Aliases for CRHBP Gene
Aliases for CRHBP Gene
External Ids for CRHBP Gene
- HGNC: 2356
- Entrez Gene: 1393
- Ensembl: ENSG00000145708
- OMIM: 122559
- UniProtKB: P24387
Previous GeneCards Identifiers for CRHBP Gene
- GC05P075055
- GC05P076483
- GC05P076287
- GC05P076332
- GC05P076284
- GC05P071455
- GC05P076248
Summaries for CRHBP Gene
-
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRHBP Gene
CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.
UniProtKB/Swiss-Prot for CRHBP Gene
-
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHBP Gene
Genomics for CRHBP Gene
GeneHancer (GH) Regulatory Elements for CRHBP Gene
Promoters and enhancers for CRHBP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J076952 | Promoter/Enhancer | 1.2 | EPDnew Ensembl dbSUPER | 665.6 | +1.2 | 1187 | 1.9 | CTCF GLIS2 SUZ12 ZBTB8A ZBTB26 EZH2 ZBTB20 | CRHBP GC05P077001 | |
| GH05J076951 | Enhancer | 0.3 | dbSUPER | 650.7 | -0.9 | -854 | 1.4 | MNT | CRHBP RNU6ATAC36P S100Z | |
| GH05J077029 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 10.3 | +78.0 | 77958 | 2.5 | HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 | AGGF1 ENSG00000285000 ENSG00000250615 SNORA47 ZBED3-AS1 CRHBP | |
| GH05J076786 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.7 | -163.0 | -162966 | 5.8 | ATF1 FOXA2 FEZF1 ZNF2 IRF4 TCF12 ZNF213 ATF7 FOS RUNX3 | F2RL1 F2R ENSG00000225407 CRHBP GC05P076755 | |
| GH05J076804 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.1 | -145.8 | -145819 | 5.8 | PKNOX1 CLOCK ATF1 FOXA2 SIN3A FEZF1 NCOA2 ETS1 TCF12 FOS | F2RL1 F2R ENSG00000225407 CRHBP ENSG00000250615 GC05P076755 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRHBP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRHBP gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- AREB6
- XBP-1
- LCR-F1
- GATA-3
- GATA-2
- GATA-1
- c-Myc
Regulatory Element Products
Genomic Locations for CRHBP Gene
Genomic Locations for CRHBP Gene
- chr5:76,952,713-76,981,158
- (GRCh38/hg38)
- Size:
- 28,446 bases
- Orientation:
- Plus strand
- chr5:76,248,538-76,276,983
- (GRCh37/hg19)
- Size:
- 28,446 bases
- Orientation:
- Plus strand
Genomic View for CRHBP Gene
Genes around CRHBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.3 by Entrez Gene
- 5q13.3 by HGNC
- 5q13.3 by Ensembl
CRHBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRHBP Gene
Proteins for CRHBP Gene
-
Protein details for CRHBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24387-CRHBP_HUMAN
- Recommended name:
- Corticotropin-releasing factor-binding protein
- Protein Accession:
- P24387
- Q53F32
- Q6FHT5
Protein attributes for CRHBP Gene
- Size:
- 322 amino acids
- Molecular mass:
- 36144 Da
- Quaternary structure:
- No Data Available
Protein Expression for CRHBP Gene
Post-translational modifications for CRHBP Gene
Other Protein References for CRHBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRHBP (CRHBP)
-
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-
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Protein Products
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-
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-
Abcam proteins for CRHBP
Assay Products
No data available for DME Specific Peptides for CRHBP Gene
Domains & Families for CRHBP Gene
Gene Families for CRHBP Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CRHBP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRHBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P24387- Family:
-
- Belongs to the CRF-binding protein family.
