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CRHR1 Gene(Protein Coding)

Corticotropin Releasing Hormone Receptor 1

GCID:
GC17P045784
GIFtS:
66
Genes Participants
UDN Logo

Aliases for CRHR1 Gene

Aliases for CRHR1 Gene

  • Corticotropin Releasing Hormone Receptor 1 2 3 5
  • CRF-R-1 3 4
  • CRH-R-1 3 4
  • CRF-R1 3 4
  • CRFR-1 3 4
  • CRH-R1 3 4
  • CRFR1 3 4
  • CRHR 3 4
  • Corticotropin-Releasing Factor Type 1 Receptor 3
  • Corticotropin-Releasing Hormone Receptor 1 4
  • Corticotropin-Releasing Factor Receptor 1 3
  • Corticotropin-Releasing Factor Receptor 2
  • Seven Transmembrane Helix Receptor 3
  • CRH Receptor 1 3
  • CRHR1L 3
  • CRF-R 3
  • CRF1 3
  • CRFR 4

External Ids for CRHR1 Gene

Previous HGNC Symbols for CRHR1 Gene

  • CRHR

Previous GeneCards Identifiers for CRHR1 Gene

  • GC17P043455
  • GC17P046107
  • GC17P043872
  • GC17P044337
  • GC17P041217
  • GC17P039548
  • GC17P043699
  • GC17P043704
  • GC17P043733
  • GC17P045622

Summaries for CRHR1 Gene

Entrez Gene Summary for CRHR1 Gene

  • This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]

GeneCards Summary for CRHR1 Gene

CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Anxiety Disorder and Koolen-De Vries Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and Activation of cAMP-Dependent PKA. GO annotations related to this gene include G-protein coupled receptor activity and protein complex binding. An important paralog of this gene is CRHR2.

UniProtKB/Swiss-Prot for CRHR1 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Tocris Summary for CRHR1 Gene

  • The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS, with major expression in the cortex, cerebellum, hippocampus and amygdala.

Gene Wiki entry for CRHR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHR1 Gene

Genomics for CRHR1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CRHR1 Gene

Enhancers for CRHR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G045941 1.2 FANTOM5 ENCODE dbSUPER 2.2 +158.0 157991 0.9 MAX RAD21 FOXA1 NR2F2 YY1 JUND ATF3 ZNF366 SMARCA4 SCRT2 LINC02210 MAPT STH CRHR1 LOC105371800 GC17P045970
GH17G045786 0.5 FANTOM5 2.6 +1.8 1793 0.1 SUZ12 CBX2 EZH2 CRHR1 LOC105371801
GH17G045783 1.2 Ensembl ENCODE 0.7 +0.1 107 2.6 ZNF2 ZNF48 ZNF121 GLIS2 GATA2 KLF7 ZNF263 SP3 SP5 REST LINC02210 FAM215B ENSG00000262539 LRRC37A CRHR1 LOC105371801
GH17G045741 0.7 ENCODE 0.3 -43.6 -43581 0.2 PKNOX1 SP3 NFYA DDX20 NFYC SP2 ELF4 ELF1 MBD2 POLR2A ENSG00000265964 CRHR1
GH17G045770 0.5 ENCODE 0.4 -13.2 -13211 0.2 ZNF664 SMARCA4 ZNF341 LINC02210 LRRC37A CRHR1 ENSG00000265964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRHR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CRHR1 gene promoter:

Genomic Location for CRHR1 Gene

Chromosome:
17
Start:
45,784,280 bp from pter
End:
45,835,828 bp from pter
Size:
51,549 bases
Orientation:
Plus strand

Genomic View for CRHR1 Gene

Genes around CRHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CRHR1 Gene

Proteins for CRHR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CRHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34998-CRFR1_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 1
    Protein Accession:
    P34998
    Secondary Accessions:
    • B4DIE9
    • Q13008
    • Q4QRJ1
    • Q9UK64

    Protein attributes for CRHR1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50719 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding.

