The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provid... See more...

Aliases for CPOX Gene

Aliases for CPOX Gene

  • Coproporphyrinogen Oxidase 2 3 5
  • CPX 2 3 4
  • Oxygen-Dependent Coproporphyrinogen-III Oxidase, Mitochondrial 3 4
  • Homozygous Coproporphyria 2 3
  • Coproporphyrinogenase 3 4
  • Coprogen Oxidase 3 4
  • EC 1.3.3.3 4 50
  • COX 3 4
  • CPO 3 4
  • HCP 2 3
  • Coproporphyrinogen Oxidase (Coproporphyria, Harderoporphyria) 2
  • Coproporphyria 2
  • HARPO 3
  • CPOX 5

External Ids for CPOX Gene

Previous HGNC Symbols for CPOX Gene

  • CPO

Previous GeneCards Identifiers for CPOX Gene

  • GC03M099619
  • GC03M099780
  • GC03M098298
  • GC03M095670
  • GC03M098239
  • GC03M098521

Summaries for CPOX Gene

Entrez Gene Summary for CPOX Gene

  • The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]

GeneCards Summary for CPOX Gene

CPOX (Coproporphyrinogen Oxidase) is a Protein Coding gene. Diseases associated with CPOX include Coproporphyria, Hereditary and Harderoporphyria. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is ENSG00000285635.

UniProtKB/Swiss-Prot Summary for CPOX Gene

  • Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

Gene Wiki entry for CPOX Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPOX Gene

Genomics for CPOX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CPOX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPOX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPOX

Top Transcription factor binding sites by QIAGEN in the CPOX gene promoter:
  • AREB6
  • c-Myc
  • FOXI1
  • GATA-3
  • HEN1
  • HFH-3
  • Max
  • Msx-1
  • Pax-4a
  • YY1

Genomic Locations for CPOX Gene

Latest Assembly
chr3:98,569,837-98,593,684
(GRCh38/hg38)
Size:
23,848 bases
Orientation:
Minus strand

Previous Assembly
chr3:98,298,290-98,312,455
(GRCh37/hg19 by Entrez Gene)
Size:
14,166 bases
Orientation:
Minus strand

chr3:98,239,976-98,312,567
(GRCh37/hg19 by Ensembl)
Size:
72,592 bases
Orientation:
Minus strand

Genomic View for CPOX Gene

Genes around CPOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPOX Gene

Proteins for CPOX Gene

  • Protein details for CPOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36551-HEM6_HUMAN
    Recommended name:
    Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
    Protein Accession:
    P36551
    Secondary Accessions:
    • A8K275
    • B4DSD5
    • Q14060
    • Q53F08
    • Q8IZ45
    • Q96AF3

    Protein attributes for CPOX Gene

    Size:
    454 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAA04033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPOX Gene

    Alternative splice isoforms for CPOX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPOX Gene

Selected DME Specific Peptides for CPOX Gene

P36551:
  • KKWCDDYF
  • RRGRYVE
  • GGIFFDD
  • VFEKAGV
  • RGIGGIF
  • EDAVHFH
  • HFNYRYFE
  • RYVEFNL
  • ARWEYMH
  • WCDDYFF

Post-translational modifications for CPOX Gene

  • Ubiquitination at Lys184
  • Modification sites at PhosphoSitePlus

Other Protein References for CPOX Gene

Antibodies for research

  • Boster Bio Antibodies for CPOX
  • Santa Cruz Biotechnology (SCBT) Antibodies for CPOX

Domains & Families for CPOX Gene

Gene Families for CPOX Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for CPOX Gene

InterPro:
Blocks:
  • Coproporphyrinogen III oxidase

Suggested Antigen Peptide Sequences for CPOX Gene

GenScript: Design optimal peptide antigens:
  • Coproporphyrinogen-III oxidase, mitochondrial (HEM6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36551

UniProtKB/Swiss-Prot:

HEM6_HUMAN :
  • Belongs to the aerobic coproporphyrinogen-III oxidase family.
Family:
  • Belongs to the aerobic coproporphyrinogen-III oxidase family.
genes like me logo Genes that share domains with CPOX: view

Function for CPOX Gene

Molecular function for CPOX Gene

UniProtKB/Swiss-Prot Function:
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX; Xref=Rhea:RHEA:18257, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:57307, ChEBI:CHEBI:57309; EC=1.3.3.3;.

Enzyme Numbers (IUBMB) for CPOX Gene

Phenotypes From GWAS Catalog for CPOX Gene

Gene Ontology (GO) - Molecular Function for CPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004109 coproporphyrinogen oxidase activity IEA,IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IDA 16176984
genes like me logo Genes that share ontologies with CPOX: view
genes like me logo Genes that share phenotypes with CPOX: view

Human Phenotype Ontology for CPOX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPOX

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPOX Gene

Localization for CPOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPOX Gene

Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPOX gene
Compartment Confidence
mitochondrion 5
cytosol 5
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion TAS,IDA --
GO:0005758 mitochondrial intermembrane space TAS --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CPOX: view

Pathways & Interactions for CPOX Gene

genes like me logo Genes that share pathways with CPOX: view

Pathways by source for CPOX Gene

UniProtKB/Swiss-Prot P36551-HEM6_HUMAN

  • Pathway: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

Interacting Proteins for CPOX Gene

Gene Ontology (GO) - Biological Process for CPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006779 porphyrin-containing compound biosynthetic process IEA --
GO:0006782 protoporphyrinogen IX biosynthetic process IBA,IEA --
GO:0006783 heme biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CPOX: view

No data available for SIGNOR curated interactions for CPOX Gene

Drugs & Compounds for CPOX Gene

(37) Drugs for CPOX Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
givosiran Approved, Investigational Pharma 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Water Approved Pharma 0
Protoporphyrin IX Experimental Pharma 25

(36) Additional Compounds for CPOX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Coproporphyrin III
  • 3,8,13,17-Tetramethylporphyrin-2,7,12,18-tetrapropanoic acid
  • 3,8,13,17-Tetramethylporphyrin-2,7,12,18-tetrapropanoate
14643-66-4
Formyl-CoA
  • Formyl coenzyme A
  • Formyl-coenzyme A
13131-49-2
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton
Protoporphyrinogen IX
  • 7,12-Diethenyl-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-dipropanoic acid
  • 7,12-Diethenyl-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-dipropanoate
  • 5,10,15,20,22,24-Hexahydro protoporphyrin IX deriv.
  • 7,12-Diethenyl-5,10,15,20,22,24-hexahydro-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoate
  • 7,12-Diethenyl-5,10,15,20,22,24-hexahydro-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid
7412-77-3
genes like me logo Genes that share compounds with CPOX: view

Transcripts for CPOX Gene

mRNA/cDNA for CPOX Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPOX

Alternative Splicing Database (ASD) splice patterns (SP) for CPOX Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for CPOX Gene

GeneLoc Exon Structure for
CPOX

Expression for CPOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPOX Gene

This gene is overexpressed in Bone (13.7), Peripheral blood mononuclear cells (10.0), and Fetal Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPOX Gene



Protein tissue co-expression partners for CPOX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPOX

SOURCE GeneReport for Unigene cluster for CPOX Gene:

Hs.476982

Evidence on tissue expression from TISSUES for CPOX Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Blood(2.5)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CPOX Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • mouth
Thorax:
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • rectum
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with CPOX: view

Primer products for research

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CPOX Gene

Orthologs for CPOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPOX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CPOX 29 30
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CPOX 30
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CPOX 29 30
  • 87.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cpox 29
  • 83.94 (n)
Mouse
(Mus musculus)
Mammalia Cpox 29 16 30
  • 83.41 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CPOX 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CPOX 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CPOX 29 30
  • 73.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CPOX 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cpox 29
  • 69.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii cpox 29 30
  • 66.76 (n)
OneToOne
-- 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10575 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004749 29
  • 61.21 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Coprox 29 30
  • 60.2 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR030C 29
  • 55.08 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HEM13 29 30
  • 54.97 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F18546g 29
  • 54.21 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LIN2 29
  • 52.7 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10363 29
Rice
(Oryza sativa)
Liliopsida Os04g0610800 29
  • 60.7 (n)
Os.17919 29
Barley
(Hordeum vulgare)
Liliopsida Hv.138 29
Wheat
(Triticum aestivum)
Liliopsida Ta.2884 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 58 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hem13 29
  • 56 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01546 29
  • 54.85 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1210 29
Species where no ortholog for CPOX was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Worm (Caenorhabditis elegans)

Evolution for CPOX Gene

ENSEMBL:
Gene Tree for CPOX (if available)
TreeFam:
Gene Tree for CPOX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPOX: view image
Alliance of Genome Resources:
Additional Orthologs for CPOX

Paralogs for CPOX Gene

Paralogs for CPOX Gene

genes like me logo Genes that share paralogs with CPOX: view

Variants for CPOX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPOX Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
1005602 Uncertain Significance: not provided 98,593,276(-) C/T
NM_000097.7(CPOX):c.229G>A (p.Gly77Arg)
MISSENSE
1016515 Uncertain Significance: not provided 98,590,646(-) A/C
NM_000097.7(CPOX):c.797T>G (p.Val266Gly)
MISSENSE
1030594 Uncertain Significance: Hereditary coproporphyria 98,585,442(-) G/A
NM_000097.7(CPOX):c.1171C>T (p.Arg391Trp)
MISSENSE
1036601 Uncertain Significance: not provided 98,593,233(-) G/A
NM_000097.7(CPOX):c.272C>T (p.Ala91Val)
MISSENSE
1036864 Uncertain Significance: not provided 98,580,736(-) T/C
NM_000097.7(CPOX):c.1312A>G (p.Lys438Glu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CPOX Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CPOX Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
dgv4819n100 CNV gain 25217958
nsv591065 CNV gain 21841781
nsv834775 CNV gain 17160897

Variation tolerance for CPOX Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.67; 93.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPOX Gene

Human Gene Mutation Database (HGMD)
CPOX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPOX
Leiden Open Variation Database (LOVD)
CPOX

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPOX Gene

Disorders for CPOX Gene

MalaCards: The human disease database

(16) MalaCards diseases for CPOX Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
coproporphyria, hereditary
  • hcp
harderoporphyria
  • harpo
porphyria
  • disorder of porphyrin and hem metabolism
acute porphyria
  • hepatic porphyria
porphyria cutanea tarda
  • pct
- elite association - COSMIC cancer census association via MalaCards
Search CPOX in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HEM6_HUMAN
  • Hereditary coproporphyria (HCP) [MIM:121300]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Hereditary coproporphyria is an acute hepatic porphyria characterized by skin photosensitivity, attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors. Hereditary coproporphyria is biochemically characterized by overexcretion of coproporphyrin III in the urine and in the feces. {ECO:0000269 PubMed:12181641, ECO:0000269 PubMed:15896662, ECO:0000269 PubMed:16398658, ECO:0000269 PubMed:7757079, ECO:0000269 PubMed:7849704, ECO:0000269 PubMed:8012360, ECO:0000269 PubMed:8990017, ECO:0000269 PubMed:9048920, ECO:0000269 PubMed:9298818, ECO:0000269 PubMed:9888388}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for CPOX

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CPOX: view

No data available for Genatlas for CPOX Gene

Publications for CPOX Gene

  1. Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase. (PMID: 8159699) Martasek P … Grandchamp B (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 72
  2. The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. (PMID: 16343843) Echeverria D … Garabedian CE (Neurotoxicology and teratology 2006) 3 22 40
  3. Structural basis of hereditary coproporphyria. (PMID: 16176984) Lee DS … Raman CS (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22
  4. The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria. (PMID: 12862310) Susa S … Kato T (The Tohoku journal of experimental medicine 2003) 3 4 22
  5. Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria. (PMID: 12181641) Wiman A … Harper P (Journal of human genetics 2002) 3 4 22

Products for CPOX Gene

Sources for CPOX Gene