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This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specif... See more...
Aliases for CREM Gene
Aliases for CREM Gene
External Ids for CREM Gene
- HGNC: 2352
- Entrez Gene: 1390
- Ensembl: ENSG00000095794
- OMIM: 123812
- UniProtKB: Q03060
Previous GeneCards Identifiers for CREM Gene
- GC10P035163
- GC10P035566
- GC10P035419
- GC10P035455
- GC10P035415
Summaries for CREM Gene
-
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
GeneCards Summary for CREM Gene
CREM (CAMP Responsive Element Modulator) is a Protein Coding gene. Diseases associated with CREM include Oligoarticular Juvenile Idiopathic Arthritis and Female Stress Incontinence. Among its related pathways are Activation of cAMP-Dependent PKA and Selenium Metabolism and Selenoproteins. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and core promoter sequence-specific DNA binding. An important paralog of this gene is CREB1.
UniProtKB/Swiss-Prot Summary for CREM Gene
-
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
-
Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Additional gene information for CREM Gene
- Monarch Initiative
- Search for CREM at DataMed
- Search for CREM at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREM Gene
Genomics for CREM Gene
GeneHancer (GH) Regulatory Elements for CREM Gene
Promoters and enhancers for CREM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CREM on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CREM gene promoter:
-
- ATF-2
Genomic Locations for CREM Gene
Genomic Locations for CREM Gene
- chr10:35,126,791-35,212,958
- (GRCh38/hg38)
- Size:
- 86,168 bases
- Orientation:
- Plus strand
- chr10:35,415,719-35,501,886
- (GRCh37/hg19)
- Size:
- 86,168 bases
- Orientation:
- Plus strand
Genomic View for CREM Gene
Genes around CREM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.21 by HGNC
- 10p11.21 by Entrez Gene
- 10p11.21 by Ensembl
CREM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CREM Gene
Proteins for CREM Gene
-
Protein details for CREM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03060-CREM_HUMAN
- Recommended name:
- cAMP-responsive element modulator
- Protein Accession:
- Q03060
- A8K014
- A8K3J7
- A8K6A1
- A8MPQ2
- B4DXC1
- C9J785
- C9JZ10
- E9PAR4
- E9PHM1
- O75519
- Q14501
- Q14503
- Q14504
- Q14505
- Q14506
- Q15731
- Q16114
- Q16116
- Q5T9H7
- Q5W1A6
- Q5W1A7
- Q5W1A8
- Q5W1A9
- Q5W1B0
- Q5W1B2
- Q7Z2Q6
- Q8IVD4
- Q96AG7
- Q9NZ98
- Q9NZ99
- Q9NZB9
Protein attributes for CREM Gene
- Size:
- 345 amino acids
- Molecular mass:
- 37006 Da
- Quaternary structure:
-
- Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34 (PubMed:10373550). May interact with TSSK4 (By similarity).
- SequenceCaution:
-
- Sequence=AAB03751.1; Type=Erroneous termination; Positions=345; Note=Translated as Tyr.; Evidence={ECO:0000305}; Sequence=AAF68266.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Alternative splice isoforms for CREM Gene
- UniProtKB/Swiss-Prot:
Protein Expression for CREM Gene
Post-translational modifications for CREM Gene
- Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
- Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CREM Gene
- ENSEMBL proteins:
-
- ENSP00000354593
- ENSP00000337138
