This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This prote... See more...

Aliases for CREB3 Gene

Aliases for CREB3 Gene

  • CAMP Responsive Element Binding Protein 3 2 3 5
  • LZIP 2 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 3 3 4
  • Transcription Factor LZIP-Alpha 3 4
  • Small Leucine Zipper Protein 2 3
  • SLZIP 2 3
  • Luman 2 4
  • Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1 3
  • CAMP Responsive Element Binding Protein 3 (Luman) 2
  • CAMP-Responsive Element-Binding Protein 3 4
  • Basic Leucine Zipper Protein 3
  • Leucin Zipper Proitein 3
  • Leucine Zipper Protein 4
  • CREB-3 4
  • LUMAN 3
  • CREB3 5

External Ids for CREB3 Gene

Previous GeneCards Identifiers for CREB3 Gene

  • GC09P036044
  • GC09P035901

Summaries for CREB3 Gene

Entrez Gene Summary for CREB3 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for CREB3 Gene

CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. Diseases associated with CREB3 include Herpes Simplex and T-Cell Lymphoblastic Leukemia/Lymphoma. Among its related pathways are ATM Pathway and NGF Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot Summary for CREB3 Gene

  • Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613).
  • [Processed cyclic AMP-responsive element-binding protein 3]: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3').
  • [Isoform 2]: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells.
  • (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression.
  • [Isoform 1]: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.
  • [Isoform 1]: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein.
  • [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters.
  • [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.

Gene Wiki entry for CREB3 Gene

Additional gene information for CREB3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREB3 Gene

Genomics for CREB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CREB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CREB3

Top Transcription factor binding sites by QIAGEN in the CREB3 gene promoter:
  • AP-1
  • ATF-2
  • c-Ets-1
  • c-Jun
  • C/EBPalpha
  • C/EBPbeta
  • HEN1
  • Pax-6
  • STAT5A
  • ZID

Genomic Locations for CREB3 Gene

Genomic Locations for CREB3 Gene
chr9:35,732,598-35,736,999
(GRCh38/hg38)
Size:
4,402 bases
Orientation:
Plus strand
chr9:35,732,317-35,737,005
(GRCh37/hg19)
Size:
4,689 bases
Orientation:
Plus strand

Genomic View for CREB3 Gene

Genes around CREB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3 Gene

Proteins for CREB3 Gene

  • Protein details for CREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43889-CREB3_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3
    Protein Accession:
    O43889
    Secondary Accessions:
    • D0PTW6
    • O14671
    • O14919
    • Q5TCV1
    • Q96GK8
    • Q9H2W3
    • Q9UE77

    Protein attributes for CREB3 Gene

    Size:
    371 amino acids
    Molecular mass:
    41379 Da
    Quaternary structure:
    • Homodimer (PubMed:10675342). Isoform 1 interacts with HCFC1; the interaction is required to stimulate CREB3 transcriptional activity (PubMed:9271389, PubMed:9389645, PubMed:10629049, PubMed:10984507). Isoform 1 interacts with CREBZF; the interaction occurs only in combination with HCFC1 (PubMed:15705566). Isoform 1 interacts (via central part and transmembrane region) with DCSTAMP (via C-terminus cytoplasmic domain) (PubMed:20546900). Isoform 1 interacts with OS9 (PubMed:20546900). Isoform 1 interacts (via leucine-zipper domain) with CREBRF (via leucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3 degradation (PubMed:18391022). Isoform 1 interacts (via C-terminal domain) with CCR1 (PubMed:15001559).
    • (Microbial infection) Interacts with the HCV core protein; homodimerization is prevented by the HCV core protein (PubMed:10675342). Isoform 1 interacts (via leucine-zipper and transmembrane domains) with HIV-1 TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability (PubMed:17054986). Processed cyclic AMP-responsive element-binding protein 3 interacts with HIV-1 Tat (PubMed:17054986).
    SequenceCaution:
    • Sequence=AAC04325.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Does not contain a helical transmembrane domain.

    Alternative splice isoforms for CREB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3 Gene

Post-translational modifications for CREB3 Gene

  • First proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by DCSTAMP. That form is rapidly degraded.
  • N-glycosylated.
  • Glycosylation at Asn307 and Asn348
  • Ubiquitination at Lys352
  • Modification sites at PhosphoSitePlus

Other Protein References for CREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREB3 Gene

Domains & Families for CREB3 Gene

Gene Families for CREB3 Gene

Protein Domains for CREB3 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
ProtoNet:

Suggested Antigen Peptide Sequences for CREB3 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor LZIP-alpha (CREB3_HUMAN)
  • Leucine zipper protein isoform (D0PTW6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43889

UniProtKB/Swiss-Prot:

CREB3_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3: view

Function for CREB3 Gene

Molecular function for CREB3 Gene

UniProtKB/Swiss-Prot Function:
Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613).
UniProtKB/Swiss-Prot Function:
[Processed cyclic AMP-responsive element-binding protein 3]: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3').
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression.
UniProtKB/Swiss-Prot Function:
[Isoform 1]: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.
UniProtKB/Swiss-Prot Function:
[Isoform 1]: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein.
UniProtKB/Swiss-Prot Function:
[Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters.
UniProtKB/Swiss-Prot Function:
[Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated upon DC maturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin (Tm). Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by NF-kappa-B.

