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Aliases for CRABP1 Gene

Aliases for CRABP1 Gene

  • Cellular Retinoic Acid Binding Protein 1 2 3 5
  • Cellular Retinoic Acid-Binding Protein I 3 4
  • Cellular Retinoic Acid-Binding Protein 1 2 3
  • CRABP-I 3 4
  • RBP5 3 4
  • CRABPI 3
  • CRABP 3

External Ids for CRABP1 Gene

Previous HGNC Symbols for CRABP1 Gene

  • RBP5

Previous GeneCards Identifiers for CRABP1 Gene

  • GC15P074711
  • GC15P071722
  • GC15P076208
  • GC15P076348
  • GC15P076419
  • GC15P078632
  • GC15P055390

Summaries for CRABP1 Gene

Entrez Gene Summary for CRABP1 Gene

  • This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRABP1 Gene

CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include Teratocarcinoma and Embryonal Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Vitamin A and Carotenoid Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP2.

UniProtKB/Swiss-Prot for CRABP1 Gene

  • Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP1 Gene

Additional gene information for CRABP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP1 Gene

Genomics for CRABP1 Gene

GeneHancer (GH) Regulatory Elements for CRABP1 Gene

Promoters and enhancers for CRABP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J078341 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +0.1 137 0.5 HIC1 ZNF335 GATA3 POLR2A ZMYM3 ELF1 EZH2 CRABP1 ENSG00000279694 GC15M078021
GH15J078328 Promoter 0.7 EPDnew 650.4 -12.5 -12546 0.1 CEBPB HNF4A CRABP1 WDR61 ENSG00000199633 SH2D7 GC15P078331 GC15M078021
GH15J078340 Enhancer 0.6 ENCODE 655.5 +1.2 1177 1.6 USF1 SIN3A ZMYM3 ELF1 HIC1 ZNF335 GATA3 CTBP2 ZFP36 EZH2 CRABP1 ENSG00000279694 CSPG4P13 GC15M078021
GH15J078564 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.4 +225.5 225503 2.2 HDGF ARNT ARID4B SIN3A TCF12 ELK1 ZNF143 SP3 NCOA1 SREBF1 CHRNA5 PSMA4 IREB2 TBC1D2B HYKK MORF4L1 ADAMTS7 CRABP1 RASGRF1 ENSG00000261762
GH15J078263 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 10.4 -74.6 -74599 4.1 CTCF SREBF2 MAX SIN3A ZNF335 TCF12 E2F1 ZNF121 ELK1 POLR2A DNAJA4 LOC105370911 CRABP1 ADAMTS7P3 IREB2 ENSG00000259562 LOC645752 LOC105370910 GC15M078021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRABP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRABP1 gene promoter:
  • AP-2alphaA
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha

Genomic Locations for CRABP1 Gene

Genomic Locations for CRABP1 Gene
chr15:78,340,324-78,348,230
(GRCh38/hg38)
Size:
7,907 bases
Orientation:
Plus strand
chr15:78,632,666-78,640,572
(GRCh37/hg19)
Size:
7,907 bases
Orientation:
Plus strand

Genomic View for CRABP1 Gene

Genes around CRABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP1 Gene

Proteins for CRABP1 Gene

  • Protein details for CRABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29762-RABP1_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 1
    Protein Accession:
    P29762
    Secondary Accessions:
    • Q6IAY7
    • Q8WTV5

    Protein attributes for CRABP1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRABP1 Gene

Post-translational modifications for CRABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRABP1 Gene

Domains & Families for CRABP1 Gene

Gene Families for CRABP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CRABP1 Gene

Suggested Antigen Peptide Sequences for CRABP1 Gene

Graphical View of Domain Structure for InterPro Entry

P29762

UniProtKB/Swiss-Prot:

RABP1_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP1: view

Function for CRABP1 Gene

Molecular function for CRABP1 Gene

UniProtKB/Swiss-Prot Function:
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
GENATLAS Biochemistry:
retinoic acid binding protein,cellular I,(lipocalin family,kernel group)

Phenotypes From GWAS Catalog for CRABP1 Gene

Gene Ontology (GO) - Molecular Function for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005501 retinoid binding TAS 1309505
GO:0005515 protein binding IPI 15607035
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
genes like me logo Genes that share ontologies with CRABP1: view
genes like me logo Genes that share phenotypes with CRABP1: view

Animal Models for CRABP1 Gene

MGI Knock Outs for CRABP1:

Animal Model Products

CRISPR Products

miRNA for CRABP1 Gene

miRTarBase miRNAs that target CRABP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRABP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP1 Gene

Localization for CRABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRABP1 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with CRABP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRABP1 Gene

