Aliases for CRB2 Gene
External Ids for CRB2 Gene
Previous GeneCards Identifiers for CRB2 Gene
This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016]
GeneCards Summary for CRB2 Gene
CRB2 (Crumbs 2, Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with CRB2 include Ventriculomegaly With Cystic Kidney Disease and Focal Segmental Glomerulosclerosis 9. Among its related pathways are Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and aspartic-type endopeptidase inhibitor activity. An important paralog of this gene is CRB1.
UniProtKB/Swiss-Prot for CRB2 Gene
Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex.