This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] See more...

Aliases for CRCP Gene

Aliases for CRCP Gene

  • CGRP Receptor Component 2 3 5
  • Calcitonin Gene-Related Peptide-Receptor Component Protein 2 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC9 3 4
  • CGRP-Receptor Component Protein 3 4
  • RNA Polymerase III Subunit C9 3 4
  • CGRP-RCP 3 4
  • CGRPRCP 3 4
  • HsC17 4
  • RCP9 3
  • RPC9 3
  • RCP 3

External Ids for CRCP Gene

Previous GeneCards Identifiers for CRCP Gene

  • GC07P065216
  • GC07P065578
  • GC07P061767

Summaries for CRCP Gene

Entrez Gene Summary for CRCP Gene

  • This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRCP Gene

CRCP (CGRP Receptor Component) is a Protein Coding gene. Diseases associated with CRCP include Communicating Hydrocephalus. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include nucleotide binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot Summary for CRCP Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
  • Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Gene Wiki entry for CRCP Gene

Additional gene information for CRCP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRCP Gene

Genomics for CRCP Gene

GeneHancer (GH) Regulatory Elements for CRCP Gene

Promoters and enhancers for CRCP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRCP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRCP

Top Transcription factor binding sites by QIAGEN in the CRCP gene promoter:
  • C/EBPalpha
  • FOXC1
  • FOXF2
  • FOXO1
  • FOXO1a
  • FOXO3a
  • FOXO3b
  • FOXO4
  • HFH-1
  • Ik-2

Genomic Locations for CRCP Gene

Genomic Locations for CRCP Gene
chr7:66,114,604-66,154,568
(GRCh38/hg38)
Size:
39,965 bases
Orientation:
Plus strand
chr7:65,579,591-65,619,555
(GRCh37/hg19)
Size:
39,965 bases
Orientation:
Plus strand

Genomic View for CRCP Gene

Genes around CRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCP Gene

Proteins for CRCP Gene

  • Protein details for CRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75575-RPC9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC9
    Protein Accession:
    O75575
    Secondary Accessions:
    • A8MUZ4
    • A8MW23
    • B2R4H4
    • B4E198
    • Q3KRA3
    • Q5HYF1
    • Q8IXL4

    Protein attributes for CRCP Gene

    Size:
    148 amino acids
    Molecular mass:
    16871 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.

    Alternative splice isoforms for CRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRCP Gene

Post-translational modifications for CRCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRCP Gene

Domains & Families for CRCP Gene

Gene Families for CRCP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRCP Gene

Suggested Antigen Peptide Sequences for CRCP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58973, highly similar to Homo sapiens calcitonin gene-related peptide-receptor component protein, transcript variant 2, mRNA (B4E198_HUMAN)
  • Calcitonin gene-related peptide-receptor component protein (RPC9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75575

UniProtKB/Swiss-Prot:

RPC9_HUMAN :
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
genes like me logo Genes that share domains with CRCP: view

Function for CRCP Gene

Molecular function for CRCP Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
UniProtKB/Swiss-Prot Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Phenotypes From GWAS Catalog for CRCP Gene

Gene Ontology (GO) - Molecular Function for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001056 contributes_to RNA polymerase III activity IBA 21873635
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0003824 catalytic activity IEA --
GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEA,IDA 12482973
genes like me logo Genes that share ontologies with CRCP: view
genes like me logo Genes that share phenotypes with CRCP: view

Animal Model Products

CRISPR Products

miRNA for CRCP Gene

miRTarBase miRNAs that target CRCP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRCP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRCP Gene

Localization for CRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRCP Gene

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRCP gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005623 cell IDA 11804624
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 RNA polymerase III complex IBA 21873635
genes like me logo Genes that share ontologies with CRCP: view

Pathways & Interactions for CRCP Gene

genes like me logo Genes that share pathways with CRCP: view

Gene Ontology (GO) - Biological Process for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006383 transcription by RNA polymerase III IDA 12482973
GO:0006384 transcription initiation from RNA polymerase III promoter IBA 21873635
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with CRCP: view

