CREG2 Gene (Protein Coding)

Cellular Repressor Of E1A Stimulated Genes 2

GC02M101331
GIFtS:
32
See more...

Aliases for CREG2 Gene

Aliases for CREG2 Gene

  • Cellular Repressor Of E1A Stimulated Genes 2 2 3 5
  • Protein CREG2 3 4
  • Cellular Repressor Of E1A-Stimulated Genes 2 4
  • CREG2 5

External Ids for CREG2 Gene

Previous GeneCards Identifiers for CREG2 Gene

  • GC02M100417
  • GC02M101569
  • GC02M101586
  • GC02M101423
  • GC02M101964
  • GC02M095728

Summaries for CREG2 Gene

GeneCards Summary for CREG2 Gene

CREG2 (Cellular Repressor Of E1A Stimulated Genes 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and FMN binding. An important paralog of this gene is CREG1.

Additional gene information for CREG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREG2 Gene

Genomics for CREG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CREG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J101387 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 264.7 +0.7 669 1.8 CTCF ZBTB7B ELF1 SIN3A MAX REST GABPB1 YY1 SMC3 FOSL1 CREG2 HSALNG0017372 RNF149
GH02J101395 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 259.5 -11.2 -11231 8 EP300 FOSL1 RAD21 USF2 CTCF SPI1 NFE2 BATF SMARCE1 EHMT2 CREG2 RNF149 SNORD89 RFX8 HSALNG0017373 HSALNG0017374
GH02J101388 Enhancer 0.5 ENCODE 256.9 -0.5 -524 0.2 CEBPB MAX FOSL1 JUND NCOA3 FOS CREG2 HSALNG0017372 HSALNG0017373 RFX8
GH02J101380 Enhancer 0.5 Ensembl 17.9 +6.7 6670 2.2 JUND FOSL1 MYC MAX EGR1 DACH1 ATF3 CREG2 SNORD89 ENSG00000226058 HSALNG0017372 RNF149
GH02J101355 Enhancer 1 FANTOM5 Ensembl ENCODE 7.4 +31.8 31806 3.3 CEBPB ELK1 MAX EP300 POLR2A TBP TCF7L2 ZNF217 MAFF DPF2 HSALNG0017369 HSALNG0017370 SNORD89 CREG2 RF00017-3285 RNF149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CREG2

Top Transcription factor binding sites by QIAGEN in the CREG2 gene promoter:
  • AhR
  • AREB6
  • CUTL1
  • ITF-2
  • Nkx6-1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta
  • TBP

Genomic Locations for CREG2 Gene

Latest Assembly
chr2:101,345,550-101,387,970
(GRCh38/hg38)
Size:
42,421 bases
Orientation:
Minus strand

Previous Assembly
chr2:101,962,012-102,003,965
(GRCh37/hg19 by Entrez Gene)
Size:
41,954 bases
Orientation:
Minus strand

chr2:101,962,013-102,004,057
(GRCh37/hg19 by Ensembl)
Size:
42,045 bases
Orientation:
Minus strand

Genomic View for CREG2 Gene

Genes around CREG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREG2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CREG2 Gene

Proteins for CREG2 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CREG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH2-CREG2_HUMAN
    Recommended name:
    Protein CREG2
    Protein Accession:
    Q8IUH2
    Secondary Accessions:
    • Q86X03
    • Q8N540
    • Q8N9E3

    Protein attributes for CREG2 Gene

    Size:
    290 amino acids
    Molecular mass:
    32109 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04464.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CREG2 Gene

Protein Expression for CREG2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CREG2 Gene

  • It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166.
  • Glycosylation at Asn165 and Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for CREG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for CREG2

No data available for DME Specific Peptides for CREG2 Gene

Domains & Families for CREG2 Gene

Gene Families for CREG2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CREG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREG2 Gene

GenScript: Design optimal peptide antigens:
  • Protein CREG2 (CREG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUH2

UniProtKB/Swiss-Prot:

CREG2_HUMAN :
  • Belongs to the CREG family.
Family:
  • Belongs to the CREG family.
genes like me logo Genes that share domains with CREG2: view

Function for CREG2 Gene

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  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for CREG2 Gene

genes like me logo Genes that share phenotypes with CREG2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREG2 Gene

