Aliases for CPSF6 Gene
- Cleavage And Polyadenylation Specific Factor 6 2 3 5
- Cleavage Factor Im Complex 68 KDa Subunit 2 3 4
- Cleavage And Polyadenylation Specificity Factor 68 KDa Subunit 3 4
- Cleavage And Polyadenylation Specificity Factor Subunit 6 3 4
- Cleavage And Polyadenylation Specific Factor 6, 68kDa 2 3
- Pre-MRNA Cleavage Factor Im 68 KDa Subunit 3 4
- CPSF 68 KDa Subunit 3 4
- Protein HPBRII-4/7 3 4
External Ids for CPSF6 Gene
Previous GeneCards Identifiers for CPSF6 Gene
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPSF6 Gene
CPSF6 (Cleavage And Polyadenylation Specific Factor 6) is a Protein Coding gene. Diseases associated with CPSF6 include Acute Promyelocytic Leukemia. Among its related pathways are FGFR1 mutant receptor activation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPSF7.
UniProtKB/Swiss-Prot Summary for CPSF6 Gene
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).