    Three dimensional structures from OCA and Proteopedia for CRHR1 Gene

    Alternative splice isoforms for CRHR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRHR1 Gene

Post-translational modifications for CRHR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
  • Glycosylation at isoforms=2, 3, 438, Asn45, isoforms=2, 478, isoforms=2, 3, 490, and Asn98
  • Modification sites at PhosphoSitePlus

Other Protein References for CRHR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRHR1 Gene

Domains & Families for CRHR1 Gene

Gene Families for CRHR1 Gene

HGNC:
IUPHAR :

Protein Domains for CRHR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34998

UniProtKB/Swiss-Prot:

CRFR1_HUMAN :
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.
  • Belongs to the G-protein coupled receptor 2 family.
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR1: view

Function for CRHR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CRHR1 Gene

GENATLAS Biochemistry:
corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Gene Ontology (GO) - Molecular Function for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 18801728
GO:0015056 corticotrophin-releasing factor receptor activity IDA 18292205
genes like me logo Genes that share ontologies with CRHR1: view
genes like me logo Genes that share phenotypes with CRHR1: view

Animal Models for CRHR1 Gene

MGI Knock Outs for CRHR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRHR1

CRISPR Products

miRNA for CRHR1 Gene

miRTarBase miRNAs that target CRHR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRHR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHR1 Gene

Localization for CRHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR1 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHR1 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 10598591
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 23863939
genes like me logo Genes that share ontologies with CRHR1: view

Pathways & Interactions for CRHR1 Gene

genes like me logo Genes that share pathways with CRHR1: view

SIGNOR curated interactions for CRHR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 7692441
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS 10598591
genes like me logo Genes that share ontologies with CRHR1: view

Drugs & Compounds for CRHR1 Gene

Products:

  1. Drug

(58) Drugs for CRHR1 Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 2137
Fluoxetine Approved, Vet_approved Pharma Channel blocker 238
Budesonide Approved Pharma Anti-inflammatory corticosteroid 432
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Triamcinolone Approved, Vet_approved Pharma Agonist 510

(14) Additional Compounds for CRHR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-helical CRF
Antagonist

(5) Tocris Compounds for CRHR1 Gene

Compound Action Cas Number
Antalarmin hydrochloride CRF1 antagonist 220953-69-5
CP 154526 Selective, non-peptide CRF1 antagonist 257639-98-8
CP 376395 hydrochloride Potent and selective CRF1 antagonist 1013933-37-3
NBI 35965 hydrochloride Potent and selective CRF1 antagonist 1782228-59-4
Stressin I CRF1 agonist

(14) ApexBio Compounds for CRHR1 Gene

Compound Action Cas Number
Antalarmin hydrochloride 220953-69-5
Astressin 170809-51-5
CP 154526 257639-98-8
CP 376395 hydrochloride 1013933-37-3
CRF (6-33) 120066-38-8
CRF (human, rat) 86784-80-7
NBI 27914 hydrochloride 1215766-76-9
NBI 35965 hydrochloride 603151-83-3
NGD 98-2 hydrochloride
Sauvagine 74434-59-6
SN 003 197801-88-0
Stressin I
Urocortin (human) 176591-49-4
α-helical CRF 9-41 Antagonist of corticotropin releasing factor receptor 90880-23-2
genes like me logo Genes that share compounds with CRHR1: view

Transcripts for CRHR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CRHR1 Gene

(6) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRHR1 Gene

Corticotropin releasing hormone receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRHR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CRHR1 Gene

GeneLoc Exon Structure for
CRHR1
ECgene alternative splicing isoforms for
CRHR1

Expression for CRHR1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRHR1 Gene

mRNA expression in normal human tissues for CRHR1 Gene
mRNA expression by BioGPS for CRHR1 GenemRNA expression by GTEx for CRHR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.3), Brain - Cerebellum (x7.3), and Pituitary (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of CRHR1 Gene:

CRHR1

SOURCE GeneReport for Unigene cluster for CRHR1 Gene:

Hs.417628

mRNA Expression by UniProt/SwissProt for CRHR1 Gene:

P34998-CRFR1_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Evidence on tissue expression from TISSUES for CRHR1 Gene

  • Nervous system(4.7)
  • Adrenal gland(2.7)
genes like me logo Genes that share expression patterns with CRHR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHR1 Gene

Orthologs for CRHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CRHR1 34 35
  • 99.62 (n)
dog
(Canis familiaris)
 Mammalia CRHR1 34 35
  • 93.49 (n)
cow
(Bos Taurus)
 Mammalia CRHR1 34 35
  • 93.09 (n)
oppossum
(Monodelphis domestica)
 Mammalia CRHR1 35
  • 93 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Crhr1 34 16 35
  • 91.08 (n)
rat
(Rattus norvegicus)
 Mammalia Crhr1 34
  • 90.76 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CRHR1 35
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CRHR1 34 35
  • 84.63 (n)
lizard
(Anolis carolinensis)
 Reptilia CRHR1 35
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100498637 34
  • 76.19 (n)
zebrafish
(Danio rerio)
 Actinopterygii crhr1 34 35
  • 78.01 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta GPRDIH1 34
  • 54.87 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Dh44-R2 34 35
  • 51.92 (n)
Dh44-R1 35
  • 32 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea C18B12.2 34
  • 43.59 (n)
Species where no ortholog for CRHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRHR1 Gene

