Aliases for CR1L Gene
Aliases for CR1L Gene
External Ids for CR1L Gene
- HGNC: 2335
- Entrez Gene: 1379
- Ensembl: ENSG00000197721
- OMIM: 605886
- UniProtKB: Q2VPA4
Previous GeneCards Identifiers for CR1L Gene
- GC01P206492
- GC01P203528
- GC01P204461
- GC01P204579
- GC01P204581
- GC01P204206
- GC01P205885
- GC01P207820
- GC01P178493
- GC01P207826
Summaries for CR1L Gene
GeneCards Summary for CR1L Gene
CR1L (Complement C3b/C4b Receptor 1 Like) is a Protein Coding gene. Diseases associated with CR1L include Complement Component Receptor 1 and Vascular Hemostatic Disease. An important paralog of this gene is CR1.
Additional gene information for CR1L Gene
- Monarch Initiative
- Search for CR1L at DataMed
- Search for CR1L at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1L Gene
Genomics for CR1L Gene
GeneHancer (GH) Regulatory Elements for CR1L Gene
Promoters and enhancers for CR1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CR1L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CR1L Gene
Genomic Locations for CR1L Gene
- chr1:207,645,113-207,738,416
- (GRCh38/hg38)
- Size:
- 93,304 bases
- Orientation:
- Plus strand
- chr1:207,818,458-207,911,761
- (GRCh37/hg19)
Genomic View for CR1L Gene
Genes around CR1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.2 by Ensembl
- 1q32.2 by Entrez Gene
- 1q32.2 by HGNC
CR1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CR1L Gene
Proteins for CR1L Gene
-
Protein details for CR1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q2VPA4-CR1L_HUMAN
- Recommended name:
- Complement component receptor 1-like protein
- Protein Accession:
- Q2VPA4
- Q32MC9
- Q8NEU7
Protein attributes for CR1L Gene
- Size:
- 569 amino acids
- Molecular mass:
- 62714 Da
- Quaternary structure:
-
- Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).
Protein Expression for CR1L Gene
Post-translational modifications for CR1L Gene
- Glycosylation at Asn48
Other Protein References for CR1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Abcam antibodies for CR1L
- Invitrogen Antibodies for CR1L
- Search GeneTex for Antibodies for CR1L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CR1L
- Origene Custom Protein Services for CR1L
- antibodies-online: Search results for 3 available CR1L Proteins ranked by validation data
- Compare Top CR1L Proteins
-
Quality Products:
- Search GeneTex for Proteins for CR1L
Assay Products
- antibodies-online: Search results for 6 available CR1L Elisa Kits ranked by validation data
- Compare Top CR1L Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CR1L Gene
Domains & Families for CR1L Gene
Gene Families for CR1L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for CR1L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CR1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q2VPA4- Family:
-
- Belongs to the receptors of complement activation (RCA) family.
Function for CR1L Gene
Molecular function for CR1L Gene
- GENATLAS Biochemistry:
- complement component (3b/4b) receptor 1-like (see RCA@)
Phenotypes From GWAS Catalog for CR1L Gene
Phenotypes for CR1L Gene
- MGI mutant phenotypes for CR1L:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CR1L:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CR1L gene
-
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- Search ViGene Biosciences for CR1L
CRISPR Products
-
OriGene CRISPR knockouts for CR1L
- genomics-online: gRNA clones - Search results for available CR1L gene related products
- Applied Biological Materials CRISPR for CR1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CR1L
- GenScript: Design CRISPR guide RNA sequences for CR1L
miRNA Products
- Search ViGene Biosciences for CR1L
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CR1L
- Browse OriGene Inhibitory RNA Products For CR1L
- genomics-online: shRNA clones - Search results for available CR1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CR1L gene
Clone Products
- Sino Biological Human cDNA Clone for CR1L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CR1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CR1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CR1L gene related products
- orf clones - Search results for available CR1L gene related products
- Applied Biological Materials Clones for CR1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CR1L
-
ViGene Biosciences adenoviral particle packaged cDNA for CR1L gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CR1L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CR1L gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CR1L Gene
Localization for CR1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for CR1L Gene
- Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043235 | receptor complex | IDA | 23382219 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CR1L Gene
Pathways & Interactions for CR1L Gene
No Data Available
Interacting Proteins for CR1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045916 | negative regulation of complement activation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CR1L Gene
Transcripts for CR1L Gene
mRNA/cDNA for CR1L Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CR1L Gene
CRISPR Products
-
OriGene CRISPR knockouts for CR1L
- genomics-online: gRNA clones - Search results for available CR1L gene related products
- Applied Biological Materials CRISPR for CR1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CR1L
- GenScript: Design CRISPR guide RNA sequences for CR1L
miRNA Products
- Search ViGene Biosciences for CR1L
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CR1L
- Browse OriGene Inhibitory RNA Products For CR1L
- genomics-online: shRNA clones - Search results for available CR1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CR1L gene
Clone Products
- Sino Biological Human cDNA Clone for CR1L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CR1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CR1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CR1L gene related products
- orf clones - Search results for available CR1L gene related products
- Applied Biological Materials Clones for CR1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - |
Expression for CR1L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CR1L Gene
This gene is overexpressed in Whole Blood (x22.6).
