This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increa... See more...

Aliases for CRABP2 Gene

Aliases for CRABP2 Gene

  • Cellular Retinoic Acid Binding Protein 2 2 3 5
  • Cellular Retinoic Acid-Binding Protein 2 2 3 4
  • Cellular Retinoic Acid-Binding Protein II 3 4
  • CRABP-II 3 4
  • RBP6 3

External Ids for CRABP2 Gene

Previous GeneCards Identifiers for CRABP2 Gene

  • GC01M154538
  • GC01M152434
  • GC01M153447
  • GC01M153886
  • GC01M153482
  • GC01M154936
  • GC01M156669
  • GC01M128026

Summaries for CRABP2 Gene

Entrez Gene Summary for CRABP2 Gene

  • This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

GeneCards Summary for CRABP2 Gene

CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with CRABP2 include Embryonal Carcinoma and Hyperlipidemia, Familial Combined, 3. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP1.

UniProtKB/Swiss-Prot Summary for CRABP2 Gene

  • Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP2 Gene

Additional gene information for CRABP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRABP2 Gene

Genomics for CRABP2 Gene

GeneHancer (GH) Regulatory Elements for CRABP2 Gene

Promoters and enhancers for CRABP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRABP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRABP2

Top Transcription factor binding sites by QIAGEN in the CRABP2 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for CRABP2 Gene

Genomic Locations for CRABP2 Gene
chr1:156,699,606-156,705,816
(GRCh38/hg38)
Size:
6,211 bases
Orientation:
Minus strand
chr1:156,669,398-156,675,608
(GRCh37/hg19)
Size:
6,211 bases
Orientation:
Minus strand

Genomic View for CRABP2 Gene

Genes around CRABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP2 Gene

Proteins for CRABP2 Gene

  • Protein details for CRABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29373-RABP2_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 2
    Protein Accession:
    P29373
    Secondary Accessions:
    • B2R4Z8
    • D3DVC5
    • F1T098
    • Q6ICN6

    Protein attributes for CRABP2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    • Interacts with RXR and RARA (By similarity). Interacts with importin alpha.

    Three dimensional structures from OCA and Proteopedia for CRABP2 Gene

neXtProt entry for CRABP2 Gene

Post-translational modifications for CRABP2 Gene

  • Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP2 Gene

No data available for DME Specific Peptides for CRABP2 Gene

Domains & Families for CRABP2 Gene

Gene Families for CRABP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRABP2 Gene

Blocks:
  • Cytosolic fatty-acid binding protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRABP2 Gene

GenScript: Design optimal peptide antigens:
  • Cellular retinoic acid binding protein 2 (F1T098_HUMAN)
  • Cellular retinoic acid-binding protein II (RABP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P29373

UniProtKB/Swiss-Prot:

RABP2_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP2: view

Function for CRABP2 Gene

Molecular function for CRABP2 Gene

UniProtKB/Swiss-Prot Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.
GENATLAS Biochemistry:
retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)

Gene Ontology (GO) - Molecular Function for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005501 retinoid binding TAS 1334086
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with CRABP2: view
genes like me logo Genes that share phenotypes with CRABP2: view

Animal Models for CRABP2 Gene

MGI Knock Outs for CRABP2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP2 Gene

Localization for CRABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP2 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRABP2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS,IEA --
genes like me logo Genes that share ontologies with CRABP2: view

Pathways & Interactions for CRABP2 Gene

PathCards logo

SuperPathways for CRABP2 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.71
.62
2 all-trans-Retinoic Acid Mediated Apoptosis
-
3 Apoptotic Pathways in Synovial Fibroblasts
.57
4 Signaling by GPCR
5 Signaling by Retinoic Acid
genes like me logo Genes that share pathways with CRABP2: view

Pathways by source for CRABP2 Gene

1 BioSystems pathway for CRABP2 Gene
2 Reactome pathways for CRABP2 Gene
1 GeneGo (Thomson Reuters) pathway for CRABP2 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
4 Qiagen pathways for CRABP2 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • all-trans-Retinoic Acid Signaling in Brain
  • Nuclear Receptor Activation by Vitamin-A
  • RAR-Gamma-RXR-Alpha Degradation

