This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010] See more...

Aliases for CPXM1 Gene

Aliases for CPXM1 Gene

  • Carboxypeptidase X, M14 Family Member 1 2 3 5
  • CPX1 2 3 4
  • Carboxypeptidase X (M14 Family), Member 1 2 3
  • Carboxypeptidase-Like Protein X1 2 3
  • Metallocarboxypeptidase CPX-1 3 4
  • Probable Carboxypeptidase X1 3 4
  • CPXM 3 4
  • EC 3.4.17.10 50
  • EC 3.4.17.3 50
  • EC 3.4.17.- 4
  • EC 3.4.17 50
  • CPXM1 5
  • CPX-1 2

External Ids for CPXM1 Gene

Previous HGNC Symbols for CPXM1 Gene

  • CPXM

Previous GeneCards Identifiers for CPXM1 Gene

  • GC20M002723

Summaries for CPXM1 Gene

Entrez Gene Summary for CPXM1 Gene

  • This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]

GeneCards Summary for CPXM1 Gene

CPXM1 (Carboxypeptidase X, M14 Family Member 1) is a Protein Coding gene. Diseases associated with CPXM1 include Mirror Movements 1. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot Summary for CPXM1 Gene

  • May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Gene Wiki entry for CPXM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPXM1 Gene

Genomics for CPXM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CPXM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002798 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 260 +0.5 522 2.7 NCOR1 NFIC ZIC2 MAFF NBN TAL1 YY1 TCF7L2 MYNN MAFK CPXM1 ZNF343 SNRPB HSALNG0128213 EBF4
GH20J002839 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.3 -40.2 -40233 2.5 BCLAF1 ZNF207 IKZF1 ZNF600 MYC SIX5 SSRP1 ZNF592 KLF9 POLR2A VPS16 PCED1A HSALNG0128219 HSALNG0128220 CPXM1 NOP56 STK35 SNRPB CDC25B ZNF343
GH20J002768 Enhancer 0.8 Ensembl ENCODE 28.1 +32.2 32226 1.6 JUND ELF1 RXRA PRDM10 SMARCE1 RAD21 DPF2 HNF4A NFIB SP1 CPXM1 C20orf141 ENSG00000241690 TMEM239 VPS16 PTPRA PCED1A HSALNG0128211 HSALNG0128210 EBF4
GH20J002771 Enhancer 0.4 Ensembl 27.8 +29.0 29027 1.6 ZIC2 GABPB1 PKNOX1 GABPA HSALNG0128211 CPXM1 VPS16 PTPRA C20orf141 ENSG00000241690 TMEM239 PCED1A HSALNG0128210 EBF4
GH20J002813 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 9.3 -15.1 -15074 3.8 NCOR1 NFIC ZIC2 REST TAL1 GABPB1 RAD21 ZBTB48 MAFK CTCF C20orf141 ENSG00000241690 TMEM239 CPXM1 VPS16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPXM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPXM1

Top Transcription factor binding sites by QIAGEN in the CPXM1 gene promoter:
  • C/EBPalpha
  • E47
  • Egr-2
  • ER-alpha
  • GATA-1
  • Ik-3
  • MRF-2
  • Pax-4a
  • Pax-6
  • XBP-1

Genomic Locations for CPXM1 Gene

Latest Assembly
chr20:2,794,074-2,800,627
(GRCh38/hg38)
Size:
6,554 bases
Orientation:
Minus strand

Previous Assembly
chr20:2,774,720-2,781,273
(GRCh37/hg19 by Entrez Gene)
Size:
6,554 bases
Orientation:
Minus strand

chr20:2,774,715-2,781,283
(GRCh37/hg19 by Ensembl)
Size:
6,569 bases
Orientation:
Minus strand

Genomic View for CPXM1 Gene

Genes around CPXM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPXM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPXM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM1 Gene

Proteins for CPXM1 Gene

  • Protein details for CPXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SM3-CPXM1_HUMAN
    Recommended name:
    Probable carboxypeptidase X1
    Protein Accession:
    Q96SM3
    Secondary Accessions:
    • Q6P4G8
    • Q6UW65
    • Q9NUB5

    Protein attributes for CPXM1 Gene

    Size:
    734 amino acids
    Molecular mass:
    81668 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM1 Gene

Selected DME Specific Peptides for CPXM1 Gene

Q96SM3:
  • GDYWRLL
  • FVLSANLHGG
  • GINHDVT
  • IPFVLSA
  • ELSCDKFP
  • YLHTNCFE
  • PNHHLPLP
  • PSMNPDGYE

Post-translational modifications for CPXM1 Gene

  • Glycosylation at Asn57, Asn210, Asn220, Asn318, Asn428, and Asn472
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CPXM1_HUMAN (1626)

Other Protein References for CPXM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPXM1 Gene

