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Aliases for CRADD Gene

Aliases for CRADD Gene

  • CASP2 And RIPK1 Domain Containing Adaptor With Death Domain 2 3 5
  • RIP-Associated ICH1/CED3-Homologous Protein With Death Domain 2 3
  • RAIDD 3 4
  • RIP-Associated Protein With A Death Domain 4
  • Caspase And RIP Adaptor With Death Domain 3
  • Caspase And RIP Adapter With Death Domain 4
  • Death Domain Containing Protein CRADD 3
  • Death Domain-Containing Protein CRADD 3
  • Death Adaptor Molecule RAIDD 3
  • CRADD/LYZ Fusion 3
  • MRT34 3

External Ids for CRADD Gene

Previous GeneCards Identifiers for CRADD Gene

  • GC12P093603
  • GC12P094592
  • GC12P094004
  • GC12P092573
  • GC12P092595
  • GC12P091137

Summaries for CRADD Gene

Entrez Gene Summary for CRADD Gene

  • This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CRADD Gene

CRADD (CASP2 And RIPK1 Domain Containing Adaptor With Death Domain) is a Protein Coding gene. Diseases associated with CRADD include Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Gene Expression and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include protease binding and death domain binding.

UniProtKB/Swiss-Prot for CRADD Gene

  • Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Gene Wiki entry for CRADD Gene

Additional gene information for CRADD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRADD Gene

Genomics for CRADD Gene

GeneHancer (GH) Regulatory Elements for CRADD Gene

Promoters and enhancers for CRADD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J093676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.5 525 2.8 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CRADD ENSG00000258365 LOC101928731
GH12J093782 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +108.0 107961 5.6 PKNOX1 ARID4B SIN3A FEZF1 BRCA1 TCF12 ZNF766 GATA2 FOS RXRA SOCS2 CRADD GC12P093788 GC12M093698
GH12J094147 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.2 +473.2 473191 5.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 YY1 ZNF207 ZNF143 SP3 SP5 PLXNC1 GC12P094149 TMCC3 NR2C1 ENSG00000258365 ENSG00000271382 CRADD ENSG00000258035
GH12J093373 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -303.4 -303363 1.7 HDGF SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 ATF7 CAVIN1 GC12P093373 ENSG00000257252 NUDT4 ENSG00000257512 CRADD LOC643339 GC12M093281 GC12P093160
GH12J093447 Enhancer 0.6 FANTOM5 ENCODE 2.2 -229.4 -229406 1.4 KAT7 BATF EGR2 CRADD UBE2N GC12M093461 ENSG00000200011
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRADD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRADD gene promoter:
  • SRF (504 AA)
  • SRF
  • Gfi-1
  • FOXD1
  • STAT1
  • STAT1alpha
  • STAT2
  • STAT3

Genomic Locations for CRADD Gene

Genomic Locations for CRADD Gene
chr12:93,677,351-93,894,840
(GRCh38/hg38)
Size:
217,490 bases
Orientation:
Plus strand
chr12:94,071,151-94,288,616
(GRCh37/hg19)
Size:
217,466 bases
Orientation:
Plus strand

Genomic View for CRADD Gene

Genes around CRADD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRADD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRADD Gene

Proteins for CRADD Gene

  • Protein details for CRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78560-CRADD_HUMAN
    Recommended name:
    Death domain-containing protein CRADD
    Protein Accession:
    P78560
    Secondary Accessions:
    • B7Z2Q5

    Protein attributes for CRADD Gene

    Size:
    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts with PIDD.

    Three dimensional structures from OCA and Proteopedia for CRADD Gene

    Alternative splice isoforms for CRADD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRADD Gene

Post-translational modifications for CRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRADD Gene

Domains & Families for CRADD Gene

Gene Families for CRADD Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CRADD Gene

Graphical View of Domain Structure for InterPro Entry

P78560

UniProtKB/Swiss-Prot:

CRADD_HUMAN :
  • Contains a death domain involved in the binding of RIP protein.
Domain:
  • Contains a death domain involved in the binding of RIP protein.
  • The CARD domain mediates the interaction with caspase-2.
genes like me logo Genes that share domains with CRADD: view

Function for CRADD Gene

Molecular function for CRADD Gene

UniProtKB/Swiss-Prot Function:
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
GENATLAS Biochemistry:
caspase 2 and RIPK2 adaptor containing with DEATH domain

Phenotypes From GWAS Catalog for CRADD Gene

Gene Ontology (GO) - Molecular Function for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9044836
GO:0005515 protein binding IPI 8985253
GO:0030674 protein binding, bridging IPI 9044836
GO:0070513 death domain binding IPI 9044836
genes like me logo Genes that share ontologies with CRADD: view
genes like me logo Genes that share phenotypes with CRADD: view

Human Phenotype Ontology for CRADD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CRADD Gene

MGI Knock Outs for CRADD:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRADD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRADD Gene

Localization for CRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRADD Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRADD gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0032449 CBM complex IBA --
genes like me logo Genes that share ontologies with CRADD: view

Pathways & Interactions for CRADD Gene

genes like me logo Genes that share pathways with CRADD: view

Gene Ontology (GO) - Biological Process for CRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP 21726810
GO:0007165 signal transduction IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IC 9044836
genes like me logo Genes that share ontologies with CRADD: view

No data available for SIGNOR curated interactions for CRADD Gene

Drugs & Compounds for CRADD Gene

No Compound Related Data Available

Transcripts for CRADD Gene

Unigene Clusters for CRADD Gene

CASP2 and RIPK1 domain containing adaptor with death domain:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRADD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - -

Relevant External Links for CRADD Gene

GeneLoc Exon Structure for
CRADD
ECgene alternative splicing isoforms for
CRADD

Expression for CRADD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRADD Gene

Protein differential expression in normal tissues from HIPED for CRADD Gene

This gene is overexpressed in Rectum (11.9), Cardia (7.4), and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRADD Gene



Protein tissue co-expression partners for CRADD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRADD Gene:

CRADD

SOURCE GeneReport for Unigene cluster for CRADD Gene:

Hs.591016

mRNA Expression by UniProt/SwissProt for CRADD Gene:

P78560-CRADD_HUMAN
Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Evidence on tissue expression from TISSUES for CRADD Gene

  • Nervous system(4.4)
  • Intestine(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CRADD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • skull
  • tooth
Thorax:
  • chest wall
  • heart
Abdomen:
  • abdominal wall
Limb:
  • foot
  • lower limb
General:
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
genes like me logo Genes that share expression patterns with CRADD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRADD Gene

Orthologs for CRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRADD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRADD 34 33
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRADD 34 33
  • 88.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cradd 16 34 33
  • 86.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRADD 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRADD 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRADD 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRADD 34 33
  • 69.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRADD 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489885 33
  • 59.39 (n)
zebrafish
(Danio rerio)
Actinopterygii cradd 34 33
  • 57.22 (n)
OneToOne
Species where no ortholog for CRADD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRADD Gene

ENSEMBL:
Gene Tree for CRADD (if available)
TreeFam:
Gene Tree for CRADD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRADD: view image

Paralogs for CRADD Gene

(1) SIMAP similar genes for CRADD Gene using alignment to 8 proteins:

  • CRADD_HUMAN
  • B5BU44_HUMAN
  • B7Z2Q5_HUMAN
  • F5H7C2_HUMAN
  • F8VV49_HUMAN
  • F8VVY5_HUMAN
  • Q53XL1_HUMAN
  • Q8IY43_HUMAN

Pseudogenes.org Pseudogenes for CRADD Gene

genes like me logo Genes that share paralogs with CRADD: view

No data available for Paralogs for CRADD Gene

Variants for CRADD Gene

Sequence variations from dbSNP and Humsavar for CRADD Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs141179774 pathogenic, Mental retardation, autosomal recessive 34 93,850,180(+) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs370916968 pathogenic, Mental retardation, autosomal recessive 34 93,850,162(+) T/G coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs387906861 pathogenic, Mental retardation, autosomal recessive 34, Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34) [MIM:614499] 93,850,053(+) G/C coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs749655461 pathogenic, Mental retardation, autosomal recessive 34 93,850,179(+) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs746685035 uncertain-significance, not specified 93,850,168(+) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CRADD Gene

Variant ID Type Subtype PubMed ID
esv2661164 CNV deletion 23128226
esv2671632 CNV deletion 23128226
esv3549594 CNV deletion 23714750
esv3630402 CNV loss 21293372
esv3630403 CNV loss 21293372
nsv442284 CNV loss 18776908
nsv477449 CNV novel sequence insertion 20440878
nsv510310 OTHER sequence alteration 20534489
nsv523282 CNV loss 19592680
nsv524248 CNV loss 19592680
nsv525412 CNV loss 19592680
nsv529049 CNV loss 19592680
nsv7234 OTHER inversion 18451855
nsv825 CNV insertion 18451855
nsv826 CNV deletion 18451855
nsv826492 CNV loss 20364138
nsv9000 CNV gain 18304495

Variation tolerance for CRADD Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRADD Gene

Human Gene Mutation Database (HGMD)
CRADD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRADD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRADD Gene

Disorders for CRADD Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRADD Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CRADD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRADD_HUMAN
  • Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. {ECO:0000269 PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CRADD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRADD: view

No data available for Genatlas for CRADD Gene

Publications for CRADD Gene

  1. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. (PMID: 16652156) Vakifahmetoglu H … Zhivotovsky B (Oncogene 2006) 3 4 22 58
  2. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. (PMID: 9695946) Chou JJ … Wagner G (Cell 1998) 3 4 22 58
  3. RAIDD is a new 'death' adaptor molecule. (PMID: 8985253) Duan H … Dixit VM (Nature 1997) 2 3 4 58
  4. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. (PMID: 9044836) Ahmad M … Alnemri ES (Cancer research 1997) 2 3 4 58
  5. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PMID: 22279524) Puffenberger EG … Strauss KA (PloS one 2012) 3 4 58

Products for CRADD Gene

Sources for CRADD Gene

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