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Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Diseases associated with CRHBP include Klebsiella Pneumonia and Hypoadrenocorticism, Familial. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18234674 |
GO:0042277 | peptide binding | ISS | -- |
GO:0051424 | corticotropin-releasing hormone binding | IEA,IPI | 18234674 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 1846945 |
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005767 | secondary lysosome | ISS | -- |
GO:0005771 | multivesicular body | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Presynaptic function of Kainate receptors | ||
3 | Peptide ligand-binding receptors | ||
4 | Corticotropin-releasing hormone signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001963 | synaptic transmission, dopaminergic | IEA,ISS | -- |
GO:0002125 | maternal aggressive behavior | IEA | -- |
GO:0006954 | inflammatory response | IDA | 18559919 |
GO:0007165 | signal transduction | TAS | 7477348 |
GO:0007565 | female pregnancy | IEP | 1846945 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | 3266 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crhbp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crhbp 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CRHBP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CRHBP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CRHBP 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | CRHBP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crhbp 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | crhbp-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | crhbp 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3847 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000955 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15537 30 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
klebsiella pneumonia |
|
|
hypoadrenocorticism, familial |
|
|
anxiety |
|
|
major depressive disorder |
|
|