- ENSP00000346804
- ENSP00000419075
- ENSP00000418450
- ENSP00000417327
- ENSP00000379225
- ENSP00000419018
- ENSP00000419810
- ENSP00000420437
- ENSP00000417130
- ENSP00000473519
- ENSP00000420681
- ENSP00000265372
- ENSP00000349387
- ENSP00000418798
- ENSP00000417399
- ENSP00000345384
- ENSP00000418336
- ENSP00000419684
- ENSP00000341875
- ENSP00000419924
- ENSP00000409220
- ENSP00000417058
- ENSP00000363866
- ENSP00000363860
- ENSP00000420511
- ENSP00000393538
- ENSP00000403938
- ENSP00000417807
- ENSP00000417165
- ENSP00000417562
- ENSP00000417460
- ENSP00000363858
- ENSP00000363853
- ENSP00000344365
- ENSP00000420453
- REFSEQ proteins:
-
- XP_016871222.1
- XP_016871212.1
- XP_024303589.1
- NP_001254495.1
- NP_001872.3
- NP_874390.1
- NP_874393.1
- NP_874392.1
- NP_001339396.1
- NP_853549.1
- XP_011517627.1
- XP_011517637.1
- XP_006717442.1
- NP_001254493.1
- XP_006717441.1
- XP_011517629.1
- NP_898883.1
- NP_001254499.1
- XP_024303591.1
- XP_016871223.1
- XP_016871213.1
- XP_016871224.1
- XP_016871214.1
- NP_898829.1
- XP_024303592.1
- XP_011517632.1
- NP_001339394.1
- NP_001339374.1
- XP_024303588.1
- NP_001254496.1
- XP_011517634.1
- NP_001254491.1
- XP_016871218.1
- XP_016871208.1
- XP_016871225.1
- XP_016871215.1
- XP_016871205.1
- XP_024303590.1
- NP_001339395.1
- NP_001339375.1
- XP_016871226.1
- XP_016871216.1
- XP_016871206.1
- NP_898831.1
- NP_898830.1
- XP_006717445.1
- XP_016871220.1
- XP_016871210.1
- XP_011517633.1
- NP_001254494.1
- XP_006717446.1
- XP_011517626.1
- NP_001254497.1
- NP_874387.1
- NP_874386.1
- NP_874389.1
- NP_874388.1
- XP_016871209.1
- XP_011517635.1
- NP_001254492.1
- XP_006717450.1
- NP_001254498.1
- NP_877573.1
- NP_877572.1
- NP_877571.1
- NP_877570.1
- XP_016871217.1
- XP_016871207.1
- XP_016871221.1
- XP_016871211.1
Antibody Products
- Atlas Antibodies Anti-CREM Antibody
- GeneTex Anti-CREM antibody
- Novus Biologicals Antibodies for CREM
- Invitrogen Antibodies for CREM (AFLGC-CREM)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CREM
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CREM
- Origene Custom Protein Services for CREM
-
Abcam proteins for CREM
Assay Products
- G Biosciences Immunotag™ cAMP-responsive element modulator ELISA Kit
- Creative Diagnostics Human CREM ELISA Matched Antibody Pair
- Aviva Systems Biology CREM ELISA Kit (Human) (OKEH03381)
- antibodies-online: Show 9 available CREM Elisa Kits ranked by validation data
- Compare Top CREM Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CREM
No data available for DME Specific Peptides for CREM Gene
Domains & Families for CREM Gene
Gene Families for CREM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for CREM Gene
Suggested Antigen Peptide Sequences for CREM Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ76503, highly similar to Homo sapiens cAMP responsive element modulator (CREM), transcript variant 8, mRNA (A8K014_HUMAN)
- cDNA FLJ76412, highly similar to Homo sapiens cAMP responsive element modulator (CREM), transcript variant 10, mRNA (A8K6A1_HUMAN)
- Inducible cAMP early repressor (CREM_HUMAN)
- cAMP responsive element modulator (Q5T9H8_HUMAN)
- cAMP responsive element modulator (Q5T9I5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03060- Family:
-
- Belongs to the bZIP family.
