CPPED1 Gene (Protein Coding)

Calcineurin Like Phosphoesterase Domain Containing 1

GC16M012659
GIFtS:
37
See more...

Aliases for CPPED1 Gene

Aliases for CPPED1 Gene

  • Calcineurin Like Phosphoesterase Domain Containing 1 2 3 5
  • CSTP1 2 3 4
  • Calcineurin-Like Phosphoesterase Domain-Containing Protein 1 3 4
  • Serine/Threonine-Protein Phosphatase CPPED1 3 4
  • Complete S-Transactivated Protein 1 3 4
  • Calcineurin-Like Phosphoesterase Domain Containing 1 2
  • Complete S Transactivated Protein 1 2
  • EC 3.1.3.16 4
  • FLJ11151 2
  • CPPED1 5

External Ids for CPPED1 Gene

Previous GeneCards Identifiers for CPPED1 Gene

  • GC16M012661
  • GC16M012753

Summaries for CPPED1 Gene

GeneCards Summary for CPPED1 Gene

CPPED1 (Calcineurin Like Phosphoesterase Domain Containing 1) is a Protein Coding gene. Diseases associated with CPPED1 include Trichostrongylosis and Trichostrongyloidiasis. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot Summary for CPPED1 Gene

  • Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

Additional gene information for CPPED1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPPED1 Gene

Genomics for CPPED1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CPPED1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPPED1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPPED1

Top Transcription factor binding sites by QIAGEN in the CPPED1 gene promoter:
  • AP-1
  • Cart-1
  • CUTL1
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HSF1 (long)
  • HSF1short
  • YY1

Genomic Locations for CPPED1 Gene

Genomic Locations for CPPED1 Gene
chr16:12,659,799-12,803,887
(GRCh38/hg38)
Size:
144,089 bases
Orientation:
Minus strand
chr16:12,753,656-12,897,874
(GRCh37/hg19)
Size:
144,219 bases
Orientation:
Minus strand

Genomic View for CPPED1 Gene

Genes around CPPED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPPED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPPED1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CPPED1 Gene

Proteins for CPPED1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CPPED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRF8-CPPED_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase CPPED1
    Protein Accession:
    Q9BRF8
    Secondary Accessions:
    • B4DQ68
    • Q6MZY9
    • Q9H9M9
    • Q9NUT6

    Protein attributes for CPPED1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35548 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPPED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPPED1 Gene

Protein Expression for CPPED1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CPPED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPPED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPPED1 Gene

Domains & Families for CPPED1 Gene

Gene Families for CPPED1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CPPED1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPPED1 Gene

GenScript: Design optimal peptide antigens:
  • Complete S-transactivated protein 1 (CPPED_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRF8

UniProtKB/Swiss-Prot:

CPPED_HUMAN :
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
Family:
  • Belongs to the metallophosphoesterase superfamily. CPPED1 family.
genes like me logo Genes that share domains with CPPED1: view

Function for CPPED1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CPPED1 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:23799035};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:23799035};.
UniProtKB/Swiss-Prot Induction:
Transactivated by the large envelope protein of the hepatitis B virus (HBV).

Enzyme Numbers (IUBMB) for CPPED1 Gene

Phenotypes From GWAS Catalog for CPPED1 Gene

Gene Ontology (GO) - Molecular Function for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CPPED1: view
genes like me logo Genes that share phenotypes with CPPED1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPPED1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPPED1 Gene

Localization for CPPED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPPED1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPPED1 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytosol 4
lysosome 4
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with CPPED1: view

Pathways & Interactions for CPPED1 Gene

PathCards logo

SuperPathways for CPPED1 Gene

genes like me logo Genes that share pathways with CPPED1: view

Pathways by source for CPPED1 Gene

3 Reactome pathways for CPPED1 Gene

Gene Ontology (GO) - Biological Process for CPPED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CPPED1: view

No data available for SIGNOR curated interactions for CPPED1 Gene

Drugs & Compounds for CPPED1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CPPED1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CPPED1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPPED1

Alternative Splicing Database (ASD) splice patterns (SP) for CPPED1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for CPPED1 Gene

GeneLoc Exon Structure for
CPPED1

Expression for CPPED1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPPED1 Gene

mRNA expression in normal human tissues for CPPED1 Gene
mRNA expression by BioGPS for CPPED1 GenemRNA expression by GTEx for CPPED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPPED1 Gene

This gene is overexpressed in Whole Blood (x18.8).

