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Aliases for CRABP2 Gene

Aliases for CRABP2 Gene

  • Cellular Retinoic Acid Binding Protein 2 2 3 5
  • Cellular Retinoic Acid-Binding Protein II 3 4
  • Cellular Retinoic Acid-Binding Protein 2 2 3
  • CRABP-II 3 4
  • RBP6 3

External Ids for CRABP2 Gene

Previous GeneCards Identifiers for CRABP2 Gene

  • GC01M154538
  • GC01M152434
  • GC01M153447
  • GC01M153886
  • GC01M153482
  • GC01M154936
  • GC01M156669
  • GC01M128026

Summaries for CRABP2 Gene

Entrez Gene Summary for CRABP2 Gene

  • This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

GeneCards Summary for CRABP2 Gene

CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with CRABP2 include Embryonal Carcinoma and Basal Cell Carcinoma. Among its related pathways are PEDF Induced Signaling and Vitamin A and Carotenoid Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP1.

UniProtKB/Swiss-Prot for CRABP2 Gene

  • Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP2 Gene

Additional gene information for CRABP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP2 Gene

Genomics for CRABP2 Gene

GeneHancer (GH) Regulatory Elements for CRABP2 Gene

Promoters and enhancers for CRABP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156703 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.6 -1.8 -1823 8.3 HDGF ARNT SIN3A ZNF2 ZBTB7B ZNF213 E2F8 ZNF143 FOS KLF13 CRABP2 GLMP PEAR1 ENSG00000223356
GH01J156725 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.3 -22.0 -21971 5.1 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 GLIS1 NBN ISG20L2 RRNAD1 CRABP2 HDGF MRPL24 GC01M156724 PIR61627
GH01J156689 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.3 +13.8 13816 6 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A ZBTB7B SLC30A9 POLR2B ZNF766 RRNAD1 ENSG00000237588 KHDC4 GON4L MSTO2P PRCC LOC246784 CCT3 LOC105371453 BCAN
GH01J156696 Enhancer 0.5 dbSUPER 7.6 +8.3 8325 2 MITF GLIS2 USF1 ZBTB33 ZIC2 PRDM1 NES LOC105371453 BCAN RRNAD1 ISG20L2 HDGF PRCC NAXE CRABP2 ENSG00000237588
GH01J156700 Enhancer 0.4 dbSUPER 7.6 +4.5 4451 1 ZNF316 MAFK CRABP2 ENSG00000237588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CRABP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRABP2 gene promoter:

Genomic Locations for CRABP2 Gene

Genomic Locations for CRABP2 Gene
6,211 bases
Minus strand

Genomic View for CRABP2 Gene

Genes around CRABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP2 Gene

Proteins for CRABP2 Gene

  • Protein details for CRABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cellular retinoic acid-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R4Z8
    • D3DVC5
    • F1T098
    • Q6ICN6

    Protein attributes for CRABP2 Gene

    138 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    • Interacts with RXR and RARA (By similarity). Interacts with importin alpha.

    Three dimensional structures from OCA and Proteopedia for CRABP2 Gene

neXtProt entry for CRABP2 Gene

Post-translational modifications for CRABP2 Gene

  • Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP2 Gene

No data available for DME Specific Peptides for CRABP2 Gene

Domains & Families for CRABP2 Gene

Gene Families for CRABP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRABP2 Gene

Suggested Antigen Peptide Sequences for CRABP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP2: view

Function for CRABP2 Gene

Molecular function for CRABP2 Gene

UniProtKB/Swiss-Prot Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.
GENATLAS Biochemistry:
retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)

Phenotypes From GWAS Catalog for CRABP2 Gene

Gene Ontology (GO) - Molecular Function for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005501 retinoid binding TAS 1334086
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with CRABP2: view
genes like me logo Genes that share phenotypes with CRABP2: view

Animal Models for CRABP2 Gene

MGI Knock Outs for CRABP2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP2 Gene

Localization for CRABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP2 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRABP2 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRABP2: view

Pathways & Interactions for CRABP2 Gene

genes like me logo Genes that share pathways with CRABP2: view

SIGNOR curated interactions for CRABP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 1334086
GO:0007165 signal transduction TAS 1654334
GO:0008544 epidermis development TAS 1654334
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0042573 retinoic acid metabolic process IEA --
genes like me logo Genes that share ontologies with CRABP2: view

