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CPSF2 (Cleavage And Polyadenylation Specific Factor 2) is a Protein Coding gene. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is INTS11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 18288197 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex | IEA,IDA | 18305108 |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
2 | Cleavage of Growing Transcript in the Termination Region | ||
3 | Processing of Capped Intronless Pre-mRNA | ||
4 | Transport of the SLBP independent Mature mRNA | ||
5 | mRNA surveillance pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
GO:0006378 | mRNA polyadenylation | IEA,IBA | 21873635 |
GO:0006379 | mRNA cleavage | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CPSF2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CPSF2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CPSF2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CPSF2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CPSF2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cpsf2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cpsf2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CPSF2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CPSF2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cpsf2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | cpsf2-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cpsf2 30 31 |
|
OneToOne | |
Dr.12526 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cpsf100 30 31 |
|
OneToOne | |
BcDNA:LD14168 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002474 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cpsf-2 30 31 |
|
OneToOne | |
F09G2.4 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CFT2 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CPSF100 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0569400 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.13623 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1267299 | CNV | insertion | 17803354 |
esv3635331 | CNV | loss | 21293372 |
esv999869 | CNV | insertion | 20482838 |
nsv1397 | CNV | insertion | 18451855 |
nsv472736 | CNV | novel sequence insertion | 20440878 |
No disorders were found for CPSF2 Gene.