ENSEMBL:
Gene Tree for CRHR1 (if available)
TreeFam:
Gene Tree for CRHR1 (if available)

Paralogs for CRHR1 Gene

Variants for CRHR1 Gene

Sequence variations from dbSNP and Humsavar for CRHR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1876828 drug-response 45,834,159(-) TAGGA(A/G)CAGGG intron-variant
rs1000047582 -- 45,786,132(+) TTTTT(-/C)TTTTT intron-variant
rs1000089367 -- 45,817,164(+) CTCAT(A/G)TAAAC intron-variant
rs1000114237 -- 45,797,520(+) TGATC(C/T)GCCCA intron-variant
rs1000169438 -- 45,828,327(+) TGCGC(A/G)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRHR1 Gene

Variant ID Type Subtype PubMed ID
dgv1474n106 CNV deletion 24896259
dgv1764e59 CNV duplication 20981092
dgv3176n100 CNV gain 25217958
dgv3177n100 CNV loss 25217958
dgv932e212 CNV loss 25503493
dgv933e212 CNV loss 25503493
dgv934e212 CNV loss 25503493
esv1593331 CNV deletion 17803354
esv26189 CNV gain+loss 19812545
esv2667768 CNV deletion 23128226
esv2715975 CNV deletion 23290073
esv275304 CNV loss 21479260
esv2758691 CNV gain+loss 17122850
esv2762433 CNV gain+loss 21179565
esv3304632 CNV mobile element insertion 20981092
esv3338016 CNV insertion 20981092
esv3364233 CNV duplication 20981092
esv3416082 CNV insertion 20981092
esv3582701 CNV loss 25503493
esv3640670 CNV loss 21293372
nsv1060303 CNV gain 25217958
nsv1064960 CNV gain 25217958
nsv1071388 CNV deletion 25765185
nsv1071389 CNV deletion 25765185
nsv1126461 CNV deletion 24896259
nsv1133406 CNV deletion 24896259
nsv1143855 CNV deletion 24896259
nsv1143856 CNV deletion 24896259
nsv1143857 CNV deletion 24896259
nsv1144804 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv2066 CNV insertion 18451855
nsv2067 CNV insertion 18451855
nsv457744 CNV gain 19166990
nsv472387 CNV novel sequence insertion 20440878
nsv476911 CNV novel sequence insertion 20440878
nsv575137 CNV loss 21841781
nsv575138 CNV gain 21841781
nsv575139 CNV loss 21841781
nsv575140 CNV loss 21841781
nsv833458 CNV gain 17160897
nsv833460 CNV loss 17160897
nsv9563 CNV gain+loss 18304495
nsv960491 CNV duplication 23825009

Variation tolerance for CRHR1 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRHR1 Gene

Human Gene Mutation Database (HGMD)
CRHR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR1 Gene

Disorders for CRHR1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CRHR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anxiety disorder
  • anxiety
koolen-de vries syndrome
  • koolen de vries syndrome
supranuclear palsy, progressive
  • progressive supranuclear palsy
generalized anxiety disorder
  • anxiety generalized
irritable bowel syndrome
  • ibd
- elite association - COSMIC cancer census association via MalaCards
Search CRHR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRHR1

Genetic Association Database (GAD)
CRHR1
Human Genome Epidemiology (HuGE) Navigator
CRHR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRHR1
genes like me logo Genes that share disorders with CRHR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHR1 Gene

Publications for CRHR1 Gene

  1. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. (PMID: 20029939) Ressler K.J. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  2. Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. (PMID: 19210659) Kim W.J. … Lee S.D. (Respirology 2009) 3 22 46 64
  3. Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. (PMID: 19596121) Tyrka A.R. … Carpenter L.L. (Biol. Psychiatry 2009) 3 22 46 64
  4. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. (PMID: 19736354) Polanczyk G. … Moffitt T.E. (Arch. Gen. Psychiatry 2009) 3 22 46 64
  5. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C. … Licinio J. (Mol. Psychiatry 2009) 3 22 46 64

Products for CRHR1 Gene

  • Addgene plasmids for CRHR1

Sources for CRHR1 Gene

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