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Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein w... See more...
Aliases for CRHBP Gene
Aliases for CRHBP Gene
External Ids for CRHBP Gene
- HGNC: 2356
- Entrez Gene: 1393
- Ensembl: ENSG00000145708
- OMIM: 122559
- UniProtKB: P24387
Previous GeneCards Identifiers for CRHBP Gene
- GC05P075055
- GC05P076483
- GC05P076287
- GC05P076332
- GC05P076284
- GC05P071455
- GC05P076248
Summaries for CRHBP Gene
-
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRHBP Gene
CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Diseases associated with CRHBP include Klebsiella Pneumonia and Hypoadrenocorticism, Familial. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.
UniProtKB/Swiss-Prot Summary for CRHBP Gene
-
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Additional gene information for CRHBP Gene
- HGNC(2356)
- Entrez Gene(1393)
- Ensembl(ENSG00000145708)
- OMIM(122559)
- UniProtKB(P24387)
- Open Targets Platform(ENSG00000145708)
- Search for CRHBP at DataMed
- Search for CRHBP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRHBP Gene
Genomics for CRHBP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRHBP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRHBP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRHBP
- Top Transcription factor binding sites by QIAGEN in the CRHBP gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- c-Myc
- GATA-1
- GATA-2
- GATA-3
- LCR-F1
- XBP-1
Genomic Locations for CRHBP Gene
Genomic Locations for CRHBP Gene
- chr5:76,952,855-76,981,158
- (GRCh38/hg38)
- Size:
- 28,304 bases
- Orientation:
- Plus strand
- chr5:76,248,538-76,276,983
- (GRCh37/hg19)
- Size:
- 28,446 bases
- Orientation:
- Plus strand
Genomic View for CRHBP Gene
Genes around CRHBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.3 by HGNC
- 5q13.3 by Entrez Gene
- 5q13.3 by Ensembl
CRHBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRHBP Gene
Proteins for CRHBP Gene
-
Protein details for CRHBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24387-CRHBP_HUMAN
- Recommended name:
- Corticotropin-releasing factor-binding protein
- Protein Accession:
- P24387
- Q53F32
- Q6FHT5
Protein attributes for CRHBP Gene
- Size:
- 322 amino acids
- Molecular mass:
- 36144 Da
- Quaternary structure:
- No Data Available
Protein Expression for CRHBP Gene
Post-translational modifications for CRHBP Gene
Other Protein References for CRHBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CRHBP Antibody
- HUABIO Anti-CRHBP Antibody
-
Custom Antibody ServicesOriGene Antibodies for CRHBP
- Novus Biologicals Antibodies for CRHBP
- Invitrogen Antibodies for CRHBP (AFLGC-CRHBP)
-
Boster Bio Antibodies for CRHBP
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRHBP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CRHBP
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- ProSpec Recombinant Proteins for CRHBP
-
ProSci Proteins for CRHBP
-
Abcam proteins for CRHBP
No data available for DME Specific Peptides for CRHBP Gene
Domains & Families for CRHBP Gene
Gene Families for CRHBP Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CRHBP Gene
- InterPro:
- Blocks:
-
- CUB domain
- Corticotropin-releasing factor binding
- ProtoNet:
Suggested Antigen Peptide Sequences for CRHBP Gene
- GenScript: Design optimal peptide antigens:
-
- Corticotropin-releasing hormone-binding protein (CRHBP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24387- Family:
-
- Belongs to the CRF-binding protein family.
