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Aliases for CPSF4L Gene
Aliases for CPSF4L Gene
External Ids for CPSF4L Gene
- HGNC: 33632
- Entrez Gene: 642843
- Ensembl: ENSG00000187959
- UniProtKB: A6NMK7
Previous GeneCards Identifiers for CPSF4L Gene
- GC17M068757
- GC17M071244
- GC17M066653
Summaries for CPSF4L Gene
GeneCards Summary for CPSF4L Gene
CPSF4L (Cleavage And Polyadenylation Specific Factor 4 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is CPSF4.
Additional gene information for CPSF4L Gene
- HGNC(33632)
- Entrez Gene(642843)
- Ensembl(ENSG00000187959)
- UniProtKB(A6NMK7)
- Open Targets Platform(ENSG00000187959)
- Search for CPSF4L at DataMed
- Search for CPSF4L at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPSF4L Gene
Genomics for CPSF4L Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CPSF4L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CPSF4L on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPSF4L
- Top Transcription factor binding sites by QIAGEN in the CPSF4L gene promoter:
-
- E47
- GATA-6
- Lmo2
- MAZR
- MZF-1
- Nkx2-5
- RSRFC4
- Tal-1
- YY1
- Zic3
Genomic Locations for CPSF4L Gene
Genomic Locations for CPSF4L Gene
- chr17:73,242,343-73,263,778
- (GRCh38/hg38)
- Size:
- 21,436 bases
- Orientation:
- Minus strand
- chr17:71,244,588-71,258,491
- (GRCh37/hg19)
- Size:
- 13,904 bases
- Orientation:
- Minus strand
Genomic View for CPSF4L Gene
Genes around CPSF4L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
CPSF4L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CPSF4L Gene
Proteins for CPSF4L Gene
-
Protein details for CPSF4L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NMK7-CPS4L_HUMAN
- Recommended name:
- Putative cleavage and polyadenylation specificity factor subunit 4-like protein
- Protein Accession:
- A6NMK7
- A8MU95
- B2RXI9
Protein attributes for CPSF4L Gene
- Size:
- 179 amino acids
- Molecular mass:
- 20727 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CPSF4L Gene
Post-translational modifications for CPSF4L Gene
Other Protein References for CPSF4L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-CPSF4L (aa 147-179) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for CPSF4L
- Novus Biologicals Antibodies for CPSF4L
- Invitrogen Antibodies for CPSF4L (AFLGC-Cpsf4l)
- antibodies-online: Show 10 available CPSF4L Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for CPSF4L
- Search Origene for MassSpec and Protein Over-expression Lysates for CPSF4L
- Origene Custom Protein Services for CPSF4L
- Novus Biologicals proteins for CPSF4L
No data available for DME Specific Peptides for CPSF4L Gene
Domains & Families for CPSF4L Gene
Gene Families for CPSF4L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CPSF4L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CPSF4L Gene
- GenScript: Design optimal peptide antigens:
-
- Putative cleavage and polyadenylation specificity factor subunit 4-like protein (CPS4L_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A6NMK7- Family:
-
- Belongs to the CPSF4/YTH1 family.
Function for CPSF4L Gene
Phenotypes From GWAS Catalog for CPSF4L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CPSF4L - Select products 50% OFF >
- * CPSF4L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CPSF4L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CPSF4L
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPSF4L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CPSF4L
- Browse OriGene Inhibitory RNA Products For CPSF4L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPSF4L
Clone Products
- Applied Biological Materials (abm): Clones for CPSF4L - Select products 50% OFF >
- * CPSF4L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CPSF4L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CPSF4L
Cell Line Products
-
Horizon Cell Lines for CPSF4L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPSF4L Gene
Localization for CPSF4L Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CPSF4L Gene
Pathways & Interactions for CPSF4L Gene
Interacting Proteins for CPSF4L Gene
GPS-Prot Interaction Network for CPSF4L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0098789 | pre-mRNA cleavage required for polyadenylation | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for CPSF4L Gene
Transcripts for CPSF4L Gene
mRNA/cDNA for CPSF4L Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000344935 647 nts (view in UCSC)
- ENST00000397671 1275 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CPSF4L - Select products 50% OFF >
- * CPSF4L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CPSF4L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CPSF4L
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPSF4L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CPSF4L
- Browse OriGene Inhibitory RNA Products For CPSF4L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPSF4L
Clone Products
- Applied Biological Materials (abm): Clones for CPSF4L - Select products 50% OFF >
- * CPSF4L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CPSF4L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CPSF4L
Relevant External Links for CPSF4L Gene
- GeneLoc Exon Structure for
- CPSF4L
Expression for CPSF4L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Secondary follicles
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
mRNA differential expression in normal tissues according to GTEx for CPSF4L Gene
This gene is overexpressed in Testis (x4.4).
This gene is overexpressed in Fetal ovary (46.0), Fetal heart (14.5), and Gallbladder (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPSF4L Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPSF4L
SOURCE GeneReport for Unigene cluster for CPSF4L Gene:
Hs.534707Primer Products
-
OriGene qPCR primer pairs for CPSF4L
-
OriGene qPCR primer pairs and template standards for CPSF4L
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF4L Gene
Orthologs for CPSF4L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CPSF4L 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CPSF4L 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Cpsf4l 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cpsf4l 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CPSF4L 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CPSF4L 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CPSF4L 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Clp 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cpsf-4 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YTH1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9063 31 |
|
OneToMany |
- Species where no ortholog for CPSF4L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for CPSF4L Gene
- ENSEMBL:
- Gene Tree for CPSF4L (if available)
- TreeFam:
- Gene Tree for CPSF4L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CPSF4L: view image
Paralogs for CPSF4L Gene
(1) SIMAP similar genes for CPSF4L Gene using alignment to 2 proteins:
- CPS4L_HUMAN
- H9KVA5_HUMAN
Pseudogenes.org Pseudogenes for CPSF4L Gene
Variants for CPSF4L Gene
Gene Damage Index Score:
0.66;
14.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CPSF4L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CPSF4L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPSF4L Gene
Disorders for CPSF4L Gene
Additional Disease Information for CPSF4L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CPSF4L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF4L Gene
Publications for CPSF4L Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
ExternalLinks
Products for CPSF4L Gene
- Custom Antibody ServicesOriGene Antibodies for CPSF4L
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CPSF4L
- Search Origene for MassSpec and Protein Over-expression Lysates for CPSF4L
- Origene Custom Protein Services for CPSF4L
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CPSF4L
- Browse OriGene Inhibitory RNA Products For CPSF4L
- OriGene qPCR primer pairs for CPSF4L
- OriGene qPCR primer pairs and template standards for CPSF4L
- OriGene CRISPR knockouts for CPSF4L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CPSF4L
- Sino Biological Human cDNA Clone for CPSF4L
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CPSF4L
- Novus Biologicals proteins for CPSF4L
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for CPSF4L (AFLGC-Cpsf4l)
- VectorBuilder Custom and pre-made DNA vectors for CPSF4L (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CPSF4L (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CPSF4L (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CPSF4L CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CPSF4L
- antibodies-online: Show 10 available CPSF4L Antibodies ranked by validation data
- antibodies-online: Search results for available CPSF4L related products ranked by validation data
- antibodies-online: Search results for available CPSF4L related products ranked by validation data
- Horizon Cell Lines for CPSF4L
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CPSF4L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CPSF4L
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CPSF4L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPSF4L
Sources for CPSF4L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB