view

Function for CRHR1 Gene

Molecular function for CRHR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
GENATLAS Biochemistry:
corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced isoforms

Phenotypes From GWAS Catalog for CRHR1 Gene

Gene Ontology (GO) - Molecular Function for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 18801728
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0015056 corticotrophin-releasing factor receptor activity IBA,IDA 18292205
genes like me logo Genes that share ontologies with CRHR1: view
genes like me logo Genes that share phenotypes with CRHR1: view

Animal Models for CRHR1 Gene

MGI Knock Outs for CRHR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRHR1

CRISPR Products

miRNA for CRHR1 Gene

miRTarBase miRNAs that target CRHR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR1

Clone Products

  • Addgene plasmids for CRHR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHR1 Gene

Localization for CRHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR1 Gene

Cell membrane. Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHR1 gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10598591
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 23863939
genes like me logo Genes that share ontologies with CRHR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHR1 Gene

Pathways & Interactions for CRHR1 Gene

genes like me logo Genes that share pathways with CRHR1: view

Pathways by source for CRHR1 Gene

SIGNOR curated interactions for CRHR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 7692441
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CRHR1: view

Drugs & Compounds for CRHR1 Gene

(55) Drugs for CRHR1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 3266
Fluoxetine Approved, Vet_approved Pharma Channel blocker, Antagonist, Inhibitor, Inhibition 278
Corticorelin ovine triflutate Approved Pharma Target, ligand 0
Budesonide Approved Pharma Anti-inflammatory corticosteroid 509
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0

(13) Additional Compounds for CRHR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CRHR1 Gene

Compound Action Cas Number
Antalarmin hydrochloride CRF1 antagonist 220953-69-5
CP 154526 Selective, non-peptide CRF1 antagonist 257639-98-8
NBI 27914 hydrochloride Selective non-peptide CRF1 antagonist 1215766-76-9
NBI 35965 hydrochloride Potent and selective CRF1 antagonist 1782228-59-4
Stressin I CRF1 agonist

(13) ApexBio Compounds for CRHR1 Gene

Compound Action Cas Number
Antalarmin hydrochloride 220953-69-5
Astressin 170809-51-5
CP 154526 257639-98-8
CRF (6-33) 120066-38-8
CRF (human, rat) 86784-80-7
NBI 27914 hydrochloride 1215766-76-9
NBI 35965 hydrochloride 603151-83-3
NGD 98-2 hydrochloride
Sauvagine 74434-59-6
SN 003 197801-88-0
Stressin I
Urocortin (human) 176591-49-4
α-helical CRF 9-41 Antagonist of corticotropin releasing factor receptor 90880-23-2
genes like me logo Genes that share compounds with CRHR1: view

Drug Products

Transcripts for CRHR1 Gene

mRNA/cDNA for CRHR1 Gene

6 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHR1

Clone Products

  • Addgene plasmids for CRHR1

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CRHR1 Gene

GeneLoc Exon Structure for
CRHR1

Expression for CRHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRHR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.3), Brain - Cerebellum (x7.3), and Pituitary (x6.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRHR1

SOURCE GeneReport for Unigene cluster for CRHR1 Gene:

Hs.417628

mRNA Expression by UniProt/SwissProt for CRHR1 Gene:

P34998-CRFR1_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Evidence on tissue expression from TISSUES for CRHR1 Gene

  • Nervous system(4.7)
  • Adrenal gland(3.2)
  • Blood(2.5)
  • Skin(2.4)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CRHR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHR1 Gene

Orthologs for CRHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CRHR1 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CRHR1 30 31
  • 93.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CRHR1 30 31
  • 93.09 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CRHR1 31
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Crhr1 30 17 31
  • 91.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Crhr1 30
  • 90.76 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CRHR1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CRHR1 30 31
  • 84.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CRHR1 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100498637 30
  • 76.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii crhr1 30 31
  • 78.01 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH1 30
  • 54.87 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Dh44-R2 30 31
  • 51.92 (n)
ManyToMany
Dh44-R1 31
  • 32 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea C18B12.2 30
  • 43.59 (n)
Species where no ortholog for CRHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CRHR1 Gene

ENSEMBL:
Gene Tree for CRHR1 (if available)
TreeFam:
Gene Tree for CRHR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRHR1: view image

Paralogs for CRHR1 Gene

(7) SIMAP similar genes for CRHR1 Gene using alignment to 13 proteins:

  • CRFR1_HUMAN
  • B3SXS2_HUMAN
  • B3TIK8_HUMAN
  • B4DMR5_HUMAN
  • H0YFR5_HUMAN
  • J3KSM0_HUMAN
  • J3QKP8_HUMAN
  • J3QQR1_HUMAN
  • J9JIC6_HUMAN
  • Q8NFN9_HUMAN
  • Q8WXR5_HUMAN
  • Q8WXR6_HUMAN
  • Q8WXR7_HUMAN
genes like me logo Genes that share paralogs with CRHR1: view

Variants for CRHR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRHR1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
708229 Benign: not provided 45,830,440(+) C/T SYNONYMOUS_VARIANT
749169 Likely Benign: not provided 45,821,425(+) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
768893 Benign: not provided 45,816,518(+) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
771768 Benign: not provided 45,816,520(+) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
780430 Benign: not provided 45,830,084(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CRHR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRHR1 Gene

Variant ID Type Subtype PubMed ID
dgv1474n106 CNV deletion 24896259
dgv1764e59 CNV duplication 20981092
dgv3176n100 CNV gain 25217958
dgv3177n100 CNV loss 25217958
dgv932e212 CNV loss 25503493
dgv933e212 CNV loss 25503493
dgv934e212 CNV loss 25503493
esv1593331 CNV deletion 17803354
esv26189 CNV gain+loss 19812545
esv2667768 CNV deletion 23128226
esv2715975 CNV deletion 23290073
esv275304 CNV loss 21479260
esv2758691 CNV gain+loss 17122850
esv2762433 CNV gain+loss 21179565
esv3304632 CNV mobile element insertion 20981092
esv3338016 CNV insertion 20981092
esv3364233 CNV duplication 20981092
esv3416082 CNV insertion 20981092
esv3582701 CNV loss 25503493
esv3640670 CNV loss 21293372
nsv1060303 CNV gain 25217958
nsv1064960 CNV gain 25217958
nsv1071388 CNV deletion 25765185
nsv1071389 CNV deletion 25765185
nsv1126461 CNV deletion 24896259
nsv1133406 CNV deletion 24896259
nsv1143855 CNV deletion 24896259
nsv1143856 CNV deletion 24896259
nsv1143857 CNV deletion 24896259
nsv1144804 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv2066 CNV insertion 18451855
nsv2067 CNV insertion 18451855
nsv457744 CNV gain 19166990
nsv472387 CNV novel sequence insertion 20440878
nsv476911 CNV novel sequence insertion 20440878
nsv575137 CNV loss 21841781
nsv575138 CNV gain 21841781
nsv575139 CNV loss 21841781
nsv575140 CNV loss 21841781
nsv833458 CNV gain 17160897
nsv833460 CNV loss 17160897
nsv9563 CNV gain+loss 18304495
nsv960491 CNV duplication 23825009

Variation tolerance for CRHR1 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRHR1 Gene

Human Gene Mutation Database (HGMD)
CRHR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR1 Gene

Disorders for CRHR1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for CRHR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anxiety
  • anxiety disorder
depression
  • major depressive disorder
irritable bowel syndrome
  • ibd
generalized anxiety disorder
  • anxiety generalized
supranuclear palsy, progressive, 1
  • psp
- elite association - COSMIC cancer census association via MalaCards
Search CRHR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRHR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CRHR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHR1 Gene

Publications for CRHR1 Gene

  1. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. (PMID: 20029939) Ressler KJ … Binder EB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41
  2. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. (PMID: 20403506) Holliday KL … McBeth J (Journal of psychosomatic research 2010) 3 23 41
  3. Association of HPA axis genes with suicidal behaviour in schizophrenia. (PMID: 18838498) De Luca V … Kennedy JL (Journal of psychopharmacology (Oxford, England) 2010) 3 23 41
  4. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C … Licinio J (Molecular psychiatry 2009) 3 23 41
  5. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. (PMID: 19736354) Polanczyk G … Moffitt TE (Archives of general psychiatry 2009) 3 23 41

Products for CRHR1 Gene

  • Addgene plasmids for CRHR1

Sources for CRHR1 Gene