The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb... See more...

Aliases for CREG1 Gene

Aliases for CREG1 Gene

  • Cellular Repressor Of E1A Stimulated Genes 1 2 3 5
  • Protein CREG1 3 4
  • CREG 3 4
  • Cellular Repressor Of E1A-Stimulated Genes 1 4
  • Cellular Repressor Of E1A-Stimulated Genes 2
  • CREG1 5

External Ids for CREG1 Gene

Previous HGNC Symbols for CREG1 Gene

  • CREG

Previous GeneCards Identifiers for CREG1 Gene

  • GC01M164241
  • GC01M165776
  • GC01M138756

Summaries for CREG1 Gene

Entrez Gene Summary for CREG1 Gene

  • The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREG1 Gene

CREG1 (Cellular Repressor Of E1A Stimulated Genes 1) is a Protein Coding gene. Diseases associated with CREG1 include Embryonal Carcinoma and Ornithosis. Among its related pathways are Innate Immune System and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and transcription corepressor activity. An important paralog of this gene is CREG2.

UniProtKB/Swiss-Prot Summary for CREG1 Gene

  • May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Gene Wiki entry for CREG1 Gene

Additional gene information for CREG1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREG1 Gene

Genomics for CREG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CREG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREG1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CREG1

Top Transcription factor binding sites by QIAGEN in the CREG1 gene promoter:
  • C/EBPalpha
  • Cdc5
  • E47
  • FOXL1
  • GR
  • GR-alpha
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1

Genomic Locations for CREG1 Gene

Genomic Locations for CREG1 Gene
chr1:167,529,117-167,553,805
(GRCh38/hg38)
Size:
24,689 bases
Orientation:
Minus strand
chr1:167,498,914-167,523,056
(GRCh37/hg19)
Size:
24,143 bases
Orientation:
Minus strand

Genomic View for CREG1 Gene

Genes around CREG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREG1 Gene

Proteins for CREG1 Gene

  • Protein details for CREG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75629-CREG1_HUMAN
    Recommended name:
    Protein CREG1
    Protein Accession:
    O75629
    Secondary Accessions:
    • B2RDD4
    • Q8N9A3

    Protein attributes for CREG1 Gene

    Size:
    220 amino acids
    Molecular mass:
    24075 Da
    Quaternary structure:
    • Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.

    Three dimensional structures from OCA and Proteopedia for CREG1 Gene

neXtProt entry for CREG1 Gene

Post-translational modifications for CREG1 Gene

  • N-glycosylated.
  • Glycosylation at Asn160, Asn193, and Asn216
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CREG1_HUMAN (1653)

Other Protein References for CREG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CREG1
  • Boster Bio Antibodies for CREG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CREG1

Assay Products

  • Signalway ELISA kits for CREG1

No data available for DME Specific Peptides for CREG1 Gene

Domains & Families for CREG1 Gene

Gene Families for CREG1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CREG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREG1 Gene

GenScript: Design optimal peptide antigens:
  • Cellular repressor of E1A-stimulated genes 1 (CREG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75629

UniProtKB/Swiss-Prot:

CREG1_HUMAN :
  • Belongs to the CREG family.
Family:
  • Belongs to the CREG family.
genes like me logo Genes that share domains with CREG1: view

Function for CREG1 Gene

Molecular function for CREG1 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Phenotypes From GWAS Catalog for CREG1 Gene

Gene Ontology (GO) - Molecular Function for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 9710587
GO:0008134 transcription factor binding IEA --
GO:0048037 cofactor binding IEA --
genes like me logo Genes that share ontologies with CREG1: view
genes like me logo Genes that share phenotypes with CREG1: view

Animal Models for CREG1 Gene

MGI Knock Outs for CREG1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREG1 Gene

Localization for CREG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREG1 gene
Compartment Confidence
extracellular 5
lysosome 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IDA 25645918
GO:0005667 transcription factor complex IEA --
GO:0035578 azurophil granule lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with CREG1: view

Pathways & Interactions for CREG1 Gene

genes like me logo Genes that share pathways with CREG1: view

Pathways by source for CREG1 Gene

1 BioSystems pathway for CREG1 Gene
3 Reactome pathways for CREG1 Gene

Gene Ontology (GO) - Biological Process for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9710587
GO:0007275 multicellular organism development TAS 9710587
GO:0040008 regulation of growth IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CREG1: view

No data available for SIGNOR curated interactions for CREG1 Gene

Drugs & Compounds for CREG1 Gene

No Compound Related Data Available

Transcripts for CREG1 Gene

mRNA/cDNA for CREG1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREG1

Alternative Splicing Database (ASD) splice patterns (SP) for CREG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CREG1 Gene

GeneLoc Exon Structure for
CREG1

Expression for CREG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CREG1 Gene

This gene is overexpressed in Heart (15.7), Vitreous humor (9.2), and Spleen (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CREG1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CREG1

SOURCE GeneReport for Unigene cluster for CREG1 Gene:

Hs.5710

Evidence on tissue expression from TISSUES for CREG1 Gene

  • Liver(4.6)
  • Nervous system(3.5)
  • Lung(3.3)
  • Heart(2.9)
  • Skin(2.8)
  • Kidney(2.8)
  • Muscle(2.8)
  • Spleen(2.7)
  • Blood(2.6)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with CREG1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREG1 Gene

Orthologs for CREG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREG1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CREG1 30 31
  • 98.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CREG1 30 31
  • 88.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CREG1 30 31
  • 85.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Creg1 30 17 31
  • 82.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Creg1 30
  • 81.03 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CREG1 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CREG1 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CREG1 30 31
  • 74.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CREG1 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia creg1 30
  • 67.06 (n)
Zebrafish
(Danio rerio)
Actinopterygii creg1 30 31
  • 65.67 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5415 30
Fruit Fly
(Drosophila melanogaster)
Insecta CREG 30 31
  • 47.65 (n)
OneToMany
Species where no ortholog for CREG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CREG1 Gene

ENSEMBL:
Gene Tree for CREG1 (if available)
TreeFam:
Gene Tree for CREG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CREG1: view image

Paralogs for CREG1 Gene

Paralogs for CREG1 Gene

(1) SIMAP similar genes for CREG1 Gene using alignment to 1 proteins:

  • CREG1_HUMAN
genes like me logo Genes that share paralogs with CREG1: view

Variants for CREG1 Gene

Additional dbSNP identifiers (rs#s) for CREG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CREG1 Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185
nsv528710 CNV gain 19592680
nsv819670 CNV loss 19587683
nsv831814 CNV loss 17160897

Variation tolerance for CREG1 Gene

Gene Damage Index Score: 0.51; 11.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CREG1 Gene

Disorders for CREG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CREG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
ornithosis
  • psittacosis
- elite association - COSMIC cancer census association via MalaCards
Search CREG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CREG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CREG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREG1 Gene

Publications for CREG1 Gene

  1. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PMID: 16344469) Sacher M … Cygler M (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
  2. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PMID: 10815803) Veal E … Gill G (Oncogene 2000) 3 4 23
  3. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PMID: 9710587) Veal E … Gill G (Molecular and cellular biology 1998) 2 3 4
  4. Lack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China. (PMID: 20951690) Wang T … Kang J (Clinica chimica acta; international journal of clinical chemistry 2011) 3 41
  5. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. (PMID: 20060003) Han Y … Yan C (Journal of molecular and cellular cardiology 2010) 3 23

Products for CREG1 Gene

  • Signalway ELISA kits for CREG1

Sources for CREG1 Gene