Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein w... See more...

Aliases for CRHBP Gene

Aliases for CRHBP Gene

  • Corticotropin Releasing Hormone Binding Protein 2 3 5
  • Corticotropin-Releasing Factor-Binding Protein 3 4
  • CRF-Binding Protein 3 4
  • CRF-BP 3 4
  • CRH-BP 3 4
  • CRFBP 3 4
  • Corticotropin-Releasing Hormone-Binding Protein 4
  • Corticotropin Releasing Hormone-Binding Protein 2

External Ids for CRHBP Gene

Previous GeneCards Identifiers for CRHBP Gene

  • GC05P075055
  • GC05P076483
  • GC05P076287
  • GC05P076332
  • GC05P076284
  • GC05P071455
  • GC05P076248

Summaries for CRHBP Gene

Entrez Gene Summary for CRHBP Gene

  • Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRHBP Gene

CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Diseases associated with CRHBP include Klebsiella Pneumonia and Hypoadrenocorticism, Familial. Among its related pathways are Signaling by GPCR and Corticotropin-releasing hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.

UniProtKB/Swiss-Prot Summary for CRHBP Gene

  • Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Gene Wiki entry for CRHBP Gene

Additional gene information for CRHBP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRHBP Gene

Genomics for CRHBP Gene

GeneHancer (GH) Regulatory Elements for CRHBP Gene

Promoters and enhancers for CRHBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J076952 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 515.6 +1.1 1063 1.8 ZBTB26 EZH2 SUZ12 CTCF RNF2 CHD1 MAZ CTBP2 ZBTB8A GLIS2 CRHBP piR-50437-540 RF00017-4735
GH05J076951 Enhancer 0.3 dbSUPER 500.7 -1.0 -976 1.4 EZH2 MNT CRHBP RF00619-033 RNU6ATAC36P S100Z RF00017-4735
GH05J076946 Enhancer 1.1 Ensembl ENCODE dbSUPER 26.5 -6.2 -6191 3.1 MYC ATF2 NCOR1 TRIM25 NFIC ARNT TRIM24 PBX2 NR2F2 TAL1 piR-30350-048 CRHBP RF00619-033 RNU6ATAC36P S100Z RF00017-4735
GH05J077029 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 +78.0 77966 2.8 ZBTB40 ZNF217 EP300 TCF12 SIN3A POLR2G SP1 GTF2E2 PHF8 ZFX AGGF1 ENSG00000285000 ENSG00000250615 SNORA47 ZBED3-AS1 CRHBP RF00017-4735
GH05J076785 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -162.8 -162834 12.4 ZSCAN5C TCF12 JUND FOS ZNF639 ZIC2 ZNF623 TRIM28 RFX1 CUX1 piR-32214-557 piR-41245-221 F2RL1 F2R ENSG00000225407 CRHBP RF01210-309 RF00017-4734 RF00017-4732
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRHBP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRHBP

Top Transcription factor binding sites by QIAGEN in the CRHBP gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • c-Myc
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • XBP-1

Genomic Locations for CRHBP Gene

Genomic Locations for CRHBP Gene
chr5:76,952,835-76,981,158
(GRCh38/hg38)
Size:
28,324 bases
Orientation:
Plus strand
chr5:76,248,538-76,276,983
(GRCh37/hg19)
Size:
28,446 bases
Orientation:
Plus strand

Genomic View for CRHBP Gene

Genes around CRHBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHBP Gene

Proteins for CRHBP Gene

  • Protein details for CRHBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24387-CRHBP_HUMAN
    Recommended name:
    Corticotropin-releasing factor-binding protein
    Protein Accession:
    P24387
    Secondary Accessions:
    • Q53F32
    • Q6FHT5

    Protein attributes for CRHBP Gene

    Size:
    322 amino acids
    Molecular mass:
    36144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRHBP Gene

Post-translational modifications for CRHBP Gene

  • Glycosylation at Asn204
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CRHBP_HUMAN (1932)

Other Protein References for CRHBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRHBP Gene

Domains & Families for CRHBP Gene

Gene Families for CRHBP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CRHBP Gene

Blocks:
  • CUB domain
  • Corticotropin-releasing factor binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRHBP Gene

GenScript: Design optimal peptide antigens:
  • Corticotropin-releasing hormone-binding protein (CRHBP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24387

UniProtKB/Swiss-Prot:

CRHBP_HUMAN :
  • Belongs to the CRF-binding protein family.
Family:
  • Belongs to the CRF-binding protein family.
genes like me logo Genes that share domains with CRHBP: view

Function for CRHBP Gene

Molecular function for CRHBP Gene

UniProtKB/Swiss-Prot Function:
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
GENATLAS Biochemistry:
corticotropin releasing hormone binding protein