Function for CREM Gene
Molecular function for CREM Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
- UniProtKB/Swiss-Prot Function:
- Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
- GENATLAS Biochemistry:
- cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor) acting as repressor,regulated in a circadian manner in the pineal gland
Phenotypes From GWAS Catalog for CREM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 16899810 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IC | -- |
| GO:0003677 | DNA binding | NAS | 7916662 |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
Phenotypes for CREM Gene
- MGI mutant phenotypes for CREM:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CREM:
Animal Models for CREM Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for CREM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CREM
- genomics-online: gRNA clones - Search for available CREM gRNA products
- Overview of 413 available CREM gene related products
- Applied Biological Materials (abm): CRISPR Clones for CREM - Select products 50% OFF >
- * CREM CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CREM CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CREM
miRNA for CREM Gene
- miRTarBase miRNAs that target CREM
-
- hsa-let-7c-5p (MIRT439169)
- hsa-mir-3117-3p (MIRT688634)
- hsa-mir-30e-5p (MIRT688635)
- hsa-mir-30d-5p (MIRT688636)
- hsa-mir-30c-5p (MIRT688637)
- hsa-mir-30b-5p (MIRT688638)
- hsa-mir-30a-5p (MIRT688639)
- hsa-mir-1288-3p (MIRT688640)
- hsa-mir-4312 (MIRT688641)
- hsa-mir-1976 (MIRT688642)
- hsa-mir-3653-5p (MIRT688643)
- hsa-mir-6747-3p (MIRT688644)
- hsa-mir-6727-3p (MIRT688645)
- hsa-mir-4722-3p (MIRT688646)
- hsa-mir-8083 (MIRT688647)
- hsa-mir-3169 (MIRT688648)
- hsa-mir-4759 (MIRT688649)
- hsa-mir-562 (MIRT688650)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CREM
- Browse OriGene Inhibitory RNA Products For CREM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREM
- genomics-online: shRNA clones - Search for available CREM shRNA products
- Overview of 413 available CREM gene related products
Clone Products
-
- MC206826
- MC208320
- MC208321
- MC208322
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- RN200400
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- SC109101
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- SC330764
- SC332854
- SC333372
- SC333431
- SC333477
- SC333618
- SC333797
-
- MG200636
- MG222531
- MG222534
- MG222538
- MG222542
- MG222544
- MG222546
- MG224349
- MG224355
- MG224371
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- MG224736
- MR200636
- MR200636L1
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- MR222542
- MR222542L3
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- MR222542L4
- MR222542L4V
- MR222544
- MR222544L3
- MR222544L3V
- MR222544L4
- MR222544L4V
- MR222546
- MR222546L3
- MR222546L3V
- MR222546L4
- MR222546L4V
- MR224349
- MR224349L3
- MR224349L3V
- MR224349L4
- MR224349L4V
- MR224355
- MR224355L3
- MR224355L3V
- MR224355L4
- MR224355L4V
- MR224371
- MR224371L3
- MR224371L3V
- MR224371L4
- MR224371L4V
- MR224729
- MR224729L3
- MR224729L3V
- MR224729L4
- MR224729L4V
- MR224736
- MR224736L3
- MR224736L3V
- MR224736L4
- MR224736L4V
- MR228979
- MR228980
- MR229145
- MR229386
- RC210636
- RC210636L3
- RC210636L3V
- RC210636L4
- RC210636L4V
- RC211565
- RC211565L3
- RC211565L3V
- RC211565L4
- RC211565L4V
- RC214748
- RC214748L3
- RC214748L3V
- RC214748L4
- RC214748L4V
- RC215303
- RC215303L1
- RC215303L1V
- RC215303L2
- RC215303L2V
- RC215303L3
- RC215303L3V
- RC215303L4
- RC215303L4V
- RC215521
- RC215521L1
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- RC215521L3
- RC215521L3V
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- RC215521L4V
- RC215666
- RC215666L3
- RC215666L3V
- RC215666L4
- RC215666L4V
- RC215729
- RC215729L3
- RC215729L3V
- RC215729L4
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- RC215834
- RC215834L3
- RC215834L3V
- RC215834L4
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- RC215948
- RC215948L3
- RC215948L3V
- RC215948L4
- RC215948L4V
- RC216170
- RC216170L3
- RC216170L3V
- RC216170L4
- RC216170L4V
- RC216360
- RC216360L3
- RC216360L3V
- RC216360L4
- RC216360L4V
- RC216380
- RC216380L3
- RC216380L3V
- RC216380L4
- RC216380L4V
- RC216406
- RC216406L3
- RC216406L3V
- RC216406L4
- RC216406L4V
- RC217044
- RC217044L1
- RC217044L1V
- RC217044L2
- RC217044L2V
- RC217044L3
- RC217044L3V
- RC217044L4
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- RC217095
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- RC231734
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- RG210636
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- RG217789
- RG218534
- RG231734
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- RG231987
- RG233637
- RR200400
- RR200400L3
- RR200400L3V
- RR200400L4
- RR200400L4V
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- RR215789
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- RR215848
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- RR216467
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CREM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CREM
- genomics-online: cdna clones - Search for available CREM CDNA products
- Overview of 413 available CREM gene related products
- orf clones - Search for available CREM ORF products
- Overview of 413 available CREM gene related products
- Applied Biological Materials (abm): Clones for CREM - Select products 50% OFF >
- * CREM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CREM tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CREM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREM Gene
Localization for CREM Gene
Subcellular locations from UniProtKB/Swiss-Prot for CREM Gene
- Nucleus.
