This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011] See more...

Aliases for CPO Gene

Aliases for CPO Gene

  • Carboxypeptidase O 2 3 4 5
  • Metallocarboxypeptidase C 2 3
  • Metallocarboxypeptidase O 2 3
  • EC 3.4.17.- 4
  • EC 3.4.17 52

External Ids for CPO Gene

Previous GeneCards Identifiers for CPO Gene

  • GC03M094920
  • GC03M097601
  • GC03M099579
  • GC02P208007
  • GC02P208008
  • GC02P207629
  • GC02P207512
  • GC02P207804
  • GC02P199655
  • GC02P206939

Summaries for CPO Gene

Entrez Gene Summary for CPO Gene

  • This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]

GeneCards Summary for CPO Gene

CPO (Carboxypeptidase O) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPB1.

UniProtKB/Swiss-Prot Summary for CPO Gene

  • Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

Additional gene information for CPO Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPO Gene

Genomics for CPO Gene

GeneHancer (GH) Regulatory Elements for CPO Gene

Promoters and enhancers for CPO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J206810 Promoter 0.3 EPDnew 500.2 -69.3 -69276 0.1 piR-37432-063 piR-37656-140 piR-56399-029 CPO KY945933 ENSG00000229321
GH02J206939 Promoter 0.3 EPDnew 500.2 +60.1 60116 0.1 CPO piR-32325-087 piR-32810-057 lnc-KLF7-2
GH02J206788 Promoter 0.3 EPDnew 500.2 -90.5 -90497 0.1 lnc-MDH1B-4 lnc-MDH1B-5 CPO FASTKD2 MDH1B DYTN ENSG00000229321
GH02J206914 Enhancer 0.8 Ensembl ENCODE 12.2 +36.0 35950 1.1 TCF12 FOS CREB1 FOSL2 SPI1 FOSL1 GATA2 BHLHE40 TCF7L2 JUND CPO piR-52368-077 piR-32810-057 lnc-KLF7-2 ENSG00000229321
GH02J206981 Enhancer 0.8 Ensembl ENCODE 11.3 +103.9 103918 4.2 EP300 CTCF REST RAD21 MXI1 SMC3 MAFF NR3C1 GATA3 ZNF654 CPO MIR2355 MIR1302-4 piR-50443-226 piR-32461-093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPO on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPO

Top Transcription factor binding sites by QIAGEN in the CPO gene promoter:
  • AML1a
  • C/EBPalpha
  • GATA-1
  • LCR-F1
  • NF-E2
  • NF-E2 p45
  • Nkx6-1
  • p53
  • RelA

Genomic Locations for CPO Gene

Genomic Locations for CPO Gene
chr2:206,879,383-206,971,064
(GRCh38/hg38)
Size:
91,682 bases
Orientation:
Plus strand
chr2:207,804,278-207,834,198
(GRCh37/hg19)
Size:
29,921 bases
Orientation:
Plus strand

Genomic View for CPO Gene

Genes around CPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPO Gene

Proteins for CPO Gene

  • Protein details for CPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVL8-CBPO_HUMAN
    Recommended name:
    Carboxypeptidase O
    Protein Accession:
    Q8IVL8
    Secondary Accessions:
    • Q2M277
    • Q7RTW7

    Protein attributes for CPO Gene

    Size:
    374 amino acids
    Molecular mass:
    42529 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPO Gene

neXtProt entry for CPO Gene

Selected DME Specific Peptides for CPO Gene

Q8IVL8:
  • AFCQWFV
  • GTDLNRNF
  • GIHAREW

Post-translational modifications for CPO Gene

Other Protein References for CPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPO Gene

Gene Families for CPO Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CPO Gene

Blocks:
  • Zinc carboxypeptidase A metalloprotease (M14)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPO Gene

GenScript: Design optimal peptide antigens:
  • Carboxypeptidase O (CBPO_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVL8

UniProtKB/Swiss-Prot:

CBPO_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPO: view

Function for CPO Gene

Molecular function for CPO Gene

UniProtKB/Swiss-Prot Function:
Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by potato carboxypeptidase inhibitor, and the chelating agents EDTA and 1,10-phenanthroline. Also inhibited by compounds with multiple carboxylic acid groups such as citrate and succinate, and to a lesser exent the amino acids aspartate and glutamate. Not significantly inhibited by benzylsuccinic acid.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=325 uM for 3-(2-furyl)acryloyl-Glu-Glu (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=284 uM for 3-(2-furyl)acryloyl-Phe-Phe (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=549 uM for 3-(2-furyl)acryloyl-Phe-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=614 uM for 3-(2-furyl)acryloyl-Lys-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028};
GENATLAS Biochemistry:
coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth step of porphyrin biosynthesis

Enzyme Numbers (IUBMB) for CPO Gene

Phenotypes From GWAS Catalog for CPO Gene

Gene Ontology (GO) - Molecular Function for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IDA 21921028
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPO: view
genes like me logo Genes that share phenotypes with CPO: view

