CPVL Gene (Protein Coding)

Carboxypeptidase Vitellogenic Like

GC07M028995
GIFtS:
41
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017] See more...

Aliases for CPVL Gene

Aliases for CPVL Gene

  • Carboxypeptidase Vitellogenic Like 2 3 5
  • Vitellogenic Carboxypeptidase-Like Protein 2 3 4
  • Probable Serine Carboxypeptidase CPVL 3 4
  • Carboxypeptidase, Vitellogenic-Like 2 4
  • CP-Mac Carboxypeptidase 2 3
  • Carboxypeptidase WUG 2 3
  • VCP-Like Protein 3 4
  • HVLP 3 4
  • EC 3.4.16.- 4
  • EC 3.4.16 54
  • VLP 4

External Ids for CPVL Gene

Previous GeneCards Identifiers for CPVL Gene

  • GC07M028677
  • GC07M028743
  • GC07M028777
  • GC07M028808
  • GC07M029001
  • GC07M028917

Summaries for CPVL Gene

Entrez Gene Summary for CPVL Gene

  • The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]

GeneCards Summary for CPVL Gene

CPVL (Carboxypeptidase Vitellogenic Like) is a Protein Coding gene. Diseases associated with CPVL include Encephalomalacia and Aspiration Pneumonitis. Gene Ontology (GO) annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CTSA.

UniProtKB/Swiss-Prot Summary for CPVL Gene

  • May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Gene Wiki entry for CPVL Gene

Additional gene information for CPVL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPVL Gene

Genomics for CPVL Gene

GeneHancer (GH) Regulatory Elements for CPVL Gene

Promoters and enhancers for CPVL Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J029193 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.3 327 3.4 ZBTB6 NR2F6 MNT ELF3 PRDM1 KAT8 ZNF547 GLIS2 ZIC2 ZBTB8A CHN2 CPVL ENSG00000285081 PLEKHA8 ENSG00000285162
GH07J029145 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 765.5 +49.1 49050 3.2 POLR2A ZNF362 HLF CBFA2T2 TFE3 SP7 ZSCAN21 GLIS2 ZIC2 CEBPA CHN2 CPVL LOC100506497 LOC101928168 ENSG00000285162
GH07J029139 Promoter/Enhancer 1.2 Ensembl ENCODE 17.7 +53.1 53134 4.9 MLX RBPJ NR2F1 NR2F6 CREB1 MIXL1 NFYC HLF ZNF652 RERE CPVL CHN2 LOC101928168 ENSG00000285162
GH07J029112 Enhancer 0.9 Ensembl ENCODE 21.2 +80.7 80650 5.6 CTCF RAD21 ZNF652 ELF3 SP7 PRDM1 FOSL2 CEBPA GATAD2A CTBP1 CPVL CHN2 CPVL-AS1 ENSG00000235669 ENSG00000285412 RF00017-6094
GH07J029336 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -142.1 -142073 2.2 MLX RBPJ NR2F6 ATF1 CREB1 MIXL1 HLF ZNF652 RERE ELF3 CHN2 CPVL ENSG00000235669 RF00017-6095 HSALNG0056953 ENSG00000285162
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPVL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPVL gene promoter:
  • AML1a
  • C/EBPalpha
  • CUTL1
  • Evi-1
  • HOXA3
  • IRF-2
  • POU2F1
  • POU3F2
  • RSRFC4
  • S8

Genomic Locations for CPVL Gene

Genomic Locations for CPVL Gene
chr7:28,995,235-29,195,451
(GRCh38/hg38)
Size:
200,217 bases
Orientation:
Minus strand
chr7:29,034,847-29,235,067
(GRCh37/hg19)
Size:
200,221 bases
Orientation:
Minus strand

Genomic View for CPVL Gene

Genes around CPVL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPVL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPVL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CPVL Gene

Proteins for CPVL Gene

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  • Protein details for CPVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3G5-CPVL_HUMAN
    Recommended name:
    Probable serine carboxypeptidase CPVL
    Protein Accession:
    Q9H3G5
    Secondary Accessions:
    • A4D1A4
    • Q6UX20
    • Q8NBL7
    • Q96AR7
    • Q9HB41

    Protein attributes for CPVL Gene

    Size:
    476 amino acids
    Molecular mass:
    54164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CPVL Gene

Protein Expression for CPVL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CPVL Gene

Q9H3G5:
  • NSNLFFW
  • PVGTGFS
  • TGESYAG
  • NLFFWFFPA

Post-translational modifications for CPVL Gene

  • Glycosylation at Asn81, Asn132, Asn307, and Asn346
  • Ubiquitination at Lys280, Lys331, Lys423, and Lys469
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CPVL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPVL Gene

Gene Families for CPVL Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CPVL Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPVL Gene

GenScript: Design optimal peptide antigens:
  • Vitellogenic carboxypeptidase-like protein (CPVL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H3G5

UniProtKB/Swiss-Prot:

CPVL_HUMAN :
  • Belongs to the peptidase S10 family.
Family:
  • Belongs to the peptidase S10 family.
genes like me logo Genes that share domains with CPVL: view

Function for CPVL Gene

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  1. Animal Model
  2. CRISPR
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  4. Inhibitory RNA
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  6. Cell Line

Molecular function for CPVL Gene

UniProtKB/Swiss-Prot Function:
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Enzyme Numbers (IUBMB) for CPVL Gene