Phenotypes From GWAS Catalog for CREB3 Gene

Gene Ontology (GO) - Molecular Function for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16940180
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16940180
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IMP 16940180
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with CREB3: view
genes like me logo Genes that share phenotypes with CREB3: view

Animal Models for CREB3 Gene

MGI Knock Outs for CREB3:
  • Creb3 Creb3<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for CREB3 Gene

miRTarBase miRNAs that target CREB3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREB3 Gene

Localization for CREB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3 Gene

[Isoform 1]: Endoplasmic reticulum membrane. Single-pass type II membrane protein. Golgi apparatus. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756). Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756). {ECO:0000269 PubMed:10623756, ECO:0000269 PubMed:20546900}.
[Isoform 2]: Nucleus. Cytoplasm. Note=Predominantly in the nucleus (PubMed:19779205). Not associated with membranes (PubMed:19779205). {ECO:0000269 PubMed:19779205}.
[Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB). {ECO:0000269 PubMed:10675342, ECO:0000269 PubMed:15705566, ECO:0000269 PubMed:18391022, ECO:0000269 PubMed:20546900}.
[Isoform 1]: Cytoplasm. Note=(Microbial infection) Sequestered into the cytoplasm by the HCV core protein. {ECO:0000269 PubMed:10675342}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IC,IDA 20546900
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CREB3: view

Pathways & Interactions for CREB3 Gene

PathCards logo

SuperPathways for CREB3 Gene

SuperPathway Contained pathways
1 Aldosterone synthesis and secretion
2 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
3 CREB Pathway
.68
.68
.63
.50
4 Relaxin signaling pathway
5 nNOS Signaling in Skeletal Muscle
.44
.44
.01
genes like me logo Genes that share pathways with CREB3: view

Pathways by source for CREB3 Gene

45 Qiagen pathways for CREB3 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Akt Signaling
  • ATM Pathway

SIGNOR curated interactions for CREB3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006935 chemotaxis IEA --
GO:0006986 response to unfolded protein IEA --
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IDA 16940180
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CREB3: view

Drugs & Compounds for CREB3 Gene

(6) Drugs for CREB3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(4) Additional Compounds for CREB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB3: view

Transcripts for CREB3 Gene

mRNA/cDNA for CREB3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREB3

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3 Gene

No ASD Table

Relevant External Links for CREB3 Gene

GeneLoc Exon Structure for
CREB3

Expression for CREB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CREB3

SOURCE GeneReport for Unigene cluster for CREB3 Gene:

Hs.522110

mRNA Expression by UniProt/SwissProt for CREB3 Gene:

O43889-CREB3_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:9271389, PubMed:19779205). Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level) (PubMed:20546900).

Evidence on tissue expression from TISSUES for CREB3 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Pancreas(4.4)
  • Lung(2.7)
  • Kidney(2.5)
  • Liver(2.4)
  • Intestine(2.3)
  • Heart(2.3)
  • Muscle(2.3)
  • Spleen(2.2)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with CREB3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB3 Gene

Orthologs for CREB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CREB3 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CREB3 30 31
  • 83.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CREB3 30 31
  • 82.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Creb3 30 17 31
  • 76.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Creb3 30
  • 72.92 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CREB3 31
  • 50 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CREB3 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CREB3 30 31
  • 60.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CREB3 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia creb3 30
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16347 30
Zebrafish
(Danio rerio)
Actinopterygii creb3l3l 30 31
  • 59.76 (n)
OneToOne
wufj05f07 30
Worm
(Caenorhabditis elegans)
Secernentea let-607 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Species where no ortholog for CREB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CREB3 Gene

ENSEMBL:
Gene Tree for CREB3 (if available)
TreeFam:
Gene Tree for CREB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CREB3: view image

Paralogs for CREB3 Gene

Paralogs for CREB3 Gene

genes like me logo Genes that share paralogs with CREB3: view

Variants for CREB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CREB3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
720313 Benign: not provided 35,736,222(+) T/C INTRON_VARIANT
786136 Benign: not provided 35,736,102(+) C/T SYNONYMOUS_VARIANT
rs869025236 Uncertain Significance: Ductal breast carcinoma 35,736,433(+) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CREB3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CREB3 Gene

Variant ID Type Subtype PubMed ID
esv25437 CNV loss 19812545
nsv1125318 OTHER inversion 24896259

Variation tolerance for CREB3 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CREB3 Gene

Human Gene Mutation Database (HGMD)
CREB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREB3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB3 Gene

Disorders for CREB3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CREB3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
prostate cancer
  • prostate cancer, somatic
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards
Search CREB3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CREB3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CREB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB3 Gene

Publications for CREB3 Gene

  1. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PMID: 9271389) Lu R … Misra V (Molecular and cellular biology 1997) 2 3 4 23
  2. A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. (PMID: 19779205) Kang H … Ko J (Molecular endocrinology (Baltimore, Md.) 2009) 3 4 23
  3. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. (PMID: 17296613) Jang SW … Ko J (The Journal of biological chemistry 2007) 3 4 23
  4. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PMID: 16940180) Liang G … Lu R (Molecular and cellular biology 2006) 3 4 23
  5. Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. (PMID: 15705566) Misra V … Korchinski P (The Journal of biological chemistry 2005) 3 4 23

Products for CREB3 Gene

Sources for CREB3 Gene