Aliases for CRAMP1 Gene

Aliases for CRAMP1 Gene

  • Cramped Chromatin Regulator Homolog 1 2 3 4 5
  • Hematological And Neurological Expressed 1-Like Protein 3 4
  • Protein Cramped-Like 3 4
  • KIAA1426 2 4
  • CRAMP1L 3 4
  • HN1L 3 4
  • Crm, Cramped-Like (Drosophila) 2
  • Crm (Cramped Drosophila)-Like 2
  • T-Complex Expressed Gene 4 3
  • Crm, Cramped-Like 3
  • C16orf34 4
  • CRAMP1 5
  • TCE4 3

External Ids for CRAMP1 Gene

Previous HGNC Symbols for CRAMP1 Gene


Previous GeneCards Identifiers for CRAMP1 Gene

  • GC16P001613
  • GC16P001615
  • GC16P001628

Summaries for CRAMP1 Gene

GeneCards Summary for CRAMP1 Gene

CRAMP1 (Cramped Chromatin Regulator Homolog 1) is a Protein Coding gene. Diseases associated with CRAMP1 include Deafness, Autosomal Dominant 40. An important paralog of this gene is ENSG00000261732.

Additional gene information for CRAMP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRAMP1 Gene

Genomics for CRAMP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRAMP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRAMP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRAMP1

Genomic Locations for CRAMP1 Gene

Genomic Locations for CRAMP1 Gene
65,572 bases
Plus strand
65,584 bases
Plus strand

Genomic View for CRAMP1 Gene

Genes around CRAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRAMP1 Gene

Proteins for CRAMP1 Gene

  • Protein details for CRAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein cramped-like
    Protein Accession:
    Secondary Accessions:
    • A8MZL1
    • B1AJY1
    • Q8NDN1
    • Q9P2C1

    Protein attributes for CRAMP1 Gene

    1269 amino acids
    Molecular mass:
    134718 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAD38692.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for CRAMP1 Gene

Post-translational modifications for CRAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRAMP1 Gene

No data available for DME Specific Peptides for CRAMP1 Gene

Domains & Families for CRAMP1 Gene

Gene Families for CRAMP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CRAMP1 Gene


Suggested Antigen Peptide Sequences for CRAMP1 Gene

GenScript: Design optimal peptide antigens:
  • Crm, cramped-like (Drosophila) (A7MD53_HUMAN)
  • Hematological and neurological expressed 1-like protein (CRML_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cramped family.
  • Belongs to the cramped family.
genes like me logo Genes that share domains with CRAMP1: view

Function for CRAMP1 Gene

Phenotypes From GWAS Catalog for CRAMP1 Gene

Gene Ontology (GO) - Molecular Function for CRAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA 21873635
genes like me logo Genes that share ontologies with CRAMP1: view
genes like me logo Genes that share phenotypes with CRAMP1: view

Animal Model Products

CRISPR Products

miRNA for CRAMP1 Gene

miRTarBase miRNAs that target CRAMP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRAMP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRAMP1 Gene

Localization for CRAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRAMP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRAMP1 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with CRAMP1: view

Pathways & Interactions for CRAMP1 Gene

PathCards logo

SuperPathways for CRAMP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRAMP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRAMP1 Gene

Drugs & Compounds for CRAMP1 Gene

No Compound Related Data Available

Transcripts for CRAMP1 Gene

mRNA/cDNA for CRAMP1 Gene

8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRAMP1

Alternative Splicing Database (ASD) splice patterns (SP) for CRAMP1 Gene

No ASD Table

Relevant External Links for CRAMP1 Gene

GeneLoc Exon Structure for

Expression for CRAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRAMP1

Evidence on tissue expression from TISSUES for CRAMP1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CRAMP1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRAMP1 Gene

Orthologs for CRAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRAMP1L 30 31
  • 97.68 (n)
(Canis familiaris)
Mammalia CRAMP1L 30 31
  • 84.67 (n)
(Bos Taurus)
Mammalia CRAMP1L 30 31
  • 83.97 (n)
(Mus musculus)
Mammalia Cramp1l 30 17 31
  • 81.7 (n)
(Rattus norvegicus)
Mammalia Cramp1l 30
  • 81.63 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
(Monodelphis domestica)
Mammalia CRAMP1L 31
  • 68 (a)
(Gallus gallus)
Aves CRAMP1L 30
  • 72.3 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cramp1l 30
  • 64.69 (n)
(Danio rerio)
Actinopterygii cramp1l 30
  • 63.36 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta crm 31
  • 23 (a)
(Caenorhabditis elegans)
Secernentea R151.8 31
  • 20 (a)
Species where no ortholog for CRAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CRAMP1 Gene

Gene Tree for CRAMP1 (if available)
Gene Tree for CRAMP1 (if available)
Evolutionary constrained regions (ECRs) for CRAMP1: view image

Paralogs for CRAMP1 Gene

Paralogs for CRAMP1 Gene

genes like me logo Genes that share paralogs with CRAMP1: view

Variants for CRAMP1 Gene

Additional dbSNP identifiers (rs#s) for CRAMP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRAMP1 Gene

Variant ID Type Subtype PubMed ID
dgv4855n54 CNV loss 21841781
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv3637620 CNV loss 21293372
esv3637621 CNV loss 21293372
nsv1051692 CNV loss 25217958
nsv1143803 CNV deletion 24896259
nsv428317 CNV gain 18775914
nsv518641 CNV loss 19592680
nsv827496 CNV gain 20364138
nsv827497 CNV gain 20364138
nsv833118 CNV loss 17160897

Variation tolerance for CRAMP1 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRAMP1 Gene

Disorders for CRAMP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRAMP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal dominant 40
  • dfna40
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CRAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRAMP1 Gene

Publications for CRAMP1 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  3. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for CRAMP1 Gene

Sources for CRAMP1 Gene