Aliases for CREB1 Gene
External Ids for CREB1 Gene
Previous GeneCards Identifiers for CREB1 Gene
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
GeneCards Summary for CREB1 Gene
CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is CREM.
UniProtKB/Swiss-Prot Summary for CREB1 Gene
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.