This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this ... See more...

Aliases for CREB1 Gene

Aliases for CREB1 Gene

  • CAMP Responsive Element Binding Protein 1 2 3 5
  • Cyclic AMP-Responsive Element-Binding Protein 1 3 4
  • CREB-1 3 4
  • Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein CREB 3
  • Cyclic Adenosine 3',5'-Monophosphate Response Element Binding Protein 3
  • CAMP-Responsive Element-Binding Protein 1 4
  • CAMP-Response Element-Binding Protein-1 3
  • Active Transcription Factor CREB 3
  • Transactivator Protein 3
  • CREB1 5
  • CREB 3

External Ids for CREB1 Gene

Previous GeneCards Identifiers for CREB1 Gene

  • GC02P206611
  • GC02P207119
  • GC02P208358
  • GC02P208597
  • GC02P208220
  • GC02P208102
  • GC02P200237
  • GC02P208394

Summaries for CREB1 Gene

Entrez Gene Summary for CREB1 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for CREB1 Gene

CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is CREM.

UniProtKB/Swiss-Prot Summary for CREB1 Gene

  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Wiki entry for CREB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CREB1 Gene

Genomics for CREB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CREB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CREB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CREB1

Top Transcription factor binding sites by QIAGEN in the CREB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for CREB1 Gene

Genomic Locations for CREB1 Gene
chr2:207,529,737-207,605,988
(GRCh38/hg38)
Size:
76,252 bases
Orientation:
Plus strand
chr2:208,394,461-208,470,284
(GRCh37/hg19)
Size:
75,824 bases
Orientation:
Plus strand

Genomic View for CREB1 Gene

Genes around CREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB1 Gene

Proteins for CREB1 Gene

  • Protein details for CREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16220-CREB1_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 1
    Protein Accession:
    P16220
    Secondary Accessions:
    • P21934
    • Q6V963
    • Q9UMA7

    Protein attributes for CREB1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36688 Da
    Quaternary structure:
    • Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-133 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431).
    • (Microbial infection) Interacts with hepatitis B virus/HBV protein X.
    • (Microbial infection) Interacts with HTLV-1 protein Tax.
    Miscellaneous:
    • [Isoform 3]: Highly expressed in adult testis and sperm.

    Three dimensional structures from OCA and Proteopedia for CREB1 Gene

    Alternative splice isoforms for CREB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB1 Gene

Post-translational modifications for CREB1 Gene

  • Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-133 (PubMed:15964553).
  • Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
  • Ubiquitination at Lys136
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CREB1

No data available for DME Specific Peptides for CREB1 Gene

Domains & Families for CREB1 Gene

Gene Families for CREB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CREB1 Gene

InterPro:
Blocks:
  • bZIP transcription factor, bZIP_1
  • cAMP response element binding (CREB) protein signature
  • Coactivator CBP, pKID
ProtoNet:

Suggested Antigen Peptide Sequences for CREB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57667, highly similar to cAMP response element-binding protein (B7Z7P1_HUMAN)
  • Cyclic AMP-responsive element-binding protein 1 (CREB1_HUMAN)
  • cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA (Q53X93_HUMAN)
  • cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA (Q5U0J5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16220

UniProtKB/Swiss-Prot:

CREB1_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREB1: view

Function for CREB1 Gene

Molecular function for CREB1 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
GENATLAS Biochemistry:
cAMP response element binding protein 1 (transcription regulator)

Phenotypes From GWAS Catalog for CREB1 Gene

Gene Ontology (GO) - Molecular Function for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 9065434
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISM 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19861239
GO:0001225 RNA polymerase II transcription coactivator binding IEA --
genes like me logo Genes that share ontologies with CREB1: view
genes like me logo Genes that share phenotypes with CREB1: view

Human Phenotype Ontology for CREB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CREB1 Gene

MGI Knock Outs for CREB1:

Animal Model Products

CRISPR Products

miRNA for CREB1 Gene

miRTarBase miRNAs that target CREB1

Transcription Factor Targets for CREB1 Gene

Selected GeneGlobe predicted Target genes for CREB1
Targeted motifs for CREB1 Gene
HOMER Transcription Factor Regulatory Elements motif CREB1
  • Consensus sequence: CGGTGACGTCAC Submotif: canonical Cell Type: NA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREB1

Clone Products

  • Addgene plasmids for CREB1

No data available for Enzyme Numbers (IUBMB) for CREB1 Gene

Localization for CREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 3
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
cytosol 3
peroxisome 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IDA 8798441
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with CREB1: view

Pathways & Interactions for CREB1 Gene

PathCards logo

SuperPathways for CREB1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 DAG and IP3 signaling
.50
.35
.32
3 RET signaling
4 Aldosterone synthesis and secretion
5 Post NMDA receptor activation events
genes like me logo Genes that share pathways with CREB1: view

Pathways by source for CREB1 Gene

24 GeneGo (Thomson Reuters) pathways for CREB1 Gene
  • Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
  • Beta-2 adrenergic-dependent CFTR expression
  • Development A1 receptor signaling
  • Development A2A receptor signaling
  • Development A2B receptor- action via G-protein alpha s
50 Qiagen pathways for CREB1 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Akt Signaling
  • ATM Pathway
1 Cell Signaling Technology pathway for CREB1 Gene
1 GeneTex pathway for CREB1 Gene

Gene Ontology (GO) - Biological Process for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006468 protein phosphorylation IDA 8798441
GO:0007165 signal transduction TAS 2974179
genes like me logo Genes that share ontologies with CREB1: view

Drugs & Compounds for CREB1 Gene

(94) Drugs for CREB1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naloxone Approved, Vet_approved Pharma Antagonist, Target, other/unknown 348
Adenosine monophosphate Approved, Investigational Nutra Target, activator 0
Citalopram Approved Pharma 597
Magnesium Approved, Experimental, Investigational Pharma 0
cyclic amp Experimental Pharma 0

(49) Additional Compounds for CREB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB1: view

Transcripts for CREB1 Gene

mRNA/cDNA for CREB1 Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CREB1

Clone Products

  • Addgene plasmids for CREB1

Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for CREB1 Gene

GeneLoc Exon Structure for
CREB1

Expression for CREB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREB1 Gene

Protein differential expression in normal tissues from HIPED for CREB1 Gene

This gene is overexpressed in Monocytes (14.1), CD4 Tcells (9.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CREB1 Gene



Protein tissue co-expression partners for CREB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CREB1

SOURCE GeneReport for Unigene cluster for CREB1 Gene:

Hs.516646

Evidence on tissue expression from TISSUES for CREB1 Gene

  • Liver(4.7)
  • Eye(4.6)
  • Nervous system(4.5)
  • Blood(3.9)
  • Muscle(3.5)
  • Skin(3.4)
  • Adrenal gland(3.4)
  • Intestine(3.3)
  • Heart(3.3)
  • Pancreas(3.3)
  • Kidney(3.2)
  • Lung(3.2)
  • Spleen(3.1)
  • Bone marrow(3.1)
  • Lymph node(3.1)
  • Thyroid gland(3.1)
  • Stomach(2.6)
  • Bone(2.6)
  • Gall bladder(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB1 Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Regions:
General:
  • skin
genes like me logo Genes that share expression patterns with CREB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREB1 Gene

Orthologs for CREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CREB1 30 31
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CREB1 30 31
  • 96.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CREB1 30 31
  • 95.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Creb1 30 17 31
  • 95.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Creb1 30
  • 95.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia CREB1 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CREB1 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CREB1 30 31
  • 85.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CREB1 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia creb1 30
  • 82.47 (n)
Str.10048 30
African clawed frog
(Xenopus laevis)
Amphibia creb1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii creb1b 31
  • 91 (a)
OneToMany
creb1a 30 31
  • 76.52 (n)
OneToMany
zgc55598 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6298 30
Fruit Fly
(Drosophila melanogaster)
Insecta CrebB-17A 31
  • 29 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea crh-1