Aliases for CPZ Gene
External Ids for CPZ Gene
Previous GeneCards Identifiers for CPZ Gene
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPZ Gene
CPZ (Carboxypeptidase Z) is a Protein Coding gene. Diseases associated with CPZ include Locked-In Syndrome and Epithelial-Stromal Tgfbi Dystrophy. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPXM1.
UniProtKB/Swiss-Prot Summary for CPZ Gene
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.