Aliases for CRB3 Gene
External Ids for CRB3 Gene
Previous GeneCards Identifiers for CRB3 Gene
This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
GeneCards Summary for CRB3 Gene
CRB3 (Crumbs Cell Polarity Complex Component 3) is a Protein Coding gene. Diseases associated with CRB3 include Charcot-Marie-Tooth Disease, Demyelinating, Type 4F and Retinitis Pigmentosa 12. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and SH3 domain binding. An important paralog of this gene is CRB2.
UniProtKB/Swiss-Prot Summary for CRB3 Gene
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.