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Aliases for CREB3L4 Gene

Aliases for CREB3L4 Gene

  • CAMP Responsive Element Binding Protein 3 Like 4 2 3 5
  • CAMP-Responsive Element-Binding Protein 3-Like Protein 4 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 4 3 4
  • Transcript Induced In Spermiogenesis Protein 40 3 4
  • Androgen-Induced Basic Leucine Zipper Protein 3 4
  • CAMP-Responsive Element-Binding Protein 4 3 4
  • Attaching To CRE-Like 1 3 4
  • Tisp40 3 4
  • AIBZIP 3 4
  • CREB-4 3 4
  • ATCE1 3 4
  • CREB4 3 4
  • HJAL 3 4
  • JAL 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 3
  • CAMP Responsive Element Binding Protein 1 3
  • CREB3 3

External Ids for CREB3L4 Gene

Previous GeneCards Identifiers for CREB3L4 Gene

  • GC01P151157
  • GC01P150753
  • GC01P152207
  • GC01P153940
  • GC01P125302

Summaries for CREB3L4 Gene

Entrez Gene Summary for CREB3L4 Gene

  • This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CREB3L4 Gene

CREB3L4 (CAMP Responsive Element Binding Protein 3 Like 4) is a Protein Coding gene. Diseases associated with CREB3L4 include Prostate Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3L4 Gene

  • Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5-T[GT]ACGT[GA][GT]-3 and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).

Additional gene information for CREB3L4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3L4 Gene

Genomics for CREB3L4 Gene

GeneHancer (GH) Regulatory Elements for CREB3L4 Gene

Promoters and enhancers for CREB3L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I153965 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568 -0.2 -203 3.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CREB3L4 ENSG00000273026 SLC39A1 UBAP2L ILF2 CRTC2 SLC27A3 INTS3 CHTOP ENSG00000238279
GH01I153989 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.2 +24.1 24057 3.2 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 RPS27 GC01P153990 GC01P153994 CREB3L4 CRTC2 UBAP2L SLC27A3 CHTOP SHC1 INTS3
GH01I154218 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.3 +253.2 253181 5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 NFYC UBAP2L C1orf43 CREB3L4 CHTOP INTS3 THBS3 SLC27A3 KRTCAP2 CRTC2 SHC1
GH01I154935 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.7 +970.1 970117 3.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 PMVK ENSG00000270361 GON4L CLK2 KHDC4 ENSG00000271267 UBAP2L THBS3 RUSC1-AS1 CRTC2
GH01I153919 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.9 -45.7 -45742 5.4 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GATAD2B LOC101928059 UBAP2L CRTC2 ILF2 INTS3 CHTOP CREB3L4 SLC27A3 ENSG00000272654
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CREB3L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CREB3L4 gene promoter:

Genomic Locations for CREB3L4 Gene

Genomic Locations for CREB3L4 Gene
chr1:153,967,534-153,974,364
(GRCh38/hg38)
Size:
6,831 bases
Orientation:
Plus strand
chr1:153,940,010-153,946,839
(GRCh37/hg19)

Genomic View for CREB3L4 Gene

Genes around CREB3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3L4 Gene

Proteins for CREB3L4 Gene

  • Protein details for CREB3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEY5-CR3L4_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 4
    Protein Accession:
    Q8TEY5
    Secondary Accessions:
    • D3DV62
    • Q5T4L0
    • Q86YW6

    Protein attributes for CREB3L4 Gene

    Size:
    395 amino acids
    Molecular mass:
    43432 Da
    Quaternary structure:
    • Binds DNA as a dimer.

    Alternative splice isoforms for CREB3L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3L4 Gene

Post-translational modifications for CREB3L4 Gene

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
  • N-glycosylated in the C-terminal region.
  • Ubiquitination at posLast=5151 and posLast=194194
  • Glycosylation at posLast=344344, posLast=349349, and posLast=366366

No data available for DME Specific Peptides for CREB3L4 Gene

Domains & Families for CREB3L4 Gene

Gene Families for CREB3L4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for CREB3L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TEY5

UniProtKB/Swiss-Prot:

CR3L4_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3L4: view

Function for CREB3L4 Gene

Molecular function for CREB3L4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5-T[GT]ACGT[GA][GT]-3 and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
UniProtKB/Swiss-Prot Induction:
By androgens.

