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Aliases for CPXM2 Gene

Aliases for CPXM2 Gene

  • Carboxypeptidase X, M14 Family Member 2 2 3 5
  • Carboxypeptidase X (M14 Family), Member 2 2 3
  • Cytosolic Carboxypeptidase 2 3
  • CPX2 3 4
  • Inactive Carboxypeptidase-Like Protein X2 3
  • Carboxypeptidase-Like Protein X2 3
  • Carboxypeptidase Hlo 3
  • 4632435C11Rik 3
  • UNQ676 3

External Ids for CPXM2 Gene

Previous GeneCards Identifiers for CPXM2 Gene

  • GC10M125495
  • GC10M125462
  • GC10M119120

Summaries for CPXM2 Gene

GeneCards Summary for CPXM2 Gene

CPXM2 (Carboxypeptidase X, M14 Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is AEBP1.

UniProtKB/Swiss-Prot for CPXM2 Gene

  • May be involved in cell-cell interactions.

Additional gene information for CPXM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXM2 Gene

Genomics for CPXM2 Gene

GeneHancer (GH) Regulatory Elements for CPXM2 Gene

Promoters and enhancers for CPXM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J123887 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 695.4 +50.1 50104 4.8 ATF4 CTBP2 ATF2 EZH2 NR2F2 CPXM2 LOC105378534 LOC105378533
GH10J123863 Enhancer 0.8 ENCODE dbSUPER 26.3 +74.0 73967 5.6 CTCF PKNOX1 ATF2 ZNF644 ATF4 CEBPA CREB1 CREM CPXM2 LOC105378534 LOC105378533
GH10J123878 Enhancer 0.5 ENCODE dbSUPER 20.3 +61.2 61174 2 NR2F6 CPXM2 LOC105378534 LOC105378533
GH10J123832 Enhancer 0.6 dbSUPER 15.2 +105.0 104991 4.7 RB1 NR2F1 TRIM22 EBF1 MEF2B DPF2 BATF RELA TARDBP IKZF1 CPXM2 LOC105378533 LOC105378534
GH10J123573 Enhancer 0.8 ENCODE 10.4 +366.8 366840 0.2 CTCF PKNOX1 NFIB KLF17 SIN3A KLF14 ZIC2 RAD21 HIC1 GLIS2 ENSG00000234542 CPXM2 LOC105378530
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPXM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPXM2 gene promoter:
  • RFX1
  • GATA-2
  • RSRFC4
  • CUTL1
  • TBP
  • S8
  • FOXC1
  • Max1

Genomic Locations for CPXM2 Gene

Genomic Locations for CPXM2 Gene
234,061 bases
Minus strand
234,061 bases
Minus strand

Genomic View for CPXM2 Gene

Genes around CPXM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPXM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPXM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM2 Gene

Proteins for CPXM2 Gene

  • Protein details for CPXM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive carboxypeptidase-like protein X2
    Protein Accession:
    Secondary Accessions:
    • B4E3Q2

    Protein attributes for CPXM2 Gene

    756 amino acids
    Molecular mass:
    85870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM2 Gene

Post-translational modifications for CPXM2 Gene

  • Glycosylation at posLast=491491, posLast=337337, Asn281, posLast=241241, and posLast=231231
  • Modification sites at PhosphoSitePlus

Other Protein References for CPXM2 Gene

No data available for DME Specific Peptides for CPXM2 Gene

Domains & Families for CPXM2 Gene

Gene Families for CPXM2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CPXM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPXM2: view

Function for CPXM2 Gene

Molecular function for CPXM2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interactions.

