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Aliases for CPO Gene

Aliases for CPO Gene

  • Carboxypeptidase O 2 3 5
  • Metallocarboxypeptidase O 2
  • Metallocarboxypeptidase C 2
  • EC 3.4.17.- 4
  • EC 3.4.17 56

External Ids for CPO Gene

Previous GeneCards Identifiers for CPO Gene

  • GC03M094920
  • GC03M097601
  • GC03M099579
  • GC02P208007
  • GC02P208008
  • GC02P207629
  • GC02P207512
  • GC02P207804
  • GC02P199655

Summaries for CPO Gene

Entrez Gene Summary for CPO Gene

  • This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]

GeneCards Summary for CPO Gene

CPO (Carboxypeptidase O) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPB1.

UniProtKB/Swiss-Prot for CPO Gene

  • Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

Additional gene information for CPO Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPO Gene

Genomics for CPO Gene

GeneHancer (GH) Regulatory Elements for CPO Gene

Promoters and enhancers for CPO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I206939 Promoter 0.5 EPDnew 550.2 +60.1 60116 0.1 CPO PIR53902
GH02I206914 Enhancer 0.7 Ensembl ENCODE 12.2 +36.0 35971 1 FOSL1 JUND MAX FOSL2 FOS SPI1 CPO PIR53902
GH02I206800 Enhancer 0.8 Ensembl ENCODE 10.2 -78.5 -78487 1 ELF3 CTCF ZNF654 TRIM22 REST BMI1 RAD21 SMC3 MDH1B DYTN CPO MIR3130-1 ENSG00000260171
GH02I207007 Enhancer 0.8 Ensembl ENCODE 10.2 +129.0 129016 2.5 SP1 CTCF ZBTB21 POLR2A JUN MAX NFE2 REST CPO MIR2355 PIR53902
GH02I206981 Enhancer 0.6 ENCODE 10.9 +102.5 102529 0.2 CTCF ZNF654 REST ZNF2 RAD21 POLR2A SMC3 ZNF143 RCOR1 CHD2 CPO PIR53902
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPO gene promoter:

Genomic Locations for CPO Gene

Genomic Locations for CPO Gene
91,682 bases
Plus strand

Genomic View for CPO Gene

Genes around CPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPO Gene

Proteins for CPO Gene

  • Protein details for CPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase O
    Protein Accession:
    Secondary Accessions:
    • Q2M277
    • Q7RTW7

    Protein attributes for CPO Gene

    374 amino acids
    Molecular mass:
    42529 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPO Gene

Selected DME Specific Peptides for CPO Gene


Post-translational modifications for CPO Gene

Other Protein References for CPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CPO Gene

Gene Families for CPO Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for CPO Gene

Suggested Antigen Peptide Sequences for CPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPO: view

Function for CPO Gene

Molecular function for CPO Gene

GENATLAS Biochemistry:
coproporphyrinogen oxidase,71-74kDa,catalyzing protoporphyrinogen formation,mitochondrial,catalyzing the sixth step of porphyrin biosynthesis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=325 uM for 3-(2-furyl)acryloyl-Glu-Glu (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=284 uM for 3-(2-furyl)acryloyl-Phe-Phe (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=549 uM for 3-(2-furyl)acryloyl-Phe-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028}; KM=614 uM for 3-(2-furyl)acryloyl-Lys-Ala (at pH 7.5) {ECO:0000269 PubMed:21921028};
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by potato carboxypeptidase inhibitor, and the chelating agents EDTA and 1,10-phenanthroline. Also inhibited by compounds with multiple carboxylic acid groups such as citrate and succinate, and to a lesser exent the amino acids aspartate and glutamate. Not significantly inhibited by benzylsuccinic acid.
UniProtKB/Swiss-Prot Function:
Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.

