Aliases for CPOX Gene
External Ids for CPOX Gene
Previous HGNC Symbols for CPOX Gene
Previous GeneCards Identifiers for CPOX Gene
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]
GeneCards Summary for CPOX Gene
CPOX (Coproporphyrinogen Oxidase) is a Protein Coding gene. Diseases associated with CPOX include Coproporphyria, Hereditary and Harderoporphyria. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is ENSG00000285635.
UniProtKB/Swiss-Prot Summary for CPOX Gene
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.