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Aliases for CREBZF Gene

Aliases for CREBZF Gene

  • CREB/ATF BZIP Transcription Factor 2 3 3 5
  • Host Cell Factor-Binding Transcription Factor Zhangfei 3 4
  • HCF-Binding Transcription Factor Zhangfei 3 4
  • Zhangfei 2 3
  • ZF 3 4
  • SHP-Interacting Leucine Zipper Protein 3
  • SMILE 3

External Ids for CREBZF Gene

Previous GeneCards Identifiers for CREBZF Gene

  • GC11M085046
  • GC11M085368
  • GC11M081665

Summaries for CREBZF Gene

GeneCards Summary for CREBZF Gene

CREBZF (CREB/ATF BZIP Transcription Factor) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and MAPK-Erk Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and identical protein binding.

UniProtKB/Swiss-Prot for CREBZF Gene

  • Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Additional gene information for CREBZF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBZF Gene

Genomics for CREBZF Gene

GeneHancer (GH) Regulatory Elements for CREBZF Gene

Promoters and enhancers for CREBZF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J085661 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.4 +18.4 18380 5.5 HDGF CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CREBZF TMEM126A EED CCDC89 SYTL2 GC11M085678
GH11J085684 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 -2.9 -2919 2.9 ZBTB6 SAP130 MZF1 ZNF335 GLIS2 ZBTB48 ZNF600 RFX1 NFIA SP2 CCDC89 CREBZF SYTL2
GH11J085682 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 +0.1 64 1.3 DMAP1 KLF5 ZNF335 GATAD1 POLR2A SCRT2 ZNF143 ZNF639 L3MBTL2 NRF1 GC11M085678 CREBZF SYTL2 CCDC89
GH11J086243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 43.3 -562.2 -562152 3.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 EED CREBZF HIKESHI MIR6755
GH11J086171 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 49.6 -493.2 -493193 9.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF766 FOS JUNB ZNF592 EED CREBZF PICALM RNU6-560P LOC100289518 ENSG00000254699
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREBZF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CREBZF gene promoter:
  • ATF-2
  • ATF6
  • S8
  • POU3F2
  • PPAR-gamma1

Genomic Locations for CREBZF Gene

Genomic Locations for CREBZF Gene
chr11:85,657,564-85,682,908
(GRCh38/hg38)
Size:
25,345 bases
Orientation:
Minus strand
chr11:85,368,608-85,393,951
(GRCh37/hg19)
Size:
25,344 bases
Orientation:
Minus strand

Genomic View for CREBZF Gene

Genes around CREBZF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBZF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBZF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBZF Gene

Proteins for CREBZF Gene

  • Protein details for CREBZF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS37-ZHANG_HUMAN
    Recommended name:
    CREB/ATF bZIP transcription factor
    Protein Accession:
    Q9NS37
    Secondary Accessions:
    • B2R8Q9
    • Q0P5U9
    • Q52LT3

    Protein attributes for CREBZF Gene

    Size:
    354 amino acids
    Molecular mass:
    37134 Da
    Quaternary structure:
    • Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity (PubMed:10871379, PubMed:15705566). Interacts with CREB3; the interaction occurs only in combination with HCFC1 (PubMed:15705566).
    Miscellaneous:
    • Named Zhangfei after a legendary Chinese warrior who was contemporary with Luman in around 220 AD.
    SequenceCaution:
    • Sequence=AAD28325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD28325.1; Type=Frameshift; Positions=5, 49; Evidence={ECO:0000305}; Sequence=AAZ42189.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36256.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36256.1; Type=Frameshift; Positions=59; Evidence={ECO:0000305};

neXtProt entry for CREBZF Gene

Post-translational modifications for CREBZF Gene

  • Ubiquitination at Lys184
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CREBZF Gene

Domains & Families for CREBZF Gene

Gene Families for CREBZF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CREBZF Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBZF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS37

UniProtKB/Swiss-Prot:

ZHANG_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREBZF: view

Function for CREBZF Gene

Molecular function for CREBZF Gene

UniProtKB/Swiss-Prot Function:
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Phenotypes From GWAS Catalog for CREBZF Gene