Function for CRHBP Gene
Molecular function for CRHBP Gene
- UniProtKB/Swiss-Prot Function:
- Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
- GENATLAS Biochemistry:
- corticotropin releasing hormone binding protein
Phenotypes From GWAS Catalog for CRHBP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18234674 |
| GO:0042277 | peptide binding | ISS | -- |
| GO:0051424 | corticotropin-releasing hormone binding | IEA,IPI | 18234674 |
Phenotypes for CRHBP Gene
- MGI mutant phenotypes for CRHBP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CRHBP:
Animal Models for CRHBP Gene
- MGI Knock Outs for CRHBP:
-
- Crhbp Crhbp<tm1Afs>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRHBP - Select products 50% OFF >
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-
OriGene CRISPR knockouts for CRHBP
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-
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miRNA for CRHBP Gene
- miRTarBase miRNAs that target CRHBP
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for CRHBP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRHBP
Cell Line Products
-
Horizon Cell Lines for CRHBP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHBP Gene
Localization for CRHBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRHBP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| endosome | 4 |
| lysosome | 4 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| peroxisome | 0 |
| golgi apparatus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 1846945 |
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005767 | secondary lysosome | ISS | -- |
| GO:0005771 | multivesicular body | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRHBP Gene
Pathways & Interactions for CRHBP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Presynaptic function of Kainate receptors | ||
| 3 | Peptide ligand-binding receptors | ||
| 4 | Corticotropin-releasing hormone signaling pathway | ||
Pathways by source for CRHBP Gene
1 BioSystems pathway for CRHBP Gene
4 Reactome pathways for CRHBP Gene
Interacting Proteins for CRHBP Gene
GPS-Prot Interaction Network for CRHBP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001963 | synaptic transmission, dopaminergic | IEA,ISS | -- |
| GO:0002125 | maternal aggressive behavior | IEA | -- |
| GO:0006954 | inflammatory response | IDA | 18559919 |
| GO:0007165 | signal transduction | TAS | 7477348 |
| GO:0007565 | female pregnancy | IEP | 1846945 |
No data available for SIGNOR curated interactions for CRHBP Gene
Drugs & Compounds for CRHBP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | 3266 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CRHBP Gene
mRNA/cDNA for CRHBP Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000274368 1645 nts (view in UCSC)
- ENST00000506501 912 nts (view in UCSC)
- ENST00000512446 751 nts (view in UCSC)
- ENST00000514258 665 nts (view in UCSC)
- ENST00000503763 455 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRHBP - Select products 50% OFF >
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-
OriGene CRISPR knockouts for CRHBP
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CRHBP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRHBP
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Clone Products
- Applied Biological Materials (abm): Clones for CRHBP - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CRHBP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRHBP
Relevant External Links for CRHBP Gene
- GeneLoc Exon Structure for
- CRHBP
Expression for CRHBP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
- Inner Cell Mass (Early Embryonic Tissues)
-
Spleen (Hematopoietic System)
-
Kidney (Urinary System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CRHBP Gene
This gene is overexpressed in Brain - Hypothalamus (x8.7), Liver (x7.5), Kidney - Cortex (x5.0), and Spleen (x4.7).
This gene is overexpressed in Serum (65.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRHBP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRHBP
SOURCE GeneReport for Unigene cluster for CRHBP Gene:
Hs.115617Evidence on tissue expression from TISSUES for CRHBP Gene
- Nervous system(4.8)
- Liver(4.6)
- Kidney(4.4)
- Adrenal gland(2.9)
- Muscle(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for CRHBP
-
OriGene qPCR primer pairs and template standards for CRHBP
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRHBP Gene
Orthologs for CRHBP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRHBP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crhbp 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crhbp 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CRHBP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRHBP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRHBP 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | CRHBP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crhbp 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | crhbp-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | crhbp 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3847 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000955 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG15537 30 31 |
|
OneToOne |
- Species where no ortholog for CRHBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CRHBP Gene
- ENSEMBL:
- Gene Tree for CRHBP (if available)
- TreeFam:
- Gene Tree for CRHBP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRHBP: view image
Paralogs for CRHBP Gene
No data available for Paralogs for CRHBP Gene
Variants for CRHBP Gene
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRHBP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRHBP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHBP Gene
Disorders for CRHBP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| klebsiella pneumonia |
|
|
| hypoadrenocorticism, familial |
|
|
| anxiety |
|
|
| major depressive disorder |
|
|
Search CRHBP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRHBP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRHBP Gene
Publications for CRHBP Gene
- Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) (PMID: 8198617) Behan DP … Vale WW (Genomics 1993) 2 3 4 23
- Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PMID: 19131402) Ryckman KK … Williams SM (Molecular human reproduction 2009) 3 23 41
- Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PMID: 18974851) Enoch MA … Goldman D (PloS one 2008) 3 23 41
- Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PMID: 17599466) Van Den Eede F … Claes SJ (Psychiatry research 2007) 3 23 41
- The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S … Van Broeckhoven C (Biological psychiatry 2003) 3 23 41
ExternalLinks
Products for CRHBP Gene
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- OriGene qPCR primer pairs for CRHBP
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Sources for CRHBP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (44) Atlas
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
- (87) ApexBio
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- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
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- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB