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Aliases for CRCT1 Gene

Aliases for CRCT1 Gene

  • Cysteine Rich C-Terminal 1 2 3 5
  • Protein NICE-1 3 4
  • C1orf42 3 4
  • NICE1 3 4
  • Cysteine-Rich C-Terminal Protein 1 3
  • Chromosome 1 Open Reading Frame 42 2
  • Cysteine-Rich C-Terminal 1 2
  • NICE-1 3

External Ids for CRCT1 Gene

Previous HGNC Symbols for CRCT1 Gene

  • C1orf42

Previous GeneCards Identifiers for CRCT1 Gene

  • GC01P150756
  • GC01P152486
  • GC01P123860

Summaries for CRCT1 Gene

GeneCards Summary for CRCT1 Gene

CRCT1 (Cysteine Rich C-Terminal 1) is a Protein Coding gene.

Additional gene information for CRCT1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCT1 Gene

Genomics for CRCT1 Gene

GeneHancer (GH) Regulatory Elements for CRCT1 Gene

Promoters and enhancers for CRCT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152514 Promoter 0.5 EPDnew 650.7 0.0 -39 0.1 CRCT1 LCE5A
GH01J152459 Enhancer 1 Ensembl ENCODE 10.4 -54.2 -54199 1.4 HDGF SIX4 CTCF PKNOX1 EBF1 YBX1 RAD21 ZFHX2 POLR2A SMC3 CRCT1 LCE5A S100A11 RPTN CRNN PIR42758
GH01J152461 Enhancer 0.7 ENCODE 10.4 -52.7 -52742 0.2 CTCF CEBPG BMI1 RAD21 GATA3 ZNF143 SMC3 ZNF444 SRF SMARCA5 CRCT1 LCE5A S100A11 RPTN PIR42758
GH01J152458 Enhancer 0.6 ENCODE 9.9 -55.9 -55922 0.2 SMARCA5 CTCF PKNOX1 ZNF654 TRIM22 RAD21 RFX5 ZNF217 GATA3 ZNF341 FLG2 CRCT1 RPTN PIR42758 LCE5A
GH01J152480 Enhancer 0.4 ENCODE 11.1 -34.2 -34242 0.2 PCBP2 SMARCA5 CTCF LCE5A CRCT1 LCE3A LCE3D HRNR CRNN PIR42758
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRCT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRCT1 gene promoter:
  • p53
  • GATA-1
  • AML1a
  • LyF-1
  • FOXI1
  • C/EBPbeta
  • HFH-3
  • Ik-2
  • JunB

Genomic Locations for CRCT1 Gene

Genomic Locations for CRCT1 Gene
1,509 bases
Plus strand
1,509 bases
Plus strand

Genomic View for CRCT1 Gene

Genes around CRCT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRCT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCT1 Gene

Proteins for CRCT1 Gene

  • Protein details for CRCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich C-terminal protein 1
    Protein Accession:
    Secondary Accessions:
    • A4QN00
    • Q6IAD7

    Protein attributes for CRCT1 Gene

    99 amino acids
    Molecular mass:
    9736 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRCT1 Gene

Post-translational modifications for CRCT1 Gene

No Post-translational modifications

Other Protein References for CRCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRCT1 Gene

Domains & Families for CRCT1 Gene

Gene Families for CRCT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRCT1 Gene


Suggested Antigen Peptide Sequences for CRCT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRCT1: view

No data available for UniProtKB/Swiss-Prot for CRCT1 Gene

Function for CRCT1 Gene

Phenotypes From GWAS Catalog for CRCT1 Gene

Gene Ontology (GO) - Molecular Function for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRCT1: view
genes like me logo Genes that share phenotypes with CRCT1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRCT1 Gene

Localization for CRCT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRCT1 gene
Compartment Confidence
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CRCT1 Gene

Pathways & Interactions for CRCT1 Gene

SuperPathways for CRCT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRCT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRCT1 Gene

Drugs & Compounds for CRCT1 Gene

No Compound Related Data Available

Transcripts for CRCT1 Gene

mRNA/cDNA for CRCT1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRCT1 Gene

Cysteine-rich C-terminal 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRCT1 Gene

No ASD Table

Relevant External Links for CRCT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRCT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRCT1 Gene

mRNA differential expression in normal tissues according to GTEx for CRCT1 Gene

This gene is overexpressed in Esophagus - Mucosa (x26.4), Vagina (x9.2), and Cervix - Ectocervix (x8.1).

Protein differential expression in normal tissues from HIPED for CRCT1 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRCT1 Gene

Protein tissue co-expression partners for CRCT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRCT1 Gene:


SOURCE GeneReport for Unigene cluster for CRCT1 Gene:

genes like me logo Genes that share expression patterns with CRCT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRCT1 Gene

Orthologs for CRCT1 Gene

Evolution for CRCT1 Gene

Gene Tree for CRCT1 (if available)
Gene Tree for CRCT1 (if available)
Evolutionary constrained regions (ECRs) for CRCT1: view image

No data available for Orthologs for CRCT1 Gene

Paralogs for CRCT1 Gene

No data available for Paralogs for CRCT1 Gene

Variants for CRCT1 Gene

Sequence variations from dbSNP and Humsavar for CRCT1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000945768 -- 152,515,182(+) A/G intron_variant
rs1001119443 -- 152,514,578(+) G/A intron_variant
rs1001708475 -- 152,515,955(+) A/G 3_prime_UTR_variant
rs1002123755 -- 152,515,752(+) G/T 3_prime_UTR_variant
rs1002177519 -- 152,515,999(+) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CRCT1 Gene

Variant ID Type Subtype PubMed ID
dgv415n100 CNV loss 25217958
esv2750810 CNV gain 17911159
esv2758970 CNV gain+loss 17122850
nsv518413 CNV loss 19592680
nsv524241 CNV loss 19592680

Variation tolerance for CRCT1 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRCT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRCT1 Gene

Disorders for CRCT1 Gene

Additional Disease Information for CRCT1

No disorders were found for CRCT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRCT1 Gene

Publications for CRCT1 Gene

  1. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I … Mischke D (Genome research 2001) 2 3 4 58
  2. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. (PMID: 21804549) Torgerson DG … Nicolae DL (Nature genetics 2011) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer. (PMID: 26718216) Wu N … Chen Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58

Products for CRCT1 Gene

Sources for CRCT1 Gene

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