Aliases for CPSF4L Gene
Aliases for CPSF4L Gene
External Ids for CPSF4L Gene
- HGNC: 33632
- Entrez Gene: 642843
- Ensembl: ENSG00000187959
- UniProtKB: A6NMK7
Previous GeneCards Identifiers for CPSF4L Gene
- GC17M068757
- GC17M071244
- GC17M066653
Summaries for CPSF4L Gene
GeneCards Summary for CPSF4L Gene
CPSF4L (Cleavage And Polyadenylation Specific Factor 4 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.
Additional gene information for CPSF4L Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4L Gene
Genomics for CPSF4L Gene
GeneHancer (GH) Regulatory Elements for CPSF4L Gene
Promoters and enhancers for CPSF4L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CPSF4L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CPSF4L gene promoter:
-
- Nkx2-5
- RSRFC4
- MAZR
- Lmo2
- GATA-6
- MZF-1
- YY1
- Zic3
- Tal-1
- E47
Regulatory Element Products
Genomic Locations for CPSF4L Gene
Genomic Locations for CPSF4L Gene
- chr17:73,242,343-73,262,532
- (GRCh38/hg38)
- Size:
- 20,190 bases
- Orientation:
- Minus strand
- chr17:71,244,588-71,258,491
- (GRCh37/hg19)
- Size:
- 13,904 bases
- Orientation:
- Minus strand
Genomic View for CPSF4L Gene
Genes around CPSF4L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
- 17q25.1 by Ensembl
CPSF4L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CPSF4L Gene
Proteins for CPSF4L Gene
-
Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NMK7-CPS4L_HUMAN
- Recommended name:
- Putative cleavage and polyadenylation specificity factor subunit 4-like protein
- Protein Accession:
- A6NMK7
- A8MU95
- B2RXI9
Protein attributes for CPSF4L Gene
- Size:
- 179 amino acids
- Molecular mass:
- 20727 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CPSF4L Gene
Post-translational modifications for CPSF4L Gene
Other Protein References for CPSF4L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CPSF4L
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for CPSF4L Gene
Domains & Families for CPSF4L Gene
Gene Families for CPSF4L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CPSF4L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CPSF4L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NMK7- Family:
-
- Belongs to the CPSF4/YTH1 family.
Function for CPSF4L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA | -- |
| GO:0004521 | endoribonuclease activity | IBA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Animal Model Products
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-
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-
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- Applied Biological Materials CRISPR for CPSF4L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPSF4L
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CPSF4L
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-
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Cell Line Products
-
Horizon Cell Lines for CPSF4L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPSF4L Gene
Localization for CPSF4L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| extracellular | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CPSF4L Gene
Pathways & Interactions for CPSF4L Gene
No Data Available
Interacting Proteins for CPSF4L Gene
GPS-Prot Interaction Network for CPSF4L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006378 | mRNA polyadenylation | IBA | -- |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | IEA | -- |
| GO:0098789 | pre-mRNA cleavage required for polyadenylation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CPSF4L Gene
Transcripts for CPSF4L Gene
mRNA/cDNA for CPSF4L Gene
- (2) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000344935 647 bps (uc010dfk.1)
- ENST00000397671 1275 bps (uc060jmf.1)
Unigene Clusters for CPSF4L Gene
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CPSF4L
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CPSF4L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Secondary follicles
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene
This gene is overexpressed in Testis (x4.4).
This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPSF4L Gene
NURSA nuclear receptor signaling pathways regulating expression of CPSF4L Gene:
CPSF4LSOURCE GeneReport for Unigene cluster for CPSF4L Gene:
Hs.534707Primer Products
-
OriGene qPCR primer pairs for CPSF4L
-
OriGene qPCR primer pairs and template standards for CPSF4L
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Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF4L Gene
Orthologs for CPSF4L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CPSF4L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CPSF4L 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cpsf4l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cpsf4l 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CPSF4L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CPSF4L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CPSF4L 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Clp 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cpsf-4 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YTH1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9063 34 |
|
OneToMany |
- Species where no ortholog for CPSF4L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for CPSF4L Gene
- ENSEMBL:
- Gene Tree for CPSF4L (if available)
- TreeFam:
- Gene Tree for CPSF4L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CPSF4L: view image
Paralogs for CPSF4L Gene
(1) SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins:
- CPS4L_HUMAN
- H9KVA5_HUMAN
Pseudogenes.org Pseudogenes for CPSF4L Gene
Variants for CPSF4L Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000087812 | -- | 73,244,762(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000147716 | -- | 73,245,599(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000321260 | -- | 73,250,731(-) | C/T | intron_variant | |
| rs1000413759 | -- | 73,251,225(-) | C/T | intron_variant | |
| rs1000483653 | -- | 73,256,475(-) | G/A | intron_variant |
Gene Damage Index Score:
0.66;
14.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CPSF4L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CPSF4L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF4L Gene
Disorders for CPSF4L Gene
Additional Disease Information for CPSF4L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CPSF4L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF4L Gene
Publications for CPSF4L Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
Products for CPSF4L Gene
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Sources for CPSF4L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt