Aliases for CRHBP Gene
External Ids for CRHBP Gene
Previous GeneCards Identifiers for CRHBP Gene
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRHBP Gene
CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Diseases associated with CRHBP include Klebsiella Pneumonia and Hypoadrenocorticism, Familial. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.
UniProtKB/Swiss-Prot Summary for CRHBP Gene
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.