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Aliases for CPSF2 Gene

Aliases for CPSF2 Gene

  • Cleavage And Polyadenylation Specific Factor 2 2 3 5
  • Cleavage And Polyadenylation Specificity Factor 100 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 2, 100kDa 2 3
  • CPSF 100 KDa Subunit 3 4
  • CPSF100 3 4
  • Cleavage And Polyadenylation Specific Factor 2, 100kD Subunit 2
  • Cleavage And Polyadenylation Specificity Factor Subunit 2 3
  • CPSF 100kDa Subunit 3
  • KIAA1367 4

External Ids for CPSF2 Gene

Previous GeneCards Identifiers for CPSF2 Gene

  • GC14P090094
  • GC14P086404
  • GC14P090578
  • GC14P091658
  • GC14P092588
  • GC14P072769

Summaries for CPSF2 Gene

GeneCards Summary for CPSF2 Gene

CPSF2 (Cleavage And Polyadenylation Specific Factor 2) is a Protein Coding gene. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CPSF2 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Gene Wiki entry for CPSF2 Gene

Additional gene information for CPSF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPSF2 Gene

Genomics for CPSF2 Gene

GeneHancer (GH) Regulatory Elements for CPSF2 Gene

Promoters and enhancers for CPSF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J092120 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 685.1 +0.1 145 3 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CPSF2 NDUFB1 ATXN3 PPP4R3A TRIP11 GC14P092168
GH14J092038 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.9 -82.1 -82082 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B TRIP11 PIR36842 PPP4R3A ATXN3 CPSF2 GOLGA5 TC2N CATSPERB NDUFB1 GC14P091891
GH14J092792 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.3 +672.3 672251 3.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B GOLGA5 ATXN3 CPSF2 BTBD7 TRIP11 LGMN GC14P092353
GH14J092105 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.1 -15.7 -15746 2.2 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ATXN3 PPP4R3A CPSF2 NDUFB1 TRIP11 RIN3 SLC24A4 CATSPERB
GH14J091507 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 -612.3 -612255 4.2 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC PPP4R3A TRIP11 ATXN3 CCDC88C RPS18P2 CPSF2 TC2N ENSG00000258446
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPSF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPSF2 gene promoter:
  • TBP
  • TFIID

Genomic Locations for CPSF2 Gene

Genomic Locations for CPSF2 Gene
chr14:92,121,937-92,172,145
(GRCh38/hg38)
Size:
50,209 bases
Orientation:
Plus strand
chr14:92,588,281-92,630,755
(GRCh37/hg19)
Size:
42,475 bases
Orientation:
Plus strand

Genomic View for CPSF2 Gene

Genes around CPSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPSF2 Gene

Proteins for CPSF2 Gene

  • Protein details for CPSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2I0-CPSF2_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 2
    Protein Accession:
    Q9P2I0
    Secondary Accessions:
    • B3KME1
    • Q6NSJ1
    • Q9H3W7

    Protein attributes for CPSF2 Gene

    Size:
    782 amino acids
    Molecular mass:
    88487 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK. Interacts with ZC3H3 (By similarity).

neXtProt entry for CPSF2 Gene

Post-translational modifications for CPSF2 Gene

  • Ubiquitination at posLast=725725, posLast=375375, posLast=324324, and posLast=130130
  • Modification sites at PhosphoSitePlus

Other Protein References for CPSF2 Gene

No data available for DME Specific Peptides for CPSF2 Gene

Domains & Families for CPSF2 Gene

Gene Families for CPSF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9P2I0

UniProtKB/Swiss-Prot:

CPSF2_HUMAN :
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
genes like me logo Genes that share domains with CPSF2: view

Function for CPSF2 Gene

Molecular function for CPSF2 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3 end pre-mRNA processing.

Phenotypes From GWAS Catalog for CPSF2 Gene

Gene Ontology (GO) - Molecular Function for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17353931
genes like me logo Genes that share ontologies with CPSF2: view
genes like me logo Genes that share phenotypes with CPSF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPSF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPSF2 Gene

Localization for CPSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPSF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPSF2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA,IDA 18305108
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CPSF2: view

Pathways & Interactions for CPSF2 Gene

genes like me logo Genes that share pathways with CPSF2: view

Pathways by source for CPSF2 Gene

Gene Ontology (GO) - Biological Process for CPSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA --
GO:0006379 mRNA cleavage IEA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CPSF2: view

No data available for SIGNOR curated interactions for CPSF2 Gene

Drugs & Compounds for CPSF2 Gene

No Compound Related Data Available

Transcripts for CPSF2 Gene

Unigene Clusters for CPSF2 Gene

Cleavage and polyadenylation specific factor 2, 100kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPSF2

Alternative Splicing Database (ASD) splice patterns (SP) for CPSF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: - - - - -
SP3:

Relevant External Links for CPSF2 Gene

GeneLoc Exon Structure for
CPSF2
ECgene alternative splicing isoforms for
CPSF2

Expression for CPSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPSF2 Gene

Protein differential expression in normal tissues from HIPED for CPSF2 Gene

This gene is overexpressed in Lymph node (14.2), Peripheral blood mononuclear cells (6.7), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPSF2 Gene



Protein tissue co-expression partners for CPSF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPSF2 Gene:

CPSF2

SOURCE GeneReport for Unigene cluster for CPSF2 Gene:

Hs.657632

Evidence on tissue expression from TISSUES for CPSF2 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Lymph node(4.2)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CPSF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPSF2 Gene

Orthologs for CPSF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF2 34 33
  • 99.7 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF2 34 33
  • 93.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF2 34 33
  • 93.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf2 33
  • 89.09 (n)
mouse
(Mus musculus)
Mammalia Cpsf2 16 34 33
  • 88.7 (n)
chicken
(Gallus gallus)
Aves CPSF2 34 33
  • 84.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF2 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf2 33
  • 79.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia cpsf2-A 33
zebrafish
(Danio rerio)
Actinopterygii cpsf2 34 33
  • 72.98 (n)
OneToOne
Dr.12526 33
fruit fly
(Drosophila melanogaster)
Insecta Cpsf100 34 33
  • 56.94 (n)
OneToOne
BcDNA:LD14168 35
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002474 33
  • 56.64 (n)
worm
(Caenorhabditis elegans)
Secernentea cpsf-2 34 33
  • 53.63 (n)
OneToOne
F09G2.4 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT2 36 34
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF100 33
  • 50.51 (n)
rice
(Oryza sativa)
Liliopsida Os09g0569400 33
  • 50.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.13623 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13623 33
Species where no ortholog for CPSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPSF2 Gene

ENSEMBL:
Gene Tree for CPSF2 (if available)
TreeFam:
Gene Tree for CPSF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPSF2: view image

Paralogs for CPSF2 Gene

No data available for Paralogs for CPSF2 Gene

Variants for CPSF2 Gene

Sequence variations from dbSNP and Humsavar for CPSF2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000040093 -- 92,157,249(+) T/C intron_variant
rs1000066590 -- 92,122,001(+) C/G 5_prime_UTR_variant
rs1000102024 -- 92,146,690(+) A/G intron_variant
rs1000218911 -- 92,147,770(+) C/T intron_variant
rs1000308397 -- 92,152,339(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPSF2 Gene

Variant ID Type Subtype PubMed ID
esv1267299 CNV insertion 17803354
esv3635331 CNV loss 21293372
esv999869 CNV insertion 20482838
nsv1397 CNV insertion 18451855
nsv472736 CNV novel sequence insertion 20440878

Variation tolerance for CPSF2 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPSF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPSF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPSF2 Gene

Disorders for CPSF2 Gene

Additional Disease Information for CPSF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPSF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPSF2 Gene

Publications for CPSF2 Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M … Freedman BI (American journal of nephrology 2011) 3 44 58
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  3. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PMID: 21102410) Laishram RS … Anderson RA (The EMBO journal 2010) 3 4 58
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58
  5. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PMID: 18688255) Kolev NG … Steitz JA (EMBO reports 2008) 3 4 58

Products for CPSF2 Gene

Sources for CPSF2 Gene

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