Localization for CREG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREG2 gene
Compartment Confidence
extracellular 4
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CREG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CREG2 Gene

Pathways & Interactions for CREG2 Gene

PathCards logo

SuperPathways for CREG2 Gene

No Data Available

Interacting Proteins for CREG2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000315203 Q8IUH2-CREG2_HUMAN for CREG2 Gene via STRING IID

GPS-Prot Interaction Network for CREG2

Gene Ontology (GO) - Biological Process for CREG2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CREG2 Gene

Drugs & Compounds for CREG2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for CREG2 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for CREG2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREG2

Alternative Splicing Database (ASD) splice patterns (SP) for CREG2 Gene

No ASD Table

Relevant External Links for CREG2 Gene

GeneLoc Exon Structure for
CREG2

Expression for CREG2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREG2 Gene

mRNA expression in normal human tissues for CREG2 Gene
mRNA expression by GTEx for CREG2 Gene

mRNA differential expression in normal tissues according to GTEx for CREG2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.4), Brain - Anterior cingulate cortex (BA24) (x11.5), Brain - Cortex (x9.6), Brain - Hippocampus (x5.8), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for CREG2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CREG2 Gene



Protein tissue co-expression partners for CREG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CREG2

SOURCE GeneReport for Unigene cluster for CREG2 Gene:

Hs.732289

mRNA Expression by UniProt/SwissProt for CREG2 Gene:

Q8IUH2-CREG2_HUMAN
Tissue specificity: Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum.

Evidence on tissue expression from TISSUES for CREG2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CREG2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREG2 Gene

Orthologs for CREG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CREG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CREG2 30 31
  • 98.85 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CREG2 30 31
  • 88.39 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CREG2 30 31
  • 86.38 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Creg2 30 17 31
  • 83.03 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Creg2 30
  • 79.39 (n)
Oppossum
(Monodelphis domestica)
 Mammalia CREG2 31
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CREG2 30 31
  • 72.16 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CREG2 31
  • 59 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia creg2 30
  • 60.78 (n)
Zebrafish
(Danio rerio)
 Actinopterygii creg2 30 31
  • 58.27 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CREG 31
  • 21 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT2G04690 30
  • 51.38 (n)
Rice
(Oryza sativa)
 Liliopsida Os06g0238300 30
  • 50.5 (n)
Species where no ortholog for CREG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CREG2 Gene

ENSEMBL:
Gene Tree for CREG2 (if available)
TreeFam:
Gene Tree for CREG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CREG2: view image

Paralogs for CREG2 Gene

Paralogs for CREG2 Gene

(1) SIMAP similar genes for CREG2 Gene using alignment to 3 proteins:

  • CREG2_HUMAN
  • Q4ZFW3_HUMAN
  • Q580X0_HUMAN
genes like me logo Genes that share paralogs with CREG2: view

Variants for CREG2 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CREG2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11554173 - p.Pro96Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CREG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CREG2 Gene

Variant ID Type Subtype PubMed ID
dgv1978n106 CNV deletion 24896259
esv1298629 CNV deletion 17803354
esv2147665 CNV deletion 18987734
esv2423576 CNV deletion 19546169
esv2720447 CNV deletion 23290073
esv2843014 CNV deletion 24192839
esv34123 CNV loss 18971310
esv3559855 CNV deletion 23714750
esv3591766 CNV loss 21293372
esv3892993 CNV gain 25118596
esv4768 CNV loss 18987735
esv8755 CNV loss 19470904
nsv1072427 CNV deletion 25765185
nsv1150183 CNV deletion 26484159
nsv511800 CNV loss 21212237
nsv954719 CNV deletion 24416366
nsv961464 CNV duplication 23825009

Variation tolerance for CREG2 Gene

Gene Damage Index Score: 4.75; 66.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREG2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREG2 Gene

Disorders for CREG2 Gene

Additional Disease Information for CREG2

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CREG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREG2 Gene

Publications for CREG2 Gene

  1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. (PMID: 12408961) Kunita R … Ikeda JE (Genomics 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for CREG2 gene in Mastermind

Products for CREG2 Gene

Sources for CREG2 Gene