The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different iso... See more...

Aliases for CREB5 Gene

Aliases for CREB5 Gene

  • CAMP Responsive Element Binding Protein 5 2 3 5
  • Cyclic AMP-Responsive Element-Binding Protein 5 3 4
  • CAMP-Response Element-Binding Protein A 3 4
  • CREB-5 3 4
  • CREBPA 3 4
  • CAMP Response Element-Binding Protein CRE-BPa 3
  • CAMP Response Element Binding Protein CRE-Bpa 2
  • CAMP-Responsive Element-Binding Protein 5 4
  • CRE-BPA 3
  • CRE-BPa 4

External Ids for CREB5 Gene

Previous GeneCards Identifiers for CREB5 Gene

  • GC07P028047
  • GC07P028194
  • GC07P028081
  • GC07P028112

Summaries for CREB5 Gene

Entrez Gene Summary for CREB5 Gene

  • The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREB5 Gene

CREB5 (CAMP Responsive Element Binding Protein 5) is a Protein Coding gene. Diseases associated with CREB5 include Ohdo Syndrome and Trichuriasis. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF7.

UniProtKB/Swiss-Prot Summary for CREB5 Gene

Gene Wiki entry for CREB5 Gene

Additional gene information for CREB5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREB5 Gene

Genomics for CREB5 Gene

GeneHancer (GH) Regulatory Elements for CREB5 Gene

Promoters and enhancers for CREB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J028407 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 751.6 +110.8 110829 4.9 ZBTB6 POLR2A CTBP1 CREB1 MYC ETV6 HLF MAX ZNF121 TEAD4 CREB5 lnc-TAX1BP1-4 CHN2 RF00017-6089
GH07J028684 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 763.2 +387.3 387312 5.3 FOXK2 ZBTB6 ZNF362 ETV6 HLF RAD21 ZNF121 SP1 ZNF384 CEBPG CREB5 AC005105 ENSG00000225286 lnc-TRIL-5
GH07J028300 Enhancer 0.8 Ensembl ENCODE 766.9 +2.0 1989 1.3 SP1 CREB1 RXRA FOXA2 ATF7 JUND YY1 ZBTB33 HNF4A ATF2 CREB5 HSALNG0056918
GH07J028303 Enhancer 0.6 Ensembl 750.6 +0.2 179 0.6 CTCF RAD21 SP1 MAFK SMC3 YY1 ZFP69B CEBPB ZNF335 ZNF143 CREB5 piR-38351-425 HSALNG0056918
GH07J028301 Enhancer 0.5 Ensembl 750.6 -0.4 -420 0.2 CTCF RAD21 MAFK NFE2L2 SMC3 ZFP69B ZNF143 YY1 BACH1 CREB5 piR-38351-425
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CREB5 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • IRF-2
  • POU2F1
  • POU2F1a
  • RP58

Genomic Locations for CREB5 Gene

Genomic Locations for CREB5 Gene
chr7:28,299,321-28,825,894
(GRCh38/hg38)
Size:
526,574 bases
Orientation:
Plus strand
chr7:28,338,940-28,865,511
(GRCh37/hg19)
Size:
526,572 bases
Orientation:
Plus strand

Genomic View for CREB5 Gene

Genes around CREB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB5 Gene

Proteins for CREB5 Gene

  • Protein details for CREB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02930-CREB5_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 5
    Protein Accession:
    Q02930
    Secondary Accessions:
    • A8KA51
    • B4DU13
    • B5BUH3
    • C9JK47
    • Q05886
    • Q06246
    • Q75N02
    • Q86UJ9

    Protein attributes for CREB5 Gene

    Size:
    508 amino acids
    Molecular mass:
    56918 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.

    Alternative splice isoforms for CREB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB5 Gene

Post-translational modifications for CREB5 Gene

  • Ubiquitination at Lys432
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CREB5 Gene

Domains & Families for CREB5 Gene

Gene Families for CREB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CREB5 Gene

Suggested Antigen Peptide Sequences for CREB5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79086, highly similar to cAMP response element-binding protein 5 (B4DU13_HUMAN)
  • CRE-BPa (CREB5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02930

UniProtKB/Swiss-Prot:

CREB5_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREB5: view

Function for CREB5 Gene

Molecular function for CREB5 Gene

UniProtKB/Swiss-Prot Function:
Binds to the cAMP response element and activates transcription.

Phenotypes From GWAS Catalog for CREB5 Gene

Gene Ontology (GO) - Molecular Function for CREB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IDA 8378084
GO:0005515 protein binding IPI 8440710
genes like me logo Genes that share ontologies with CREB5: view
genes like me logo Genes that share phenotypes with CREB5: view

Animal Models for CREB5 Gene

MGI Knock Outs for CREB5:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREB5 Gene

Localization for CREB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB5 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CREB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IEA 8378084
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CREB5: view

Pathways & Interactions for CREB5 Gene

genes like me logo Genes that share pathways with CREB5: view

SIGNOR curated interactions for CREB5 Gene

Gene Ontology (GO) - Biological Process for CREB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II TAS 8378084
GO:0045893 positive regulation of transcription, DNA-templated IDA 8378084
genes like me logo Genes that share ontologies with CREB5: view

Drugs & Compounds for CREB5 Gene

(1) Drugs for CREB5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CREB5: view

Transcripts for CREB5 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREB5 Gene

No ASD Table

Relevant External Links for CREB5 Gene

GeneLoc Exon Structure for
CREB5
ECgene alternative splicing isoforms for
CREB5

Expression for CREB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREB5 Gene

This gene is overexpressed in Whole Blood (x14.3).

Protein differential expression in normal tissues from HIPED for CREB5 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CREB5 Gene



Protein tissue co-expression partners for CREB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CREB5 Gene:

CREB5

SOURCE GeneReport for Unigene cluster for CREB5 Gene:

Hs.437075

Evidence on tissue expression from TISSUES for CREB5 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CREB5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB5 Gene

Orthologs for CREB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CREB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 33
  • 100 (a)
OneToMany
-- 33
  • 98 (a)
OneToMany
CREB5 32
  • 93.55 (n)
chimpanzee
(Pan troglodytes)
Mammalia CREB5 33 32
  • 99.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB5 33
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB5 33
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB5 33 32
  • 93.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb5 32
  • 91.54 (n)
mouse
(Mus musculus)
Mammalia Creb5 17 33 32
  • 91.12 (n)
chicken
(Gallus gallus)
Aves CREB5 33 32
  • 86.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREB5 33
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creb5 32
  • 79.53 (n)
zebrafish
(Danio rerio)
Actinopterygii creb5b 33 32
  • 70.5 (n)
OneToOne
Species where no ortholog for CREB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREB5 Gene

ENSEMBL:
Gene Tree for CREB5 (if available)
TreeFam:
Gene Tree for CREB5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CREB5: view image

Paralogs for CREB5 Gene

Paralogs for CREB5 Gene

(2) SIMAP similar genes for CREB5 Gene using alignment to 5 proteins:

  • CREB5_HUMAN
  • C9JN33_HUMAN
  • H0YFV2_HUMAN
  • H9KVC5_HUMAN
  • L8ECP5_HUMAN
genes like me logo Genes that share paralogs with CREB5: view

Variants for CREB5 Gene

Sequence variations from dbSNP and Humsavar for CREB5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000005154 -- 28,329,264(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000006373 -- 28,358,924(+) CCCC/CCC genic_upstream_transcript_variant, intron_variant
rs1000015808 -- 28,465,948(+) A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000018774 -- 28,492,889(+) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000024544 -- 28,305,850(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CREB5 Gene

Variant ID Type Subtype PubMed ID
dgv11245n54 CNV loss 21841781
dgv11246n54 CNV loss 21841781
dgv11247n54 CNV loss 21841781
dgv1189e199 CNV deletion 23128226
esv1447352 CNV insertion 17803354
esv2141048 CNV deletion 18987734
esv2470943 CNV deletion 19546169
esv24798 CNV gain+loss 19812545
esv25736 CNV loss 19812545
esv2659069 CNV deletion 23128226
esv2662053 CNV deletion 23128226
esv2676680 CNV deletion 23128226
esv2734175 CNV deletion 23290073
esv2734176 CNV deletion 23290073
esv3333 CNV loss 18987735
esv3541386 CNV deletion 23714750
esv3541387 CNV deletion 23714750
esv3571715 CNV loss 25503493
esv3612672 CNV loss 21293372
esv3612674 CNV loss 21293372
esv3612676 CNV loss 21293372
nsv1117704 CNV deletion 24896259
nsv464414 CNV gain 19166990
nsv511954 CNV loss 21212237
nsv5678 CNV deletion 18451855
nsv5679 CNV deletion 18451855
nsv606470 CNV gain 21841781
nsv821171 CNV deletion 20802225
nsv824044 CNV gain 20364138
nsv830931 CNV gain 17160897
nsv830932 CNV gain+loss 17160897
nsv830933 CNV loss 17160897

Variation tolerance for CREB5 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREB5 Gene

Human Gene Mutation Database (HGMD)
CREB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREB5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB5 Gene

Disorders for CREB5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CREB5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ohdo syndrome
  • ohdo blepharophimosis syndrome
trichuriasis
  • infection by trichuris trichura
opitz-kaveggia syndrome
  • oks
- elite association - COSMIC cancer census association via MalaCards
Search CREB5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CREB5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CREB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB5 Gene

Publications for CREB5 Gene

  1. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. (PMID: 8440710) Nomura N … Ishii S (The Journal of biological chemistry 1993) 2 3 4 23 56
  2. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. (PMID: 8378084) Zu YL … Ishii S (Oncogene 1993) 2 3 4 23 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 43 56
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 43 56

Products for CREB5 Gene

Sources for CREB5 Gene