Phenotypes From GWAS Catalog for CPVL Gene

Gene Ontology (GO) - Molecular Function for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004185 serine-type carboxypeptidase activity IEA,IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPVL: view
genes like me logo Genes that share phenotypes with CPVL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPVL

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPVL

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPVL Gene

Localization for CPVL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPVL gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 1
peroxisome 1
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CPVL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CPVL Gene

Pathways & Interactions for CPVL Gene

PathCards logo

SuperPathways for CPVL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0051603 proteolysis involved in cellular protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CPVL: view

No data available for Pathways by source and SIGNOR curated interactions for CPVL Gene

Drugs & Compounds for CPVL Gene

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  1. Drug
No Compound Related Data Available

Transcripts for CPVL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CPVL Gene

(17) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(242) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPVL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPVL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for CPVL Gene

GeneLoc Exon Structure for
CPVL
ECgene alternative splicing isoforms for
CPVL

Expression for CPVL Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPVL Gene

mRNA expression in normal human tissues for CPVL Gene
mRNA expression by GTEx for CPVL GenemRNA expression by BioGPS for CPVL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPVL Gene

This gene is overexpressed in Whole Blood (x8.0), Spleen (x6.0), and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for CPVL Gene

This gene is overexpressed in Fetal gut (12.9), Spleen (10.4), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPVL Gene



Protein tissue co-expression partners for CPVL Gene

NURSA nuclear receptor signaling pathways regulating expression of CPVL Gene:

CPVL

SOURCE GeneReport for Unigene cluster for CPVL Gene:

Hs.233389

mRNA Expression by UniProt/SwissProt for CPVL Gene:

Q9H3G5-CPVL_HUMAN
Tissue specificity: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Evidence on tissue expression from TISSUES for CPVL Gene

  • Lung(4.4)
  • Liver(4.2)
  • Nervous system(3.4)
  • Kidney(2.2)
  • Spleen(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with CPVL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPVL Gene

Orthologs for CPVL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPVL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CPVL 33 32
  • 99.23 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CPVL 33 32
  • 83.96 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CPVL 33 32
  • 83.9 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cpvl 32
  • 79.32 (n)
mouse
(Mus musculus)
 Mammalia Cpvl 17 33 32
  • 79.18 (n)
oppossum
(Monodelphis domestica)
 Mammalia CPVL 33
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CPVL 33
  • 67 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CPVL 33
  • 50 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cpvl 32
  • 65.17 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.22832 32
zebrafish
(Danio rerio)
 Actinopterygii cpvl 33 32 32
  • 62.79 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2569 32
fruit fly
(Drosophila melanogaster)
 Insecta CG4572 33 34 32
  • 53.13 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007505 32
  • 53.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 33
  • 21 (a)
 ManyToMany
PRC1 33
  • 20 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons scpl50 32
  • 48 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0215100 32
  • 45.97 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 31 (a)
 ManyToMany
-- 33
  • 28 (a)
 ManyToMany
-- 33
  • 26 (a)
 ManyToMany
CSA.11111 33
  • 16 (a)
 ManyToMany
Species where no ortholog for CPVL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPVL Gene

ENSEMBL:
Gene Tree for CPVL (if available)
TreeFam:
Gene Tree for CPVL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPVL: view image

Paralogs for CPVL Gene

Paralogs for CPVL Gene

(3) SIMAP similar genes for CPVL Gene using alignment to 10 proteins:

  • CPVL_HUMAN
  • C9J6L4_HUMAN
  • C9JI22_HUMAN
  • C9JLV0_HUMAN
  • C9JVI2_HUMAN
  • C9JZ94_HUMAN
  • H7C0X5_HUMAN
  • H7C218_HUMAN
  • O75225_HUMAN
  • Q75MM4_HUMAN
genes like me logo Genes that share paralogs with CPVL: view

Variants for CPVL Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CPVL Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000015142 -- 29,175,232(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000029828 -- 29,133,734(-) C/A intron_variant
rs1000044601 -- 29,111,656(-) C/G/T intron_variant
rs1000068472 -- 29,190,550(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000153231 -- 29,010,056(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPVL Gene

Variant ID Type Subtype PubMed ID
esv2173744 CNV deletion 18987734
esv2734179 CNV deletion 23290073
esv2734180 CNV deletion 23290073
esv2734181 CNV deletion 23290073
esv3305886 CNV mobile element insertion 20981092
esv3363043 CNV insertion 20981092
esv3424078 CNV insertion 20981092
esv3450095 CNV insertion 20981092
esv3612679 CNV loss 21293372
esv3612685 CNV loss 21293372
esv3612687 CNV loss 21293372
esv3612688 CNV loss 21293372
nsv1137205 CNV deletion 24896259
nsv525084 CNV loss 19592680

Variation tolerance for CPVL Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPVL Gene

Human Gene Mutation Database (HGMD)
CPVL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPVL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPVL Gene

Disorders for CPVL Gene

MalaCards: The human disease database

(5) MalaCards diseases for CPVL Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CPVL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPVL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CPVL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPVL Gene

Publications for CPVL Gene

  1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. (PMID: 11401439) Mahoney JA … McKnight AJ (Genomics 2001) 2 3 4 23 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PMID: 20460425) Maeda S … Nakamura Y (Diabetes 2010) 3 43 56
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 43 56
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 3 43 56

ExternalLinks

View latest publications for CPVL gene in Mastermind

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