Function for CRHBP Gene
Molecular function for CRHBP Gene
- UniProtKB/Swiss-Prot Function:
- Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
- GENATLAS Biochemistry:
- corticotropin releasing hormone binding protein
Phenotypes From GWAS Catalog for CRHBP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18234674 |
| GO:0042277 | peptide binding | ISS | -- |
| GO:0051424 | corticotropin-releasing hormone binding | IEA,IPI | 18234674 |
Phenotypes for CRHBP Gene
- MGI mutant phenotypes for CRHBP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CRHBP:
Animal Models for CRHBP Gene
- MGI Knock Outs for CRHBP:
-
- Crhbp Crhbp<tm1Afs>
Animal Model Products
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-
CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for CRHBP Gene
- miRTarBase miRNAs that target CRHBP
miRNA Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRHBP
- Applied Biological Materials Clones for CRHBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CRHBP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHBP Gene
Localization for CRHBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRHBP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 4 |
| lysosome | 4 |
| endosome | 4 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA,IEA | 1846945 |
| GO:0005622 | intracellular | IEA,ISS | -- |
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005767 | secondary lysosome | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHBP Gene
Pathways & Interactions for CRHBP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Presynaptic function of Kainate receptors | ||
| 3 | Peptide ligand-binding receptors | ||
| 4 | Corticotropin-releasing hormone signaling pathway | ||
Pathways by source for CRHBP Gene
1 BioSystems pathway for CRHBP Gene
4 Reactome pathways for CRHBP Gene
Interacting Proteins for CRHBP Gene
GPS-Prot Interaction Network for CRHBP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001963 | synaptic transmission, dopaminergic | ISS | -- |
| GO:0002125 | maternal aggressive behavior | IEA | -- |
| GO:0006954 | inflammatory response | IDA | 18559919 |
| GO:0007165 | signal transduction | TAS | 7477348 |
| GO:0007565 | female pregnancy | IEP | 1846945 |
No data available for SIGNOR curated interactions for CRHBP Gene
Transcripts for CRHBP Gene
mRNA/cDNA for CRHBP Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000274368 1980 bps (uc003ker.4)
- ENST00000506501 912 bps (uc010izx.4)
- ENST00000512446 751 bps (uc063esh.1)
- ENST00000514258 665 bps (uc063esi.1)
- ENST00000503763 455 bps (uc063esj.1)
Unigene Clusters for CRHBP Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRHBP
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRHBP
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CRHBP
- VectorBuilder custom plasmid, inducible vectors for CRHBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRHBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRHBP
- Applied Biological Materials Clones for CRHBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CRHBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
- Inner Cell Mass (Early Embryonic Tissues)
-
Spleen (Hematopoietic System)
-
Kidney (Urinary System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CRHBP Gene
This gene is overexpressed in Brain - Hypothalamus (x8.7), Liver (x7.5), Kidney - Cortex (x5.0), and Spleen (x4.7).
This gene is overexpressed in Serum (65.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRHBP Gene
NURSA nuclear receptor signaling pathways regulating expression of CRHBP Gene:
CRHBPSOURCE GeneReport for Unigene cluster for CRHBP Gene:
Hs.115617Evidence on tissue expression from TISSUES for CRHBP Gene
- Nervous system(4.7)
- Kidney(4.4)
- Liver(4.4)
- Adrenal gland(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for CRHBP
-
OriGene qPCR primer pairs for CRHBP
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Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHBP Gene
Orthologs for CRHBP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRHBP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CRHBP 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CRHBP 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Crhbp 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crhbp 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRHBP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRHBP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRHBP 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | CRHBP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crhbp 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | crhbp-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crhbp 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3847 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000955 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG15537 34 33 |
|
OneToOne |
- Species where no ortholog for CRHBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CRHBP Gene
- ENSEMBL:
- Gene Tree for CRHBP (if available)
- TreeFam:
- Gene Tree for CRHBP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRHBP: view image
Paralogs for CRHBP Gene
No data available for Paralogs for CRHBP Gene
Variants for CRHBP Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017236 | -- | 76,974,829(+) | A/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000158126 | -- | 76,963,230(+) | T/C | intron_variant | |
| rs1000266830 | -- | 76,955,984(+) | A/G | intron_variant | |
| rs1000454365 | -- | 76,974,313(+) | G/A/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000646927 | -- | 76,971,131(+) | T/C | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRHBP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRHBP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHBP Gene
Disorders for CRHBP Gene
Additional Disease Information for CRHBP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CRHBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRHBP Gene
Publications for CRHBP Gene
- Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) (PMID: 8198617) Behan DP … Vale WW (Genomics 1993) 2 3 4 22 58
- Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PMID: 19131402) Ryckman KK … Williams SM (Molecular human reproduction 2009) 3 22 44 58
- Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PMID: 18974851) Enoch MA … Goldman D (PloS one 2008) 3 22 44 58
- Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PMID: 17599466) Van Den Eede F … Claes SJ (Psychiatry research 2007) 3 22 44 58
- The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S … Van Broeckhoven C (Biological psychiatry 2003) 3 22 44 58
Products for CRHBP Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 44 available CRHBP Antibodies ranked by validation data
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Sources for CRHBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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