Animal Model Products

CRISPR Products

miRNA for CPO Gene

miRTarBase miRNAs that target CPO

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPO

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPO Gene

Localization for CPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPO Gene

Apical cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPO gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytoskeleton 0
nucleus 0

Gene Ontology (GO) - Cellular Components for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CPO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPO Gene

Pathways & Interactions for CPO Gene

PathCards logo

SuperPathways for CPO Gene

No Data Available

Interacting Proteins for CPO Gene

;

Gene Ontology (GO) - Biological Process for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA 21873635
genes like me logo Genes that share ontologies with CPO: view

No data available for Pathways by source and SIGNOR curated interactions for CPO Gene

Drugs & Compounds for CPO Gene

(2) Drugs for CPO Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic acid Approved, Investigational Pharma Target 11
propanoic acid Approved, Vet_approved Pharma Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with CPO: view

Transcripts for CPO Gene

mRNA/cDNA for CPO Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPO

Alternative Splicing Database (ASD) splice patterns (SP) for CPO Gene

No ASD Table

Relevant External Links for CPO Gene

GeneLoc Exon Structure for
CPO

Expression for CPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPO Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPO

SOURCE GeneReport for Unigene cluster for CPO Gene:

Hs.684103

mRNA Expression by UniProt/SwissProt for CPO Gene:

Q8IVL8-CBPO_HUMAN
Tissue specificity: Detected in enterocytes of the ileum.

Evidence on tissue expression from TISSUES for CPO Gene

  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CPO: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPO Gene

Orthologs for CPO Gene

This gene was present in the common ancestor of animals.

Orthologs for CPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPO 31 30
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CPO 31 30
  • 86.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CPO 31 30
  • 85.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPO 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPO 31 30
  • 66.1 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpo 30
  • 63.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100005630 30
  • 57.06 (n)
cpo 31
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Coprox 32
  • 59 (a)
CG14820 32 30
  • 50.23 (n)
CG3097 32
  • 40 (a)
CG7025 32
  • 39 (a)
CG4017 32
  • 38 (a)
CG18585 32
  • 38 (a)
CG3108 32
  • 37 (a)
CG2915 32
  • 36 (a)
CG17633 32
  • 36 (a)
CG18417 32
  • 35 (a)
CG8560 32
  • 35 (a)
CG8562 32
  • 34 (a)
CG8563 32
  • 34 (a)
CG4408 32
  • 33 (a)
CG12374 32
  • 32 (a)
CG18415 32
  • 31 (a)
CG15769 32
  • 30 (a)
CG8945 32
  • 29 (a)
CG8539 32
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea R11A5.7 32
  • 36 (a)
T06A4.3 32
  • 34 (a)
Y59C2A.1 32
  • 32 (a)
W01A8.6 32
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
ManyToMany
CSA.4459 31
  • 28 (a)
ManyToMany
Species where no ortholog for CPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPO Gene

ENSEMBL:
Gene Tree for CPO (if available)
TreeFam:
Gene Tree for CPO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPO: view image

Paralogs for CPO Gene

Paralogs for CPO Gene

(8) SIMAP similar genes for CPO Gene using alignment to 1 proteins:

  • CBPO_HUMAN
genes like me logo Genes that share paralogs with CPO: view

Variants for CPO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPO Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1001805 Likely Benign: Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency 206,794,807(+) A/G THREE_PRIME_UTR_VARIANT
rs10655467 Uncertain Significance: Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency 206,794,123(+) T/TAC THREE_PRIME_UTR_VARIANT
rs111441789 Likely Benign: Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency 206,793,276(+) A/AC THREE_PRIME_UTR_VARIANT
rs111954117 Likely Benign: Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency 206,793,017(+) G/A THREE_PRIME_UTR_VARIANT
rs114333222 Uncertain Significance: Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency 206,792,982(+) G/C THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for CPO Gene

Structural Variations from Database of Genomic Variants (DGV) for CPO Gene

Variant ID Type Subtype PubMed ID
esv275226 CNV gain+loss 21479260
nsv1011347 CNV gain 25217958

Variation tolerance for CPO Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.46; 96.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPO Gene

Disorders for CPO Gene

Genatlas disease for CPO Gene

coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurological disturbances with an overproduction of coproporphyrin,including harderoporphyria

Additional Disease Information for CPO

genes like me logo Genes that share disorders with CPO: view

No data available for MalaCards and UniProtKB/Swiss-Prot for CPO Gene

Publications for CPO Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S … Fricker LD (The Journal of biological chemistry 2002) 2 3 4 54
  2. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. (PMID: 21921028) Lyons PJ … Fricker LD (The Journal of biological chemistry 2011) 3 4 54
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. (PMID: 29636417) Garcia-Guerrero MC … Reverter D (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54

Products for CPO Gene

Sources for CPO Gene