Phenotypes From GWAS Catalog for CREB3L4 Gene

Gene Ontology (GO) - Molecular Function for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0035497 cAMP response element binding IEA --
genes like me logo Genes that share ontologies with CREB3L4: view
genes like me logo Genes that share phenotypes with CREB3L4: view

Animal Models for CREB3L4 Gene

MGI Knock Outs for CREB3L4:

Animal Model Products

CRISPR Products

miRNA for CREB3L4 Gene

miRTarBase miRNAs that target CREB3L4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREB3L4 Gene

Localization for CREB3L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3L4 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB3L4 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005783 endoplasmic reticulum IDA 16236796
genes like me logo Genes that share ontologies with CREB3L4: view

Pathways & Interactions for CREB3L4 Gene

genes like me logo Genes that share pathways with CREB3L4: view

Gene Ontology (GO) - Biological Process for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006986 response to unfolded protein IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with CREB3L4: view

No data available for SIGNOR curated interactions for CREB3L4 Gene

Drugs & Compounds for CREB3L4 Gene

No Compound Related Data Available

Transcripts for CREB3L4 Gene

Unigene Clusters for CREB3L4 Gene

CAMP responsive element binding protein 3-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for CREB3L4 Gene

GeneLoc Exon Structure for
CREB3L4
ECgene alternative splicing isoforms for
CREB3L4

Expression for CREB3L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREB3L4 Gene

mRNA differential expression in normal tissues according to GTEx for CREB3L4 Gene

This gene is overexpressed in Prostate (x6.9).

Protein differential expression in normal tissues from HIPED for CREB3L4 Gene

This gene is overexpressed in Skin (61.4) and Adipocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CREB3L4 Gene



Protein tissue co-expression partners for CREB3L4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CREB3L4 Gene:

CREB3L4

SOURCE GeneReport for Unigene cluster for CREB3L4 Gene:

Hs.372924

mRNA Expression by UniProt/SwissProt for CREB3L4 Gene:

Q8TEY5-CR3L4_HUMAN
Tissue specificity: According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.

Evidence on tissue expression from TISSUES for CREB3L4 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with CREB3L4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB3L4 Gene

Orthologs for CREB3L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3L4 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia CREB3L4 33 34
  • 86.51 (n)
dog
(Canis familiaris)
Mammalia CREB3L4 33 34
  • 85.22 (n)
rat
(Rattus norvegicus)
Mammalia Creb3l4 33
  • 80.74 (n)
mouse
(Mus musculus)
Mammalia Creb3l4 33 16 34
  • 79.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CREB3L4 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3l4 33
  • 64.4 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333318 33
  • 58.56 (n)
CREB3L4 34
  • 41 (a)
OneToOne
wufb26f10 33
worm
(Caenorhabditis elegans)
Secernentea let-607 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for CREB3L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3L4 Gene

ENSEMBL:
Gene Tree for CREB3L4 (if available)
TreeFam:
Gene Tree for CREB3L4 (if available)

Paralogs for CREB3L4 Gene

Paralogs for CREB3L4 Gene

(2) SIMAP similar genes for CREB3L4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CREB3L4: view

Variants for CREB3L4 Gene

Sequence variations from dbSNP and Humsavar for CREB3L4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000001382 -- 153,972,654(+) A/G intron_variant
rs1000069787 -- 153,967,407(+) G/C upstream_transcript_variant
rs1000101967 -- 153,967,761(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001142587 -- 153,966,841(+) T/C upstream_transcript_variant
rs1001172019 -- 153,967,289(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CREB3L4 Gene

Variant ID Type Subtype PubMed ID
nsv1125326 OTHER inversion 24896259

Variation tolerance for CREB3L4 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREB3L4 Gene

Human Gene Mutation Database (HGMD)
CREB3L4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREB3L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB3L4 Gene

Disorders for CREB3L4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CREB3L4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CREB3L4

genes like me logo Genes that share disorders with CREB3L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB3L4 Gene

Publications for CREB3L4 Gene

  1. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. (PMID: 11830526) Qi H … Labrie C (Cancer research 2002) 3 4 22 58
  2. Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. (PMID: 17712038) Ben Aicha S … Labrie C (Physiological genomics 2007) 3 22 58
  3. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. (PMID: 16236796) Stirling J … O'hare P (Molecular biology of the cell 2006) 3 4 58
  4. Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4). (PMID: 12111373) Cao G … Mao Y (Journal of human genetics 2002) 3 4 58
  5. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. (PMID: 25241761) Chen TC … Huang CY (Journal of proteome research 2014) 3 58

Products for CREB3L4 Gene

Sources for CREB3L4 Gene

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