This gene is overexpressed in Serum (50.9) and Peripheral blood mononuclear cells (18.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CR1L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CR1L Gene:
CR1LSOURCE GeneReport for Unigene cluster for CR1L Gene:
Hs.655194mRNA Expression by UniProt/SwissProt for CR1L Gene:
Q2VPA4-CR1L_HUMAN
Tissue specificity:
Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.
Evidence on tissue expression from TISSUES for CR1L Gene
- Bone marrow(4.2)
Primer Products
-
OriGene qPCR primer pairs for CR1L
- genomics-online: primer clones - Search results for available CR1L gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CR1L Gene
Orthologs for CR1L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CR1L 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cr1l 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cr1l 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | sele 34 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CR1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CR1L Gene
Variants for CR1L Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018085 | -- | 207,681,988(+) | G/A | intron_variant | |
| rs1000020108 | -- | 207,720,710(+) | A/C | intron_variant | |
| rs1000126229 | -- | 207,643,224(+) | A/G | upstream_transcript_variant | |
| rs1000215624 | -- | 207,669,622(+) | G/A | intron_variant | |
| rs1000286858 | -- | 207,653,915(+) | T/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv945269 | CNV | duplication | 23825009 |
| nsv8757 | CNV | gain | 18304495 |
| nsv8746 | CNV | loss | 18304495 |
| nsv8735 | CNV | gain | 18304495 |
| esv3891082 | CNV | loss | 25118596 |
| esv3588675 | CNV | loss | 21293372 |
| esv3588674 | CNV | gain | 21293372 |
| esv3578397 | CNV | loss | 25503493 |
| esv3545666 | CNV | deletion | 23714750 |
| esv2758993 | CNV | gain+loss | 17122850 |
| esv27524 | CNV | loss | 19812545 |
| esv2722117 | CNV | deletion | 23290073 |
| esv2722106 | CNV | deletion | 23290073 |
| esv2676306 | CNV | deletion | 23128226 |
| esv2675458 | CNV | deletion | 23128226 |
| esv25546 | CNV | loss | 19812545 |
Residual Variation Intolerance Score:
98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.60;
86.19% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CR1L Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CR1L Gene
Disorders for CR1L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| complement component receptor 1 |
|
|
| vascular hemostatic disease |
|
|
Search CR1L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CR1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CR1L Gene
Publications for CR1L Gene
- Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. (PMID: 21700265) Kullo IJ … Chute CG (American journal of human genetics 2011) 3 44 58
- Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C … Peltonen L (Nature genetics 2009) 3 44 58
- A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue. (PMID: 14687939) Logar CM … Birmingham DJ (Molecular immunology 2004) 3 4 58
- Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. (PMID: 2295627) Hourcade D … Atkinson JP (The Journal of biological chemistry 1990) 2 3 58
- Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
Products for CR1L Gene
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- Invitrogen Antibodies for CR1L
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- VectorBuilder custom plasmid, inducible vectors for CR1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CR1L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available CR1L Antibodies ranked by validation data
- Compare Top CR1L Antibodies
- antibodies-online: Search results for 6 available CR1L Elisa Kits ranked by validation data
- Compare Top CR1L Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available CR1L Proteins ranked by validation data
- Compare Top CR1L Proteins
- Quality Products:
- Search GeneTex for Antibodies for CR1L
- Search GeneTex for Proteins for CR1L
- ViGene Biosciences adenoviral particle packaged cDNA for CR1L gene
- ViGene Biosciences lentiviral particle packaged cDNA for CR1L gene
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- Search ViGene Biosciences for CR1L
- Horizon Cell Lines for CR1L
- genomics-online: cdna clones - Search results for available CR1L gene related products
- orf clones - Search results for available CR1L gene related products
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Sources for CR1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew