Aliases for CRAT Gene
External Ids for CRAT Gene
Previous GeneCards Identifiers for CRAT Gene
This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016]
GeneCards Summary for CRAT Gene
CRAT (Carnitine O-Acetyltransferase) is a Protein Coding gene. Diseases associated with CRAT include Neurodegeneration With Brain Iron Accumulation 8 and Neurodegeneration With Brain Iron Accumulation. Among its related pathways are AMPK Enzyme Complex Pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and carnitine O-acetyltransferase activity. An important paralog of this gene is CHAT.
UniProtKB/Swiss-Prot Summary for CRAT Gene
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643).