Gene Families for CPXM1 Gene

Protein Domains for CPXM1 Gene

InterPro:
Blocks:
  • Coagulation factor 5/8 type C domain (FA58C)

Suggested Antigen Peptide Sequences for CPXM1 Gene

GenScript: Design optimal peptide antigens:
  • Metallocarboxypeptidase CPX-1 (CPXM1_HUMAN)
  • cDNA PSEC0206 fis, clone HEMBA1002913, weakly similar to CARBOXYPEPTIDASE H (EC 3.4.17.10) (Q8N2F1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96SM3

UniProtKB/Swiss-Prot:

CPXM1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPXM1: view

Function for CPXM1 Gene

Molecular function for CPXM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Enzyme Numbers (IUBMB) for CPXM1 Gene

Phenotypes From GWAS Catalog for CPXM1 Gene

Gene Ontology (GO) - Molecular Function for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0004181 metallocarboxypeptidase activity IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPXM1: view
genes like me logo Genes that share phenotypes with CPXM1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPXM1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPXM1 Gene

Localization for CPXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPXM1 gene
Compartment Confidence
extracellular 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with CPXM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPXM1 Gene

Pathways & Interactions for CPXM1 Gene

PathCards logo

SuperPathways for CPXM1 Gene

No Data Available

Interacting Proteins for CPXM1 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000369979 Q96SM3-CPXM1_HUMAN for CPXM1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CPXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA 21873635
GO:0016485 protein processing IBA 21873635
genes like me logo Genes that share ontologies with CPXM1: view

No data available for Pathways by source and SIGNOR curated interactions for CPXM1 Gene

Drugs & Compounds for CPXM1 Gene

No Compound Related Data Available

Transcripts for CPXM1 Gene

mRNA/cDNA for CPXM1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPXM1

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for CPXM1 Gene

GeneLoc Exon Structure for
CPXM1

Expression for CPXM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPXM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM1 Gene

This gene is overexpressed in Cervix - Ectocervix (x7.1), Adipose - Visceral (Omentum) (x5.8), Uterus (x5.2), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for CPXM1 Gene

This gene is overexpressed in Uterus (13.1), Placenta (12.3), Gallbladder (7.6), Ovary (7.5), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPXM1 Gene



Protein tissue co-expression partners for CPXM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPXM1

SOURCE GeneReport for Unigene cluster for CPXM1 Gene:

Hs.659346

Evidence on tissue expression from TISSUES for CPXM1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CPXM1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPXM1 Gene

Orthologs for CPXM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CPXM1 29 30
  • 97.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CPXM1 29 30
  • 88.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CPXM1 29 30
  • 86.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cpxm1 29 16 30
  • 84.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cpxm1 29
  • 83.84 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CPXM1 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CPXM1 30
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CPXM1 30
  • 65 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CPXM1 30
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cpxm1 29
  • 65.83 (n)
Str.17581 29
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-19p15.7 29
  • 64.24 (n)
CPXM1 (1 of 2) 30
  • 55 (a)
OneToMany
CU469518.1 30
  • 42 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
Species where no ortholog for CPXM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CPXM1 Gene

ENSEMBL:
Gene Tree for CPXM1 (if available)
TreeFam:
Gene Tree for CPXM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPXM1: view image
Alliance of Genome Resources:
Additional Orthologs for CPXM1

Paralogs for CPXM1 Gene

Paralogs for CPXM1 Gene

(7) SIMAP similar genes for CPXM1 Gene using alignment to 1 proteins:

  • CPXM1_HUMAN
genes like me logo Genes that share paralogs with CPXM1: view

Variants for CPXM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPXM1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs144323253 Benign: not provided 2,797,045(-) A/G
NM_019609.5(CPXM1):c.882T>C (p.Pro294=)
SYNONYMOUS
rs41297632 Benign: not provided 2,794,264(-) G/A
NM_019609.5(CPXM1):c.2131C>T (p.Leu711=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CPXM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CPXM1 Gene

Variant ID Type Subtype PubMed ID
esv2762056 CNV gain 21179565
nsv1057464 CNV gain 25217958
nsv510780 CNV deletion 20534489
nsv522009 CNV gain 19592680
nsv833895 CNV loss 17160897
nsv952977 CNV deletion 24416366

Variation tolerance for CPXM1 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPXM1 Gene

Human Gene Mutation Database (HGMD)
CPXM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPXM1
Leiden Open Variation Database (LOVD)
CPXM1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXM1 Gene

Disorders for CPXM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPXM1 Gene - From: COP

Disorder Aliases PubMed IDs
mirror movements 1
  • mrmv1
- elite association - COSMIC cancer census association via MalaCards
Search CPXM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPXM1

genes like me logo Genes that share disorders with CPXM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPXM1 Gene

Publications for CPXM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  2. Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein. (PMID: 26603934) Kim YH … Whitehead JP (Biochemical and biophysical research communications 2015) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for CPXM1 Gene

Sources for CPXM1 Gene