Gene Ontology (GO) - Molecular Function for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding NAS 10871379
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 10871379
GO:0042802 identical protein binding IPI 16343488
genes like me logo Genes that share ontologies with CREBZF: view
genes like me logo Genes that share phenotypes with CREBZF: view

Animal Model Products

CRISPR Products

miRNA for CREBZF Gene

miRTarBase miRNAs that target CREBZF

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREBZF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBZF Gene

Localization for CREBZF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBZF Gene

Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREBZF gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15705566
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CREBZF: view

Pathways & Interactions for CREBZF Gene

genes like me logo Genes that share pathways with CREBZF: view

Pathways by source for CREBZF Gene

Gene Ontology (GO) - Biological Process for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA,IEA 10871379
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009615 response to virus IDA 10871379
GO:0045814 negative regulation of gene expression, epigenetic IEP 15705566
genes like me logo Genes that share ontologies with CREBZF: view

No data available for SIGNOR curated interactions for CREBZF Gene

Drugs & Compounds for CREBZF Gene

No Compound Related Data Available

Transcripts for CREBZF Gene

Unigene Clusters for CREBZF Gene

CREB/ATF bZIP transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREBZF

Alternative Splicing Database (ASD) splice patterns (SP) for CREBZF Gene

No ASD Table

Relevant External Links for CREBZF Gene

GeneLoc Exon Structure for
CREBZF
ECgene alternative splicing isoforms for
CREBZF

Expression for CREBZF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREBZF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CREBZF Gene

This gene is overexpressed in Pancreatic juice (37.9), Fetal Liver (20.4), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CREBZF Gene



Protein tissue co-expression partners for CREBZF Gene

NURSA nuclear receptor signaling pathways regulating expression of CREBZF Gene:

CREBZF

SOURCE GeneReport for Unigene cluster for CREBZF Gene:

Hs.535319

mRNA Expression by UniProt/SwissProt for CREBZF Gene:

Q9NS37-ZHANG_HUMAN
Tissue specificity: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.

Evidence on tissue expression from TISSUES for CREBZF Gene

  • Nervous system(4.7)
  • Bone marrow(4.2)
  • Liver(4.2)
  • Intestine(3.9)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with CREBZF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREBZF Gene

Orthologs for CREBZF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CREBZF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBZF 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CREBZF 34 33
  • 92.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CREBZF 34 33
  • 90.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crebzf 16 34 33
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Crebzf 33
  • 86.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CREBZF 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBZF 34
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crebzf 34
  • 42 (a)
OneToOne
Species where no ortholog for CREBZF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBZF Gene

ENSEMBL:
Gene Tree for CREBZF (if available)
TreeFam:
Gene Tree for CREBZF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CREBZF: view image

Paralogs for CREBZF Gene

No data available for Paralogs for CREBZF Gene

Variants for CREBZF Gene

Sequence variations from dbSNP and Humsavar for CREBZF Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000515093 -- 85,663,237(-) C/A/T 3_prime_UTR_variant, intron_variant
rs1000897710 -- 85,663,733(-) T/G 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000947660 -- 85,659,040(-) A/ATA 3_prime_UTR_variant, non_coding_transcript_variant
rs1001557988 -- 85,666,038(-) G/A upstream_transcript_variant
rs1002170288 -- 85,662,098(-) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CREBZF Gene

Variant ID Type Subtype PubMed ID
esv2759845 CNV gain+loss 17122850

Variation tolerance for CREBZF Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREBZF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREBZF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBZF Gene

Disorders for CREBZF Gene

Additional Disease Information for CREBZF

No disorders were found for CREBZF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBZF Gene

Publications for CREBZF Gene

  1. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PMID: 10871379) Lu R … Misra V (Nucleic acids research 2000) 2 3 4 58
  2. Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. (PMID: 15705566) Misra V … Korchinski P (The Journal of biological chemistry 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CREBZF Gene

Sources for CREBZF Gene

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