Drugs & Compounds for CRABP2 Gene

(15) Drugs for CRABP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Transporter, substrate 242
Alitretinoin Approved, Investigational Pharma Agonist, Carrier, agonist 17
1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene Experimental Pharma Carrier 0
6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID Experimental Pharma Carrier 0
Ro 12-7310 Experimental Pharma Carrier 0

(11) Additional Compounds for CRABP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRABP2: view

Transcripts for CRABP2 Gene

mRNA/cDNA for CRABP2 Gene

Unigene Clusters for CRABP2 Gene

Cellular retinoic acid binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for CRABP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRABP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.1), Vagina (x9.2), and Cervix - Ectocervix (x5.2).

Protein differential expression in normal tissues from HIPED for CRABP2 Gene

This gene is overexpressed in Breast (24.0), Urine (7.6), Oral epithelium (7.0), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRABP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRABP2 Gene:


SOURCE GeneReport for Unigene cluster for CRABP2 Gene:


Evidence on tissue expression from TISSUES for CRABP2 Gene

  • Nervous system(4.5)
  • Eye(4.3)
  • Intestine(4.2)
  • Pancreas(3.9)
  • Skin(3.2)
genes like me logo Genes that share expression patterns with CRABP2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRABP2 Gene

Orthologs for CRABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRABP2 34 33
  • 99.76 (n)
(Bos Taurus)
Mammalia CRABP2 34 33
  • 93.96 (n)
(Monodelphis domestica)
Mammalia CRABP2 34
  • 93 (a)
(Canis familiaris)
Mammalia CRABP2 34 33
  • 89.86 (n)
(Mus musculus)
Mammalia Crabp2 16 34 33
  • 89.37 (n)
(Gallus gallus)
Aves CRABP2 34
  • 76 (a)
(Anolis carolinensis)
Reptilia CRABP2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp2 33
  • 80.19 (n)
Str.1681 33
African clawed frog
(Xenopus laevis)
Amphibia crabp2-A 33
(Danio rerio)
Actinopterygii crabp2a 34 34 33
  • 70.77 (n)
crabp2b 34
  • 66 (a)
crabp2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9548 33
fruit fly
(Drosophila melanogaster)
Insecta fabp 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea lbp-6 34
  • 44 (a)
lbp-5 34
  • 38 (a)
lbp-7 34
  • 36 (a)
lbp-8 34
  • 35 (a)
lbp-9 34
  • 30 (a)
Species where no ortholog for CRABP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP2 Gene

Gene Tree for CRABP2 (if available)
Gene Tree for CRABP2 (if available)
Evolutionary constrained regions (ECRs) for CRABP2: view image

Paralogs for CRABP2 Gene

Paralogs for CRABP2 Gene

(16) SIMAP similar genes for CRABP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRABP2: view

Variants for CRABP2 Gene

Sequence variations from dbSNP and Humsavar for CRABP2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000018049 -- 156,712,631(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000427804 -- 156,699,430(-) G/A downstream_transcript_variant
rs1000528267 -- 156,712,392(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000820964 -- 156,700,317(-) G/C intron_variant
rs1000864166 -- 156,710,994(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP2 Gene

Variant ID Type Subtype PubMed ID
esv2675449 CNV deletion 23128226
esv3541134 CNV deletion 23714750
esv3587640 CNV loss 21293372
nsv523181 CNV loss 19592680
nsv831648 CNV loss 17160897
nsv952216 CNV deletion 24416366

Variation tolerance for CRABP2 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRABP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRABP2 Gene

Disorders for CRABP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRABP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
basal cell carcinoma
  • basal cell cancer
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRABP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRABP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP2 Gene

Publications for CRABP2 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Aström A … Voorhees JJ (The Journal of biological chemistry 1991) 2 3 4 22 58
  2. Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol. (PMID: 17484622) Salazar J … Ribalta J (Clinical chemistry and laboratory medicine 2007) 3 22 44 58
  3. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. (PMID: 15866176) Sessler RJ … Noy N (Molecular cell 2005) 3 4 22 58
  4. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (PMID: 11909957) Budhu AS … Noy N (Molecular and cellular biology 2002) 3 4 22 58
  5. NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. (PMID: 9737883) Wang L … Yan H (Biochemistry 1998) 3 4 22 58

Products for CRABP2 Gene

Sources for CRABP2 Gene

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