Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein w... See more...

Aliases for CRHBP Gene

Aliases for CRHBP Gene

  • Corticotropin Releasing Hormone Binding Protein 2 3 5
  • CRF-BP 2 3 4
  • CRFBP 2 3 4
  • Corticotropin-Releasing Factor-Binding Protein 3 4
  • CRF-Binding Protein 3 4
  • CRH-BP 3 4
  • Corticotropin Releasing Hormone-Binding Protein 2
  • Corticotropin-Releasing Hormone-Binding Protein 4
  • CRHBP 5

External Ids for CRHBP Gene

Previous GeneCards Identifiers for CRHBP Gene

  • GC05P075055
  • GC05P076483
  • GC05P076287
  • GC05P076332
  • GC05P076284
  • GC05P071455
  • GC05P076248

Summaries for CRHBP Gene

Entrez Gene Summary for CRHBP Gene

  • Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRHBP Gene

CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Diseases associated with CRHBP include Klebsiella Pneumonia and Opioid Addiction. Among its related pathways are Presynaptic function of Kainate receptors and Corticotropin-releasing hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.

UniProtKB/Swiss-Prot Summary for CRHBP Gene

  • Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Gene Wiki entry for CRHBP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRHBP Gene

Genomics for CRHBP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRHBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J076952 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 265.6 +1.3 1343 2.4 CTCF ZBTB8A GLIS2 ZBTB20 EZH2 ZBTB26 CRHBP HSALNG0042808 HSALNG0042810 AGGF1 RF00017-4275
GH05J076951 Enhancer 0.3 dbSUPER 250.7 -1.0 -996 1.4 MNT CRHBP HSALNG0042808 RNU6ATAC36P RF00619-029 S100Z RF00017-4275
GH05J076946 Enhancer 1.1 Ensembl ENCODE dbSUPER 26.4 -6.2 -6211 3.1 NCOR1 IKZF1 ATF2 NFIC ARNT TAL1 JUND PRDM10 SMARCA4 FOXM1 HSALNG0042806 piR-30350-048 CRHBP S100Z RF00017-4275
GH05J077029 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 +77.9 77946 2.8 BCLAF1 SP1 MYC ZNF600 ZNF592 POLR2A CEBPA ZSCAN16 YY1 MXD4 AGGF1 ENSG00000285000 ENSG00000250615 SNORA47 ZBED3-AS1 CRHBP MK280269-052 RF00017-4275
GH05J076786 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -161.4 -161354 9.4 IKZF1 NCOR1 ZNF600 JUND NFIC ZIC2 BCL11A CEBPB FEZF1 ZNF639 F2RL1 F2R ENSG00000225407 CRHBP HSALNG0042793 piR-32214-557 piR-41245-221 RF00017-4272
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRHBP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRHBP

Top Transcription factor binding sites by QIAGEN in the CRHBP gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • c-Myc
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • XBP-1

Genomic Locations for CRHBP Gene

Latest Assembly
chr5:76,952,855-76,981,158
(GRCh38/hg38)
Size:
28,304 bases
Orientation:
Plus strand

Previous Assembly
chr5:76,248,870-76,265,296
(GRCh37/hg19 by Entrez Gene)
Size:
16,427 bases
Orientation:
Plus strand

chr5:76,248,538-76,276,983
(GRCh37/hg19 by Ensembl)
Size:
28,446 bases
Orientation:
Plus strand

Genomic View for CRHBP Gene

Genes around CRHBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHBP Gene

Proteins for CRHBP Gene

  • Protein details for CRHBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24387-CRHBP_HUMAN
    Recommended name:
    Corticotropin-releasing factor-binding protein
    Protein Accession:
    P24387
    Secondary Accessions:
    • Q53F32
    • Q6FHT5

    Protein attributes for CRHBP Gene

    Size:
    322 amino acids
    Molecular mass:
    36144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRHBP Gene

Post-translational modifications for CRHBP Gene

  • Glycosylation at Asn204
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CRHBP_HUMAN (1932)

Other Protein References for CRHBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRHBP Gene

Domains & Families for CRHBP Gene

Gene Families for CRHBP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CRHBP Gene

InterPro:
Blocks:
  • CUB domain
  • Corticotropin-releasing factor binding

Suggested Antigen Peptide Sequences for CRHBP Gene

GenScript: Design optimal peptide antigens:
  • Corticotropin-releasing hormone-binding protein (CRHBP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24387

UniProtKB/Swiss-Prot:

CRHBP_HUMAN :
  • Belongs to the CRF-binding protein family.
Family:
  • Belongs to the CRF-binding protein family.
genes like me logo Genes that share domains with CRHBP: view

Function for CRHBP Gene

Molecular function for CRHBP Gene

UniProtKB/Swiss-Prot Function:
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
GENATLAS Biochemistry:
corticotropin releasing hormone binding protein

