Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CPTP Gene

Aliases for CPTP Gene

  • Ceramide-1-Phosphate Transfer Protein 2 3 3 5
  • Glycolipid Transfer Protein Domain-Containing Protein 1 3 4
  • Glycolipid Transfer Protein Domain Containing 1 2 3
  • GLTP Domain-Containing Protein 1 3 4
  • GLTPD1 3 4

External Ids for CPTP Gene

Previous HGNC Symbols for CPTP Gene

  • GLTPD1

Summaries for CPTP Gene

GeneCards Summary for CPTP Gene

CPTP (Ceramide-1-Phosphate Transfer Protein) is a Protein Coding gene. Diseases associated with CPTP include Ovarian Squamous Cell Carcinoma. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include phospholipid binding and glycolipid binding. An important paralog of this gene is GLTPD2.

UniProtKB/Swiss-Prot for CPTP Gene

  • Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).

Additional gene information for CPTP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPTP Gene

Genomics for CPTP Gene

GeneHancer (GH) Regulatory Elements for CPTP Gene

Promoters and enhancers for CPTP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001323 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 333 2.6 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 POLR2B GLIS2 INTS11 CPTP ANKRD65 SCNN1D MRPL20 PIR50275
GH01J001235 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5 -85.2 -85195 7.9 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 GLIS2 KLF7 FOS DEK SDF4 ATAD3B B3GALT6 CCNL2 SLC35E2A LOC100129381 FAAP20 SLC35E2B LOC100288379 INTS11
GH01J001019 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 -304.0 -304035 3.4 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF121 GLIS2 ZNF143 ZNF207 ZFP91 AGRN ENSG00000272512 PLEKHN1 C1orf159 UBE2J2 DVL1 CPTP ISG15 PUSL1 NOC2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPTP on UCSC Golden Path with GeneCards custom track

Genomic Locations for CPTP Gene

Genomic Locations for CPTP Gene
chr1:1,324,756-1,328,897
(GRCh38/hg38)
Size:
4,142 bases
Orientation:
Plus strand
chr1:1,260,136-1,264,277
(GRCh37/hg19)

Genomic View for CPTP Gene

Genes around CPTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPTP Gene

Proteins for CPTP Gene

  • Protein details for CPTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA50-CPTP_HUMAN
    Recommended name:
    Ceramide-1-phosphate transfer protein
    Protein Accession:
    Q5TA50
    Secondary Accessions:
    • Q4G0E6
    • Q7L5A4

    Protein attributes for CPTP Gene

    Size:
    214 amino acids
    Molecular mass:
    24365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW56230.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPTP Gene

neXtProt entry for CPTP Gene

Post-translational modifications for CPTP Gene

No Post-translational modifications

Other Protein References for CPTP Gene

No data available for DME Specific Peptides for CPTP Gene

Domains & Families for CPTP Gene

Gene Families for CPTP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPTP Gene

Suggested Antigen Peptide Sequences for CPTP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TA50

UniProtKB/Swiss-Prot:

CPTP_HUMAN :
  • Belongs to the GLTP family.
Family:
  • Belongs to the GLTP family.
genes like me logo Genes that share domains with CPTP: view

Function for CPTP Gene

Molecular function for CPTP Gene

UniProtKB/Swiss-Prot Function:
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).

Phenotypes From GWAS Catalog for CPTP Gene

Gene Ontology (GO) - Molecular Function for CPTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding IDA 23863933
GO:0005548 phospholipid transporter activity IDA 23863933
GO:0008289 lipid binding IEA --
GO:0120013 intermembrane lipid transfer activity IEA --
GO:1902387 ceramide 1-phosphate binding IDA 23863933
genes like me logo Genes that share ontologies with CPTP: view
genes like me logo Genes that share phenotypes with CPTP: view

Animal Model Products

miRNA for CPTP Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPTP Gene

Localization for CPTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPTP Gene

Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPTP gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
golgi apparatus 3
endosome 3
extracellular 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CPTP: view

Pathways & Interactions for CPTP Gene

genes like me logo Genes that share pathways with CPTP: view

Pathways by source for CPTP Gene

Interacting Proteins for CPTP Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343890%0d%0a9606.ENSP00000222008%0d%0a9606.ENSP00000417175%0d%0a9606.ENSP00000345656%0d%0a9606.ENSP00000223054%0d%0a9606.ENSP00000299138%0d%0a
Selected Interacting proteins: Q5TA50-CPTP_HUMAN ENSP00000343890 for CPTP Gene via IID STRING