Phenotypes From GWAS Catalog for CRHBP Gene

Gene Ontology (GO) - Molecular Function for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18234674
GO:0042277 peptide binding ISS --
GO:0051424 corticotropin-releasing hormone binding IEA,IPI 18234674
genes like me logo Genes that share ontologies with CRHBP: view
genes like me logo Genes that share phenotypes with CRHBP: view

Animal Models for CRHBP Gene

MGI Knock Outs for CRHBP:

Animal Model Products

CRISPR Products

miRNA for CRHBP Gene

miRTarBase miRNAs that target CRHBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHBP Gene

Localization for CRHBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHBP gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 4
endosome 4
lysosome 4
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 1846945
GO:0005634 nucleus IEA,ISS --
GO:0005767 secondary lysosome ISS --
GO:0005771 multivesicular body ISS --
genes like me logo Genes that share ontologies with CRHBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHBP Gene

Pathways & Interactions for CRHBP Gene

genes like me logo Genes that share pathways with CRHBP: view

Pathways by source for CRHBP Gene

Gene Ontology (GO) - Biological Process for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic ISS --
GO:0002125 maternal aggressive behavior IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7477348
GO:0007565 female pregnancy IEP 1846945
genes like me logo Genes that share ontologies with CRHBP: view

No data available for SIGNOR curated interactions for CRHBP Gene

Drugs & Compounds for CRHBP Gene

(10) Drugs for CRHBP Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 3220

(1) Additional Compounds for CRHBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRHBP: view

Transcripts for CRHBP Gene

mRNA/cDNA for CRHBP Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRHBP Gene

No ASD Table

Relevant External Links for CRHBP Gene

GeneLoc Exon Structure for
CRHBP

Expression for CRHBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRHBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHBP Gene

This gene is overexpressed in Brain - Hypothalamus (x8.7), Liver (x7.5), Kidney - Cortex (x5.0), and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for CRHBP Gene

This gene is overexpressed in Serum (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRHBP Gene



Protein tissue co-expression partners for CRHBP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRHBP

SOURCE GeneReport for Unigene cluster for CRHBP Gene:

Hs.115617

Evidence on tissue expression from TISSUES for CRHBP Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Liver(4.4)
  • Adrenal gland(2.5)
genes like me logo Genes that share expression patterns with CRHBP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHBP Gene

Orthologs for CRHBP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRHBP 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRHBP 31 30
  • 88.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRHBP 31 30
  • 88.1 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crhbp 17 31 30
  • 85.92 (n)
rat
(Rattus norvegicus)
Mammalia Crhbp 30
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia CRHBP 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHBP 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRHBP 30
  • 74.74 (n)
-- 31
  • 69 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CRHBP 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crhbp 30
  • 68.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia crhbp-A 30
zebrafish
(Danio rerio)
Actinopterygii crhbp 31 30
  • 65.3 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3847 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000955 30
  • 44.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15537 31 30
  • 43.56 (n)
OneToOne
Species where no ortholog for CRHBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRHBP Gene

ENSEMBL:
Gene Tree for CRHBP (if available)
TreeFam:
Gene Tree for CRHBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRHBP: view image

Paralogs for CRHBP Gene

No data available for Paralogs for CRHBP Gene

Variants for CRHBP Gene

Additional dbSNP identifiers (rs#s) for CRHBP Gene

Structural Variations from Database of Genomic Variants (DGV) for CRHBP Gene

Variant ID Type Subtype PubMed ID
nsv1027236 CNV gain 25217958
nsv823102 CNV gain 20364138
nsv830355 CNV gain 17160897

Variation tolerance for CRHBP Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRHBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRHBP Gene

Disorders for CRHBP Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRHBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
klebsiella pneumonia
  • pneumonia due to klebsiella pneumoniae
hypoadrenocorticism, familial
  • adrenal hypoplasia
anxiety
  • anxiety disorder
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search CRHBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRHBP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRHBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHBP Gene

Publications for CRHBP Gene

  1. Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) (PMID: 8198617) Behan DP … Vale WW (Genomics 1993) 2 3 4 23 54
  2. Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PMID: 19131402) Ryckman KK … Williams SM (Molecular human reproduction 2009) 3 23 41 54
  3. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PMID: 18974851) Enoch MA … Goldman D (PloS one 2008) 3 23 41 54
  4. Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PMID: 17599466) Van Den Eede F … Claes SJ (Psychiatry research 2007) 3 23 41 54
  5. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S … Van Broeckhoven C (Biological psychiatry 2003) 3 23 41 54

Products for CRHBP Gene

Sources for CRHBP Gene