Phenotypes From GWAS Catalog for CRHBP Gene

Gene Ontology (GO) - Molecular Function for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18234674
GO:0042277 peptide binding ISS --
GO:0051424 corticotropin-releasing hormone binding IEA,IPI 18234674
genes like me logo Genes that share ontologies with CRHBP: view
genes like me logo Genes that share phenotypes with CRHBP: view

Animal Models for CRHBP Gene

MGI Knock Outs for CRHBP:

miRNA for CRHBP Gene

miRTarBase miRNAs that target CRHBP

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHBP Gene

Localization for CRHBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRHBP gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 4
endosome 4
lysosome 4
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,IDA 1846945
GO:0005634 nucleus ISS --
GO:0005767 secondary lysosome ISS --
GO:0005771 multivesicular body ISS --
genes like me logo Genes that share ontologies with CRHBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHBP Gene

Pathways & Interactions for CRHBP Gene

genes like me logo Genes that share pathways with CRHBP: view

Pathways by source for CRHBP Gene

Gene Ontology (GO) - Biological Process for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic ISS --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7477348
GO:0007565 female pregnancy IEP 1846945
GO:0007611 learning or memory TAS 7477348
genes like me logo Genes that share ontologies with CRHBP: view

No data available for SIGNOR curated interactions for CRHBP Gene

Drugs & Compounds for CRHBP Gene

(10) Drugs for CRHBP Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 3544

(1) Additional Compounds for CRHBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRHBP: view

Transcripts for CRHBP Gene

mRNA/cDNA for CRHBP Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRHBP

Alternative Splicing Database (ASD) splice patterns (SP) for CRHBP Gene

No ASD Table

Relevant External Links for CRHBP Gene

GeneLoc Exon Structure for
CRHBP

Expression for CRHBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRHBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHBP Gene

This gene is overexpressed in Brain - Hypothalamus (x8.7), Liver (x7.5), Kidney - Cortex (x5.0), and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for CRHBP Gene

This gene is overexpressed in Serum (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRHBP Gene



Protein tissue co-expression partners for CRHBP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRHBP

SOURCE GeneReport for Unigene cluster for CRHBP Gene:

Hs.115617

Evidence on tissue expression from TISSUES for CRHBP Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Kidney(4.4)
  • Adrenal gland(2.6)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CRHBP: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHBP Gene

Orthologs for CRHBP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHBP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CRHBP 29 30
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CRHBP 29 30
  • 88.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CRHBP 29 30
  • 88.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Crhbp 29 16 30
  • 85.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Crhbp 29
  • 84.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia CRHBP 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CRHBP 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CRHBP 29
  • 74.74 (n)
-- 30
  • 69 (a)
OneToMany
-- 30
  • 61 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia CRHBP 30
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia crhbp 29
  • 68.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia crhbp-A 29
Zebrafish
(Danio rerio)
Actinopterygii crhbp 29 30
  • 65.3 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3847 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000955 29
  • 44.19 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG15537 29 30
  • 43.56 (n)
OneToOne
Species where no ortholog for CRHBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CRHBP Gene

ENSEMBL:
Gene Tree for CRHBP (if available)
TreeFam:
Gene Tree for CRHBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRHBP: view image
Alliance of Genome Resources:
Additional Orthologs for CRHBP

Paralogs for CRHBP Gene

No data available for Paralogs for CRHBP Gene

Variants for CRHBP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRHBP Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs34761141 Benign: not provided 76,954,120(+) C/G
NM_001882.4(CRHBP):c.267C>G (p.Pro89=)
SYNONYMOUS
rs78115247 Benign: not provided 76,953,678(+) G/A
NM_001882.4(CRHBP):c.159G>A (p.Pro53=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CRHBP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CRHBP Gene

Variant ID Type Subtype PubMed ID
nsv1027236 CNV gain 25217958
nsv823102 CNV gain 20364138
nsv830355 CNV gain 17160897

Variation tolerance for CRHBP Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRHBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRHBP
Leiden Open Variation Database (LOVD)
CRHBP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHBP Gene

Disorders for CRHBP Gene

MalaCards: The human disease database

(7) MalaCards diseases for CRHBP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
klebsiella pneumonia
  • pneumonia due to klebsiella pneumoniae
opioid addiction
  • opiate addiction
hypoadrenocorticism, familial
  • adrenal hypoplasia
alcoholic gastritis
  • alcoholic gastritis, with hemorrhage
anxiety
  • anxiety disorder
- elite association - COSMIC cancer census association via MalaCards
Search CRHBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRHBP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CRHBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHBP Gene

Publications for CRHBP Gene

  1. Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) (PMID: 8198617) Behan DP … Vale WW (Genomics 1993) 2 3 4 22
  2. Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PMID: 19131402) Ryckman KK … Williams SM (Molecular human reproduction 2009) 3 22 40
  3. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PMID: 18974851) Enoch MA … Goldman D (PloS one 2008) 3 22 40
  4. Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PMID: 17599466) Van Den Eede F … Claes SJ (Psychiatry research 2007) 3 22 40
  5. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S … Van Broeckhoven C (Biological psychiatry 2003) 3 22 40

Products for CRHBP Gene

Sources for CRHBP Gene