Gene Ontology (GO) - Biological Process for CPTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006869 lipid transport IEA --
GO:0010507 negative regulation of autophagy IMP 29164996
GO:0046836 NOT glycolipid transport IDA 23863933
GO:0050713 negative regulation of interleukin-1 beta secretion IMP,IEA 29164996
genes like me logo Genes that share ontologies with CPTP: view

No data available for SIGNOR curated interactions for CPTP Gene

Drugs & Compounds for CPTP Gene

(3) Drugs for CPTP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(515) Additional Compounds for CPTP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • 3-dehydro-D-Sphinganine
  • 3-Ketodihydrosphingosine
  • 3-Ketosphinganine
  • (2S)-2-amino-1-Hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with CPTP: view

Transcripts for CPTP Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPTP Gene

No ASD Table

Relevant External Links for CPTP Gene

GeneLoc Exon Structure for
CPTP
ECgene alternative splicing isoforms for
CPTP

Expression for CPTP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPTP Gene

Protein differential expression in normal tissues from HIPED for CPTP Gene

This gene is overexpressed in Bone (52.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPTP Gene



NURSA nuclear receptor signaling pathways regulating expression of CPTP Gene:

CPTP

mRNA Expression by UniProt/SwissProt for CPTP Gene:

Q5TA50-CPTP_HUMAN
Tissue specificity: Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CPTP Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CPTP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPTP Gene

Orthologs for CPTP Gene

This gene was present in the common ancestor of animals.

Orthologs for CPTP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTPD1 34 33
  • 99.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLTPD1 34 33
  • 83.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GLTPD1 34 33
  • 83.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gltpd1 34 33
  • 81.15 (n)
OneToOne
Cptp 16
rat
(Rattus norvegicus)
Mammalia Gltpd1 33
  • 78.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GLTPD1 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLTPD1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLTPD1 34 33
  • 74.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTPD1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltpd1 33
  • 60.59 (n)
zebrafish
(Danio rerio)
Actinopterygii gltpd1 34 33
  • 60.74 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005990 33
  • 52.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30392 34 33
  • 48.06 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-296 34 33
  • 44.52 (n)
ManyToMany
K08E4.2 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.402 34
  • 22 (a)
OneToMany
Species where no ortholog for CPTP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPTP Gene

ENSEMBL:
Gene Tree for CPTP (if available)
TreeFam:
Gene Tree for CPTP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPTP: view image

Paralogs for CPTP Gene

Paralogs for CPTP Gene

genes like me logo Genes that share paralogs with CPTP: view

Variants for CPTP Gene

Sequence variations from dbSNP and Humsavar for CPTP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003240 -- 1,324,638(+) G/A/T upstream_transcript_variant
rs1000073352 -- 1,325,526(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000113484 -- 1,328,688(+) G/A 3_prime_UTR_variant
rs1000143029 -- 1,328,848(+) C/T 3_prime_UTR_variant
rs1000438273 -- 1,324,775(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CPTP Gene

Variant ID Type Subtype PubMed ID
dgv26n54 CNV loss 21841781
dgv2n67 CNV gain 20364138
dgv6n100 CNV gain+loss 25217958
dgv7n100 CNV loss 25217958
esv2758912 CNV loss 17122850
esv3584992 CNV gain 21293372
esv3890636 CNV loss 25118596
nsv1000169 CNV gain 25217958
nsv1009541 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160772 CNV duplication 26073780
nsv1160788 CNV deletion 26073780
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv544969 CNV loss 21841781
nsv544971 CNV loss 21841781
nsv544972 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv997291 CNV gain 25217958

Variation tolerance for CPTP Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPTP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPTP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPTP Gene

Disorders for CPTP Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPTP Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian squamous cell carcinoma
  • ovarian squamous cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CPTP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPTP

genes like me logo Genes that share disorders with CPTP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPTP Gene

Publications for CPTP Gene

  1. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. (PMID: 23863933) Simanshu DK … Patel DJ (Nature 2013) 2 3 4 58
  2. CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation. (PMID: 29164996) Mishra SK … Brown RE (Autophagy 2018) 3 4 58
  3. Phosphatidylserine Stimulates Ceramide 1-Phosphate (C1P) Intermembrane Transfer by C1P Transfer Proteins. (PMID: 28011644) Zhai X … Brown RE (The Journal of biological chemistry 2017) 4 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for CPTP Gene

Sources for CPTP Gene

Content
Loading form....