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CPSF4L Gene(Protein Coding)

Cleavage And Polyadenylation Specific Factor 4 Like

GCID:
GC17M073248
GIFtS:
36
Genes Participants
UDN Logo

Aliases for CPSF4L Gene

Aliases for CPSF4L Gene

  • Cleavage And Polyadenylation Specific Factor 4 Like 2 3 5
  • Putative Cleavage And Polyadenylation Specificity Factor Subunit 4-Like Protein 3

External Ids for CPSF4L Gene

Previous GeneCards Identifiers for CPSF4L Gene

  • GC17M068757
  • GC17M071244
  • GC17M066653

Summaries for CPSF4L Gene

GeneCards Summary for CPSF4L Gene

CPSF4L (Cleavage And Polyadenylation Specific Factor 4 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.

Additional gene information for CPSF4L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF4L Gene

Genomics for CPSF4L Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CPSF4L Gene

Promoters and enhancers for CPSF4L Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J073261 Enhancer 1.3 Ensembl ENCODE dbSUPER 650.7 0.0 -44 2 FOXA2 ZFP64 ARID4B DMAP1 ZNF48 YY1 NFKBIZ RXRA SP5 MXD4 CPSF4L COG1 PIR39589
GH17J073264 Enhancer 0.4 dbSUPER 650.7 -1.7 -1692 0.4 IKZF5 ZBTB25 CPSF4L PIR39589
GH17J073287 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17 -29.2 -29218 7.7 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 C17orf80 CDC42EP4 CPSF4L FAM104A GC17P073281 GC17M073290 GC17M073288 GC17M073289
GH17J073298 Enhancer 1 ENCODE dbSUPER 11.7 -36.0 -35959 0.8 HDAC1 TAF9B MZF1 THRB RARA GATA2 EGR1 ATF7 RCOR1 EGR2 C17orf80 CPSF4L FAM104A GC17M073288 GC17M073290 CDC42EP4 GC17P073281 GC17M073289
GH17J073277 Enhancer 1.3 Ensembl ENCODE dbSUPER 8.4 -16.4 -16414 2.3 FOXA2 ARID4B FEZF1 ZNF48 YY1 PAF1 RXRA SP5 MIER2 NFIL3 C17orf80 CDC42EP4 FAM104A CPSF4L COG1 GC17P073281 PIR39589
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPSF4L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPSF4L gene promoter:

Genomic Locations for CPSF4L Gene

Genomic Locations for CPSF4L Gene
chr17:73,242,343-73,262,532
(GRCh38/hg38)
Size:
20,190 bases
Orientation:
Minus strand
chr17:71,244,588-71,258,491
(GRCh37/hg19)

Genomic View for CPSF4L Gene

Genes around CPSF4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF4L Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CPSF4L Gene

Proteins for CPSF4L Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMK7-CPS4L_HUMAN
    Recommended name:
    Putative cleavage and polyadenylation specificity factor subunit 4-like protein
    Protein Accession:
    A6NMK7
    Secondary Accessions:
    • A8MU95
    • B2RXI9

    Protein attributes for CPSF4L Gene

    Size:
    179 amino acids
    Molecular mass:
    20727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CPSF4L Gene

Protein Expression for CPSF4L Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CPSF4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPSF4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPSF4L Gene

Domains & Families for CPSF4L Gene

Gene Families for CPSF4L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPSF4L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPSF4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMK7

UniProtKB/Swiss-Prot:

CPS4L_HUMAN :
  • Belongs to the CPSF4/YTH1 family.
Family:
  • Belongs to the CPSF4/YTH1 family.
genes like me logo Genes that share domains with CPSF4L: view

Function for CPSF4L Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004521 endoribonuclease activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPSF4L: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPSF4L Gene

Localization for CPSF4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPSF4L gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with CPSF4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CPSF4L Gene

Pathways & Interactions for CPSF4L Gene

SuperPathways for CPSF4L Gene

PathCards logo More details on SuperPathways for CPSF4L
No Data Available

Gene Ontology (GO) - Biological Process for CPSF4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IBA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
GO:0098789 pre-mRNA cleavage required for polyadenylation IBA --
genes like me logo Genes that share ontologies with CPSF4L: view

No data available for Pathways by source and SIGNOR curated interactions for CPSF4L Gene

Drugs & Compounds for CPSF4L Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CPSF4L Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CPSF4L Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPSF4L Gene

Cleavage and polyadenylation specific factor 4-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF4L Gene

No ASD Table

Relevant External Links for CPSF4L Gene

GeneLoc Exon Structure for
CPSF4L
ECgene alternative splicing isoforms for
CPSF4L

Expression for CPSF4L Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPSF4L Gene

mRNA expression in normal human tissues for CPSF4L Gene
mRNA expression by GTEx for CPSF4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for CPSF4L Gene

This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPSF4L Gene



Protein tissue co-expression partners for CPSF4L Gene

NURSA nuclear receptor signaling pathways regulating expression of CPSF4L Gene:

CPSF4L

SOURCE GeneReport for Unigene cluster for CPSF4L Gene:

Hs.534707
genes like me logo Genes that share expression patterns with CPSF4L: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF4L Gene

Orthologs for CPSF4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPSF4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CPSF4L 34 33
  • 99.63 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CPSF4L 33
  • 83.97 (n)
rat
(Rattus norvegicus)
 Mammalia Cpsf4l 33
  • 82.53 (n)
mouse
(Mus musculus)
 Mammalia Cpsf4l 16 34 33
  • 81.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia CPSF4L 34
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CPSF4L 34
  • 42 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CPSF4L 34
  • 29 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Clp 34
  • 33 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea cpsf-4 34
  • 28 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YTH1 34
  • 31 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.9063 34
  • 34 (a)
 OneToMany
Species where no ortholog for CPSF4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPSF4L Gene

ENSEMBL:
Gene Tree for CPSF4L (if available)
TreeFam:
Gene Tree for CPSF4L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPSF4L: view image

Paralogs for CPSF4L Gene

Paralogs for CPSF4L Gene

(1) SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins:

  • CPS4L_HUMAN
  • H9KVA5_HUMAN

Pseudogenes.org Pseudogenes for CPSF4L Gene

genes like me logo Genes that share paralogs with CPSF4L: view

Variants for CPSF4L Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CPSF4L Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000087812 -- 73,244,762(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000147716 -- 73,245,599(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000321260 -- 73,250,731(-) C/T intron_variant
rs1000413759 -- 73,251,225(-) C/T intron_variant
rs1000483653 -- 73,256,475(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF4L Gene

Variant ID Type Subtype PubMed ID
esv3641216 CNV loss 21293372
nsv2138 CNV insertion 18451855
nsv833534 CNV loss 17160897

Variation tolerance for CPSF4L Gene

Gene Damage Index Score: 0.66; 14.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPSF4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF4L Gene

Disorders for CPSF4L Gene

Additional Disease Information for CPSF4L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPSF4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF4L Gene

Publications for CPSF4L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

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Sources for CPSF4L Gene

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