Aliases for CREG2 Gene

Aliases for CREG2 Gene

  • Cellular Repressor Of E1A Stimulated Genes 2 2 3 5
  • Protein CREG2 3 4
  • Cellular Repressor Of E1A-Stimulated Genes 2 4

External Ids for CREG2 Gene

Previous GeneCards Identifiers for CREG2 Gene

  • GC02M100417
  • GC02M101569
  • GC02M101586
  • GC02M101423
  • GC02M101964
  • GC02M095728

Summaries for CREG2 Gene

GeneCards Summary for CREG2 Gene

CREG2 (Cellular Repressor Of E1A Stimulated Genes 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and FMN binding. An important paralog of this gene is CREG1.

Additional gene information for CREG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREG2 Gene

Genomics for CREG2 Gene

GeneHancer (GH) Regulatory Elements for CREG2 Gene

Promoters and enhancers for CREG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J101387 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 514.7 +0.7 687 1.8 CTCF ZFX REST ZBTB26 ZBTB7A SKI EZH2 MXI1 HDAC2 SIN3A CREG2 lnc-CNOT11-5 ENSG00000226058
GH02J101395 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 509.5 -11.2 -11213 8.4 TCF12 JUND FOS CTCF OSR2 ZNF266 RAD21 FOSL2 POLR2A JUN CREG2 RNF149 SNORD89 RFX8 HSALNG0017374
GH02J101388 Enhancer 0.5 ENCODE 506.9 -0.5 -506 0.2 FOS CEBPB FOSL1 JUND MAX FOSL2 NCOA3 ZNF770 MYC CREG2 HSALNG0017374
GH02J101380 Enhancer 0.5 Ensembl 17.9 +6.7 6688 2.2 FOS FOSL1 JUND MYC MAX DACH1 ATF3 EGR1 CREG2 SNORD89 ENSG00000226058 lnc-CNOT11-5
GH02J101355 Enhancer 1 FANTOM5 Ensembl ENCODE 7.4 +31.6 31624 3.7 EP300 SREBF2 SMARCC2 FOS CEBPB CHD2 JUN RCOR1 ELK1 ELK4 SNORD89 CREG2 RF00017-3285 piR-44253-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CREG2

Top Transcription factor binding sites by QIAGEN in the CREG2 gene promoter:
  • AhR
  • AREB6
  • CUTL1
  • ITF-2
  • Nkx6-1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta
  • TBP

Genomic Locations for CREG2 Gene

Genomic Locations for CREG2 Gene
42,439 bases
Minus strand
42,045 bases
Minus strand

Genomic View for CREG2 Gene

Genes around CREG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREG2 Gene

Proteins for CREG2 Gene

  • Protein details for CREG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CREG2
    Protein Accession:
    Secondary Accessions:
    • Q86X03
    • Q8N540
    • Q8N9E3

    Protein attributes for CREG2 Gene

    290 amino acids
    Molecular mass:
    32109 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04464.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CREG2 Gene

Post-translational modifications for CREG2 Gene

  • It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166.
  • Glycosylation at Asn165 and Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for CREG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREG2 Gene

Domains & Families for CREG2 Gene

Gene Families for CREG2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CREG2 Gene


Suggested Antigen Peptide Sequences for CREG2 Gene

GenScript: Design optimal peptide antigens:
  • Protein CREG2 (CREG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CREG family.
  • Belongs to the CREG family.
genes like me logo Genes that share domains with CREG2: view

Function for CREG2 Gene

Phenotypes From GWAS Catalog for CREG2 Gene

Gene Ontology (GO) - Molecular Function for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048037 cofactor binding IEA --
genes like me logo Genes that share ontologies with CREG2: view
genes like me logo Genes that share phenotypes with CREG2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREG2 Gene

Localization for CREG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREG2 gene
Compartment Confidence
extracellular 4
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CREG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CREG2 Gene

Pathways & Interactions for CREG2 Gene

PathCards logo

SuperPathways for CREG2 Gene

No Data Available

Interacting Proteins for CREG2 Gene


Gene Ontology (GO) - Biological Process for CREG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CREG2 Gene

Drugs & Compounds for CREG2 Gene

No Compound Related Data Available

Transcripts for CREG2 Gene

mRNA/cDNA for CREG2 Gene

4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREG2 Gene

No ASD Table

Relevant External Links for CREG2 Gene

GeneLoc Exon Structure for

Expression for CREG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREG2 Gene

mRNA differential expression in normal tissues according to GTEx for CREG2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.4), Brain - Anterior cingulate cortex (BA24) (x11.5), Brain - Cortex (x9.6), Brain - Hippocampus (x5.8), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for CREG2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CREG2 Gene

Protein tissue co-expression partners for CREG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CREG2

SOURCE GeneReport for Unigene cluster for CREG2 Gene:


mRNA Expression by UniProt/SwissProt for CREG2 Gene:

Tissue specificity: Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum.

Evidence on tissue expression from TISSUES for CREG2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CREG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREG2 Gene

Orthologs for CREG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CREG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CREG2 31 30
  • 98.85 (n)
(Bos Taurus)
Mammalia CREG2 31 30
  • 88.39 (n)
(Canis familiaris)
Mammalia CREG2 31 30
  • 86.38 (n)
(Mus musculus)
Mammalia Creg2 17 31 30
  • 83.03 (n)
(Rattus norvegicus)
Mammalia Creg2 30
  • 79.39 (n)
(Monodelphis domestica)
Mammalia CREG2 31
  • 63 (a)
(Gallus gallus)
Aves CREG2 31 30
  • 72.16 (n)
(Anolis carolinensis)
Reptilia CREG2 31
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia creg2 30
  • 60.78 (n)
(Danio rerio)
Actinopterygii creg2 31 30
  • 58.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CREG 31
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04690 30
  • 51.38 (n)
(Oryza sativa)
Liliopsida Os06g0238300 30
  • 50.5 (n)
Species where no ortholog for CREG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREG2 Gene

Gene Tree for CREG2 (if available)
Gene Tree for CREG2 (if available)
Evolutionary constrained regions (ECRs) for CREG2: view image

Paralogs for CREG2 Gene

Paralogs for CREG2 Gene

(1) SIMAP similar genes for CREG2 Gene using alignment to 3 proteins:

  • Q580X0_HUMAN
genes like me logo Genes that share paralogs with CREG2: view

Variants for CREG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CREG2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11554173 - p.Pro96Gln

Additional dbSNP identifiers (rs#s) for CREG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CREG2 Gene

Variant ID Type Subtype PubMed ID
dgv1978n106 CNV deletion 24896259
esv1298629 CNV deletion 17803354
esv2147665 CNV deletion 18987734
esv2423576 CNV deletion 19546169
esv2720447 CNV deletion 23290073
esv2843014 CNV deletion 24192839
esv34123 CNV loss 18971310
esv3559855 CNV deletion 23714750
esv3591766 CNV loss 21293372
esv3892993 CNV gain 25118596
esv4768 CNV loss 18987735
esv8755 CNV loss 19470904
nsv1072427 CNV deletion 25765185
nsv1150183 CNV deletion 26484159
nsv511800 CNV loss 21212237
nsv954719 CNV deletion 24416366
nsv961464 CNV duplication 23825009

Variation tolerance for CREG2 Gene

Gene Damage Index Score: 4.75; 66.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREG2 Gene

Disorders for CREG2 Gene

Additional Disease Information for CREG2

No disorders were found for CREG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREG2 Gene

Publications for CREG2 Gene

  1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. (PMID: 12408961) Kunita R … Ikeda JE (Genomics 2002) 2 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for CREG2 Gene

Sources for CREG2 Gene