- Isoform 6: Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleus (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS,TAS | 8206879 |
| GO:0005667 | transcription factor complex | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for CREM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 3 | cGMP-PKG signaling pathway | ||
| 4 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
| 5 | DREAM Repression and Dynorphin Expression |
DREAM Repression and Dynorphin Expression
.44
|
|
Pathways by source for CREM Gene
3 BioSystems pathways for CREM Gene
2 Reactome pathways for CREM Gene
1 KEGG pathway for CREM Gene
1 GeneGo (Thomson Reuters) pathway for CREM Gene
6 Qiagen pathways for CREM Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- cAMP Pathway
- Dopamine-DARPP32 Feedback onto cAMP Pathway
- DREAM Repression and Dynorphin Expression
Interacting Proteins for CREM Gene
Selected Interacting proteins:
Q03060-CREM_HUMAN
ENSP00000265372
for CREM Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CREM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 12626549 |
| GO:0006006 | glucose metabolic process | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 7916662 |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006687 | glycosphingolipid metabolic process | IEA | -- |
Drugs & Compounds for CREM Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CREM Gene
mRNA/cDNA for CREM Gene
- (35) REFSEQ mRNAs :
- (48) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (48) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000474362 1030 bps (ENST00000474362.5)
- ENST00000374721 2020 bps (ENST00000374721.7)
- ENST00000496626 596 bps (ENST00000496626.5)
- ENST00000482646 715 bps (ENST00000482646.5)
- ENST00000489388 1022 bps (ENST00000489388.5)
CRISPR Products
-
OriGene CRISPR knockouts for CREM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CREM
- genomics-online: gRNA clones - Search for available CREM gRNA products
- Overview of 413 available CREM gene related products
- Applied Biological Materials (abm): CRISPR Clones for CREM - Select products 50% OFF >
- * CREM CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CREM CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CREM
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CREM
- Browse OriGene Inhibitory RNA Products For CREM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREM
- genomics-online: shRNA clones - Search for available CREM shRNA products
- Overview of 413 available CREM gene related products
Clone Products
-
- MC206826
- MC208320
- MC208321
- MC208322
- MC208323
- MC208324
- MC208325
- MC208326
- MC208327
- MC208328
- MC208329
- MC208330
- MC226768
- MC226769
- MC226934
- MC227175
- RN200400
- RN200401
- RN215789
- RN215813
- RN215834
- RN215848
- RN215849
- RN216467
- SC109101
- SC207591
- SC212839
- SC215327
- SC215328
- SC215329
- SC215330
- SC215331
- SC215332
- SC215333
- SC215334
- SC215335
- SC307493
- SC307494
- SC307495
- SC307496
- SC307497
- SC307498
- SC307499
- SC307511
- SC307512
- SC307513
- SC307523
- SC307551
- SC307552
- SC307553
- SC307554
- SC309484
- SC309485
- SC310675
- SC311180
- SC324245
- SC330762
- SC330763
- SC330764
- SC332854
- SC333372
- SC333431
- SC333477
- SC333618
- SC333797
-
- MG200636
- MG222531
- MG222534
- MG222538
- MG222542
- MG222544
- MG222546
- MG224349
- MG224355
- MG224371
- MG224729
- MG224736
- MR200636
- MR200636L1
- MR200636L1V
- MR200636L2
- MR200636L2V
- MR200636L3
- MR200636L3V
- MR200636L4
- MR200636L4V
- MR222531
- MR222531L3
- MR222531L3V
- MR222531L4
- MR222531L4V
- MR222534
- MR222534L3
- MR222534L3V
- MR222534L4
- MR222534L4V
- MR222538
- MR222538L3
- MR222538L3V
- MR222538L4
- MR222538L4V
- MR222542
- MR222542L3
- MR222542L3V
- MR222542L4
- MR222542L4V
- MR222544
- MR222544L3
- MR222544L3V
- MR222544L4
- MR222544L4V
- MR222546
- MR222546L3
- MR222546L3V
- MR222546L4
- MR222546L4V
- MR224349
- MR224349L3
- MR224349L3V
- MR224349L4
- MR224349L4V
- MR224355
- MR224355L3
- MR224355L3V
- MR224355L4
- MR224355L4V
- MR224371
- MR224371L3
- MR224371L3V
- MR224371L4
- MR224371L4V
- MR224729
- MR224729L3
- MR224729L3V
- MR224729L4
- MR224729L4V
- MR224736
- MR224736L3
- MR224736L3V
- MR224736L4
- MR224736L4V
- MR228979
- MR228980
- MR229145
- MR229386
- RC210636
- RC210636L3
- RC210636L3V
- RC210636L4
- RC210636L4V
- RC211565
- RC211565L3
- RC211565L3V
- RC211565L4
- RC211565L4V
- RC214748
- RC214748L3
- RC214748L3V
- RC214748L4
- RC214748L4V
- RC215303
- RC215303L1
- RC215303L1V
- RC215303L2
- RC215303L2V
- RC215303L3
- RC215303L3V
- RC215303L4
- RC215303L4V
- RC215521
- RC215521L1
- RC215521L1V
- RC215521L2
- RC215521L2V
- RC215521L3
- RC215521L3V
- RC215521L4
- RC215521L4V
- RC215666
- RC215666L3
- RC215666L3V
- RC215666L4
- RC215666L4V
- RC215729
- RC215729L3
- RC215729L3V
- RC215729L4
- RC215729L4V
- RC215834
- RC215834L3
- RC215834L3V
- RC215834L4
- RC215834L4V
- RC215948
- RC215948L3
- RC215948L3V
- RC215948L4
- RC215948L4V
- RC216170
- RC216170L3
- RC216170L3V
- RC216170L4
- RC216170L4V
- RC216360
- RC216360L3
- RC216360L3V
- RC216360L4
- RC216360L4V
- RC216380
- RC216380L3
- RC216380L3V
- RC216380L4
- RC216380L4V
- RC216406
- RC216406L3
- RC216406L3V
- RC216406L4
- RC216406L4V
- RC217044
- RC217044L1
- RC217044L1V
- RC217044L2
- RC217044L2V
- RC217044L3
- RC217044L3V
- RC217044L4
- RC217044L4V
- RC217095
- RC217095L3
- RC217095L3V
- RC217095L4
- RC217095L4V
- RC217789
- RC217789L3
- RC217789L3V
- RC217789L4
- RC217789L4V
- RC218534
- RC218534L1
- RC218534L1V
- RC218534L2
- RC218534L2V
- RC218534L3
- RC218534L3V
- RC218534L4
- RC218534L4V
- RC231734
- RC231786
- RC231987
- RC233637
- RC235478
- RC235537
- RC235583
- RC235724
- RC235903
- RG210636
- RG211565
- RG214748
- RG215303
- RG215521
- RG215666
- RG215729
- RG215834
- RG215948
- RG216170
- RG216360
- RG216380
- RG216406
- RG217044
- RG217095
- RG217789
- RG218534
- RG231734
- RG231786
- RG231987
- RG233637
- RR200400
- RR200400L3
- RR200400L3V
- RR200400L4
- RR200400L4V
- RR200401
- RR200401L3
- RR200401L3V
- RR200401L4
- RR200401L4V
- RR215789
- RR215813
- RR215834
- RR215848
- RR215849
- RR216467
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CREM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CREM
- genomics-online: cdna clones - Search for available CREM CDNA products
- Overview of 413 available CREM gene related products
- orf clones - Search for available CREM ORF products
- Overview of 413 available CREM gene related products
- Applied Biological Materials (abm): Clones for CREM - Select products 50% OFF >
- * CREM as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CREM tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
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| SP24: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP25: | - |
| ExUns: | 10f | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | · | 18d | · | 18e | ^ | 19a | · | 19b | · | 19c | · | 19d | · | 19e | · | 19f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
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| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
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| SP13: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP22: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP23: | - | ||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP25: |
Expression for CREM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Spermatid Seminiferous Tubules
- Testis Interstitium
-
Gonad
- Spermatid Seminiferous Tubules
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Adrenal Gland (Endocrine System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CREM Gene
This gene is overexpressed in Testis (x5.1).
This gene is overexpressed in Testis (54.2) and Ovary (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CREM Gene
NURSA nuclear receptor signaling pathways regulating expression of CREM Gene:
CREMSOURCE GeneReport for Unigene cluster for CREM Gene:
Hs.200250mRNA Expression by UniProt/SwissProt for CREM Gene:
Q03060-CREM_HUMAN
Tissue specificity:
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Evidence on tissue expression from TISSUES for CREM Gene
- Nervous system(4.7)
- Adrenal gland(4.6)
- Heart(4.4)
- Blood(2.9)
- Liver(2.2)
- Intestine(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for CREM
-
OriGene qPCR primer pairs and template standards for CREM
- genomics-online: primer clones - Search for available CREM Primer products
- Overview of 413 available CREM gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CREM Gene
Orthologs for CREM Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CREM 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CREM 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Crem 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Crem 17 33 32 |
|
||
| cow (Bos Taurus) |
Mammalia | CREM 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CREM 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CREM 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CREM 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CREM 33 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | crema 33 32 |
|
ManyToMany | |
| cremb 33 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CrebB-17A 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | crh-1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.714 33 |
|
OneToMany | |
| Cin.3621 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3621 32 |
|
- Species where no ortholog for CREM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for CREM Gene
- ENSEMBL:
- Gene Tree for CREM (if available)
- TreeFam:
- Gene Tree for CREM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CREM: view image
Paralogs for CREM Gene
Paralogs for CREM Gene
(5) SIMAP similar genes for CREM Gene using alignment to 17 proteins:
- CREM_HUMAN
- C9IYM9_HUMAN
- C9J2J0_HUMAN
- C9J5A7_HUMAN
- C9JK96_HUMAN
- C9K092_HUMAN
- E9PAR2_HUMAN
- E9PB41_HUMAN
- E9PBM5_HUMAN
- F8WB03_HUMAN
- F8WDF2_HUMAN
- G5E998_HUMAN
- H7C4X0_HUMAN
- J3KQC0_HUMAN
- J3KR46_HUMAN
- Q9BYY5_HUMAN
- R4GN75_HUMAN
Variants for CREM Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022950 | -- | 35,132,082(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000069706 | -- | 35,126,713(+) | C/T | upstream_transcript_variant | |
| rs1000074583 | -- | 35,181,201(+) | C/A | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000092954 | -- | 35,201,862(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000121464 | -- | 35,134,145(+) | C/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv706n100 | CNV | gain | 25217958 |
| dgv707n100 | CNV | gain | 25217958 |
| dgv96e201 | CNV | deletion | 23290073 |
| esv2659986 | CNV | deletion | 23128226 |
| esv2668859 | CNV | deletion | 23128226 |
| esv2735328 | CNV | deletion | 23290073 |
| esv2735362 | CNV | deletion | 23290073 |
| esv3546152 | CNV | deletion | 23714750 |
| esv3576372 | CNV | gain | 25503493 |
| esv3622893 | CNV | loss | 21293372 |
| esv3622894 | CNV | loss | 21293372 |
| nsv1039051 | CNV | gain | 25217958 |
| nsv475915 | CNV | novel sequence insertion | 20440878 |
| nsv550398 | CNV | gain | 21841781 |
| nsv820199 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.31;
76.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CREM Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CREM
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREM Gene
Disorders for CREM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oligoarticular juvenile idiopathic arthritis |
|
|
| female stress incontinence |
|
|
| type 1 diabetes mellitus 10 |
|
|
Search CREM in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CREM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CREM Gene
Publications for CREM Gene
- Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PMID: 7916662) Masquilier D … Sassone-Corsi P (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993) 2 3 4 23 56
- Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. (PMID: 12397208) Gellersen B … Behr R (Molecular human reproduction 2002) 3 4 23 56
- Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D … Plon SE (Molecular and cellular biology 1999) 3 4 23 56
- Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. (PMID: 8206879) Fujimoto T … Yoshida M (Journal of biochemistry 1994) 3 4 23 56
- Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. (PMID: 1461747) Meyer TE … Habener JF (Nucleic acids research 1992) 2 3 4 56
ExternalLinks
Products for CREM Gene
- Custom Antibody ServicesOriGene Antibodies for CREM
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for