Phenotypes From GWAS Catalog for CPXM2 Gene

Gene Ontology (GO) - Molecular Function for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 NOT metallocarboxypeptidase activity IBA --
GO:0004185 NOT serine-type carboxypeptidase activity IBA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPXM2: view
genes like me logo Genes that share phenotypes with CPXM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPXM2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPXM2 Gene

Localization for CPXM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPXM2 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA --
GO:0031012 extracellular matrix IDA --
genes like me logo Genes that share ontologies with CPXM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPXM2 Gene

Pathways & Interactions for CPXM2 Gene

SuperPathways for CPXM2 Gene

No Data Available

Interacting Proteins for CPXM2 Gene

Gene Ontology (GO) - Biological Process for CPXM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 NOT peptide metabolic process IBA --
GO:0016485 NOT protein processing IBA --
genes like me logo Genes that share ontologies with CPXM2: view

No data available for Pathways by source and SIGNOR curated interactions for CPXM2 Gene

Drugs & Compounds for CPXM2 Gene

No Compound Related Data Available

Transcripts for CPXM2 Gene

Unigene Clusters for CPXM2 Gene

Carboxypeptidase X (M14 family), member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - -

Relevant External Links for CPXM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPXM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPXM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM2 Gene

This gene is overexpressed in Artery - Aorta (x10.7), Artery - Coronary (x6.3), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for CPXM2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (31.2) and Colon (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPXM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPXM2 Gene:


SOURCE GeneReport for Unigene cluster for CPXM2 Gene:


Evidence on tissue expression from TISSUES for CPXM2 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CPXM2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPXM2 Gene

Orthologs for CPXM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPXM2 34 33
  • 99.23 (n)
(Canis familiaris)
Mammalia CPXM2 34 33
  • 89.16 (n)
(Bos Taurus)
Mammalia CPXM2 34 33
  • 88.23 (n)
(Mus musculus)
Mammalia Cpxm2 16 34 33
  • 85.79 (n)
(Rattus norvegicus)
Mammalia Cpxm2 33
  • 85.19 (n)
(Monodelphis domestica)
Mammalia CPXM2 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia CPXM2 34
  • 82 (a)
(Gallus gallus)
Aves CPXM2 34 33
  • 75.8 (n)
(Anolis carolinensis)
Reptilia CPXM2 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpxm2 33
  • 71.11 (n)
(Danio rerio)
Actinopterygii CABZ01090975.1 34
  • 72 (a)
LOC793308 33
  • 63.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for CPXM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPXM2 Gene

Gene Tree for CPXM2 (if available)
Gene Tree for CPXM2 (if available)
Evolutionary constrained regions (ECRs) for CPXM2: view image

Paralogs for CPXM2 Gene

Paralogs for CPXM2 Gene

(9) SIMAP similar genes for CPXM2 Gene using alignment to 2 proteins:

  • Q49AT5_HUMAN
genes like me logo Genes that share paralogs with CPXM2: view

Variants for CPXM2 Gene

Sequence variations from dbSNP and Humsavar for CPXM2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs869025241 uncertain-significance, Ductal breast carcinoma 123,862,630(-) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000001076 -- 123,815,783(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000007137 -- 123,939,510(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015908 -- 123,936,809(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000060024 -- 123,857,745(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPXM2 Gene

Variant ID Type Subtype PubMed ID
dgv988n100 CNV loss 25217958
esv2220029 CNV deletion 18987734
esv27822 CNV loss 19812545
nsv1077323 CNV duplication 25765185
nsv1121463 CNV deletion 24896259
nsv1124478 CNV deletion 24896259
nsv1124484 CNV deletion 24896259
nsv1134066 CNV deletion 24896259
nsv1139370 CNV deletion 24896259
nsv1145487 CNV deletion 24896259
nsv25320 CNV deletion 16902084
nsv820023 CNV loss 19587683
nsv832011 CNV gain+loss 17160897
nsv982901 CNV duplication 23825009

Variation tolerance for CPXM2 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPXM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXM2 Gene

Disorders for CPXM2 Gene

Additional Disease Information for CPXM2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPXM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPXM2 Gene

Publications for CPXM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CPXM2 Gene

Sources for CPXM2 Gene

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