Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREBRF Gene

Aliases for CREBRF Gene

  • CREB3 Regulatory Factor 2 3 3 5
  • Luman/CREB3 Recruitment Factor 2 3
  • Luman Recruitment Factor 3 4
  • C5orf41 3 4
  • LRF 3 4
  • Chromosome 5 Open Reading Frame 41 2
  • UPF0474 Protein C5orf41 3
  • Luman-Recruiting Factor 3
  • Adult Retina Protein 3

External Ids for CREBRF Gene

Previous HGNC Symbols for CREBRF Gene

  • C5orf41

Previous GeneCards Identifiers for CREBRF Gene

  • GC05P172484

Summaries for CREBRF Gene

GeneCards Summary for CREBRF Gene

CREBRF (CREB3 Regulatory Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBRF Gene

  • Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

Additional gene information for CREBRF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBRF Gene

Genomics for CREBRF Gene

GeneHancer (GH) Regulatory Elements for CREBRF Gene

Promoters and enhancers for CREBRF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J173055 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 633 3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 CREBRF BNIP1 BOD1 SH3PXD2B CDC42P5
GH05J173075 Promoter 1 EPDnew 650.4 +19.5 19473 0.1 HDGF GTF2F1 ESRRA CLOCK SUZ12 NEUROD1 ZKSCAN1 CTBP1 GATA3 ZNF207 CREBRF CDC42P5
GH05J172763 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 36.5 -284.2 -284150 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DUSP1 CREBRF KLF3P1 ERGIC1 SH3PXD2B ENSG00000253628 ENSG00000253172 SMIM23 BOD1 EFCAB9
GH05J172787 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -260.6 -260607 16.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 ZBTB7B IRF4 YY1 CREBRF ERGIC1 BOD1 SH3PXD2B DUSP1 FBXW11 LOC105377730 LOC401218 CDC42P5 LOC100130394
GH05J173322 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 20 +271.3 271255 9.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 STC2 SH3PXD2B BOD1 CREBRF LOC102724551 ENSG00000253172 ENSG00000253628 RPL12P22 ENSG00000254011 LOC100268168
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREBRF on UCSC Golden Path with GeneCards custom track

Genomic Locations for CREBRF Gene

Genomic Locations for CREBRF Gene
82,945 bases
Plus strand
82,937 bases
Plus strand

Genomic View for CREBRF Gene

Genes around CREBRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBRF Gene

Proteins for CREBRF Gene

  • Protein details for CREBRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CREB3 regulatory factor
    Protein Accession:
    Secondary Accessions:
    • B3DFH2
    • B3KW49
    • D3DQM2
    • F5GXN3
    • Q5HYG4
    • Q5HYK0
    • Q86YR3
    • Q8IZG1

    Protein attributes for CREBRF Gene

    639 amino acids
    Molecular mass:
    72149 Da
    Quaternary structure:
    • Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.
    • Sequence=AC008378; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CREBRF Gene


neXtProt entry for CREBRF Gene

Post-translational modifications for CREBRF Gene

No data available for DME Specific Peptides for CREBRF Gene

Domains & Families for CREBRF Gene

Gene Families for CREBRF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CREBRF Gene


Suggested Antigen Peptide Sequences for CREBRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. CREBRF subfamily.
  • Belongs to the bZIP family. CREBRF subfamily.
genes like me logo Genes that share domains with CREBRF: view

Function for CREBRF Gene

Molecular function for CREBRF Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for CREBRF Gene

Gene Ontology (GO) - Molecular Function for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16940180
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 16940180
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18391022
genes like me logo Genes that share ontologies with CREBRF: view
genes like me logo Genes that share phenotypes with CREBRF: view

Animal Model Products

miRNA for CREBRF Gene

miRTarBase miRNAs that target CREBRF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBRF Gene

Localization for CREBRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBRF Gene

Nucleus. Note=Colocalizes with CREB3 in nuclear foci.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREBRF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with CREBRF: view

Pathways & Interactions for CREBRF Gene

SuperPathways for CREBRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006986 response to unfolded protein IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Pathways by source and SIGNOR curated interactions for CREBRF Gene

Drugs & Compounds for CREBRF Gene

No Compound Related Data Available

Transcripts for CREBRF Gene

Unigene Clusters for CREBRF Gene

CREB3 regulatory factor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREBRF Gene

No ASD Table

Relevant External Links for CREBRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CREBRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREBRF Gene

mRNA differential expression in normal tissues according to GTEx for CREBRF Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CREBRF Gene

This gene is overexpressed in Liver, secretome (24.9), Platelet (8.9), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CREBRF Gene

NURSA nuclear receptor signaling pathways regulating expression of CREBRF Gene:


SOURCE GeneReport for Unigene cluster for CREBRF Gene:


Evidence on tissue expression from TISSUES for CREBRF Gene

  • Lung(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CREBRF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREBRF Gene

Orthologs for CREBRF Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CREBRF 34 33
  • 99.9 (n)
(Canis familiaris)
Mammalia CREBRF 34 33
  • 95.04 (n)
(Bos Taurus)
Mammalia CREBRF 34
  • 94 (a)
C20H5orf41 33
  • 93.95 (n)
(Monodelphis domestica)
Mammalia CREBRF 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Crebrf 33
  • 90.51 (n)
(Mus musculus)
Mammalia Crebrf 16 34 33
  • 89.88 (n)
(Ornithorhynchus anatinus)
Mammalia CREBRF 34
  • 88 (a)
(Gallus gallus)
Aves C13H5ORF41 34 33
  • 80.67 (n)
(Anolis carolinensis)
Reptilia CREBRF 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crebrf 33
  • 70.82 (n)
(Danio rerio)
Actinopterygii crebrf 34 33
  • 70.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13624 34
  • 17 (a)
Species where no ortholog for CREBRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBRF Gene

Gene Tree for CREBRF (if available)
Gene Tree for CREBRF (if available)
Evolutionary constrained regions (ECRs) for CREBRF: view image

Paralogs for CREBRF Gene

No data available for Paralogs for CREBRF Gene

Variants for CREBRF Gene

Sequence variations from dbSNP and Humsavar for CREBRF Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000146760 -- 173,130,369(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000168626 -- 173,097,755(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000169934 -- 173,101,844(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000174262 -- 173,115,670(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000286214 -- 173,089,336(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CREBRF Gene

Variant ID Type Subtype PubMed ID
esv2662674 CNV deletion 23128226
esv2731109 CNV deletion 23290073
esv3607606 CNV loss 21293372
esv3607607 CNV loss 21293372
esv3607608 CNV loss 21293372
nsv1137048 CNV deletion 24896259
nsv507310 OTHER sequence alteration 20534489
nsv980753 CNV duplication 23825009

Variation tolerance for CREBRF Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREBRF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBRF Gene

Disorders for CREBRF Gene

Additional Disease Information for CREBRF

No disorders were found for CREBRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBRF Gene

Publications for CREBRF Gene

  1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PMID: 18391022) Audas TE … Lu R (Molecular and cellular biology 2008) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations. (PMID: 28405013) Naka I … Ohashi J (Journal of human genetics 2017) 3 58
  5. A thrifty variant in CREBRF strongly influences body mass index in Samoans. (PMID: 27455349) Minster RL … McGarvey ST (Nature genetics 2016) 3 58

Products for CREBRF Gene

Sources for CREBRF Gene

Loading form....