Protein differential expression in normal tissues from HIPED for CPPED1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPPED1 Gene



Protein tissue co-expression partners for CPPED1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPPED1

SOURCE GeneReport for Unigene cluster for CPPED1 Gene:

Hs.460002

mRNA Expression by UniProt/SwissProt for CPPED1 Gene:

Q9BRF8-CPPED_HUMAN
Tissue specificity: Expressed in subcutaneous adipose tissue.

Evidence on tissue expression from TISSUES for CPPED1 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Blood(3.3)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with CPPED1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPPED1 Gene

Orthologs for CPPED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPPED1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CPPED1 30 31
  • 98.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CPPED1 30 31
  • 85.49 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CPPED1 30 31
  • 84.88 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cpped1 30
  • 82.91 (n)
Mouse
(Mus musculus)
 Mammalia Cpped1 30 17 31
  • 81.41 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CPPED1 31
  • 73 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CPPED1 31
  • 71 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CPPED1 30 31
  • 66.88 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CPPED1 31
  • 70 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cpped1 30
  • 65.91 (n)
Str.265 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.11444 30
Zebrafish
(Danio rerio)
 Actinopterygii cpped1 30 31
  • 63.85 (n)
 OneToOne
Dr.16752 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3773 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 49 (a)
 OneToMany
-- 31
  • 41 (a)
 OneToMany
Species where no ortholog for CPPED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CPPED1 Gene

ENSEMBL:
Gene Tree for CPPED1 (if available)
TreeFam:
Gene Tree for CPPED1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPPED1: view image

Paralogs for CPPED1 Gene

Pseudogenes.org Pseudogenes for CPPED1 Gene

genes like me logo Genes that share paralogs with CPPED1: view

No data available for Paralogs for CPPED1 Gene

Variants for CPPED1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPPED1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11645068 - p.His290Pro
rs1713480 - p.Lys241Arg
rs3748976 - p.Ala19Asp
rs3748980 - p.Val86Ile

Additional dbSNP identifiers (rs#s) for CPPED1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CPPED1 Gene

Variant ID Type Subtype PubMed ID
dgv115e55 CNV loss 17911159
dgv2736n100 CNV loss 25217958
dgv479e214 CNV loss 21293372
dgv4911n54 CNV loss 21841781
esv2751549 CNV loss 17911159
esv3582011 CNV loss 25503493
esv3637967 CNV loss 21293372
esv3637968 CNV loss 21293372
esv3637969 CNV loss 21293372
esv3637972 CNV loss 21293372
nsv1043773 CNV loss 25217958
nsv1052802 CNV loss 25217958
nsv1053617 CNV loss 25217958
nsv1070328 CNV deletion 25765185
nsv1108988 CNV deletion 24896259
nsv473518 CNV novel sequence insertion 20440878
nsv525286 CNV loss 19592680
nsv571463 CNV loss 21841781

Variation tolerance for CPPED1 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.52; 91.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPPED1 Gene

Human Gene Mutation Database (HGMD)
CPPED1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPPED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPPED1 Gene

Disorders for CPPED1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPPED1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trichostrongylosis
  • infection by trichostrongylus
trichostrongyloidiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CPPED1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CPPED1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPPED1 Gene

Publications for CPPED1 Gene

  1. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. (PMID: 23939394) Vaittinen M … Pulkkinen L (Diabetes 2013) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases? (PMID: 18771593) Hadler KS … Flanagan JU (BMC research notes 2008) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Expression of CPPED1 in human trophoblasts is associated with timing of term birth. (PMID: 29193784) Haapalainen AM … Rämet M (Journal of cellular and molecular medicine 2018) 3

ExternalLinks

View latest publications for CPPED1 gene in Mastermind

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