Aliases for CREBRF Gene

Aliases for CREBRF Gene

  • CREB3 Regulatory Factor 2 3 4 5
  • Luman/CREB3 Recruitment Factor 2 3
  • Luman Recruitment Factor 3 4
  • C5orf41 3 4
  • LRF 3 4
  • Chromosome 5 Open Reading Frame 41 2
  • UPF0474 Protein C5orf41 3
  • Luman-Recruiting Factor 3
  • Adult Retina Protein 3

External Ids for CREBRF Gene

Previous HGNC Symbols for CREBRF Gene

  • C5orf41

Previous GeneCards Identifiers for CREBRF Gene

  • GC05P172484

Summaries for CREBRF Gene

GeneCards Summary for CREBRF Gene

CREBRF (CREB3 Regulatory Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot Summary for CREBRF Gene

  • Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

Additional gene information for CREBRF Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREBRF Gene

Genomics for CREBRF Gene

GeneHancer (GH) Regulatory Elements for CREBRF Gene

Promoters and enhancers for CREBRF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREBRF on UCSC Golden Path with GeneCards custom track

Genomic Locations for CREBRF Gene

Genomic Locations for CREBRF Gene
82,945 bases
Plus strand
82,937 bases
Plus strand

Genomic View for CREBRF Gene

Genes around CREBRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBRF Gene

Proteins for CREBRF Gene

  • Protein details for CREBRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CREB3 regulatory factor
    Protein Accession:
    Secondary Accessions:
    • B3DFH2
    • B3KW49
    • D3DQM2
    • F5GXN3
    • Q5HYG4
    • Q5HYK0
    • Q86YR3
    • Q8IZG1

    Protein attributes for CREBRF Gene

    639 amino acids
    Molecular mass:
    72149 Da
    Quaternary structure:
    • Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.
    • Sequence=AC008378; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CREBRF Gene


neXtProt entry for CREBRF Gene

Post-translational modifications for CREBRF Gene

No data available for DME Specific Peptides for CREBRF Gene

Domains & Families for CREBRF Gene

Gene Families for CREBRF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CREBRF Gene


Suggested Antigen Peptide Sequences for CREBRF Gene

GenScript: Design optimal peptide antigens:
  • UPF0474 protein C5orf41 (CE041_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. CREBRF subfamily.
  • Belongs to the bZIP family. CREBRF subfamily.
genes like me logo Genes that share domains with CREBRF: view

Function for CREBRF Gene

Molecular function for CREBRF Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for CREBRF Gene

Gene Ontology (GO) - Molecular Function for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16940180
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 16940180
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18391022
genes like me logo Genes that share ontologies with CREBRF: view
genes like me logo Genes that share phenotypes with CREBRF: view

Animal Model Products

CRISPR Products

miRNA for CREBRF Gene

miRTarBase miRNAs that target CREBRF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBRF Gene

Localization for CREBRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBRF Gene

Nucleus. Note=Colocalizes with CREB3 in nuclear foci.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREBRF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with CREBRF: view

Pathways & Interactions for CREBRF Gene

PathCards logo

SuperPathways for CREBRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006986 response to unfolded protein IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0042711 maternal behavior IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 16940180
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Pathways by source and SIGNOR curated interactions for CREBRF Gene

Drugs & Compounds for CREBRF Gene

No Compound Related Data Available

Transcripts for CREBRF Gene


CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREBRF Gene

No ASD Table

Relevant External Links for CREBRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CREBRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREBRF Gene

mRNA differential expression in normal tissues according to GTEx for CREBRF Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CREBRF Gene

This gene is overexpressed in Liver, secretome (24.9), Platelet (8.9), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CREBRF Gene

NURSA nuclear receptor signaling pathways regulating expression of CREBRF Gene:


SOURCE GeneReport for Unigene cluster for CREBRF Gene:


Evidence on tissue expression from TISSUES for CREBRF Gene

  • Lung(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CREBRF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREBRF Gene

Orthologs for CREBRF Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CREBRF 33 32
  • 99.9 (n)
(Canis familiaris)
Mammalia CREBRF 33 32
  • 95.04 (n)
(Bos Taurus)
Mammalia CREBRF 33
  • 94 (a)
C20H5orf41 32
  • 93.95 (n)
(Monodelphis domestica)
Mammalia CREBRF 33
  • 91 (a)
(Rattus norvegicus)
Mammalia Crebrf 32
  • 90.51 (n)
(Mus musculus)
Mammalia Crebrf 17 33 32
  • 89.88 (n)
(Ornithorhynchus anatinus)
Mammalia CREBRF 33
  • 88 (a)
(Gallus gallus)
Aves C13H5ORF41 33 32
  • 80.67 (n)
(Anolis carolinensis)
Reptilia CREBRF 33
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crebrf 32
  • 70.82 (n)
(Danio rerio)
Actinopterygii crebrf 33 32
  • 70.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13624 33
  • 17 (a)
Species where no ortholog for CREBRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBRF Gene

Gene Tree for CREBRF (if available)
Gene Tree for CREBRF (if available)
Evolutionary constrained regions (ECRs) for CREBRF: view image

Paralogs for CREBRF Gene

No data available for Paralogs for CREBRF Gene

Variants for CREBRF Gene

Sequence variations from dbSNP and Humsavar for CREBRF Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000146760 -- 173,130,369(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000168626 -- 173,097,755(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000169934 -- 173,101,844(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000174262 -- 173,115,670(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000286214 -- 173,089,336(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CREBRF Gene

Variant ID Type Subtype PubMed ID
esv2662674 CNV deletion 23128226
esv2731109 CNV deletion 23290073
esv3607606 CNV loss 21293372
esv3607607 CNV loss 21293372
esv3607608 CNV loss 21293372
nsv1137048 CNV deletion 24896259
nsv507310 OTHER sequence alteration 20534489
nsv980753 CNV duplication 23825009

Variation tolerance for CREBRF Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREBRF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBRF Gene

Disorders for CREBRF Gene

Additional Disease Information for CREBRF

No disorders were found for CREBRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBRF Gene

Publications for CREBRF Gene

  1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PMID: 18391022) Audas TE … Lu R (Molecular and cellular biology 2008) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  4. CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway. (PMID: 29729692) Han J … Huang C (Cellular and molecular biology (Noisy-le-Grand, France) 2018) 3 56
  5. Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. (PMID: 29721634) Krishnan M … Merriman TR (Diabetologia 2018) 3 56

Products for CREBRF Gene

Sources for CREBRF Gene