SIGNOR curated interactions for CRABP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002138 retinoic acid biosynthetic process IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 1334086
GO:0007165 signal transduction TAS 1654334
GO:0008544 epidermis development TAS 1654334
GO:0035115 embryonic forelimb morphogenesis IEA --
genes like me logo Genes that share ontologies with CRABP2: view

Drugs & Compounds for CRABP2 Gene

(15) Drugs for CRABP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Transporter, substrate 260
Alitretinoin Approved, Investigational Pharma Agonist, Carrier, agonist 17
1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene Experimental Pharma Carrier 0
6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID Experimental Pharma Carrier 0
Ro 12-7310 Experimental Pharma Carrier 0

(11) Additional Compounds for CRABP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRABP2: view

Transcripts for CRABP2 Gene

mRNA/cDNA for CRABP2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CRABP2 Gene

GeneLoc Exon Structure for
CRABP2

Expression for CRABP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.1), Vagina (x9.2), and Cervix - Ectocervix (x5.2).

Protein differential expression in normal tissues from HIPED for CRABP2 Gene

This gene is overexpressed in Breast (24.0), Urine (7.6), Oral epithelium (7.0), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRABP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRABP2

SOURCE GeneReport for Unigene cluster for CRABP2 Gene:

Hs.405662

Evidence on tissue expression from TISSUES for CRABP2 Gene

  • Nervous system(4.5)
  • Eye(4.3)
  • Intestine(4.2)
  • Pancreas(3.9)
  • Skin(3.2)
genes like me logo Genes that share expression patterns with CRABP2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRABP2 Gene

Orthologs for CRABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRABP2 31 30
  • 99.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRABP2 31 30
  • 93.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRABP2 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRABP2 31 30
  • 89.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crabp2 17 31 30
  • 89.37 (n)
chicken
(Gallus gallus)
Aves CRABP2 31
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRABP2 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp2 30
  • 80.19 (n)
Str.1681 30
African clawed frog
(Xenopus laevis)
Amphibia crabp2-A 30
zebrafish
(Danio rerio)
Actinopterygii crabp2a 31 31 30
  • 70.77 (n)
OneToMany
crabp2b 31
  • 66 (a)
OneToMany
crabp2 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9548 30
fruit fly
(Drosophila melanogaster)
Insecta fabp 31
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-6 31
  • 44 (a)
ManyToMany
lbp-5 31
  • 38 (a)
ManyToMany
lbp-7 31
  • 36 (a)
ManyToMany
lbp-8 31
  • 35 (a)
ManyToMany
lbp-9 31
  • 30 (a)
ManyToMany
Species where no ortholog for CRABP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP2 Gene

ENSEMBL:
Gene Tree for CRABP2 (if available)
TreeFam:
Gene Tree for CRABP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRABP2: view image

Paralogs for CRABP2 Gene

(16) SIMAP similar genes for CRABP2 Gene using alignment to 2 proteins:

  • RABP2_HUMAN
  • Q5SYZ4_HUMAN
genes like me logo Genes that share paralogs with CRABP2: view

Variants for CRABP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRABP2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
718267 Likely Benign: not provided 156,700,542(-) C/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CRABP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRABP2 Gene

Variant ID Type Subtype PubMed ID
esv2675449 CNV deletion 23128226
esv3541134 CNV deletion 23714750
esv3587640 CNV loss 21293372
nsv523181 CNV loss 19592680
nsv831648 CNV loss 17160897
nsv952216 CNV deletion 24416366

Variation tolerance for CRABP2 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRABP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRABP2 Gene

Disorders for CRABP2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CRABP2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRABP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRABP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP2 Gene

Publications for CRABP2 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Aström A … Voorhees JJ (The Journal of biological chemistry 1991) 2 3 4 23 54
  2. Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol. (PMID: 17484622) Salazar J … Ribalta J (Clinical chemistry and laboratory medicine 2007) 3 23 41 54
  3. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. (PMID: 15866176) Sessler RJ … Noy N (Molecular cell 2005) 3 4 23 54
  4. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (PMID: 11909957) Budhu AS … Noy N (Molecular and cellular biology 2002) 3 4 23 54
  5. NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. (PMID: 9737883) Wang L … Yan H (Biochemistry 1998) 3 4 23 54

Products for CRABP2 Gene

Sources for CRABP2 Gene