Pathways & Interactions for CRABP1 Gene

genes like me logo Genes that share pathways with CRABP1: view

Pathways by source for CRABP1 Gene

1 BioSystems pathway for CRABP1 Gene
1 GeneGo (Thomson Reuters) pathway for CRABP1 Gene

Interacting Proteins for CRABP1 Gene

Gene Ontology (GO) - Biological Process for CRABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1309505
GO:0007275 multicellular organism development TAS 1309505
GO:0034653 retinoic acid catabolic process IEA --
genes like me logo Genes that share ontologies with CRABP1: view

No data available for SIGNOR curated interactions for CRABP1 Gene

Drugs & Compounds for CRABP1 Gene

(12) Drugs for CRABP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Transporter, substrate 242
Alitretinoin Approved, Investigational Pharma Agonist, Carrier, agonist 17
Tamibarotene Approved, Investigational Pharma Agonist, Carrier RARα agonist 0
Etretinate Withdrawn Pharma Carrier 0

(6) Additional Compounds for CRABP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRABP1: view

Transcripts for CRABP1 Gene

mRNA/cDNA for CRABP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRABP1 Gene

Cellular retinoic acid binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRABP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP1 Gene

No ASD Table

Relevant External Links for CRABP1 Gene

GeneLoc Exon Structure for
CRABP1
ECgene alternative splicing isoforms for
CRABP1

Expression for CRABP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP1 Gene

This gene is overexpressed in Thyroid (x7.3), Brain - Caudate (basal ganglia) (x6.1), Spleen (x5.8), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x4.9), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for CRABP1 Gene

This gene is overexpressed in Retina (46.6) and Cerebral cortex (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRABP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CRABP1 Gene:

CRABP1

SOURCE GeneReport for Unigene cluster for CRABP1 Gene:

Hs.346950

Evidence on tissue expression from TISSUES for CRABP1 Gene

  • Nervous system(4.6)
  • Eye(3)
  • Thyroid gland(2.7)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with CRABP1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRABP1 Gene

Orthologs for CRABP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRABP1 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRABP1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRABP1 34 33
  • 94.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crabp1 33
  • 93.67 (n)
mouse
(Mus musculus)
Mammalia Crabp1 16 34 33
  • 91.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRABP1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRABP-I 34
  • 96 (a)
OneToOne
CRABP1 33
  • 83.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp1 33
  • 72.79 (n)
zebrafish
(Danio rerio)
Actinopterygii crabp1b 34
  • 85 (a)
OneToMany
crabp1a 34 33
  • 77.21 (n)
OneToMany
crabp1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2517 33
fruit fly
(Drosophila melanogaster)
Insecta fabp 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-6 34
  • 39 (a)
ManyToMany
lbp-7 34
  • 36 (a)
ManyToMany
lbp-5 34
  • 35 (a)
ManyToMany
lbp-8 34
  • 32 (a)
ManyToMany
lbp-9 34
  • 28 (a)
ManyToMany
Species where no ortholog for CRABP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP1 Gene

ENSEMBL:
Gene Tree for CRABP1 (if available)
TreeFam:
Gene Tree for CRABP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRABP1: view image

Paralogs for CRABP1 Gene

Paralogs for CRABP1 Gene

(14) SIMAP similar genes for CRABP1 Gene using alignment to 3 proteins:

  • RABP1_HUMAN
  • B5MCB5_HUMAN
  • F1T0F7_HUMAN
genes like me logo Genes that share paralogs with CRABP1: view

Variants for CRABP1 Gene

Sequence variations from dbSNP and Humsavar for CRABP1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000533445 -- 78,340,050(+) A/G upstream_transcript_variant
rs1000576819 -- 78,347,880(+) G/C intron_variant
rs1000650487 -- 78,348,165(+) T/C 3_prime_UTR_variant
rs1000681553 -- 78,348,354(+) G/C downstream_transcript_variant
rs1000811062 -- 78,342,169(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRABP1 Gene

Variant ID Type Subtype PubMed ID
nsv1052910 CNV gain 25217958
nsv1116464 OTHER inversion 24896259
nsv833063 CNV loss 17160897

Variation tolerance for CRABP1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRABP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRABP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRABP1 Gene

Disorders for CRABP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CRABP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
acute promyelocytic leukemia
  • apl
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CRABP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP1 Gene

Publications for CRABP1 Gene

  1. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. (PMID: 9154115) Flagiello D … Malfoy B (Cytogenetics and cell genetics 1997) 2 3 22 58
  2. The molecular cloning and expression of two CRABP cDNAs from human skin. (PMID: 1309505) Eller MS … Gilchrest BA (Experimental cell research 1992) 3 4 22 58
  3. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Aström A … Voorhees JJ (The Journal of biological chemistry 1991) 3 4 22 58
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  5. Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. (PMID: 17438526) Tanaka K … Inazawa J (Oncogene 2007) 3 22 58

Products for CRABP1 Gene

Sources for CRABP1 Gene

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