Enzyme Numbers (IUBMB) for CPO Gene

Phenotypes From GWAS Catalog for CPO Gene

Gene Ontology (GO) - Molecular Function for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IDA 21921028
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPO: view
genes like me logo Genes that share phenotypes with CPO: view

Animal Model Products

CRISPR Products

miRNA for CPO Gene

miRTarBase miRNAs that target CPO

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPO Gene

Localization for CPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPO Gene

Apical cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPO gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CPO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPO Gene

Pathways & Interactions for CPO Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPO: view

No data available for Pathways by source and SIGNOR curated interactions for CPO Gene

Drugs & Compounds for CPO Gene

No Compound Related Data Available

Transcripts for CPO Gene

mRNA/cDNA for CPO Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPO Gene

Carboxypeptidase O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPO Gene

No ASD Table

Relevant External Links for CPO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPO Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.4).

NURSA nuclear receptor signaling pathways regulating expression of CPO Gene:


SOURCE GeneReport for Unigene cluster for CPO Gene:


mRNA Expression by UniProt/SwissProt for CPO Gene:

Tissue specificity: Detected in enterocytes of the ileum.
genes like me logo Genes that share expression patterns with CPO: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPO Gene

Orthologs for CPO Gene

This gene was present in the common ancestor of animals.

Orthologs for CPO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPO 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia CPO 33 34
  • 86.52 (n)
(Bos Taurus)
Mammalia CPO 33 34
  • 85.74 (n)
(Monodelphis domestica)
Mammalia CPO 34
  • 69 (a)
(Gallus gallus)
Aves CPO 33 34
  • 66.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpo 33
  • 63.28 (n)
(Danio rerio)
Actinopterygii LOC100005630 33
  • 57.06 (n)
cpo 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Coprox 35
  • 59 (a)
CG14820 35 33
  • 50.23 (n)
CG3097 35
  • 40 (a)
CG7025 35
  • 39 (a)
CG18585 35
  • 38 (a)
CG4017 35
  • 38 (a)
CG3108 35
  • 37 (a)
CG17633 35
  • 36 (a)
CG2915 35
  • 36 (a)
CG18417 35
  • 35 (a)
CG8560 35
  • 35 (a)
CG8562 35
  • 34 (a)
CG8563 35
  • 34 (a)
CG4408 35
  • 33 (a)
CG12374 35
  • 32 (a)
CG18415 35
  • 31 (a)
CG15769 35
  • 30 (a)
CG8539 35
  • 29 (a)
CG8945 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea R11A5.7 35
  • 36 (a)
T06A4.3 35
  • 34 (a)
Y59C2A.1 35
  • 32 (a)
W01A8.6 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
CSA.4459 34
  • 28 (a)
Species where no ortholog for CPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPO Gene

Gene Tree for CPO (if available)
Gene Tree for CPO (if available)

Paralogs for CPO Gene

Paralogs for CPO Gene

(8) SIMAP similar genes for CPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPO: view

Variants for CPO Gene

Sequence variations from dbSNP and Humsavar for CPO Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs896000260 A colorectal cancer sample 206,968,304(+) G/T coding_sequence_variant, missense_variant
rs1000025355 -- 206,969,945(+) G/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000190743 -- 206,930,997(+) T/C upstream_transcript_variant
rs1000230162 -- 206,951,678(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPO Gene

Variant ID Type Subtype PubMed ID
esv275226 CNV gain+loss 21479260
nsv1011347 CNV gain 25217958

Variation tolerance for CPO Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.46; 96.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPO Gene

Disorders for CPO Gene

Genatlas disease for CPO Gene

coproporphyria,hereditary acute hepatic porphyria characterized by cutaneous photosensibility and neurological disturbances with an overproduction of coproporphyrin,including harderoporphyria

Additional Disease Information for CPO

genes like me logo Genes that share disorders with CPO: view

No data available for MalaCards and UniProtKB/Swiss-Prot for CPO Gene

Publications for CPO Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S … Fricker LD (The Journal of biological chemistry 2002) 2 3 4 58
  2. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity. (PMID: 21921028) Lyons PJ … Fricker LD (The Journal of biological chemistry 2011) 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58

Products for CPO Gene

Sources for CPO Gene

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