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The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
CPVL (Carboxypeptidase Vitellogenic Like) is a Protein Coding gene. Diseases associated with CPVL include Encephalomalacia and Periventricular Leukomalacia. Gene Ontology (GO) annotations related to this gene include serine-type carboxypeptidase activity. An important paralog of this gene is CTSA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004180 | carboxypeptidase activity | IEA | -- |
GO:0004185 | serine-type carboxypeptidase activity | IEA,IBA | 21873635 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070062 | extracellular exosome | HDA | 19056867 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0051603 | proteolysis involved in cellular protein catabolic process | IBA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CPVL 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CPVL 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CPVL 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cpvl 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cpvl 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CPVL 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CPVL 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CPVL 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cpvl 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.22832 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cpvl 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2569 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4572 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007505 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
ManyToMany | |
PRC1 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | scpl50 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0215100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
CSA.11111 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713575 | Likely Benign: not provided | 29,121,048(-) | A/G | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
733777 | Likely Benign: not provided | 28,995,812(-) | C/T | MISSENSE_VARIANT | |
rs1052200 | - | p.Arg398His | |||
rs34219043 | - | p.Arg25His | |||
rs36074676 | - | p.Ser11Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2173744 | CNV | deletion | 18987734 |
esv2734179 | CNV | deletion | 23290073 |
esv2734180 | CNV | deletion | 23290073 |
esv2734181 | CNV | deletion | 23290073 |
esv3305886 | CNV | mobile element insertion | 20981092 |
esv3363043 | CNV | insertion | 20981092 |
esv3424078 | CNV | insertion | 20981092 |
esv3450095 | CNV | insertion | 20981092 |
esv3612679 | CNV | loss | 21293372 |
esv3612685 | CNV | loss | 21293372 |
esv3612687 | CNV | loss | 21293372 |
esv3612688 | CNV | loss | 21293372 |
nsv1137205 | CNV | deletion | 24896259 |
nsv525084 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
encephalomalacia |
|
|
periventricular leukomalacia |
|
|
patent ductus arteriosus 1 |
|
|
perinatal necrotizing enterocolitis |
|
|
exudative vitreoretinopathy 1 |
|
|