No data available for SIGNOR curated interactions for CRCP Gene

Drugs & Compounds for CRCP Gene

(1) Drugs for CRCP Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-3207 HCl Pharma 0 0

(1) ApexBio Compounds for CRCP Gene

Compound Action Cas Number
MK-3207 HCl 0 957116-20-0
genes like me logo Genes that share compounds with CRCP: view

Drug Products

Transcripts for CRCP Gene

mRNA/cDNA for CRCP Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRCP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRCP Gene

No ASD Table

Relevant External Links for CRCP Gene

GeneLoc Exon Structure for
CRCP

Expression for CRCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRCP Gene

Protein differential expression in normal tissues from HIPED for CRCP Gene

This gene is overexpressed in CD8 Tcells (47.6), Prostate (10.7), and Urinary Bladder (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRCP Gene



Protein tissue co-expression partners for CRCP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRCP

SOURCE GeneReport for Unigene cluster for CRCP Gene:

Hs.300684

mRNA Expression by UniProt/SwissProt for CRCP Gene:

O75575-RPC9_HUMAN
Tissue specificity: Ubiquitous. Most prevalent in testis.

Evidence on tissue expression from TISSUES for CRCP Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Adrenal gland(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with CRCP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRCP Gene

Orthologs for CRCP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRCP 31 30
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRCP 31 30
  • 90.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRCP 31 30
  • 88.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crcp 17 31 30
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Crcp 30
  • 83.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRCP 31
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRCP 31
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRCP 31 30
  • 78.7 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crcp 30
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii crcp 31 30
  • 68.09 (n)
OneToOne
Dr.15889 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007220 30
  • 52.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rcp 31 30
  • 48.23 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M106.7 31
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea Cin.13606 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13606 30
Species where no ortholog for CRCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRCP Gene

ENSEMBL:
Gene Tree for CRCP (if available)
TreeFam:
Gene Tree for CRCP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRCP: view image

Paralogs for CRCP Gene

(38) SIMAP similar genes for CRCP Gene using alignment to 3 proteins:

  • RPC9_HUMAN
  • C9J2T4_HUMAN
  • H7BY40_HUMAN

Pseudogenes.org Pseudogenes for CRCP Gene

genes like me logo Genes that share paralogs with CRCP: view

No data available for Paralogs for CRCP Gene

Variants for CRCP Gene

Additional dbSNP identifiers (rs#s) for CRCP Gene

Structural Variations from Database of Genomic Variants (DGV) for CRCP Gene

Variant ID Type Subtype PubMed ID
dgv1113n67 CNV loss 20364138
dgv11431n54 CNV loss 21841781
dgv11432n54 CNV loss 21841781
dgv11433n54 CNV loss 21841781
esv1751958 CNV insertion 17803354
esv2656542 CNV deletion 23128226
esv2664145 CNV deletion 23128226
esv2674673 CNV deletion 23128226
esv27174 CNV loss 19812545
esv2761079 CNV gain+loss 21179565
esv3541796 CNV deletion 23714750
esv3571888 CNV loss 25503493
esv3613500 CNV loss 21293372
esv3613502 CNV loss 21293372
nsv1021186 CNV gain 25217958
nsv511363 CNV loss 21212237
nsv511969 CNV loss 21212237
nsv607396 CNV loss 21841781
nsv607400 CNV loss 21841781
nsv607414 CNV loss 21841781

Variation tolerance for CRCP Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRCP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRCP Gene

Disorders for CRCP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRCP Gene - From: DISEASES

Disorder Aliases PubMed IDs
communicating hydrocephalus
- elite association - COSMIC cancer census association via MalaCards
Search CRCP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRCP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRCP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRCP Gene

Publications for CRCP Gene

  1. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PMID: 12482973) Siaut M … Conesa C (Molecular and cellular biology 2003) 2 3 4 23 54
  2. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PMID: 10067875) Balkan W … Roos BA (Endocrinology 1999) 2 3 4 23 54
  3. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PMID: 21223598) Wineinger NE … Tiwari HK (BMC medical genomics 2011) 3 41 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. (PMID: 17853344) Goharkhay N … Wing DA (American journal of perinatology 2007) 3 23 54

Products for CRCP Gene

Sources for CRCP Gene